KEGG ORTHOLOGY: K13534

ORTHOLOGY: K13534

Entry

K13534                      KO

Symbol

PNPLA3

Name

patatin-like phospholipase domain-containing protein 3 [EC:3.1.1.3 2.3.1.-]

Pathway

map00561

Glycerolipid metabolism

map01100

Metabolic pathways

Module

M00098

Acylglycerol degradation

Reaction

R02250

triacylglycerol acylhydrolase

R02687

1,2-diacyl-sn-glycerol acylhydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K13534  PNPLA3; patatin-like phospholipase domain-containing protein 3
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.3  triacylglycerol lipase
     K13534  PNPLA3; patatin-like phospholipase domain-containing protein 3

Other DBs

GO:

0004806

Genes

HSA:	80339(PNPLA3)

PTR:	107970265(PNPLA3)

PPS:	100986741(PNPLA3)

GGO:	101131854(PNPLA3)

PON:	100441666(PNPLA3)

NLE:	100586704(PNPLA3)

HMH:	116458897(PNPLA3)

MCC:	712340(PNPLA3)

MCF:	102120325(PNPLA3)

MTHB:

126963601

MNI:	105464541(PNPLA3)

CSAB:

103223452(PNPLA3)

CATY:

105598304(PNPLA3)

PANU:

100998885(PNPLA3)

TGE:	112633807(PNPLA3)

MLEU:

105542486(PNPLA3)

RRO:	104667397(PNPLA3)

RBB:	108513994(PNPLA3)

TFN:	117096352(PNPLA3)

PTEH:

111549125(PNPLA3)

CANG:

105506596(PNPLA3)

CJC:	100406659(PNPLA3)

SBQ:	101045702(PNPLA3)

CIMI:

108305011(PNPLA3)

CSYR:

103254929(PNPLA3)

MMUR:

105867509

LCAT:

123639236(PNPLA3)

PCOQ:

105826283(PNPLA3)

OGA:	100944146(PNPLA3)

MMU:	116939(Pnpla3)

MCAL:

110310684(Pnpla3)

MPAH:

110335319(Pnpla3)

RNO:	362972(Pnpla3)

MCOC:

116077053(Pnpla3)

ANU:	117718952(Pnpla3)

MUN:	110545027(Pnpla3)

CGE:	100768979(Pnpla3)

MAUA:

101824852(Pnpla3)

PROB:

127225890(Pnpla3)

PLEU:

114682758(Pnpla3)

MORG:

121461275(Pnpla3)

MFOT:

126493369

AAMP:

119822942(Pnpla3)

NGI:	103743433(Pnpla3)

CPOC:

100723270(Pnpla3)

CCAN:

109693120(Pnpla3)

DORD:

105992723(Pnpla3)

DSP:	122123621(Pnpla3)

PLOP:

125357330(Pnpla3)

NCAR:

124982708

MMMA:

107155813(Pnpla3)

OCU:

100344884

OPI:	101530626(PNPLA3)

TUP:	102472692(PNPLA3)

GVR:	103597677(PNPLA3)

CFA:	609368(PNPLA3)

CLUD:

112666318(PNPLA3)

VVP:	112934000(PNPLA3)

VLG:	121490574(PNPLA3)

NPO:	129511508(PNPLA3)

AML:	100475489(PNPLA3)

UMR:	103674044(PNPLA3)

UAH:	113241673(PNPLA3)

UAR:	123780722(PNPLA3)

ELK:

111157584

LLV:

125106350

MPUF:

101685368(PNPLA3)

MNP:	132019138(PNPLA3)

MLK:	131839593(PNPLA3)

NVS:	122891928(PNPLA3)

ORO:	101370781(PNPLA3)

EJU:	114218479(PNPLA3)

ZCA:	113922026(PNPLA3)

MLX:	117998588(PNPLA3)

NSU:	110578275(PNPLA3)

LWW:	102731724(PNPLA3)

FCA:	101093621(PNPLA3)

PYU:	121040205(PNPLA3)

PCOO:

112863414(PNPLA3)

PBG:	122472875(PNPLA3)

PVIV:

125170050(PNPLA3)

LRUF:

124501032

PTG:	102956251(PNPLA3)

PPAD:

109265689(PNPLA3)

PUC:

125919681

AJU:

106967279

HHV:	120234936(PNPLA3)

BTA:	100297709 786474(PNPLA3)

BBUB:

112584429(PNPLA3) 123333147 123465659

BBIS:

104986905(PNPLA3)

CHX:	102169567(PNPLA3)

OAS:	101117659(PNPLA3)

BTAX:

128048271(PNPLA3)

ODA:	120858136(PNPLA3)

CCAD:

122423323(PNPLA3) 122423623

MBEZ:

129535850(PNPLA3)

SSC:	100049690(PNPLA3)

CFR:	102505167(PNPLA3)

CBAI:

105073038(PNPLA3)

CDK:	105091858(PNPLA3)

VPC:	102536665(PNPLA3)

BACU:

103016193(PNPLA3)

BMUS:

118902174(PNPLA3)

LVE:	103089344(PNPLA3)

OOR:	101278189(PNPLA3)

DLE:	111186449(PNPLA3)

PCAD:

102986399(PNPLA3)

PSIU:

116760905(PNPLA3)

NASI:

112394721(PNPLA3)

ECB:	100050604(PNPLA3)

EPZ:	103557941(PNPLA3)

EAI:	106845951(PNPLA3)

MYB:	102245670 102263864

MYD:	102766405(PNPLA3) 102770143 102774324

MMYO:

118648938 118649720 118650109 118650378(PNPLA3) 118650379 118650766

MLF:

102442459

PKL:	118708793 118708804

EFUS:

103298677 114229874

MNA:	107534850(PNPLA3)

DRO:	112321605(PNPLA3)

AJM:	119060531(PNPLA3)

PDIC:

114513948(PNPLA3)

PHAS:

123816274(PNPLA3)

MMF:	118618081 118623259 118623260

PPAM:

129077912(PNPLA3)

HAI:	109376426(PNPLA3)

RFQ:	117029263(PNPLA3)

PALE:

102881734(PNPLA3)

PGIG:

120602901(PNPLA3)

PVP:

105307461

RAY:	107505539(PNPLA3)

TOD:	119248174(PNPLA3)

SARA:

101556267(PNPLA3)

SETR:

126006241

LAV:	100674949(PNPLA3)

TMU:

101341242

ETF:	101639613(PNPLA3)

DNM:	101427399 101427837 101445469 101447589

MDO:	100013152(PNPLA3)

GAS:	123249359(PNPLA3)

SHR:	100934275(PNPLA3)

AFZ:

127538496

PCW:	110205893(PNPLA3)

OAA:	100078844 100078936

MGP:

ACS:

PVT:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PMUA:

ZVI:

GJA:

XLA:	108712532 447273(pnpla3.L)

XTR:	548410(pnpla3)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	436610(pnpla3)

SRX:	107726050 107743702

SANH:

107656255 107658728

SGH:	107580453 107592239

CCAR:

109112031

CAUA:

113048282 113058931

CGIB:

127956748 127977117 128013885

PTET:

122330997 122343232(pnpla3)

LROH:

127156734 127164601(pnpla3)

OMC:	131534181 131538932(pnpla3)

PPRM:

120476607(pnpla3)

RKG:	130079791(pnpla3) 130085172

MAMB:

125246259(pnpla3) 125247229

CIDE:

127507202 127511508

MASI:

127435257 127435650 127436898

TROS:

130547535(pnpla3) 130552214

TDW:	130413760 130420874(pnpla3)

MANU:

129431785(pnpla3) 129433891

IPU:	108279447(pnpla3)

IFU:	128611605 128623242(pnpla3)

PHYP:

113532140 113532141

SMEO:

124386313 124400801(pnpla3)

TFD:	113636090 113645504(pnpla3)

TVC:	132855786 132859391(pnpla3)

AMEX:

103023312

CMAO:

118812567(pnpla3)

EEE:

113583918

CHAR:

105890593(pnpla3) 105891509

TRU:

101063598

TFS:	130519387(pnpla3)

TNG:	GSTEN00013930G001

LCO:

104927298

NCC:

104964946

TBEN:

117483053(pnpla3)

CGOB:

115028656

PGEO:

117439009(pnpla3)

GACU:

117547135(pnpla3)

EMAC:

134879135(pnpla3)

ELY:	117249276(pnpla3)

EFO:	125883002(pnpla3)

PLEP:

121961313(pnpla3)

SLUC:

116042110(pnpla3)

ECRA:

117938929(pnpla3)

ESP:

116673144

PFLV:

114550248

GAT:	120817412(pnpla3)

PPUG:

119211004(pnpla3)

AFB:	129112599(pnpla3)

CLUM:

117726404(pnpla3)

PSWI:

130200688(pnpla3)

MSAM:

119893136 119893478 119918049(pnpla3)

SCHU:

122870906(pnpla3)

CUD:	121505659(pnpla3)

ALAT:

119032811(pnpla3)

MZE:

101486959

ONL:

100697802

OAU:	116316270(pnpla3)

OLA:

101164861

OML:	112140368(pnpla3)

CSAI:

133424280(pnpla3)

XMA:	102217980 111611837

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122826084(pnpla3)

PPRL:

129376029(pnpla3)

CVG:

107101622

CTUL:

119779326(pnpla3)

GMU:	124883202(pnpla3)

NFU:

107381587

KMR:	108228234(pnpla3)

ALIM:

106525901

NWH:	119428366(pnpla3)

AOCE:

111564028

MCEP:

125000196(pnpla3)

POV:

109637445

SSEN:

122767145(pnpla3)

HHIP:

117757665(pnpla3)

HSP:	118101290(pnpla3)

SMAU:

118289477(pnpla3)

LCF:	108897505(pnpla3)

SDU:

111224913

SLAL:

111664228

XGL:	120792810 120802040(pnpla3)

BPEC:

110166219

MALB:

109960900

BSPL:

114862610(pnpla3)

SJO:	128385330(pnpla3)

SASA:

106576159 106609320

STRU:

115180353 115180413 115198794

OTW:	112214297 112216898

OMY:	110490313 110490314 110500175 110500176

OGO:	123995629(pnpla3)

ONE:	115106995 115106996 115133126 115133727

OKI:	109864287 109887443 109896728 109896730

OKE:	118372257 118372261 118392372 118392564

SALP:

111951406 112067822

SNH:	120031825 120032052 120032320 120050029 120050030

CCLU:

121540821 121542556 121542557 121575707 121576065

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

121299722 121318463(pnpla3) 121319636

ARUT:

117415161 117419537 117429117 117962414

PSEX:

120534329(pnpla3)

RTP:

109912258

CPLA:

122559550(pnpla3)

HOC:	132824757(pnpla3) 132828267

LERI:

129706170(pnpla3)

PMRN:

LRJ:

BBEL:

XEN:

Reference

PMID:22560221

Authors

Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R

Title

Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.

Journal

Cell Metab 15:691-702 (2012)
DOI:10.1016/j.cmet.2012.04.008

Sequence

[hsa:80339]

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (4)   
Gene (406)   
   KEGG GENES (360)   
   KEGG MGENES (41)   
   RefGene (2)   
   OC (3)   
Literature (1)   
   PubMed (1)   
All databases (422)   

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