KEGG ORTHOLOGY: K16039

ORTHOLOGY: K16039

Entry

K16039                      KO

Symbol

asm25

Name

N-glycosyltransferase [EC:2.4.1.-]

Pathway

map01051

Biosynthesis of ansamycins

map01110

Biosynthesis of secondary metabolites

Reaction

R09857

UDP-glucose:N-demethylansamitocin-P-3 beta-D-glucosyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01051 Biosynthesis of ansamycins
    K16039  asm25; N-glycosyltransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16039  asm25; N-glycosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Glycosyltransferase
   K16039  asm25; N-glycosyltransferase

Genes

APRE:

CNX65_16305

AMI:

Amir_3199

Reference

PMID:18721757

Authors

Zhao P, Bai L, Ma J, Zeng Y, Li L, Zhang Y, Lu C, Dai H, Wu Z, Li Y, Wu X, Chen G, Hao X, Shen Y, Deng Z, Floss HG

Title

Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.

Journal

Chem Biol 15:863-74 (2008)
DOI:10.1016/j.chembiol.2008.06.007

Reference

PMID:12060743

Authors

Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG

Title

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.

Journal

Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199

Sequence

[apre:CNX65_16305]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (5)   
   KEGG GENES (2)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (16)   

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ORTHOLOGY: K15937

Entry

K15937            Tight     KO

Symbol

urdGT1a

Name

glycosyltransferase

Pathway

map01057

Biosynthesis of type II polyketide products

map01110

Biosynthesis of secondary metabolites

Reaction

R06664

R06666

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15937  urdGT1a; glycosyltransferase

Other DBs

CAZy:

GT1

Genes

AG:	AAF00214(urdGT1a)

Reference

PMID:10662691

Authors

Trefzer A, Hoffmeister D, Kunzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A

Title

Function of glycosyltransferase genes involved in urdamycin A biosynthesis.

Journal

Chem Biol 7:133-42 (2000)
DOI:10.1016/S1074-5521(00)00079-X

Sequence

[ag:AAF00214]

All links

Ontology (2)   
   KEGG BRITE (1)   
   CAZY (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (5)   
   KEGG REACTION (2)   
   KEGG RCLASS (3)   
Gene (1)   
   KEGG GENES (1)   
Literature (1)   
   PubMed (1)   
All databases (13)   

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ORTHOLOGY: K15936

Entry

K15936            Tight     KO

Symbol

urdGT2

Name

glycosyltransferase [EC:2.4.1.-]

Pathway

map01057

Biosynthesis of type II polyketide products

map01110

Biosynthesis of secondary metabolites

Reaction

R09345

dTDP-D-olivose:UWM6 9-C-beta-D-olivosyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15936  urdGT2; glycosyltransferase

Other DBs

CAZy:

GT1

Genes

AG:	AAF00209(urdGT2)

Reference

PMID:17640665

Authors

Mittler M, Bechthold A, Schulz GE

Title

Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.

Journal

J Mol Biol 372:67-76 (2007)
DOI:10.1016/j.jmb.2007.06.005

Reference

PMID:17061307

Authors

Baig I, Kharel M, Kobylyanskyy A, Zhu L, Rebets Y, Ostash B, Luzhetskyy A, Bechthold A, Fedorenko VA, Rohr J

Title

On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).

Journal

Angew Chem Int Ed Engl 45:7842-6 (2006)
DOI:10.1002/anie.200603176

All links

Ontology (2)   
   KEGG BRITE (1)   
   CAZY (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (12)   

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ORTHOLOGY: K13003

Entry

K13003                      KO

Symbol

wbtG

Name

glycosyltransferase WbtG [EC:2.4.1.-]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01005 Lipopolysaccharide biosynthesis proteins
    K13003  wbtG; glycosyltransferase WbtG
Lipopolysaccharide biosynthesis proteins [BR:ko01005]
O-antigen repeat unit
  K13003  wbtG; glycosyltransferase WbtG

Other DBs

COG:

COG0438

CAZy:

GT4

Genes

FTU:	FTT_1457c(wbtG)

FTQ:

RO31_1712

FTF:	FTF1457c(wbtG)

FTW:	FTW_0418(wbtG)

FTR:	NE061598_08140

FTT:	FTV_1391(wbtG)

FTG:	FTU_1475(wbtG)

FTL:

FTL_0599

FTH:

FTH_0599

FTA:	FTA_0633(wbtG)

FTS:

F92_03270

FTI:

FTS_0598

FTO:	X557_03180

FTC:

DA46_84

FTV:

CH67_912

FTZ:

CH68_646

FTM:	FTM_1491(wbtG)

FTN:	FTN_1423(wbtG)

FTX:

AW25_578

FHI:	FSC454_07350

» show all

Reference

PMID:17074846

Authors

Thomas RM, Titball RW, Oyston PC, Griffin K, Waters E, Hitchen PG, Michell SL, Grice ID, Wilson JC, Prior JL

Title

The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens.

Journal

Infect Immun 75:371-8 (2007)
DOI:10.1128/IAI.01241-06

Sequence

[ftn:FTN_1423]

All links

Ontology (4)   
   KEGG BRITE (2)   
   COG (1)   
   CAZY (1)   
Gene (21)   
   KEGG GENES (20)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (26)   

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ORTHOLOGY: K13002

Entry

K13002                      KO

Symbol

wbyL

Name

glycosyltransferase [EC:2.4.1.-]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01005 Lipopolysaccharide biosynthesis proteins
    K13002  wbyL; glycosyltransferase
Lipopolysaccharide biosynthesis proteins [BR:ko01005]
O-antigen repeat unit
  K13002  wbyL; glycosyltransferase

Other DBs

COG:

COG0463

CAZy:

GT2

Genes

CTEL:

GBC03_14065

CITZ:

E4Z61_02615

YPE:	YPO3098(wbyL)

YPK:

y1082

YPH:	YPC_3380(wbyL)

YPA:

YPA_2593

YPN:

YPN_0989

YPM:	YP_0828(wbyL)

YPP:	YPDSF_2737

YPG:	YpAngola_A1255

YPZ:	YPZ3_2730(wbyL)

YPT:	A1122_10465

YPD:	YPD4_2718(wbyL)

YPX:	YPD8_2710(wbyL)

YPW:

YPJ:

YPV:

YPL:

YPS:	YPTB1012(wbyL)

YPO:

BZ17_1536

YPI:	YpsIP31758_3038

YPF:

BZ19_369

YMO:	HRD69_10925

YEG:	PL78_00750

SPRO:

N7E60_09425

CHOR:

MKQ68_19915

FRR:	IB67_01455

» show all

Reference

PMID:10931327

Authors

Skurnik M, Peippo A, Ervela E

Title

Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.

Journal

Mol Microbiol 37:316-30 (2000)
DOI:10.1046/j.1365-2958.2000.01993.x

Sequence

[ypf:BZ19_369]

All links

Ontology (4)   
   KEGG BRITE (2)   
   COG (1)   
   CAZY (1)   
Gene (29)   
   KEGG GENES (27)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (34)   

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ORTHOLOGY: K15946

Entry

K15946            Tight     KO

Symbol

aknS

Name

aklavinone 7-alpha-L-rhodosaminyltransferase [EC:2.4.1.326]

Pathway

map01057

Biosynthesis of type II polyketide products

map01110

Biosynthesis of secondary metabolites

Reaction

R09331

dTDP-beta-L-rhodosamine:aklavinone 7-alpha-L-rhodosaminyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15946  aknS; aklavinone 7-alpha-L-rhodosaminyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.326  aklavinone 7-L-rhodosaminyltransferase
     K15946  aknS; aklavinone 7-alpha-L-rhodosaminyltransferase

Other DBs

CAZy:

GT1

Genes

SGAL:

CP966_28995

AG:	AAF73455(aknS)

Reference

PMID:17685523

Authors

Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D

Title

Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.

Journal

J Am Chem Soc 129:10546-50 (2007)
DOI:10.1021/ja072909o

Sequence

[ag:AAF73455]

All links

Ontology (3)   
   KEGG BRITE (2)   
   CAZY (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG GENES (2)   
Literature (1)   
   PubMed (1)   
All databases (14)   

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ORTHOLOGY: K15960

Entry

K15960            Tight     KO

Symbol

mtmGIV

Name

glycosyltransferase [EC:2.4.1.-]

Pathway

map01057

Biosynthesis of type II polyketide products

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00782

Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin

Reaction

R06716

dTDP-D-olivose:premithramycinone D-olivosyltransferase

R06718

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15960  mtmGIV; glycosyltransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15960  mtmGIV; glycosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Glycosyltransferase
   K15960  mtmGIV; glycosyltransferase

Other DBs

CAZy:

GT1

Genes

AG:	CAK50788(mtmGIV)

Reference

PMID:10660060

Authors

Blanco G, Fernandez E, Fernandez MJ, Brana AF, Weissbach U, Kunzel E, Rohr J, Mendez C, Salas JA

Title

Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.

Journal

Mol Gen Genet 262:991-1000 (2000)
DOI:10.1007/PL00008667

Sequence

[ag:CAK50788]

All links

Ontology (3)   
   KEGG BRITE (2)   
   CAZY (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (5)   
   KEGG REACTION (2)   
   KEGG RCLASS (3)   
Gene (1)   
   KEGG GENES (1)   
Literature (1)   
   PubMed (1)   
All databases (17)   

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ORTHOLOGY: K15961

Entry

K15961            Tight     KO

Symbol

mtmGIII

Name

glycosyltransferase [EC:2.4.1.-]

Pathway

map01057

Biosynthesis of type II polyketide products

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00782

Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin

Reaction

R06717

dTDP-D-oliose:premithramycin-A1 D-oliosyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15961  mtmGIII; glycosyltransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15961  mtmGIII; glycosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Glycosyltransferase
   K15961  mtmGIII; glycosyltransferase

Other DBs

CAZy:

GT1

Genes

AG:	CAK50789(mtmGIII)

Reference

PMID:10660060

Authors

Blanco G, Fernandez E, Fernandez MJ, Brana AF, Weissbach U, Kunzel E, Rohr J, Mendez C, Salas JA

Title

Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.

Journal

Mol Gen Genet 262:991-1000 (2000)
DOI:10.1007/PL00008667

Sequence

[ag:CAK50789]

All links

Ontology (3)   
   KEGG BRITE (2)   
   CAZY (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1)   
   KEGG GENES (1)   
Literature (1)   
   PubMed (1)   
All databases (15)   

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ORTHOLOGY: K15939

Entry

K15939            Tight     KO

Symbol

urdGT1b

Name

glycosyltransferase [EC:2.4.1.-]

Pathway

map01057

Biosynthesis of type II polyketide products

map01110

Biosynthesis of secondary metabolites

Reaction

R06660

dTDP-D-olivose:compound-100-1 O-beta-D-olivosyltransferase

R06662

R06664

R06668

dTDP-D-olivose:urdamycin-G D-olivosyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15939  urdGT1b; glycosyltransferase

Other DBs

CAZy:

GT1

Genes

AG:	AAF00215(urdGT1b)

Reference

PMID:10662691

Authors

Trefzer A, Hoffmeister D, Kunzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A

Title

Function of glycosyltransferase genes involved in urdamycin A biosynthesis.

Journal

Chem Biol 7:133-42 (2000)
DOI:10.1016/S1074-5521(00)00079-X

Sequence

[ag:AAF00215]

Reference

PMID:11410375

Authors

Hoffmeister D, Ichinose K, Bechthold A

Title

Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.

Journal

Chem Biol 8:557-67 (2001)
DOI:10.1016/S1074-5521(01)00039-4

All links

Ontology (2)   
   KEGG BRITE (1)   
   CAZY (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (7)   
   KEGG REACTION (4)   
   KEGG RCLASS (3)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (16)   

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ORTHOLOGY: K15938

Entry

K15938            Tight     KO

Symbol

urdGT1c

Name

glycosyltransferase

Pathway

map01057

Biosynthesis of type II polyketide products

map01110

Biosynthesis of secondary metabolites

Reaction

R06659

R06662

R06664

R06667

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15938  urdGT1c; glycosyltransferase

Other DBs

CAZy:

GT1

Genes

AG:	AAF00217(urdGT1c)

Reference

PMID:10662691

Authors

Trefzer A, Hoffmeister D, Kunzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A

Title

Function of glycosyltransferase genes involved in urdamycin A biosynthesis.

Journal

Chem Biol 7:133-42 (2000)
DOI:10.1016/S1074-5521(00)00079-X

Sequence

[ag:AAF00217]

Reference

PMID:11410375

Authors

Hoffmeister D, Ichinose K, Bechthold A

Title

Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.

Journal

Chem Biol 8:557-67 (2001)
DOI:10.1016/S1074-5521(01)00039-4

All links

Ontology (2)   
   KEGG BRITE (1)   
   CAZY (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (7)   
   KEGG REACTION (4)   
   KEGG RCLASS (3)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (16)   

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