KEGG   ORTHOLOGY: K15647
Entry
K15647                      KO                                     
Symbol
cmaE
Name
coronamic acid synthetase CmaE, aminoacyltransferase [EC:2.3.2.28]
Reaction
R11103  L-allo-isoleucyl-[peptidyl-carrier protein]:[peptidyl-carrier protein] L-allo-isoleucyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15647  cmaE; coronamic acid synthetase CmaE, aminoacyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.28  L-allo-isoleucyltransferase
     K15647  cmaE; coronamic acid synthetase CmaE, aminoacyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  PKS-NRPS hybrid
   Bacterial type (modular)
    Coronatine hybrid PKS-NRPS
     K15647  cmaE; coronamic acid synthetase CmaE, aminoacyltransferase
Genes
PST: PSPTO_4708(cmaE)
PAMG: BKM19_029790
PCAB: JGS08_03180
PCOF: POR16_03580
PTRE: I9H09_26085
PSEP: C4K39_4305
Reference
  Authors
Vaillancourt FH, Yeh E, Vosburg DA, O'Connor SE, Walsh CT
  Title
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.
  Journal
Nature 436:1191-4 (2005)
DOI:10.1038/nature03797
  Sequence
Reference
  Authors
Lai JR, Koglin A, Walsh CT
  Title
Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis.
  Journal
Biochemistry 45:14869-79 (2006)
DOI:10.1021/bi061979p
Reference
  Authors
Strieter ER, Vaillancourt FH, Walsh CT
  Title
CmaE: a transferase shuttling aminoacyl groups between carrier protein domains in the coronamic acid biosynthetic pathway.
  Journal
Biochemistry 46:7549-57 (2007)
DOI:10.1021/bi700243h
  Sequence

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