KEGG   ORTHOLOGY: K16172Help
Entry
K16172                      KO                                     

Name
IRS1
Definition
insulin receptor substrate 1
Pathway
ko04022  cGMP-PKG signaling pathway
ko04068  FoxO signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04960  Aldosterone-regulated sodium reabsorption
ko05206  MicroRNAs in cancer
Module
M00676  PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04022 cGMP-PKG signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04151 PI3K-Akt signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04152 AMPK signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04150 mTOR signaling pathway
    K16172  IRS1; insulin receptor substrate 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K16172  IRS1; insulin receptor substrate 1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04923 Regulation of lipolysis in adipocytes
    K16172  IRS1; insulin receptor substrate 1
   04920 Adipocytokine signaling pathway
    K16172  IRS1; insulin receptor substrate 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K16172  IRS1; insulin receptor substrate 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
  09149 Aging
   04211 Longevity regulating pathway
    K16172  IRS1; insulin receptor substrate 1
   04212 Longevity regulating pathway - worm
    K16172  IRS1; insulin receptor substrate 1
   04213 Longevity regulating pathway - multiple species
    K16172  IRS1; insulin receptor substrate 1
 09160 Human Diseases
  09161 Cancers: Overview
   05206 MicroRNAs in cancer
    K16172  IRS1; insulin receptor substrate 1
  09167 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K16172  IRS1; insulin receptor substrate 1
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K16172  IRS1; insulin receptor substrate 1
   04931 Insulin resistance
    K16172  IRS1; insulin receptor substrate 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00676  PI3K-Akt signaling
     K16172  IRS1; insulin receptor substrate 1
BRITE hierarchy
Genes
HSA: 3667(IRS1)
PTR: 459985(IRS1)
PPS: 100971596(IRS1)
GGO: 101132740(IRS1)
PON: 100442255(IRS1)
NLE: 100607873(IRS1)
MCC: 707870(IRS1)
MCF: 102117978(IRS1)
CSAB: 103217981(IRS1)
RRO: 104656078(IRS1)
RBB: 108538753(IRS1)
CJC: 100387742(IRS1)
SBQ: 101035868(IRS1)
MMU: 16367(Irs1)
RNO: 25467(Irs1)
CGE: 100755710(Irs1)
NGI: 103727788(Irs1)
HGL: 101708189(Irs1)
CCAN: 109696750(Irs1)
OCU: 100339981(IRS1)
TUP: 102496620(IRS1)
CFA: 486148(IRS1)
AML: 100477645(IRS1)
UMR: 103662712(IRS1)
ORO: 101367978(IRS1)
FCA: 101087257(IRS1)
PTG: 102965599(IRS1)
AJU: 106972296(IRS1)
BTA: 538598(IRS1)
BOM: 102284664(IRS1)
BIU: 109571355(IRS1)
PHD: 102316951(IRS1)
CHX: 102184858(IRS1)
OAS: 101102293(IRS1)
SSC: 100512686(IRS1)
CFR: 102512682(IRS1)
CDK: 105088301(IRS1)
BACU: 103011761(IRS1)
LVE: 103074278(IRS1)
OOR: 101271463(IRS1)
ECB: 100061987(IRS1)
EPZ: 103547143(IRS1)
EAI: 106827854(IRS1)
MYB: 102247525(IRS1)
MYD: 102752666(IRS1)
HAI: 109396328(IRS1)
RSS: 109449902(IRS1)
PALE: 102891583(IRS1)
LAV: 100664968(IRS1)
TMU: 101356151
MDO: 100021838(IRS1)
SHR: 100918116(IRS1)
GGA: 107051846
MGP: 100539255(IRS1)
CJO: 107318049(IRS1)
APLA: 101797251(IRS1)
ACYG: 106036186(IRS1)
TGU: 100220553(IRS1)
GFR: 102044407(IRS1)
FAB: 101810426(IRS1)
PHI: 102101540(IRS1)
PMAJ: 107208936(IRS1)
CCAE: 111933626(IRS1)
CCW: 104693429(IRS1)
FPG: 101922249(IRS1)
FCH: 102052001(IRS1)
CLV: 102083619(IRS1)
EGZ: 104127063(IRS1)
AAM: 106485843(IRS1)
ASN: 102372136(IRS1)
AMJ: 102574179(IRS1)
PSS: 102455771 102463626(IRS1)
CMY: 102945843(IRS1)
CPIC: 101931522(IRS1)
ACS: 100565100(irs1) 103282162
PVT: 110078456(IRS1) 110082325
PBI: 103048511 103055013(IRS1)
GJA: 107116003(IRS1) 107124425
XLA: 108718134 399299(irs1.S)
XTR: 100495320(irs1)
NPR: 108796838(IRS1)
DRE: 559281(irs1)
IPU: 108260367 108267519(Irs1) 108278298(irs1)
AMEX: 103025632(irs1) 103042975
LCO: 104923989
XMA: 102224423
PRET: 103480483
KMR: 108241811
LCF: 108888061
MALB: 109966482
ELS: 105020633
LCM: 102366510(IRS1) 102367331
CMK: 103180489(irs1)
CIN: 100185541
SPU: 100890677
APLC: 110985759
SKO: 102809894
DME: Dmel_CG5686(chico)
DSI: Dsimw501_GD22290(Dsim_GD22290)
AME: 408438
BIM: 100742603
BTER: 100644779
SOC: 105202010
ACEP: 105627057
PBAR: 105427691
HST: 105180459
DQU: 106741422
CFO: 105251794
LHU: 105679317
PGC: 109861371
PCF: 106792141
NVI: 100119908
MDL: 103578429
TCA: 103313904
NVL: 108563039
BMOR: 101745072
PMAC: 106718294
PRAP: 110993911
HAW: 110376740
API: 100569479
DNX: 107161961
CLEC: 106667510
ZNE: 110835233
FCD: 110847979
TUT: 107366694
CEL: CELE_C54D1.3(ist-1)
CBR: CBG10979(Cbr-ist-1)
BMY: Bm1_00475
TSP: Tsp_03690
CRG: 105342662
MYI: 110464153
OBI: 106875365
EPA: 110236656
ADF: 107342456
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Sisci D, Morelli C, Cascio S, Lanzino M, Garofalo C, Reiss K, Garcia M, Russo A, Ando S, Surmacz E
  Title
The estrogen receptor alpha:insulin receptor substrate 1 complex in breast cancer: structure-function relationships.
  Journal
Ann Oncol 18 Suppl 6:vi81-5 (2007)
DOI:10.1093/annonc/mdm232
Reference
PMID:7541045
  Authors
Craparo A, O'Neill TJ, Gustafson TA
  Title
Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.
  Journal
J Biol Chem 270:15639-43 (1995)
DOI:10.1074/jbc.270.26.15639
Reference
PMID:1380456
  Authors
Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, et al.
  Title
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
  Journal
EMBO J 11:3469-79 (1992)
  Sequence
[rno:25467]

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