KEGG   ORTHOLOGY: K16340Help
Entry
K16340                      KO                                     

Name
PHLPP
Definition
PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
Pathway
ko04151  PI3K-Akt signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Mg2+- or Mn2+- dependent protein phosphatases (PPMs)
   PPM1 phosphatases (PP2C)
    K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase
BRITE hierarchy
Other DBs
GO: 0004722
Genes
HSA: 23035(PHLPP2) 23239(PHLPP1)
PTR: 454384(PHLPP2) 468563(PHLPP1)
PPS: 100984856(PHLPP1) 100988777(PHLPP2)
GGO: 101143090(PHLPP2) 101144212(PHLPP1)
PON: 100436971(PHLPP1) 100445641(PHLPP2)
NLE: 100581581(PHLPP2) 100601604(PHLPP1)
MCC: 705882(PHLPP1) 707575(PHLPP2)
MCF: 102127713(PHLPP1) 102142978(PHLPP2)
CSAB: 103233169(PHLPP2) 103244170(PHLPP1)
RRO: 104654754(PHLPP2) 104682250(PHLPP1)
RBB: 108526411(PHLPP1) 108527462(PHLPP2)
CJC: 100395153(PHLPP1) 100409942(PHLPP2)
SBQ: 101028467(PHLPP2) 101051691(PHLPP1)
MMU: 244650(Phlpp2) 98432(Phlpp1)
MCAL: 110293215(Phlpp1) 110300030(Phlpp2)
MPAH: 110321667(Phlpp1) 110337414(Phlpp2)
RNO: 498949(Phlpp2) 59265(Phlpp1)
MUN: 110546030(Phlpp2) 110557799(Phlpp1) 110565735 110565736
CGE: 100750559(Phlpp1) 100754973(Phlpp2)
NGI: 103735625(Phlpp2) 103740117(Phlpp1)
HGL: 101699656(Phlpp2) 101701316(Phlpp1)
CCAN: 109693758(Phlpp1) 109694284(Phlpp2)
OCU: 100356030(PHLPP2) 100359297(PHLPP1)
TUP: 102480906(PHLPP1)
CFA: 476179(PHLPP1) 489724(PHLPP2)
VVP: 112919202(PHLPP1) 112929492(PHLPP2)
AML: 100483835(PHLPP1) 100484269(PHLPP2)
UMR: 103673589(PHLPP2) 103676186(PHLPP1)
UAH: 113252456(PHLPP2) 113253488(PHLPP1)
ORO: 101362683(PHLPP2) 101380084(PHLPP1)
ELK: 111152971 111154258
FCA: 101080345(PHLPP2) 101091156(PHLPP1)
PTG: 102949246(PHLPP2) 102956659(PHLPP1)
PPAD: 109270669(PHLPP2) 109275628(PHLPP1)
AJU: 106985225(PHLPP1) 106987862(PHLPP2)
BTA: 533130(PHLPP2) 615982(PHLPP1)
BOM: 102267150(PHLPP2) 102269424(PHLPP1)
BIU: 109572765(PHLPP2) 109577942(PHLPP1)
BBUB: 102395674(PHLPP1) 102409509(PHLPP2)
CHX: 102178032(PHLPP1) 102180148(PHLPP2)
OAS: 101104420(PHLPP2) 101119357(PHLPP1)
SSC: 100154633(PHLPP1) 100628113(PHLPP2)
CFR: 102517124(PHLPP2) 102523580(PHLPP1)
CDK: 105088376(PHLPP2) 105088998(PHLPP1)
BACU: 103011132(PHLPP1) 103011828(PHLPP2)
LVE: 103079968(PHLPP1) 103088926(PHLPP2)
OOR: 101275266(PHLPP2) 101276502(PHLPP1)
DLE: 111179553(PHLPP2) 111180201(PHLPP1)
PCAD: 102975676(PHLPP1) 102978697(PHLPP2)
ECB: 100054529(PHLPP2) 100057142(PHLPP1)
EPZ: 103550778(PHLPP1) 103551740(PHLPP2)
EAI: 106830903(PHLPP2) 106832858(PHLPP1)
MYB: 102242412(PHLPP1) 102255957(PHLPP2)
MYD: 102760981(PHLPP2) 102769173(PHLPP1)
MNA: 107524301(PHLPP2) 107545410(PHLPP1)
HAI: 109389025(PHLPP2) 109390773(PHLPP1)
DRO: 112300771(PHLPP2) 112322856(PHLPP1)
PALE: 102886914(PHLPP1) 102892249(PHLPP2)
RAY: 107501513 107503916 107520538(PHLPP2)
MJV: 108384043(PHLPP2) 108391456(PHLPP1)
LAV: 100661325(PHLPP1) 100666486(PHLPP2)
TMU: 101355703 101360015
MDO: 100020771(PHLPP2) 100024744(PHLPP1)
SHR: 100915217(PHLPP1) 100925568(PHLPP2)
PCW: 110192449(PHLPP2) 110214692(PHLPP1)
OAA: 100076821(PHLPP2) 100079031(PHLPP1)
GGA: 415881(PHLPP2) 420904(PHLPP1)
MGP: 100545158(PHLPP1) 100550506(PHLPP2)
CJO: 107309595(PHLPP1) 107319448(PHLPP2)
NMEL: 110394857(PHLPP1) 110404164(PHLPP2)
APLA: 101793975(PHLPP2) 101796170(PHLPP1)
ACYG: 106039931(PHLPP1) 106046606(PHLPP2)
TGU: 100220847(PHLPP2) 100226834(PHLPP1)
LSR: 110468753(PHLPP2) 110470696(PHLPP1)
SCAN: 103815305(PHLPP1) 103816918(PHLPP2)
GFR: 102042976(PHLPP2) 102044574(PHLPP1)
FAB: 101813247(PHLPP2) 101817708(PHLPP1)
PHI: 102100675(PHLPP1) 102114198(PHLPP2)
PMAJ: 107200052(PHLPP1) 107209859(PHLPP2)
CCAE: 111923862(PHLPP1) 111945251(PHLPP2)
CCW: 104691963(PHLPP2) 104698172(PHLPP1)
ETL: 114065308(PHLPP1) 114067577(PHLPP2)
FPG: 101918797(PHLPP2) 101921897(PHLPP1)
FCH: 102056419(PHLPP1) 102060003(PHLPP2)
CLV: 102084780(PHLPP2) 102092669(PHLPP1)
EGZ: 104123470(PHLPP1) 104126426(PHLPP2)
NNI: 104021922(PHLPP1) 104023602(PHLPP2)
ACUN: 113476572(PHLPP1) 113484611(PHLPP2)
PADL: 103915543 103916513 103919229(PHLPP1) 103919463
AAM: 106498814(PHLPP2) 106500214(PHLPP1)
ASN: 102368990(PHLPP2) 102378639(PHLPP1)
AMJ: 102564286(PHLPP1) 106736923(PHLPP2)
PSS: 102446836(PHLPP1)
CMY: 102941170(PHLPP1) 102947678(PHLPP2)
CPIC: 101937851(PHLPP1) 101940704(PHLPP2)
ACS: 100558951(phlpp1)
PVT: 110075415(PHLPP1)
PBI: 103058606(PHLPP1)
PMUR: 107283570(PHLPP1)
TSR: 106554158 106554200
PMUA: 114600981(PHLPP1)
GJA: 107122712(PHLPP1)
XLA: 108705361(phlpp2.L) 108719102(phlpp1.L) 108720088(phlpp1.S) 733362(phlpp2.S)
XTR: 100497530(phlpp1)
NPR: 108786567(PHLPP2) 108793656(PHLPP1)
DRE: 100331906(phlpp1)
SRX: 107715440 107721116 107722298 107738356
SANH: 107659136 107662547(phlpp1) 107698933
SGH: 107553000 107553001 107561505 107563078 107563109 107571400
CCAR: 109047612(phlpp1) 109048455 109055304 109073724 109085703
IPU: 108267724(phlpp1) 108270694(phlpp2)
PHYP: 113536510(phlpp2) 113547250
AMEX: 103023122(phlpp2) 103044693(phlpp1)
EEE: 113575770(phlpp2) 113582972
TRU: 101064810 101070914(phlpp2) 101073770(phlpp1) 115247209
TNG: GSTEN00006434G001 GSTEN00011824G001 GSTEN00017734G001
LCO: 104919469(phlpp2) 104927727 104931536(phlpp1)
NCC: 104942124(phlpp2) 104947935 104962716 104966896
MZE: 101464301 101473477(phlpp2) 101477421(phlpp1)
ONL: 100702044 100705906(phlpp1) 100712534(phlpp2)
OLA: 101166954 101166990 101174820(phlpp2)
XMA: 102221757(phlpp2) 102225687 102231120
XCO: 114142941(phlpp2) 114146570 114151084
PRET: 103462503(phlpp2) 103463407 103479552
CVG: 107083029 107090665(phlpp2) 107092423 107095638
NFU: 107381364(phlpp2) 107383910 107393043
KMR: 108229462(phlpp2) 108239649(phlpp1) 108248355
ALIM: 106526011 106531538(phlpp2) 106533915
AOCE: 111566209(phlpp2) 111568698 111569880
CSEM: 103378737(phlpp2) 103396280 103399859
POV: 109636728(phlpp2) 109641602 109643533 109646586
LCF: 108879536 108883413 108887715(phlpp2)
SDU: 111220744(phlpp2) 111227541 111231259
SLAL: 111655122(phlpp2) 111670482 111671731
HCQ: 109521239 109524926 109526029(phlpp2)
BPEC: 110157373 110172250 110175316(phlpp2)
MALB: 109957739 109961248 109964100(phlpp2)
SASA: 106560398 106569160 106587330 106587351 106599727
OTW: 112226838 112249173 112251329 112260581 112263706
SALP: 111956712 111969373 111973653 111975515 111976167 111979247
ELS: 105011967 105016643(phlpp2) 105018588
SFM: 108931855 108934558(phlpp2) 108937595
PKI: 111833020(phlpp2) 111845853 111850047(phlpp1) 111855141
LCM: 102359442(PHLPP2)
CMK: 103176029(phlpp2) 103179960(phlpp1)
RTP: 109911732 109916593 109921415(phlpp1)
BFO: BRAFLDRAFT_214316
DME: Dmel_CG10493(Phlpp)
DER: 6549381
DSE: Dsec_GM17320
DSI: Dsimw501_GD24180(Dsim_GD24180)
DYA: Dyak_GE13228
DAN: Dana_GF14696
DSR: 110181455
DPO: Dpse_GA10351
DPE: 6593811
DMN: 108162077
DWI: 6643839
DGR: Dgri_GH10896
DMO: Dmoj_GI13118
DAZ: 108611605
DNV: 115563587
DHE: 111598935
DVI: Dvir_GJ11657
MDE: 101888993
LCQ: 111688669
AGA: AgaP_AGAP009087
AAG: 5568773
AALB: 109404812 109423908
CQU: CpipJ_CPIJ013310
AME: 410926
BIM: 100742132
BTER: 100646325
CCAL: 108622092 113464545
OBB: 114874981
SOC: 105197592
MPHA: 105837892
AEC: 105151504
ACEP: 105627338
PBAR: 105432812
VEM: 105562445
HST: 105186804
DQU: 106747814
CFO: 105250930
LHU: 105674942
PGC: 109858302
OBO: 105281519
NVI: 100118202
CSOL: 105369047
MDL: 103575479
TCA: 662191
DPA: 109537531
ATD: 109599652
NVL: 108568931
BMOR: 101745921
BMAN: 114246376
DPL: KGM_211074
PMAC: 106712185
PRAP: 111001769
HAW: 110371918
TNL: 113493509
PXY: 105380348
BTAB: 109034160
CLEC: 106667006
ZNE: 110832775
FCD: 110863112
PVM: 113814688 113817188
ISC: IscW_ISCW008143
CSCU: 111623405
PTEP: 107437232
CEL: CELE_F43C1.1(phlp-2)
CBR: CBG20149
LOA: LOAG_04501
TSP: Tsp_01667
LGI: LOTGIDRAFT_155730
PCAN: 112577395
CRG: 105333565
MYI: 110458682
OBI: 106883129
LAK: 106158698
AQU: 105314514 109590967 109591977
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
O'Neill AK, Niederst MJ, Newton AC
  Title
Suppression of survival signalling pathways by the phosphatase PHLPP.
  Journal
FEBS J 280:572-83 (2013)
DOI:10.1111/j.1742-4658.2012.08537.x
  Sequence
[hsa:23239]
Reference
  Authors
Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T
  Title
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis.
  Journal
Oncogene 28:994-1004 (2009)
DOI:10.1038/onc.2008.450
  Sequence
[hsa:23239 23035]

  All links  
Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1351)   
   KEGG GENES (420)   
   KEGG MGENES (416)   
   RefGene (509)   
   OC (6)   
Protein sequence (115)   
   UniProt (109)   
   SWISS-PROT (6)   
Literature (2)   
   PubMed (2)   
All databases (1475)   

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