KEGG   ORTHOLOGY: K15955
Entry
K15955            Tight     KO                                     

Name
doxA, CYP129A
Definition
13-deoxydaunorubicin hydroxylase [EC:1.14.13.181]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15955  doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K15955  doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.181  13-deoxydaunorubicin hydroxylase
     K15955  doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP129 family
   K15955  doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
Other DBs
RN: R06688 R06689 R06690 R06691 R06692
COG: COG2124
Genes
AG: AAB08049(doxA) AAD04715(doxA)
Reference
  Authors
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A
  Title
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
  Journal
Nat Prod Rep 24:162-90 (2007)
DOI:10.1039/b507395m
Reference
PMID:9864344
  Authors
Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR
  Title
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.
  Journal
J Bacteriol 181:305-18 (1999)
DOI:10.1128/JB.181.1.305-318.1999
  Sequence
Reference
PMID:9098063
  Authors
Dickens ML, Priestley ND, Strohl WR
  Title
In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA.
  Journal
J Bacteriol 179:2641-50 (1997)
DOI:10.1128/JB.179.8.2641-2650.1997
  Sequence

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