| Entry |
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| Symbol |
pikAIV
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| Name |
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| Pathway |
| map00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| map01110 | Biosynthesis of secondary metabolites |
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| Module |
| M00776 | Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin |
|
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| Reaction |
| R06459 | (2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (narbonolide forming) |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01052 Type I polyketide structures
K16003 pikAIV; narbonolide synthase
00522 Biosynthesis of 12-, 14- and 16-membered macrolides
K16003 pikAIV; narbonolide synthase
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins
K16003 pikAIV; narbonolide synthase
Enzymes [BR:ko01000]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.240 narbonolide synthase
K16003 pikAIV; narbonolide synthase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide synthase (PKS)
Modular type I PKS
cis-AT PKS
Pikromycin PKS
K16003 pikAIV; narbonolide synthase
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| Genes |
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| Reference |
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| Authors |
Xue Y, Zhao L, Liu HW, Sherman DH |
|---|
| Title |
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity. |
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| Journal |
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| Sequence |
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