KEGG   ORTHOLOGY: K16056Help
Entry
K16056                      KO                                     

Name
ORAI1
Definition
calcium release-activated calcium channel protein 1
Pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04611  Platelet activation
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04927  Cortisol synthesis and secretion
ko04934  Cushing's syndrome
ko05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiencies (CIDs)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    K16056  ORAI1; calcium release-activated calcium channel protein 1
   04024 cAMP signaling pathway
    K16056  ORAI1; calcium release-activated calcium channel protein 1
 Organismal Systems
  Immune system
   04611 Platelet activation
    K16056  ORAI1; calcium release-activated calcium channel protein 1
  Endocrine system
   04924 Renin secretion
    K16056  ORAI1; calcium release-activated calcium channel protein 1
   04925 Aldosterone synthesis and secretion
    K16056  ORAI1; calcium release-activated calcium channel protein 1
   04927 Cortisol synthesis and secretion
    K16056  ORAI1; calcium release-activated calcium channel protein 1
 Human Diseases
  Immune diseases
   05340 Primary immunodeficiency
    K16056  ORAI1; calcium release-activated calcium channel protein 1
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K16056  ORAI1; calcium release-activated calcium channel protein 1
Transporters [BR:ko02000]
 Other Transporters
  Pores ion channels
   K16056  ORAI1; calcium release-activated calcium channel protein 1
Ion channels [BR:ko04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   K16056  ORAI1; calcium release-activated calcium channel protein 1
BRITE hierarchy
Other DBs
GO: 0015279
TC: 1.A.52.1.1 1.A.52.2 1.A.52.3
Genes
HSA: 84876(ORAI1)
PTR: 473293(ORAI1)
PPS: 100987781(ORAI1)
GGO: 101149689(ORAI1)
PON: 100432306(ORAI1)
NLE: 100591849(ORAI1)
MCC: 700190(ORAI1)
MCF: 102129315(ORAI1)
CSAB: 103239286(ORAI1)
RRO: 104666279(ORAI1)
RBB: 108529632(ORAI1)
CJC: 100400670(ORAI1)
SBQ: 101044294(ORAI1)
MMU: 109305(Orai1)
RNO: 304496(Orai1)
CGE: 100752394(Orai1)
NGI: 103739067(Orai1)
HGL: 101699660(Orai1)
CCAN: 109686395(Orai1)
OCU: 100349347(ORAI1)
TUP: 102475070(ORAI1)
CFA: 486261(ORAI1)
AML: 100477778(ORAI1)
UMR: 103661271(ORAI1)
ORO: 101368790(ORAI1)
FCA: 101096922(ORAI1)
PTG: 102972831(ORAI1)
AJU: 106967590(ORAI1)
BTA: 517688(ORAI1)
BOM: 102274230(ORAI1)
BIU: 109571127(ORAI1)
PHD: 102316875(ORAI1)
CHX: 102171809(ORAI1)
OAS: 101102013(ORAI1)
SSC: 100154923(ORAI1)
CFR: 102503461(ORAI1)
CDK: 105102512(ORAI1)
BACU: 103004835(ORAI1)
LVE: 103088422(ORAI1)
OOR: 101279655(ORAI1)
ECB: 100059726(ORAI1)
EPZ: 103541373(ORAI1)
EAI: 106842218(ORAI1)
MYB: 102253522(ORAI1)
MYD: 102775355(ORAI1)
HAI: 109386109(ORAI1)
RSS: 109448588(ORAI1)
PALE: 102883130(ORAI1)
LAV: 100669326(ORAI1)
TMU: 101348360
MDO: 100015978(ORAI1)
SHR: 111719559(ORAI1)
OAA: 100079447(ORAI1)
GGA: 416845(ORAI1)
MGP: 100542708(ORAI1)
CJO: 107321339(ORAI1)
APLA: 101802702(ORAI1)
ACYG: 106031142(ORAI1)
TGU: 100218031(ORAI1)
GFR: 102045243(ORAI1)
FAB: 101813302(ORAI1)
PHI: 102113680(ORAI1)
PMAJ: 107211567(ORAI1)
CCW: 104688700(ORAI1)
FPG: 101912221(ORAI1)
FCH: 102050948(ORAI1)
CLV: 102084504(ORAI1)
EGZ: 104130104(ORAI1)
AAM: 106495677(ORAI1)
ASN: 102379313(ORAI1)
AMJ: 102565923(ORAI1)
PSS: 102446257(ORAI1)
CPIC: 101940211(ORAI1)
ACS: 100556544(orai1)
PBI: 103061493(ORAI1)
GJA: 107115887(ORAI1)
XLA: 108716807 734537(orai2.S)
XTR: 100380109(orai2)
NPR: 108787479(ORAI1)
DRE: 402892(orai1b) 566671(orai1a)
IPU: 108264930(orai1) 108276842(orai1)
AMEX: 103031227 103036052(orai1)
TRU: 101064627(orai1) 101071466
XMA: 102221509(orai1) 102228317
NFU: 107373313(orai1) 107393664
LCF: 108878716 108879826(orai1)
SFM: 108921846 108935040(orai1)
LCM: 102365455(ORAI1)
CMK: 103184306(orai1)
CIN: 100180182
SKO: 100371578
DME: Dmel_CG11430(olf186-F)
DSI: Dsimw501_GD11325(Dsim_GD11325)
MDE: 101900497
AAG: 5579438
AME: 102655332 412524(olf186-F)
BMOR: 100188931(Orai1) 101739927
PXY: 105381117
CEL: CELE_C09F5.2(orai-1)
CBR: CBG15255(Cbr-orai-1)
BMY: Bm1_12470
TSP: Tsp_01599
CRG: 105328659
OBI: 106870551
SHX: MS3_09421
EPA: 110241367
ADF: 107332597
HMG: 100213417
CRE: CHLREDRAFT_195496(SSA12)
VCN: VOLCADRAFT_127367(ssa12)
MNG: MNEG_2934
SPAR: SPRG_02055
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A
  Title
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
  Journal
Nature 441:179-85 (2006)
DOI:10.1038/nature04702
  Sequence
[hsa:84876] [dme:Dmel_CG11430]

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