KEGG   ORTHOLOGY: K15941
Entry
K15941                      KO                                     

Name
snoaB, dnrG, aknX
Definition
deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.22  deoxynogalonate monooxygenase
     K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
    1.13.12.-  
     K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Other DBs
RN: R06679 R09327
Genes
AORI: SD37_34175
MAU: Micau_3995
MIL: ML5_4426
AG: AAA65205(dnrG) AAF70105(aknX) CAA12015(snoaB)
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
  Authors
Grocholski T, Koskiniemi H, Lindqvist Y, Mantsala P, Niemi J, Schneider G
  Title
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.
  Journal
Biochemistry 49:934-44 (2010)
DOI:10.1021/bi901985b
Reference
  Authors
Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y
  Title
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.
  Journal
J Bacteriol 184:6115-22 (2002)
DOI:10.1128/JB.184.22.6115-6122.2002
  Sequence

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (7)   
   KEGG GENES (6)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (23)   

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