K15791                      KO                                     

probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:]
ko00310  Lysine degradation
ko00380  Tryptophan metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
H00264  Charcot-Marie-Tooth disease
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
   00380 Tryptophan metabolism
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor  oxoglutarate dehydrogenase (succinyl-transferring)
     K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
Other DBs
RN: R01933 R01940
GO: 0004591
HSA: 55526(DHTKD1)
PTR: 736115(DHTKD1)
PPS: 100977202(DHTKD1)
GGO: 101146441(DHTKD1)
PON: 100173320(DHTKD1)
NLE: 100601330(DHTKD1)
MCC: 696445(DHTKD1)
MCF: 102119673(DHTKD1)
CSAB: 103238141(DHTKD1)
RRO: 104664886(DHTKD1)
RBB: 108538522(DHTKD1)
CJC: 100385948(DHTKD1)
SBQ: 101035476(DHTKD1)
MMU: 209692(Dhtkd1)
MCAL: 110283664(Dhtkd1)
MPAH: 110333984(Dhtkd1)
RNO: 361272(Dhtkd1)
MUN: 110560545(Dhtkd1)
CGE: 100753689(Dhtkd1)
NGI: 103738703(Dhtkd1)
HGL: 101721202(Dhtkd1)
CCAN: 109682443(Dhtkd1)
OCU: 100356735(DHTKD1)
TUP: 102477878(DHTKD1)
CFA: 478008(DHTKD1)
VVP: 112933405(DHTKD1)
AML: 100484376(DHTKD1)
UMR: 103676290(DHTKD1)
UAH: 113241065(DHTKD1)
ORO: 101364717(DHTKD1)
ELK: 111155533
FCA: 101086155(DHTKD1)
PTG: 102950462(DHTKD1)
PPAD: 109273731(DHTKD1)
AJU: 106971004(DHTKD1)
BTA: 517113(DHTKD1)
BOM: 102284154(DHTKD1)
BIU: 109567875(DHTKD1)
BBUB: 102411718(DHTKD1)
CHX: 102173669(DHTKD1)
OAS: 101117008(DHTKD1)
SSC: 102166829(DHTKD1)
CFR: 102505405(DHTKD1)
CDK: 105100312(DHTKD1)
BACU: 103016269(DHTKD1)
LVE: 103088004(DHTKD1)
OOR: 101270888(DHTKD1)
DLE: 111178001(DHTKD1)
PCAD: 102985620(DHTKD1)
ECB: 100056844(DHTKD1)
EPZ: 103563359(DHTKD1)
EAI: 106836524(DHTKD1)
MYB: 102255818(DHTKD1)
MYD: 102774163(DHTKD1)
MNA: 107530246(DHTKD1)
HAI: 109390477(DHTKD1)
DRO: 112322617(DHTKD1)
PALE: 102895062(DHTKD1)
RAY: 107504853(DHTKD1)
MJV: 108395805(DHTKD1)
LAV: 100677553(DHTKD1)
TMU: 101351336
MDO: 100013507(DHTKD1)
SHR: 100931159(DHTKD1)
PCW: 110217338(DHTKD1)
OAA: 100085444(DHTKD1)
GGA: 426076(DHTKD1)
MGP: 100540782(DHTKD1)
CJO: 107317305(DHTKD1)
NMEL: 110392260(DHTKD1)
APLA: 101799410(DHTKD1)
ACYG: 106046213(DHTKD1)
TGU: 100227746(DHTKD1)
LSR: 110470969(DHTKD1)
SCAN: 103813742(DHTKD1)
GFR: 102045028(DHTKD1)
FAB: 101819529(DHTKD1)
PHI: 102106815(DHTKD1)
PMAJ: 107204632(DHTKD1)
CCAE: 111923121(DHTKD1)
CCW: 104694504(DHTKD1)
ETL: 114066624(DHTKD1)
FPG: 101914531(DHTKD1)
FCH: 102046202(DHTKD1)
CLV: 102086057(DHTKD1)
EGZ: 104135760(DHTKD1)
NNI: 104014635(DHTKD1)
ACUN: 113491537(DHTKD1)
PADL: 103915024(DHTKD1)
AAM: 106485083(DHTKD1)
ASN: 102376609(DHTKD1)
AMJ: 102561159(DHTKD1)
PSS: 102453971(DHTKD1)
CMY: 102945253(DHTKD1)
CPIC: 101940398(DHTKD1)
ACS: 100551958(dhtkd1)
PVT: 110081244(DHTKD1)
PMUR: 107297191(DHTKD1) 107300248
TSR: 106550932(DHTKD1)
PMUA: 114605061(DHTKD1)
GJA: 107111049(DHTKD1)
XLA: 403360(dhtkd1.L)
XTR: 100493977(dhtkd1)
NPR: 108784821(DHTKD1)
DRE: 494076(dhtkd1)
CCAR: 109053636(dhtkd1)
IPU: 108275231(dhtkd1)
PHYP: 113530129(dhtkd1)
AMEX: 103041509(dhtkd1)
EEE: 113584502(dhtkd1)
TRU: 101070517(dhtkd1)
LCO: 104940683(dhtkd1)
NCC: 104940829
MZE: 101480158(dhtkd1)
ONL: 100705674(dhtkd1)
OLA: 101175318(dhtkd1)
XMA: 102229655(dhtkd1)
XCO: 114155128(dhtkd1)
PRET: 103465849(dhtkd1)
CVG: 107095058(dhtkd1)
NFU: 107388455(dhtkd1)
KMR: 108230154(dhtkd1)
ALIM: 106523641(dhtkd1)
AOCE: 111566787(dhtkd1)
CSEM: 103380546(dhtkd1)
POV: 109624521(dhtkd1)
LCF: 108888513(dhtkd1)
SDU: 111229832(dhtkd1)
SLAL: 111670862(dhtkd1)
HCQ: 109522972(dhtkd1)
BPEC: 110169356(dhtkd1)
MALB: 109974702(dhtkd1)
ELS: 105021851(dhtkd1)
SFM: 108931528(dhtkd1)
PKI: 111842368(dhtkd1)
LCM: 102356663(DHTKD1)
CMK: 103187915(dhtkd1)
RTP: 109929690(dhtkd1)
CIN: 100179490
SPU: 764393
APLC: 110979468
SKO: 102808810
DME: Dmel_CG1544(CG1544)
DER: 6554810
DSE: 6612954
DSI: Dsimw501_GD21563(Dsim_GD21563)
DAN: 6501192
DSR: 110187006
DPE: 6595098
DMN: 108154619
DWI: 6649550
DAZ: 108621342
DNV: 108660392
DHE: 111597832
DVI: 6632830
MDE: 101890127
LCQ: 111681550
AAG: 5566495
AME: 412569
BIM: 100746454
BTER: 100651648
CCAL: 108632091
OBB: 114880363
MPHA: 105837687
AEC: 105153258
ACEP: 105621467
PBAR: 105426032
VEM: 105564292
HST: 105187265
DQU: 106741705
CFO: 105254757
LHU: 105671323
PGC: 109860826
OBO: 105285114
PCF: 106784155
NVI: 100123741
CSOL: 105362936
MDL: 103574888
TCA: 656360(DHTKD1)
DPA: 109537220
ATD: 109599346
NVL: 108566386
BMOR: 101740126
BMAN: 114252985
PMAC: 106712864
PRAP: 110995686
HAW: 110375316
PXY: 105382046
CLEC: 106667210
ZNE: 110838858
FCD: 110859206
PVM: 113818707
TUT: 107364834
DPTE: 113789891
CSCU: 111634585
PTEP: 107447474
CEL: CELE_ZK836.2(ogdh-2)
CBR: CBG23406
PCAN: 112570201
CRG: 105317940
MYI: 110455544
OBI: 106874001
NVE: 5514893
EPA: 110232683
AMIL: 114966664
PDAM: 113684930
SPIS: 111327291
DGT: 114520034
HMG: 100204465
AQU: 100640196
TASA: A1Q1_04236
DDI: DDB_G0280353(odhA)
DFA: DFA_02482(odhA)
SPAR: SPRG_03427
 » show all
Xu W, Zhu H, Gu M, Luo Q, Ding J, Yao Y, Chen F, Wang Z
DHTKD1 is essential for mitochondrial biogenesis and function maintenance.
FEBS Lett 587:3587-92 (2013)
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
DNA Res 7:273-81 (2000)
Nemeria NS, Gerfen G, Nareddy PR, Yang L, Zhang X, Szostak M, Jordan F
The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species.
Free Radic Biol Med 115:136-145 (2018)

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