KEGG   ORTHOLOGY: K13538
Entry
K13538                      KO                                     
Symbol
CPA
Name
cysteine peptidase A [EC:3.4.22.-]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K13538  CPA; cysteine peptidase A
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.-
     K13538  CPA; cysteine peptidase A
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C1: papain family
   K13538  CPA; cysteine peptidase A
Genes
LMA: LMJF_19_1420(CPA)
LIF: LINJ_19_1460(CPA)
LDO: LDBPK_191460
LMI: LMXM_19_1420
LBZ: LBRM_19_1690(CPA)
Reference
PMID:1508041
  Authors
Mottram JC, Robertson CD, Coombs GH, Barry JD
  Title
A developmentally regulated cysteine proteinase gene of Leishmania mexicana.
  Journal
Mol Microbiol 6:1925-32 (1992)
DOI:10.1111/j.1365-2958.1992.tb01365.x
  Sequence

KEGG   ORTHOLOGY: K13537
Entry
K13537                      KO                                     
Symbol
CPB
Name
cysteine peptidase B [EC:3.4.22.-]
Pathway
map05140  Leishmaniasis
map05143  African trypanosomiasis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K13537  CPB; cysteine peptidase B
   05143 African trypanosomiasis
    K13537  CPB; cysteine peptidase B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K13537  CPB; cysteine peptidase B
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.-
     K13537  CPB; cysteine peptidase B
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C1: papain family
   K13537  CPB; cysteine peptidase B
Genes
BANY: 112054090
OFU: 114358007
TBR: Tb927.6.1000 Tb927.6.1010 Tb927.6.1020 Tb927.6.1030 Tb927.6.1040 Tb927.6.1050 Tb927.6.1060 Tb927.6.960 Tb927.6.970 Tb927.6.980 Tb927.6.990
LMA: LMJF_08_1010 LMJF_08_1020 LMJF_08_1030 LMJF_08_1040 LMJF_08_1050 LMJF_08_1060 LMJF_08_1070 LMJF_08_1080
LIF: LINJ_08_0950 LINJ_08_0960
LDO: LDBPK_080960
LMI: LmxM_08_1040_1
LBZ: LBRM_08_0810(CPB) LBRM_08_0820(CPB) LBRM_08_0830(CPB)
LPAN: LPMP_080870(CPB)
Reference
  Authors
Cameron P, McGachy A, Anderson M, Paul A, Coombs GH, Mottram JC, Alexander J, Plevin R
  Title
Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway.
  Journal
J Immunol 173:3297-304 (2004)
DOI:10.4049/jimmunol.173.5.3297
Reference
  Authors
Pollock KG, McNeil KS, Mottram JC, Lyons RE, Brewer JM, Scott P, Coombs GH, Alexander J
  Title
The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses.
  Journal
J Immunol 170:1746-53 (2003)
DOI:10.4049/jimmunol.170.4.1746

KEGG   ORTHOLOGY: K08572
Entry
K08572                      KO                                     
Symbol
CPC
Name
cysteine peptidase C [EC:3.4.22.-]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08572  CPC; cysteine peptidase C
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.-
     K08572  CPC; cysteine peptidase C
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C1: papain family
   K08572  CPC; cysteine peptidase C
Genes
TAES: 123147180
TBR: Tb927.6.560
TCR: 510535.100 511827.100
LMA: LMJF_29_0820
LIF: LINJ_29_0860
LDO: LDBPK_290860
LMI: LMXM_08_29_0820
LBZ: LBRM_29_0850
Reference
  Authors
Somanna A, Mundodi V, Gedamu L
  Title
Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta.
  Journal
J Biol Chem 277:25305-12 (2002)
DOI:10.1074/jbc.M203034200
  Sequence

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