KEGG   ORTHOLOGY: K16340Help
Entry
K16340                      KO                                     

Name
PHLPP
Definition
PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
Pathway
ko04151  PI3K-Akt signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Mg2+- or Mn2+- dependent protein phosphatases (PPMs)
   PPM1 phosphatases (PP2C)
    K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase
BRITE hierarchy
Other DBs
GO: 0004722
Genes
HSA: 23035(PHLPP2) 23239(PHLPP1)
PTR: 454384(PHLPP2) 468563(PHLPP1)
PPS: 100984856(PHLPP1) 100988777(PHLPP2)
GGO: 101143090(PHLPP2) 101144212(PHLPP1)
PON: 100436971(PHLPP1) 100445641(PHLPP2)
NLE: 100581581(PHLPP2) 100601604(PHLPP1)
MCC: 705882(PHLPP1) 707575(PHLPP2)
MCF: 102127713(PHLPP1) 102142978(PHLPP2)
CSAB: 103233169(PHLPP2) 103244170(PHLPP1)
RRO: 104654754(PHLPP2) 104682250(PHLPP1)
RBB: 108526411(PHLPP1) 108527462(PHLPP2)
CJC: 100395153(PHLPP1) 100409942(PHLPP2)
SBQ: 101028467(PHLPP2) 101051691(PHLPP1)
MMU: 244650(Phlpp2) 98432(Phlpp1)
MCAL: 110293215(Phlpp1) 110300030(Phlpp2)
MPAH: 110321667(Phlpp1) 110337414(Phlpp2)
RNO: 498949(Phlpp2) 59265(Phlpp1)
MUN: 110546030(Phlpp2) 110557799(Phlpp1) 110565735 110565736
CGE: 100750559(Phlpp1) 100754973(Phlpp2)
NGI: 103735625(Phlpp2) 103740117(Phlpp1)
HGL: 101699656(Phlpp2) 101701316(Phlpp1)
CCAN: 109693758(Phlpp1) 109694284(Phlpp2)
OCU: 100356030(PHLPP2) 100359297(PHLPP1)
TUP: 102480906(PHLPP1)
CFA: 476179(PHLPP1) 489724(PHLPP2)
VVP: 112919202(PHLPP1) 112929492(PHLPP2)
AML: 100483835(PHLPP1) 100484269(PHLPP2)
UMR: 103673589(PHLPP2) 103676186(PHLPP1)
UAH: 113252456(PHLPP2) 113253488(PHLPP1)
ORO: 101362683(PHLPP2) 101380084(PHLPP1)
FCA: 101080345(PHLPP2) 101091156(PHLPP1)
PTG: 102949246(PHLPP2) 102956659(PHLPP1)
PPAD: 109270669(PHLPP2) 109275628(PHLPP1)
AJU: 106985225(PHLPP1) 106987862(PHLPP2)
BTA: 533130(PHLPP2) 615982(PHLPP1)
BOM: 102267150(PHLPP2) 102269424(PHLPP1)
BIU: 109572765(PHLPP2) 109577942(PHLPP1)
BBUB: 102395674(PHLPP1) 102409509(PHLPP2)
CHX: 102178032(PHLPP1) 102180148(PHLPP2)
OAS: 101104420(PHLPP2) 101119357(PHLPP1)
SSC: 100154633(PHLPP1) 100628113(PHLPP2)
CFR: 102517124(PHLPP2) 102523580(PHLPP1)
CDK: 105088376(PHLPP2) 105088998(PHLPP1)
BACU: 103011132(PHLPP1) 103011828(PHLPP2)
LVE: 103079968(PHLPP1) 103088926(PHLPP2)
OOR: 101275266(PHLPP2) 101276502(PHLPP1)
DLE: 111179553(PHLPP2) 111180201(PHLPP1)
PCAD: 102975676(PHLPP1) 102978697(PHLPP2)
ECB: 100054529(PHLPP2) 100057142(PHLPP1)
EPZ: 103550778(PHLPP1) 103551740(PHLPP2)
EAI: 106830903(PHLPP2) 106832858(PHLPP1)
MYB: 102242412(PHLPP1) 102255957(PHLPP2)
MYD: 102760981(PHLPP2) 102769173(PHLPP1)
MNA: 107524301(PHLPP2) 107545410(PHLPP1)
HAI: 109389025(PHLPP2) 109390773(PHLPP1)
DRO: 112300771(PHLPP2) 112322856(PHLPP1)
PALE: 102886914(PHLPP1) 102892249(PHLPP2)
MJV: 108384043(PHLPP2) 108391456(PHLPP1)
LAV: 100661325(PHLPP1) 100666486(PHLPP2)
MDO: 100020771(PHLPP2) 100024744(PHLPP1)
SHR: 100915217(PHLPP1) 100925568(PHLPP2)
PCW: 110192449(PHLPP2) 110214692(PHLPP1)
OAA: 100076821(PHLPP2) 100079031(PHLPP1)
GGA: 415881(PHLPP2) 420904(PHLPP1)
MGP: 100545158(PHLPP1) 100550506(PHLPP2)
CJO: 107309595(PHLPP1) 107319448(PHLPP2)
NMEL: 110394857(PHLPP1) 110404164(PHLPP2)
APLA: 101793975(PHLPP2) 101796170(PHLPP1)
ACYG: 106039931(PHLPP1) 106046606(PHLPP2)
TGU: 100220847(PHLPP2) 100226834(PHLPP1)
LSR: 110468753(PHLPP2) 110470696(PHLPP1)
SCAN: 103815305(PHLPP1) 103816918(PHLPP2)
GFR: 102042976(PHLPP2) 102044574(PHLPP1)
FAB: 101813247(PHLPP2) 101817708(PHLPP1)
PHI: 102100675(PHLPP1) 102114198(PHLPP2)
PMAJ: 107200052(PHLPP1) 107209859(PHLPP2)
CCAE: 111923862(PHLPP1) 111945251(PHLPP2)
CCW: 104691963(PHLPP2) 104698172(PHLPP1)
ETL: 114065308(PHLPP1) 114067577(PHLPP2)
FPG: 101918797(PHLPP2) 101921897(PHLPP1)
FCH: 102056419(PHLPP1) 102060003(PHLPP2)
CLV: 102084780(PHLPP2) 102092669(PHLPP1)
EGZ: 104123470(PHLPP1) 104126426(PHLPP2)
NNI: 104021922(PHLPP1) 104023602(PHLPP2)
ACUN: 113476572(PHLPP1) 113484611(PHLPP2)
AAM: 106498814(PHLPP2) 106500214(PHLPP1)
ASN: 102368990(PHLPP2) 102378639(PHLPP1)
AMJ: 102564286(PHLPP1) 106736923(PHLPP2)
PSS: 102446836(PHLPP1)
CMY: 102941170(PHLPP1) 102947678(PHLPP2)
CPIC: 101937851(PHLPP1) 101940704(PHLPP2)
ACS: 100558951(phlpp1)
PVT: 110075415(PHLPP1)
PBI: 103058606(PHLPP1)
PMUR: 107283570(PHLPP1)
PMUA: 114600981(PHLPP1)
GJA: 107122712(PHLPP1)
XLA: 108705361(phlpp2.L) 108719102(phlpp1.L) 108720088(phlpp1.S) 733362(phlpp2.S)
XTR: 100497530(phlpp1)
NPR: 108786567(PHLPP2) 108793656(PHLPP1)
DRE: 100331906(phlpp1)
IPU: 108267724(phlpp1) 108270694(phlpp2)
PHYP: 113536510(phlpp2) 113547250
AMEX: 103023122(phlpp2) 103044693(phlpp1)
EEE: 113575770(phlpp2) 113582972
TRU: 101064810 101070914(phlpp2) 101073770(phlpp1) 115247209
LCO: 104919469(phlpp2) 104927727 104931536(phlpp1)
MZE: 101464301 101473477(phlpp2) 101477421(phlpp1)
ONL: 100702044 100705906(phlpp1) 100712534(phlpp2)
KMR: 108229462(phlpp2) 108239649(phlpp1) 108248355
PKI: 111833020(phlpp2) 111845853 111850047(phlpp1) 111855141
LCM: 102359442(PHLPP2)
CMK: 103176029(phlpp2) 103179960(phlpp1)
DME: Dmel_CG10493(Phlpp)
DER: 6549381
DSI: Dsimw501_GD24180(Dsim_GD24180)
DSR: 110181455
DPE: 6593811
DMN: 108162077
DWI: 6643839
DAZ: 108611605
DNV: 115563587
DHE: 111598935
MDE: 101888993
LCQ: 111688669
AAG: 5568773
AME: 410926
BIM: 100742132
BTER: 100646325
OBB: 114874981
SOC: 105197592
MPHA: 105837892
AEC: 105151504
ACEP: 105627338
PBAR: 105432812
VEM: 105562445
HST: 105186804
DQU: 106747814
CFO: 105250930
LHU: 105674942
PGC: 109858302
OBO: 105281519
NVI: 100118202
CSOL: 105369047
MDL: 103575479
TCA: 662191
DPA: 109537531
ATD: 109599652
NVL: 108568931
BMOR: 101745921
BMAN: 114246376
PMAC: 106712185
PRAP: 111001769
HAW: 110371918
TNL: 113493509
PXY: 105380348
BTAB: 109034160
CLEC: 106667006
ZNE: 110832775
FCD: 110863112
CSCU: 111623405
PTEP: 107437232
CEL: CELE_F43C1.1(phlp-2)
CBR: CBG20149
TSP: Tsp_01667
PCAN: 112577395
CRG: 105333565
MYI: 110458682
OBI: 106883129
LAK: 106158698
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
O'Neill AK, Niederst MJ, Newton AC
  Title
Suppression of survival signalling pathways by the phosphatase PHLPP.
  Journal
FEBS J 280:572-83 (2013)
DOI:10.1111/j.1742-4658.2012.08537.x
  Sequence
[hsa:23239]
Reference
  Authors
Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T
  Title
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis.
  Journal
Oncogene 28:994-1004 (2009)
DOI:10.1038/onc.2008.450
  Sequence
[hsa:23239 23035]

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