KEGG   ORTHOLOGY: K16342Help
Entry
K16342                      KO                                     

Name
PLA2G4, CPLA2
Definition
cytosolic phospholipase A2 [EC:3.1.1.4]
Pathway
ko00564  Glycerophospholipid metabolism
ko00565  Ether lipid metabolism
ko00590  Arachidonic acid metabolism
ko00591  Linoleic acid metabolism
ko00592  alpha-Linolenic acid metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04072  Phospholipase D signaling pathway
ko04217  Necroptosis
ko04270  Vascular smooth muscle contraction
ko04370  VEGF signaling pathway
ko04611  Platelet activation
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04724  Glutamatergic synapse
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04750  Inflammatory mediator regulation of TRP channels
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04921  Oxytocin signaling pathway
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00565 Ether lipid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00590 Arachidonic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00591 Linoleic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00592 alpha-Linolenic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04010 MAPK signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04370 VEGF signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04072 Phospholipase D signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04664 Fc epsilon RI signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04666 Fc gamma R-mediated phagocytosis
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  09152 Endocrine system
   04912 GnRH signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04913 Ovarian steroidogenesis
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04921 Oxytocin signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  09156 Nervous system
   04724 Glutamatergic synapse
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04726 Serotonergic synapse
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04730 Long-term depression
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.4  phospholipase A2
     K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
BRITE hierarchy
Other DBs
RN: R01315 R01317 R02053 R07064 R07379 R07387 R07859
GO: 0004623
Genes
HSA: 100137049(PLA2G4B) 123745(PLA2G4E) 255189(PLA2G4F) 283748(PLA2G4D) 5321(PLA2G4A) 8605(PLA2G4C) 8681(JMJD7-PLA2G4B)
PTR: 100610135(PLA2G4D) 453356(PLA2G4F) 467664(PLA2G4E) 468935(PLA2G4C) 469617(PLA2G4A) 747584
PPS: 100978248(PLA2G4C) 100984773(PLA2G4A) 100986585(PLA2G4F) 100986912(PLA2G4D) 100987249(PLA2G4E)
GGO: 101126764(PLA2G4C) 101130728 101137812(PLA2G4E) 101138793(PLA2G4F) 101147399(PLA2G4A) 109025233(PLA2G4D)
PON: 100173125(PLA2G4A) 100434495(PLA2G4C) 100447631(PLA2G4B) 100448616(PLA2G4F) 100454614(PLA2G4E) 100454977(PLA2G4D)
NLE: 100587969(PLA2G4C) 100591421(PLA2G4A) 100591987 100593220(PLA2G4E) 100593575(PLA2G4D) 100593907(PLA2G4F)
MCC: 100424593(PLA2G4E) 100533113(PLA2G4B) 707592(PLA2G4D) 707690(PLA2G4F) 716635(PLA2G4A) 718510
MCF: 102142596(PLA2G4C) 102143026(PLA2G4B) 102143695(PLA2G4A) 102143812(PLA2G4E) 102144463(PLA2G4D) 102146081(PLA2G4F)
CSAB: 103230418(PLA2G4A) 103235528(PLA2G4C) 103245774(PLA2G4F) 103245776(PLA2G4D) 103245777(PLA2G4E) 103246100(PLA2G4B)
RRO: 104664371(PLA2G4A) 104665267(PLA2G4F) 104666910(PLA2G4B) 104666913(PLA2G4E) 104666914(PLA2G4D) 104673480(PLA2G4C)
RBB: 108517617(PLA2G4F) 108523179(PLA2G4A) 108540165(PLA2G4C) 108544325(PLA2G4D) 108544332(PLA2G4E) 108544335(PLA2G4B)
CJC: 100391709(PLA2G4F) 100400789(PLA2G4D) 100401154(PLA2G4E) 100402439(PLA2G4A) 108590272
SBQ: 101036859(PLA2G4F) 101037291(PLA2G4D) 101037621(PLA2G4E) 101038256(PLA2G4B) 101054434(PLA2G4A)
MMU: 18783(Pla2g4a) 211429(Pla2g4b) 232889(Pla2g4c) 271844(Pla2g4f) 329502(Pla2g4e) 78390(Pla2g4d)
MCAL: 110284581(Pla2g4b) 110289370(Pla2g4f) 110289583(Pla2g4d) 110290316(Pla2g4e) 110294088(Pla2g4a) 110298861(Pla2g4c)
MPAH: 110317835(Pla2g4b) 110318542(Pla2g4f) 110318953(Pla2g4d) 110319432(Pla2g4e) 110321382(Pla2g4a) 110336949(Pla2g4c)
RNO: 24653(Pla2g4a) 296091(Pla2g4e) 311341(Pla2g4b) 691810(Pla2g4c) 691813 691905(Pla2g4d) 691907(Pla2g4f)
MUN: 110553491(Pla2g4a) 110554755(Pla2g4b) 110554759(Pla2g4e) 110554765(Pla2g4d) 110554773(Pla2g4f)
CGE: 100750927(Pla2g4a) 100754559(Pla2g4c) 100770605(Pla2g4f) 100770894(Pla2g4e) 100771756(Pla2g4b) 103158591(Pla2g4d)
NGI: 103726649(Pla2g4a) 103732429(Pla2g4c) 103744942(Pla2g4b) 103744945(Pla2g4e) 103744946(Pla2g4d) 103744947(Pla2g4f)
HGL: 101703792(Pla2g4b) 101704061(Pla2g4a) 101705849(Pla2g4e) 101706202(Pla2g4f) 101713091(Pla2g4c) 101717491(Pla2g4d)
CCAN: 109678488(Pla2g4d) 109682660(Pla2g4f) 109685136(Pla2g4a) 109693126(Pla2g4e) 109697572 109697577 109697580 109697581
OCU: 100008748(PLA2G4A) 100340517(PLA2G4F) 100340775(PLA2G4D) 100341033(PLA2G4E) 100341237(PLA2G4C) 100533118(PLA2G4B)
TUP: 102470223(PLA2G4E) 102470647(PLA2G4F) 102471767(PLA2G4D) 102472618(JMJD7) 102473333(PLA2G4C) 102477396(PLA2G4A)
CFA: 480048(PLA2G4A) 487512(PLA2G4B) 487514(PLA2G4E) 487515(PLA2G4F) 608811(PLA2G4D)
VVP: 112919809(PLA2G4D) 112919810(PLA2G4F) 112919975(PLA2G4B) 112919979(PLA2G4E) 112921831(PLA2G4A)
AML: 100469987(PLA2G4F) 100470240(PLA2G4D) 100470490(PLA2G4E) 100470998(PLA2G4B) 100482619(PLA2G4A)
UMR: 103668635(PLA2G4A) 103673432(PLA2G4E) 103673531(PLA2G4F) 103673532(PLA2G4D) 103673534(PLA2G4B)
UAH: 113241915(PLA2G4F) 113241916(PLA2G4D) 113241996(PLA2G4E) 113262763(PLA2G4A)
ORO: 101362322(PLA2G4B) 101374803(PLA2G4A) 101377203(PLA2G4F) 101377493(PLA2G4D) 101386671(PLA2G4E)
FCA: 101082033(PLA2G4A) 101082574(PLA2G4F) 101082828(PLA2G4E) 101082829(PLA2G4D) 101083342
PTG: 102948969(PLA2G4A) 102959018(PLA2G4B) 102959667(PLA2G4E) 102959937(PLA2G4F) 102964036(PLA2G4D)
PPAD: 109253583(PLA2G4A) 109263108(PLA2G4F) 109263110(PLA2G4D) 109263111(PLA2G4E)
AJU: 106968512(PLA2G4E) 106968514 106968562(PLA2G4F) 106968584(PLA2G4D) 106977949(PLA2G4A)
BTA: 505485(PLA2G4B) 522866(PLA2G4F) 525072(PLA2G4A) 526364(PLA2G4E) 531209(PLA2G4D)
BOM: 102271639(PLA2G4A) 102282019(PLA2G4B) 102282579(PLA2G4E) 102282862(PLA2G4D) 102283142(PLA2G4F)
BIU: 109564977(PLA2G4B) 109564980(PLA2G4E) 109564981(PLA2G4D) 109564982(PLA2G4F) 109570204 109570696(PLA2G4A)
BBUB: 102389740(PLA2G4A) 102397348(PLA2G4F) 102397889(PLA2G4D) 102398203(PLA2G4E) 102398843
CHX: 102175216(JMJD7) 102178930(PLA2G4A) 102187595(PLA2G4E) 102187867(PLA2G4D) 102188141(PLA2G4F)
OAS: 101111472(PLA2G4A) 101115372(PLA2G4B) 101115878(PLA2G4E) 101116150(PLA2G4D) 101116403(PLA2G4F)
SSC: 100152927(PLA2G4B) 100513834(PLA2G4F) 100514811(PLA2G4E) 100520687(PLA2G4A) 102162529(PLA2G4D)
CFR: 102507142(PLA2G4D) 102509341(PLA2G4A) 102516599(PLA2G4B) 102517096(PLA2G4E) 102517351(PLA2G4F)
CDK: 105096850(PLA2G4B) 105099290(PLA2G4A) 105101745(PLA2G4E) 105101759(PLA2G4F) 105101760(PLA2G4D)
BACU: 102997982 102999275(PLA2G4B) 103008898(PLA2G4F) 103009192(PLA2G4D) 103012091 103012675
LVE: 103083510(PLA2G4D) 103083784(PLA2G4E) 103089071(PLA2G4A) 103090681(PLA2G4F) 103090934(PLA2G4B)
OOR: 101269805(PLA2G4F) 101270052(PLA2G4E) 101270539 101270543(PLA2G4A) 101286206(PLA2G4D)
DLE: 111181572(PLA2G4D) 111181701(PLA2G4F) 111181702(PLA2G4E) 111184676(PLA2G4A)
PCAD: 102983188(PLA2G4D) 102983681(PLA2G4F) 102984239(PLA2G4E) 102985111(PLA2G4A) 102990390
ECB: 100033889(PLA2G4A) 100071016(PLA2G4F) 100071025(PLA2G4D) 100071038(PLA2G4E) 100071062(PLA2G4B)
EPZ: 103549946(PLA2G4D) 103549947(PLA2G4E) 103549950(PLA2G4B) 103549953(PLA2G4F) 103560072(PLA2G4A)
EAI: 106841342(PLA2G4F) 106841343(PLA2G4D) 106841344(PLA2G4E) 106841348(PLA2G4B) 106846782(PLA2G4A)
MYB: 102241902(PLA2G4D) 102242502(PLA2G4F) 102259120(PLA2G4A) 102260953(PLA2G4E)
MYD: 102754320(PLA2G4D) 102754611(PLA2G4E) 102771796(PLA2G4F) 102772466(JMJD7) 102774327(PLA2G4A)
MNA: 107536544(PLA2G4D) 107536549(PLA2G4F) 107536550(PLA2G4E) 107536561 107546298(PLA2G4A)
HAI: 109379089(PLA2G4A) 109383984(PLA2G4E) 109384003(PLA2G4F) 109384004(PLA2G4D) 109384055(PLA2G4B)
DRO: 112296687(PLA2G4A) 112311060(PLA2G4D) 112311538(PLA2G4E) 112311539(PLA2G4F)
PALE: 102883421(PLA2G4F) 102883684(PLA2G4E) 102886310(PLA2G4A) 102887778(PLA2G4D) 102888274
RAY: 107510914(PLA2G4E) 107510922 107510924(PLA2G4F) 107510925(PLA2G4D) 107514503 107521615(PLA2G4A)
MJV: 108385404(PLA2G4D) 108385409(PLA2G4B) 108385414(PLA2G4E) 108402518(PLA2G4F) 108410188(PLA2G4A)
LAV: 100658490(PLA2G4A) 100667057(PLA2G4E) 100675131(PLA2G4D) 100675410(PLA2G4F) 111753010(PLA2G4B)
MDO: 100009808(PLA2G4E) 100024859(PLA2G4A) 100029983(PLA2G4C) 100029998 100620032(PLA2G4D)
SHR: 100913647(PLA2G4E) 100914602(PLA2G4B) 100917893(PLA2G4D) 100918158(PLA2G4F) 100927005(PLA2G4C) 100927268(PLA2G4A)
PCW: 110206877(PLA2G4A) 110219868(PLA2G4C) 110223640(PLA2G4D) 110223689 110223735(PLA2G4F) 110223736(PLA2G4E)
OAA: 100085563 100086135(PLA2G4A) 100086783 100088450(PLA2G4E) 100088466(PLA2G4D) 100089728 100681775(PLA2G4F)
GGA: 101749229(PLA2G4B) 396394(PLA2G4A) 423226(PLA2G4EL7) 423227(PLA2G4EL6) 423229(PLA2G4EL1) 428870(PLA2G4EL3) 428871(PLA2G4F) 771552(PLA2G4EL5) 771560(PLA2G4EL4) 771574(PLA2G4EL2)
FPG: 101915779(PLA2G4C) 101918580(PLA2G4A) 101920043 101922121 101922643(PLA2G4B) 101924845 101925011(PLA2G4E) 101925028(PLA2G4F)
AMJ: 102564564(PLA2G4A) 102568256(PLA2G4B) 102568705(PLA2G4F.1) 102570036(PLA2G4C) 102571167 102571708 102571930 102572385 102572619(PLA2G4E) 102572848(PLA2G4D) 102573092 102573324(PLA2G4F) 106736657
XLA: 108698978(jmjd7-pla2g4b.L) 108699173 108699245(pla2g4f.L) 108699264 108700467 380561(pla2g4a.L)
XTR: 100145731(pla2g4a) 100485430(jmjd7-pla2g4b) 100497525(pla2g4f) 105948093
NPR: 108789293(PLA2G4F) 108789917 108793921 108798704(PLA2G4A)
DRE: 100148818(si:ch73-55i23.1) 30554(pla2g4aa) 559087(pla2g4ab) 565386(pla2g4f.2) 798864(pla2g4f.1)
AMEX: 103030644(pla2g4f) 103034242 103034573
NCC: 104955131(pla2g4a)
OLA: 101156151(pla2g4c) 101172400(pla2g4a)
XMA: 102235312(pla2g4a) 111611546(pla2g4c)
XCO: 114148573(pla2g4c) 114150820(pla2g4a)
PRET: 103468160(pla2g4c) 103468245(pla2g4a)
CVG: 107085950(pla2g4a) 107102418
NFU: 107391550(pla2g4c) 107392886(pla2g4a)
KMR: 108238355(pla2g4a) 108245365(pla2g4c)
ALIM: 106516826(pla2g4a) 106529930 106529932
AOCE: 111585764(pla2g4a) 111586157 111586158
CSEM: 103393578(pla2g4c) 103395269(pla2g4a)
POV: 109636707(pla2g4a) 109641948
SDU: 111217737(pla2g4c) 111232269(pla2g4a)
SLAL: 111645380(pla2g4a) 111669721(pla2g4c)
BPEC: 110162475 110167951(pla2g4a) 110169133
MALB: 109961725(pla2g4a) 109973708
ELS: 105028802 105029083(pla2g4a)
LCM: 102351206 102352898(PLA2G4A) 102356324(PLA2G4F) 102360293
RTP: 109933766(pla2g4a) 109936792
PVM: 113801269
CSCU: 111618634
PTEP: 107457549
OBI: 106876643
HMG: 100200456
PXB: 103942742
NCR: NCU08298
NTE: NEUTE1DRAFT60205(NEUTE1DRAFT_60205)
MGR: MGG_01523
SSCK: SPSK_00697
MAW: MAC_06783
MAJ: MAA_01120
CMT: CCM_02980
MBE: MBM_02873
ANI: AN6211.2
ANG: ANI_1_2450024(An02g04040)
CIM: CIMG_11529(CIMG05408)
PBL: PAAG_11047(PAAG_00099)
PBN: PADG_12248(PADG_07163)
ABE: ARB_00638
TVE: TRV_05103
PTE: PTT_15862
MGL: MGL_1512
MRT: MRET_3847
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schaloske RH, Dennis EA
  Title
The phospholipase A2 superfamily and its group numbering system.
  Journal
Biochim Biophys Acta 1761:1246-59 (2006)
DOI:10.1016/j.bbalip.2006.07.011
Reference
  Authors
Ghosh M, Loper R, Gelb MH, Leslie CC
  Title
Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes.
  Journal
J Biol Chem 281:16615-24 (2006)
DOI:10.1074/jbc.M601770200
Reference
  Authors
Song C, Chang XJ, Bean KM, Proia MS, Knopf JL, Kriz RW
  Title
Molecular characterization of cytosolic phospholipase A2-beta.
  Journal
J Biol Chem 274:17063-7 (1999)
DOI:10.1074/jbc.274.24.17063
  Sequence
[hsa:100137049]

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