KEGG   ORTHOLOGY: K16431
Entry
K16431                      KO                                     

Name
cepH, sgcC3, mdpC3, kedY3
Definition
FAD-dependent halogenase [EC:1.14.19.-]
Pathway
ko01055  Biosynthesis of vancomycin group antibiotics
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00832  Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis, azatyrosine => 2-aza-3-chloro-beta-tyrosyl-PCP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
   01055 Biosynthesis of vancomycin group antibiotics
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.-  
     K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
Other DBs
RN: R11368 R11393
COG: COG0644
Genes
NTP: CRH09_30915
GPO: GPOL_c23630
GOM: D7316_00962(lodB)
SGB: WQO_33760
SBH: SBI_00676
SRC: M271_00350 M271_09130
STRE: GZL_07290
SPAV: Spa2297_32975
STRT: A8713_00440
SLS: SLINC_7264
SFK: KY5_1050c
SCYA: EJ357_01705 EJ357_41000
SKA: CP970_07260
SALW: CP975_22835 CP975_34455
SHAW: CEB94_22645
SVR: CP971_08125
SAQU: EJC51_07485
SBY: H7H31_03460
SRIM: CP984_06525
SGM: GCM10017557_01930
STRR: EKD16_14345(lodB)
NOA: BKM31_54195
FRA: Francci3_2465
AOI: AORI_1485 AORI_5364
AJA: AJAP_16200 AJAP_22795
AMYY: YIM_16050(lodB)
AORI: SD37_16625 SD37_23460 SD37_33695
ACTI: UA75_18105
ACAD: UA74_17580
SAQ: Sare_2119
MSAG: GCM10017556_09720
AMS: AMIS_32430
PLK: CIK06_16755
ATL: Athai_06330
AG: ABY66006(mdpC3) AFV52210(kedY3)
 » show all
Reference
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
  Sequence
[aoi:AORI_1485]
Reference
  Authors
Lin S, Van Lanen SG, Shen B
  Title
Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
J Am Chem Soc 129:12432-8 (2007)
DOI:10.1021/ja072311g
Reference
PMID:12183628 (sgcC3)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33760]

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (10)   
   KEGG PATHWAY (8)   
   KEGG MODULE (2)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (108)   
   KEGG GENES (43)   
   KEGG MGENES (64)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (128)   

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