K14216                      KO                                     

2'-5'-oligoadenylate synthetase [EC:]
ko04621  NOD-like receptor signaling pathway
ko05160  Hepatitis C
ko05162  Measles
ko05164  Influenza A
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05171  Coronavirus disease - COVID-19
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K14216  OAS; 2'-5'-oligoadenylate synthetase
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K14216  OAS; 2'-5'-oligoadenylate synthetase
   05171 Coronavirus disease - COVID-19
    K14216  OAS; 2'-5'-oligoadenylate synthetase
   05164 Influenza A
    K14216  OAS; 2'-5'-oligoadenylate synthetase
   05162 Measles
    K14216  OAS; 2'-5'-oligoadenylate synthetase
   05168 Herpes simplex virus 1 infection
    K14216  OAS; 2'-5'-oligoadenylate synthetase
   05169 Epstein-Barr virus infection
    K14216  OAS; 2'-5'-oligoadenylate synthetase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases  2'-5' oligoadenylate synthase
     K14216  OAS; 2'-5'-oligoadenylate synthetase
Other DBs
RN: R10909 R10910
HSA: 4938(OAS1) 4939(OAS2) 4940(OAS3)
PTR: 452267(OAS3) 739129(OAS1) 739230(OAS2)
PPS: 100970211(OAS3) 100993699(OAS1) 103783986(OAS2)
GGO: 101128307(OAS1) 101128904(OAS2) 101129249(OAS3)
PON: 100172992(OAS1) 100443561(OAS3) 100444286(OAS2)
NLE: 100587554(OAS1) 100587890(OAS3) 100588209(OAS2)
MCC: 712265(OAS1) 712342(OAS3) 712401(OAS2)
MCF: 102131636(OAS1) 102132016(OAS3) 102132392(OAS2)
CSAB: 103239154(OAS1) 103239155(OAS3) 103239156(OAS2)
RRO: 104666641(OAS1) 104666642(OAS3) 104666645(OAS2)
RBB: 108540456(OAS3) 108540457(OAS1) 108540462(OAS2)
CJC: 100385368(OAS1) 100392459(OAS3) 103795420(OAS2)
SBQ: 101043239(OAS2) 101043563(OAS3) 101043879(OAS1)
MMU: 23960(Oas1g) 23961(Oas1b) 246727(Oas3) 246728(Oas2) 246730(Oas1a)
RNO: 100910735(Oas1g) 192281(Oas1a) 246268(Oas1b) 304507(Oas1i) 363938(Oas2) 494202(Oas3)
HGL: 101698818(Oas2) 101699903(Oas1)
OCU: 100340530(OAS3) 100340787(OAS2) 108178670(OAS1)
TUP: 102495865(OAS2) 106735200(OAS1)
CFA: 477490(OAS3) 608778(OAS1) 611051(OAS2)
VVP: 112935202(OAS1) 112935211(OAS3)
AML: 100468112(OAS2) 100469118(OAS1) 100469368(OAS3)
UMR: 103661196(OAS1) 103661197(OAS2) 103661290(OAS3)
UAH: 113266813(OAS3) 113266985
ORO: 101369458(OAS2) 101373749(OAS1) 101374040(OAS3)
FCA: 101087875(OAS1) 101088116(OAS3) 102902426(OAS2)
PTG: 102952232(OAS3) 107179395(OAS2)
PPAD: 109277626(OAS1) 109277795(OAS3)
BTA: 347699(OAS1X) 519922(OAS1Z) 529660(OAS2) 654488(OAS1Y)
CHX: 102186893(OAS2) 102190983
SSC: 397570(OAS1) 595128(OAS2)
CFR: 102524147(OAS1)
CDK: 105101979(OAS1)
LVE: 103087433(OAS1) 103087703(OAS2)
OOR: 101277868(OAS2) 101289192
DLE: 111162647
PCAD: 102995339(OAS2) 102995791(OAS1) 102996067
ECB: 100034147(OAS1) 791225(OAS3) 791250(OAS2)
EPZ: 103542327(OAS2) 103543308(OAS3) 103557130
EAI: 106842212 106842249(OAS1)
MYB: 102247108(OAS1) 102251057(OAS2) 102258838
MYD: 102756142(OAS3) 102756409(OAS2) 102759968(OAS1)
PALE: 102879074(OAS1) 102879322(OAS3) 102889470(OAS2)
RAY: 107513228 107513273(OAS1)
LAV: 100659469(OAS2) 104846792(OAS3) 104846793(OAS1)
MDO: 100028774(OAS3) 100028841 100028903(OAS1)
AMJ: 106737542(OAS1)
CMY: 102937233(OAS3)
CPIC: 101945210
ACS: 100562806(oas1)
PVT: 110082886
PBI: 103053194
TSR: 106554335
PMUA: 114586818
LCM: 102355743
CMK: 103184093
SKO: 102802564
FCD: 110850527
NVE: 5515274
 » show all
Benech P, Mory Y, Revel M, Chebath J
Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.
EMBO J 4:2249-56 (1985)
Marie I, Hovanessian AG
The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.
J Biol Chem 267:9933-9 (1992)
Ito M, Shichijo S, Tsuda N, Ochi M, Harashima N, Saito N, Itoh K
Molecular basis of T cell-mediated recognition of pancreatic cancer cells.
Cancer Res 61:2038-46 (2001)

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