KEGG   ORTHOLOGY: K16000
Entry
K16000            Tight     KO                                     
Symbol
pikAI
Name
narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Reaction
R06458  (2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide forming)
R06459  (2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (narbonolide forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16000  pikAI; narbonolide/10-deoxymethynolide synthase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16000  pikAI; narbonolide/10-deoxymethynolide synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16000  pikAI; narbonolide/10-deoxymethynolide synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.239  10-deoxymethynolide synthase
     K16000  pikAI; narbonolide/10-deoxymethynolide synthase
    2.3.1.240  narbonolide synthase
     K16000  pikAI; narbonolide/10-deoxymethynolide synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Pikromycin PKS
     K16000  pikAI; narbonolide/10-deoxymethynolide synthase
Genes
AG: AAC69329(pikAI)
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence
[ag:AAC69329]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (13)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
   KEGG RCLASS (9)   
Gene (1)   
   KEGG GENES (1)   
Literature (1)   
   PubMed (1)   
All databases (27)   

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