KEGG   ORTHOLOGY: K14253
Entry
K14253                      KO                                     
Symbol
oxyE
Name
6-methylpretetramide 4-monooxygenase [EC:1.14.13.232]
Pathway
map00253  Tetracycline biosynthesis
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Reaction
R05463  6-methylpretetramide,NADPH:oxygen oxidoreductase (4-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14253  oxyE; 6-methylpretetramide 4-monooxygenase
   00253 Tetracycline biosynthesis
    K14253  oxyE; 6-methylpretetramide 4-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14253  oxyE; 6-methylpretetramide 4-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.232  6-methylpretetramide 4-monooxygenase
     K14253  oxyE; 6-methylpretetramide 4-monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K14253  oxyE; 6-methylpretetramide 4-monooxygenase
Other DBs
COG: COG0654
Genes
NAH: F5544_10715
SVL: Strvi_8156
SRC: M271_30845
SMAL: SMALA_2870
SSOI: I1A49_18275
SFA: Sfla_5329
SBH: SBI_06856
STRP: F750_1294
SCI: B446_13370
SPRI: SPRI_0276 SPRI_7077
SPAV: Spa2297_32735
SGS: AVL59_46200
SGM: GCM10017557_73860
SPHW: NFX46_24965
SAUO: BV401_18000
SVR: CP971_23910
SRIM: CP984_02395
SPLA: CP981_34510
SHUN: DWB77_05163(ubiF)
SXN: IAG42_36405
SYAN: NRK68_34865
SSPN: LXH13_13990
SANT: QR300_27100
KAU: B6264_18485
KIS: HUT16_23725
KAL: KALB_7826
KUT: JJ691_15700(oxyE)
CROS: N8J89_20410
PLK: CIK06_11110
CATI: CS0771_73100
CCAZ: COUCH_15910
AG: AAZ78329(oxyE)
 » show all
Reference
PMID:16597959
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
[ag:AAZ78329]
Reference
PMID:19472250
  Authors
Wang P, Zhang W, Zhan J, Tang Y
  Title
Identification of OxyE as an ancillary oxygenase during tetracycline biosynthesis.
  Journal
Chembiochem 10:1544-50 (2009)
DOI:10.1002/cbic.200900122

  All links  
Ontology (4)   
   KEGG BRITE (3)   
   COG (1)   
Pathway (10)   
   KEGG PATHWAY (8)   
   KEGG MODULE (2)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (34)   
   KEGG GENES (33)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (53)   

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