KEGG   ORTHOLOGY: K13939
Entry
K13939                      KO                                     

Name
FOL1
Definition
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:4.1.2.25 2.7.6.3 2.5.1.15]
Pathway
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.15  dihydropteroate synthase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
  2.7  Transferring phosphorus-containing groups
   2.7.6  Diphosphotransferases
    2.7.6.3  2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.25  dihydroneopterin aldolase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
Other DBs
RN: R03066 R03067 R03503 R03504
COG: COG1539 COG0801 COG0294
GO: 0004150 0003848 0004156
Genes
SCE: YNL256W(FOL1)
AGO: AGOS_AFR647C
ERC: Ecym_1119
KLA: KLLA0_C02783g
KMX: KLMA_10126(FOL1)
LTH: KLTH0F02882g
VPO: Kpol_2000p42
ZRO: ZYRO0F16170g
CGR: CAGL0J07920g
NCS: NCAS_0A00710(NCAS0A00710)
NDI: NDAI_0F04090(NDAI0F04090)
TPF: TPHA_0B04280(TPHA0B04280)
TBL: TBLA_0A05660(TBLA0A05660)
TDL: TDEL_0C05970(TDEL0C05970)
KAF: KAFR_0D03830(KAFR0D03830)
ZMK: HG535_0A01220
PPA: PAS_chr2-2_0302
DHA: DEHA2E11704g
PIC: PICST_66087
PGU: PGUG_03380
SPAA: SPAPADRAFT_61089
LEL: LELG_03772
CAL: CAALFM_C500770CA(FOL1)
CTP: CTRG_05355
COT: CORT_0E05530
CDU: CD36_51690
CTEN: CANTEDRAFT_124080
YLI: YALI0A02541g
CLU: CLUG_03386
CLUS: A9F13_01g08085
CAUR: CJI97_001274
SLB: AWJ20_43(FOL1)
PKZ: C5L36_0B03380
BNN: FOA43_004472
BCOM: BAUCODRAFT_150674
TML: GSTUM_00011612001
SPO: SPBC1734.03
CNE: CNC04040
CNB: CNBC3140
CGI: CGB_C6150C
TMS: TREMEDRAFT_30738
TASA: A1Q1_04530
TVS: TRAVEDRAFT_52553
DSQ: DICSQDRAFT_94022
SHS: STEHIDRAFT_96629
HIR: HETIRDRAFT_65517
PSQ: PUNSTDRAFT_140849
ADL: AURDEDRAFT_181441
FME: FOMMEDRAFT_156900
GTR: GLOTRDRAFT_80794 GLOTRDRAFT_96055
MRR: Moror_15039
CCI: CC1G_15556
ABP: AGABI1DRAFT115300(AGABI1DRAFT_115300)
ABV: AGABI2DRAFT208226(AGABI2DRAFT_208226)
CPUT: CONPUDRAFT_166442
SLA: SERLADRAFT_414778
WIC: J056_003823
UMA: UMAG_05171
PFP: PFL1_03100
MRT: MRET_0826
MSYM: MSY001_3431
MLR: MELLADRAFT_94398
EHE: EHEL_050080
DDI: DDB_G0278283(fol1)
DPP: DICPUDRAFT_155477
DFA: DFA_08871(fol1)
 » show all
Reference
  Authors
Lawrence MC, Iliades P, Fernley RT, Berglez J, Pilling PA, Macreadie IG
  Title
The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae.
  Journal
J Mol Biol 348:655-70 (2005)
DOI:10.1016/j.jmb.2005.03.021
Reference
  Authors
Guldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH
  Title
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.
  Journal
Mol Biol Cell 15:3811-28 (2004)
DOI:10.1091/mbc.E03-09-0680
  Sequence
[sce:YNL256W]

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Ontology (8)   
   KEGG BRITE (2)   
   GO (3)   
   COG (3)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (13)   
   KEGG ENZYME (3)   
   KEGG REACTION (4)   
   KEGG RCLASS (6)   
Gene (78)   
   KEGG GENES (67)   
   KEGG MGENES (9)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (108)   

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