KEGG   ORTHOLOGY: K15420
Entry
K15420                      KO                                     

Name
EML4
Definition
echinoderm microtubule-associated protein-like 4
Pathway
ko05200  Pathways in cancer
ko05223  Non-small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K15420  EML4; echinoderm microtubule-associated protein-like 4
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K15420  EML4; echinoderm microtubule-associated protein-like 4
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    K15420  EML4; echinoderm microtubule-associated protein-like 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K15420  EML4; echinoderm microtubule-associated protein-like 4
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EMAP
     K15420  EML4; echinoderm microtubule-associated protein-like 4
Genes
HSA: 27436(EML4)
PTR: 459180(EML4)
PPS: 100968189(EML4)
GGO: 101144399(EML4)
PON: 100453034(EML4)
NLE: 100595819(EML4)
MCC: 715091(EML4)
MCF: 102117260(EML4)
CSAB: 103220407(EML4)
RRO: 104677542(EML4)
RBB: 108513214(EML4)
CJC: 100410033(EML4)
SBQ: 101039462(EML4)
MMU: 78798(Eml4)
MCAL: 110284386(Eml4)
MPAH: 110335391(Eml4)
RNO: 313861(Eml4)
MUN: 110555469(Eml4)
CGE: 100764725(Eml4)
NGI: 103736385(Eml4)
HGL: 101715651(Eml4)
CCAN: 109697438(Eml4)
OCU: 100352828(EML4)
TUP: 102468371(EML4)
CFA: 483048(EML4)
VVP: 112916607(EML4)
AML: 100475514(EML4)
UMR: 103671544(EML4)
UAH: 113241799(EML4)
ORO: 101370021(EML4)
ELK: 111158506
FCA: 101094586(EML4)
PTG: 102967307(EML4)
PPAD: 109265262(EML4)
AJU: 106970840(EML4)
BTA: 540187(EML4)
BOM: 102286590(EML4)
BIU: 109566017(EML4)
BBUB: 102403336(EML4)
CHX: 102187234(EML4)
OAS: 101115950(EML4)
SSC: 100515021(EML4)
CFR: 102507317(EML4)
CDK: 105103544(EML4)
BACU: 103018044(EML4)
LVE: 103073061(EML4)
OOR: 101282443(EML4)
DLE: 111174834(EML4)
PCAD: 102983752(EML4)
ECB: 100053784(EML4)
EPZ: 103557606(EML4)
EAI: 106848305(EML4)
MYB: 102256074(EML4)
MYD: 102765378(EML4)
MNA: 107539758(EML4)
HAI: 109385550(EML4)
DRO: 112297965(EML4)
PALE: 102879824(EML4)
RAY: 107509594(EML4)
MJV: 108397557(EML4)
LAV: 104846437(EML4)
TMU: 101355821
MDO: 100033382(EML4)
SHR: 100929628(EML4)
PCW: 110218476(EML4)
OAA: 100091982(EML4)
GGA: 771345(EML4)
MGP: 100541442(EML4)
CJO: 107311167(EML4)
NMEL: 110395521(EML4)
APLA: 101796290(EML4)
ACYG: 106031501(EML4)
TGU: 100219108(EML4)
LSR: 110479963(EML4)
SCAN: 103817014(EML4)
GFR: 102034770(EML4)
FAB: 101809113(EML4)
PHI: 102102750(EML4)
PMAJ: 107201852(EML4)
CCAE: 111926149(EML4)
CCW: 104685668(EML4)
ETL: 114065809(EML4)
FPG: 101918568(EML4)
FCH: 102047626(EML4)
CLV: 102088400(EML4)
EGZ: 104128728(EML4)
NNI: 104019722(EML4)
ACUN: 113477776(EML4)
PADL: 103922116(EML4)
AAM: 106490421(EML4)
ASN: 102368445(EML4)
AMJ: 102573028(EML4)
PSS: 102444410(EML4)
CMY: 102948338(EML4)
CPIC: 101945862(EML4)
ACS: 100563497(eml4)
PVT: 110084395(EML4)
PBI: 103050978(EML4)
PMUR: 107284972(EML4)
TSR: 106541016(EML4)
PMUA: 114594721(EML4)
GJA: 107114505(EML4)
XLA: 108716433(eml4.L) 735022(eml4.S)
XTR: 448764(eml4)
NPR: 108786116(EML4)
DRE: 100334728(eml4)
SRX: 107739484 107758131(eml4)
IPU: 108263481(eml4)
PHYP: 113540944(eml4)
AMEX: 103041533
EEE: 113572715(eml4)
TRU: 101074333(eml4)
LCO: 104934700(eml4)
MZE: 101483481(eml4)
ONL: 100706985(eml4)
OLA: 101175019(eml4)
XMA: 102216710(eml4)
XCO: 114137600(eml4)
PRET: 103477445
CVG: 107101396(eml4)
NFU: 107376417
KMR: 108247262
ALIM: 106529813(eml4)
AOCE: 111586050(eml4)
CSEM: 103387130(eml4)
POV: 109644340(eml4)
LCF: 108874347(eml4)
SDU: 111223863(eml4)
SLAL: 111656068(eml4)
HCQ: 109510011(eml4)
BPEC: 110166511
MALB: 109972992(eml4)
SASA: 106576747 106605231(eml4)
OTW: 112253203(eml4) 112253520
SALP: 111977475 111978351(eml4)
ELS: 105030300(eml4)
SFM: 108932634 108942755(eml4)
LCM: 102367334(EML4)
CMK: 103177997(eml4)
RTP: 109936473(eml4)
 » show all
Reference
  Authors
Pollmann M, Parwaresch R, Adam-Klages S, Kruse ML, Buck F, Heidebrecht HJ
  Title
Human EML4, a novel member of the EMAP family, is essential for microtubule formation.
  Journal
Exp Cell Res 312:3241-51 (2006)
DOI:10.1016/j.yexcr.2006.06.035
  Sequence
[hsa:27436]
Reference
  Authors
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H
  Title
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
  Journal
Nature 448:561-6 (2007)
DOI:10.1038/nature05945
  Sequence
[hsa:27436]
Reference
  Authors
Heidebrecht HJ, Buck F, Pollmann M, Siebert R, Parwaresch R
  Title
Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein.
  Journal
Genomics 68:348-50 (2000)
DOI:10.1006/geno.2000.6301
  Sequence
[hsa:27436]

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