KEGG   ORTHOLOGY: K15909
Entry
K15909                      KO                                     

Name
SHIP2, INPPL1
Definition
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
ko04662  B cell receptor signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04910  Insulin signaling pathway
Disease
H01828  Opsismodysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
   04666 Fc gamma R-mediated phagocytosis
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Other DBs
RN: R09827
GO: 0034485
Genes
HSA: 3636(INPPL1)
PTR: 451403(INPPL1)
PPS: 100992766(INPPL1)
GGO: 101127569(INPPL1)
PON: 100450015(INPPL1)
NLE: 100596562(INPPL1)
MCC: 718421(INPPL1)
MCF: 102115401(INPPL1)
CSAB: 103247996(INPPL1)
RRO: 104665152(INPPL1)
RBB: 108543771(INPPL1)
CJC: 100396447(INPPL1)
SBQ: 101029956(INPPL1)
MMU: 16332(Inppl1)
MCAL: 110297343(Inppl1)
MPAH: 110329610(Inppl1)
RNO: 65038(Inppl1)
MUN: 110550789(Inppl1)
CGE: 100772102(Inppl1)
NGI: 103750804(Inppl1)
HGL: 101698814(Inppl1)
CCAN: 109693012(Inppl1)
OCU: 100339369(INPPL1)
TUP: 102485077(INPPL1)
CFA: 485209(INPPL1)
VVP: 112928740(INPPL1)
AML: 100482460(INPPL1)
UMR: 103678107(INPPL1)
UAH: 113269258(INPPL1)
ORO: 101366414(INPPL1)
ELK: 111159402
FCA: 101095611(INPPL1)
PTG: 102956183(INPPL1)
PPAD: 109267136(INPPL1)
AJU: 106970927(INPPL1)
BTA: 783833(INPPL1)
BOM: 102278222(INPPL1)
BIU: 109569627(INPPL1)
BBUB: 102402942(INPPL1)
CHX: 102178924(INPPL1)
OAS: 101121707(INPPL1)
SSC: 100462718(INPPL1)
CFR: 102509164(INPPL1)
CDK: 105096747(INPPL1)
BACU: 102999607(INPPL1)
LVE: 103078405(INPPL1)
OOR: 101269414(INPPL1)
DLE: 111170564(INPPL1)
PCAD: 102993697(INPPL1)
ECB: 100066037(INPPL1)
EPZ: 103549328(INPPL1)
EAI: 106831625(INPPL1)
MYB: 102248134(INPPL1)
MYD: 102755641(INPPL1)
MNA: 107533662(INPPL1)
HAI: 109372436(INPPL1)
DRO: 112315920(INPPL1)
PALE: 102890098(INPPL1)
RAY: 107517370(INPPL1)
MJV: 108405095(INPPL1)
LAV: 100673994(INPPL1)
TMU: 101351608
MDO: 100015500(INPPL1)
SHR: 100930081(INPPL1)
PCW: 110195040(INPPL1)
OAA: 100088229(INPPL1)
GGA: 428692(INPPL1)
MGP: 100540799
CJO: 107312645
NMEL: 110391676(INPPL1) 110403391
ACYG: 106042953(INPPL1)
TGU: 100222691 100222899(INPPL1)
LSR: 110473122(INPPL1) 110474379
SCAN: 103816565 103820748(INPPL1)
GFR: 102032471(INPPL1) 102036900
FAB: 101807549(INPPL1) 101820739
PHI: 102101537 102102439(INPPL1)
PMAJ: 107203647 107212504(INPPL1)
CCAE: 111928734 111943484(INPPL1)
CCW: 104687164(INPPL1) 104691345
ETL: 114059614(INPPL1) 114065162
FPG: 101918373(INPPL1) 101919963
FCH: 102048151 102056978(INPPL1)
CLV: 102083667(INPPL1) 102085697
EGZ: 104135987
NNI: 104011872(INPPL1) 104012926
PADL: 103919205
AAM: 106486171(INPPL1)
ASN: 102375443 102388319(INPPL1)
AMJ: 102563685(INPPL1) 102576763
PSS: 102448035(INPPL1) 102448772
CMY: 102929300 102929354(INPPL1)
CPIC: 101932232(INPPL1) 101951468
ACS: 100556812(inppl1)
PVT: 110078090(INPPL1)
PBI: 103051579(INPPL1)
TSR: 106553455(INPPL1)
PMUA: 114595500(INPPL1)
XLA: 108698315 108708768(inppl1.L)
XTR: 100485745(inppl1) 100496685
NPR: 108785616 108801007(INPPL1)
DRE: 325179(inppl1a) 368433(inppl1b)
IPU: 108261207(SHIP-2) 108268863(inppl1b) 108277646(inppl1)
PHYP: 113529332 113544603(inppl1)
AMEX: 103026127 103027088(inppl1)
EEE: 113581578(inppl1) 113582441
TRU: 101065901(inppl1) 101069844
LCO: 104920140(inppl1) 104923483
NCC: 104958004 104968285(inppl1)
MZE: 101483507(inppl1) 101484941
ONL: 100705507(inppl1) 100706013
OLA: 101165747(inppl1) 101168299
XMA: 102222770 102228371(inppl1)
XCO: 114133153(inppl1) 114139388
PRET: 103471620 103474471(inppl1)
CVG: 107091942(inppl1) 107102648
NFU: 107378661 107380469(inppl1)
KMR: 108231420 108240501(inppl1)
ALIM: 106515304 106517268(inppl1)
AOCE: 111570870(inppl1) 111579643
CSEM: 103378565(inppl1) 103390762
POV: 109625236 109634550(inppl1)
LCF: 108872540 108886606(inppl1)
SDU: 111224118(inppl1) 111232670
SLAL: 111655298(inppl1) 111666355
HCQ: 109516555 109525465(inppl1)
BPEC: 110158855 110174275(inppl1)
MALB: 109957514 109970550(inppl1)
ELS: 105029605(inppl1)
SFM: 108923188 108932224(inppl1)
PKI: 111833861(inppl1) 111835066
LCM: 102351582 102361839(INPPL1)
CMK: 103179101(inppl1)
RTP: 109914528(inppl1) 109927453
BFO: 118427393
APLC: 110981025
PCAN: 112555824
CRG: 105320686
MYI: 110463198
OBI: 106880499
LAK: 106158330
NVE: 5515466
EPA: 110241032
ADF: 107355719
AMIL: 114953961
PDAM: 113672378
SPIS: 111330862
DGT: 114523455
HMG: 100212864
AQU: 100641488
 » show all
Reference
PMID:9660833
  Authors
Habib T, Hejna JA, Moses RE, Decker SJ
  Title
Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.
  Journal
J Biol Chem 273:18605-9 (1998)
DOI:10.1074/jbc.273.29.18605
  Sequence
[hsa:3636]

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