KEGG   ORTHOLOGY: K16050Help
Entry
K16050                      KO                                     

Name
hsaD
Definition
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17]
Pathway
ko00984  Steroid degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16050  hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.17  4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
     K16050  hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
BRITE hierarchy
Other DBs
RN: R09883
COG: COG0596
Genes
RGL: CS053_01755
VAF: D1115_22495
PRE: PCA10_13810
PPUT: L483_14175
PPUN: PP4_27040(mhpC)
PVR: PverR02_11710
PPUU: PputUW4_01659(mhpC)
PKC: PKB_4240
PFZ: AV641_10660
PLQ: AA042_19905
PSET: THL1_1432
PSIL: PMA3_11770
SPL: Spea_2147
SHL: Shal_2118
PHA: PSHAa0893(tesD)
PTN: PTRA_a1026(hsaD)
PNG: PNIG_a1077(hsaD)
REH: H16_B0600(bphD)
CNC: CNE_2c05450(fabG2)
CTI: RALTA_B0404(mhpC)
BCJ: BCAM1609
BCEN: DM39_3387
BCEO: I35_5469
BCT: GEM_4115
BCED: DM42_6349
BCON: NL30_04160
BTEI: WS51_05675
BPSL: WS57_06065
BMEC: WJ16_26770
BFN: OI25_4585
CTES: O987_07745
NAR: Saro_3690
SSAN: NX02_12715
SPKC: KC8_19645
SPHB: EP837_03392(hsaD)
MTU: Rv3569c(hsaD)
MTC: MT3674(bphD)
MRA: MRA_3608(bphD)
MTUR: CFBS_3786(bphD)
MTO: MTCTRI2_3634(bphD)
MTD: UDA_3569c(bphD)
MTN: ERDMAN_3916(bphD)
MTUC: J113_24995
MTUE: J114_19090
MTUH: I917_25075
MTUL: TBHG_03510
MTUT: HKBT1_3771(bphD)
MTUU: HKBT2_3780(bphD)
MTQ: HKBS1_3783(bphD)
MBO: BQ2027_MB3600C(hsad)
MBB: BCG_3634c(bphD)
MBT: JTY_3635(bphD)
MBM: BCGMEX_3632c(bphD)
MBX: BCGT_3436
MAF: MAF_35820(bphD)
MMIC: RN08_3946
MCE: MCAN_35821(bphD)
MCQ: BN44_110064(bphD)
MCV: BN43_90070(bphD)
MCX: BN42_90067(bphD)
MCZ: BN45_100083(bphD)
MPA: MAP_0498
MAO: MAP4_3369
MAVI: RC58_16710
MAVU: RE97_16745
MAV: MAV_0592
MIT: OCO_05010
MIA: OCU_05050
MID: MIP_00941
MYO: OEM_05070
MIR: OCQ_05160
MLP: MLM_0736
MUL: MUL_4140(bphD)
MMC: Mmcs_4708
MKM: Mkms_4794
MJL: Mjls_5093
MMI: MMAR_5064(bphD)
MMAE: MMARE11_48790(bphD)
MMM: W7S_02445
MLI: MULP_05322(bphD)
MHAD: B586_04450
MSHG: MSG_04562(hsaD)
MSG: MSMEI_5876(bphD)
MVA: Mvan_5307
MGI: Mflv_1464
MPHL: MPHLCCUG_00492(hsaD_1)
MVQ: MYVA_5217
MTHN: 4412656_04093(hsaD_3)
MHAS: MHAS_03778(hsaD_5)
ASD: AS9A_0925(mhpC)
NFA: NFA_4730
NFR: ERS450000_03763(hsaD_1)
RHA: RHA1_ro04540(hsaD)
RER: RER_07560
REY: O5Y_03675
ROP: ROP_44550
RRT: 4535765_00583(hsaD_1) 4535765_04568(hsaD_4)
TPR: Tpau_3844
SALU: DC74_7446
SALL: SAZ_38435
SALF: SMD44_02218(hsaD)
SLX: SLAV_27435(hsaD)
LMOI: VV02_04600
NCA: Noca_2775
NDK: I601_3469(hsaD_2)
PSIM: KR76_14475
AMD: AMED_2523(mhpC)
AMN: RAM_12825
AMM: AMES_2495(mhpC)
AMZ: B737_2496(mhpC)
AOI: AORI_2485(mhpC)
AJA: AJAP_26400(hsaD)
AMQ: AMETH_4837(mhpC)
AMYY: YIM_14455(hsaD1)
KAL: KALB_5123
ALO: CRK59593
SAQ: Sare_2878
AFS: AFR_13045
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD
  Title
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.
  Journal
J Biol Chem 285:434-43 (2010)
DOI:10.1074/jbc.M109.058081
  Sequence
[mtu:Rv3569c]
Reference
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009

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