KEGG   ORTHOLOGY: K16000Help
Entry
K16000            Tight     KO                                     

Name
pikAI
Definition
narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16000  pikAI; narbonolide/10-deoxymethynolide synthase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16000  pikAI; narbonolide/10-deoxymethynolide synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.239  10-deoxymethynolide synthase
     K16000  pikAI; narbonolide/10-deoxymethynolide synthase
    2.3.1.240  narbonolide synthase
     K16000  pikAI; narbonolide/10-deoxymethynolide synthase
BRITE hierarchy
Other DBs
RN: R06458 R06459
Genes
AG: AAC69329(pikAI)
TaxonomyKoalaUniProt
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence

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