KEGG ORTHOLOGY: K13369

ORTHOLOGY: K13369

Entry

K13369                      KO

Symbol

HSD17B6

Name

17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]

Pathway

map00140

Steroid hormone biosynthesis

map00830

Retinol metabolism

map01100

Metabolic pathways

map01240

Biosynthesis of cofactors

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
    1.1.1.105  all-trans-retinol dehydrogenase (NAD+)
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

Other DBs

RN:	R01836 R02124 R02352 R02353 R04681 R04682 R08945 R08980

GO:	0004303 0004745 0050327

Genes

HSA:	8630(HSD17B6)

PTR:

452001

PPS:	100996145(HSD17B6)

GGO:

101153072

PON:	100454653 100458219(HSD17B6)

NLE:

100606923

HMH:

116480891

MCC:	713549(HSD17B6)

MCF:	101926544(HSD17B6)

MTHB:

126930391

MNI:	105474127(HSD17B6)

CSAB:

103238543(HSD17B6)

CATY:

105587281(HSD17B6)

TGE:

112634424

MLEU:

105545551(HSD17B6)

RRO:	104673659(HSD17B6)

RBB:	108516069(HSD17B6)

TFN:	117089914(HSD17B6)

PTEH:

111541833(HSD17B6)

CANG:

105500532(HSD17B6)

CJC:	100387390(HSD17B6)

SBQ:	101054253(HSD17B6)

CIMI:

108309703(HSD17B6)

CSYR:

103275150(HSD17B6) 103275152

MMUR:

105865568

LCAT:

123639631 123639632(HSD17B6)

PCOQ:

105816028

OGA:

100947460

MMU:	27400(Hsd17b6)

MCAL:

110303948

MPAH:

110326955(Hsd17b6)

RNO:	286964(Hsd17b6)

MCOC:

116076149

ANU:

117696662

CGE:

100762147

PROB:

127215652(Hsd17b6)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103730224(Hsd17b6)

HGL:	101699287(Hsd17b6)

CPOC:

100717492 100717768 100718054

CCAN:

109686095

DORD:

105986857(Hsd17b6)

DSP:	122124416(Hsd17b6)

PLOP:

125362512(Hsd17b6)

TUP:	102485005(HSD17B6)

CFA:	481118(HSD17B6)

CLUD:

112678001(HSD17B6)

VVP:	112922366(HSD17B6)

VLG:	121491966(HSD17B6)

NPO:

129511964

AML:

100474694

UMR:	103656323(HSD17B6)

UAH:	113256406(HSD17B6)

UAR:	123787236(HSD17B6)

ELK:

111160200

LLV:

125106172

MPUF:

101672306(HSD17B6)

NVS:	122892252(HSD17B6)

ORO:	101368715(HSD17B6)

EJU:	114215053(HSD17B6)

ZCA:	113921488(HSD17B6)

MLX:

118008692

NSU:

110577830

LWW:	102743313(HSD17B6)

FCA:	101088341(HSD17B6)

PYU:	121040906(HSD17B6)

PCOO:

112863243(HSD17B6)

PBG:	122473787(HSD17B6)

LRUF:

124502205

PTG:	102971783(HSD17B6)

PPAD:

109270351(HSD17B6)

PUC:

125920256

AJU:

106986922

HHV:	120224864(HSD17B6)

BTA:	533086(HSD17B6)

BOM:	102283510(HSD17B6)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:	102527912 102534817 107034922

BACU:

103008169(HSD17B6)

LVE:	103076064(HSD17B6)

OOR:	101278484(HSD17B6)

DLE:	111173857(HSD17B6)

PCAD:

102988625

PSIU:

116761374

NASI:

112393956(HSD17B6)

ECB:

100052840

EPZ:	103565330(HSD17B6)

EAI:	106832977(HSD17B6)

MMF:

118623751

RFQ:

117028833

PALE:

102883634(HSD17B6)

PGIG:

120604931

PVP:

105302561

RAY:	107521200(HSD17B6)

MJV:

LAV:

TMU:

SHR:

AFZ:

PCW:

AROW:

NPD:

DNE:

ASN:	102370921 102371169

AMJ:

102567845

CPOO:

109324411 109324469

PSS:	102444001 102454079

CMY:

102944543

CCAY:

125627856

DCC:	119845913(HSD17B6)

CPIC:

103306704

TST:	117888588(HSD17B6)

CABI:

116827724

MRV:

120391156

ACS:	100564174(hsd17b6)

PVT:	110071325 110091362

SUND:

PBI:

PMUR:

CTIG:

TSR:	106545328(HSD17B6)

PGUT:

117662721

APRI:

131192991 131193302(HSD17B6)

PTEX:

113445491 113445552

NSS:	113422732 113422749

PMUA:

114592701 114592979 114592981

PRAF:

128405337 128405345 128405364 128405369 128405390

ZVI:	118077226(HSD17B6)

HCG:	128339160 128339162 128344041 128345225 128345226 128346238 128346556 128346634

GJA:	107120904(HSD17B6)

STOW:

125430225 125430298 125430340

EMC:	129328144 129346101 129346224

XTR:

GSH:

DSV:

RMP:

LOA:	LOAG_08821

LGI:	LOTGIDRAFT_141736

PCAN:

112563790 112563794 112563795

BGT:

106069124

HRJ:

124278165

CRG:

105342862

CVN:	111111885 111114621

CANU:

128162079

MYI:	110451842 110466177

PMAX:

117316732 117316733 117316734 117318303

MCAF:

127719989

MMER:

123531644 123531645 123532231

DPOL:

127855977

OBI:

106873408

HSY:

130655463

TAD:	TRIADDRAFT_22801

» show all

Reference

PMID:9188497

Authors

Biswas MG, Russell DW

Title

Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate.

Journal

J Biol Chem 272:15959-66 (1997)
DOI:10.1074/jbc.272.25.15959

Sequence

[hsa:8630] [rno:286964]

Reference

PMID:11360992

Authors

Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY

Title

Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase.

Journal

Arch Biochem Biophys 386:1-10 (2001)
DOI:10.1006/abbi.2000.2203

Sequence

[hsa:8630]

All links

Ontology (5)   
   KEGG BRITE (2)   
   GO (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (14)   
   KEGG ENZYME (3)   
   KEGG REACTION (8)   
   KEGG RCLASS (3)   
Gene (228)   
   KEGG GENES (207)   
   RefGene (19)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (257)   

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