KEGG ORTHOLOGY: K16816

ORTHOLOGY: K16816

Entry

K16816                      KO

Symbol

PNPLA2, ATGL

Name

patatin-like phospholipase domain-containing protein 2 [EC:3.1.1.3]

Pathway

map00561

Glycerolipid metabolism

map01100

Metabolic pathways

map04714

Thermogenesis

map04923

Regulation of lipolysis in adipocytes

Module

M00098

Acylglycerol degradation

Reaction

R02250

triacylglycerol acylhydrolase

R02687

1,2-diacyl-sn-glycerol acylhydrolase

Disease

H01297

Neutral lipid storage disease with myopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.3  triacylglycerol lipase
     K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2

Other DBs

GO:

0004806

Genes

HSA:	57104(PNPLA2)

PTR:	112207805 450937(PNPLA2)

PPS:	100970121(PNPLA2)

GGO:	101145251(PNPLA2)

PON:	100438169(PNPLA2)

NLE:	100607328(PNPLA2)

HMH:	116466598(PNPLA2)

MCC:	700824(PNPLA2)

MCF:	102141858(PNPLA2)

MTHB:

126935831

MNI:	105494160(PNPLA2)

CSAB:

103233992(PNPLA2)

CATY:

105577222(PNPLA2)

PANU:

101013650(PNPLA2)

TGE:	112607117(PNPLA2)

MLEU:

105549361(PNPLA2)

RRO:	104681771(PNPLA2)

RBB:	108513010(PNPLA2)

TFN:	117079862(PNPLA2)

PTEH:

111520551(PNPLA2)

CANG:

105503281(PNPLA2)

CJC:	100408814(PNPLA2)

SBQ:	101033046(PNPLA2)

CIMI:

108288767(PNPLA2)

MMUR:

105874051(PNPLA2)

LCAT:

123642954(PNPLA2)

PCOQ:

105816532(PNPLA2)

OGA:	100947855(PNPLA2)

MMU:	66853(Pnpla2)

MCAL:

110298572(Pnpla2)

MPAH:

110322307(Pnpla2)

RNO:	361676(Pnpla2)

MCOC:

116103223(Pnpla2)

ANU:	117709052(Pnpla2)

MUN:	110553920(Pnpla2)

CGE:	100753746(Pnpla2)

MAUA:

101835287(Pnpla2)

PROB:

127228542(Pnpla2)

PLEU:

114693780(Pnpla2)

MORG:

121458007(Pnpla2)

MFOT:

126498761

AAMP:

119816161(Pnpla2)

NGI:	103751092(Pnpla2)

HGL:	101701275(Pnpla2)

CPOC:

100732516(Pnpla2)

CCAN:

109698331(Pnpla2)

DORD:

105998579(Pnpla2)

DSP:	122102587(Pnpla2)

PLOP:

125361806(Pnpla2)

NCAR:

124960604

MMMA:

107157086(Pnpla2)

OCU:

127486103

OPI:	101521600(PNPLA2)

TUP:	102481526(PNPLA2)

GVR:	103604003(PNPLA2)

CFA:	611403(PNPLA2)

CLUD:

112663249(PNPLA2)

VVP:	112924122(PNPLA2)

VLG:	121471418(PNPLA2)

NPO:	129502930(PNPLA2)

AML:	100463707(PNPLA2)

UMR:	103671100(PNPLA2)

UAH:	113248812(PNPLA2)

UAR:	123775516(PNPLA2)

ELK:

111150106

LLV:

125078242

MPUF:

101692455(PNPLA2)

MNP:	132016560(PNPLA2)

MLK:	131817974(PNPLA2)

NVS:	122913231(PNPLA2)

ORO:	101376822(PNPLA2)

EJU:	114201537(PNPLA2)

ZCA:	113915050(PNPLA2)

MLX:	118016211(PNPLA2)

NSU:	110580667(PNPLA2)

LWW:	102726814(PNPLA2)

FCA:	101082263(PNPLA2)

PYU:	121022827(PNPLA2)

PCOO:

112852074(PNPLA2)

PBG:	122484151(PNPLA2)

PVIV:

125176697(PNPLA2)

LRUF:

124527533

PTG:	102955281(PNPLA2)

PPAD:

109259787(PNPLA2)

PUC:

125937770

AJU:

106988897

HHV:	120223431(PNPLA2)

BTA:	508493(PNPLA2)

BOM:	102280861(PNPLA2)

BBUB:

102409429(PNPLA2)

BBIS:

104998825(PNPLA2)

CHX:	100860889(PNPLA2)

OAS:	101123166(PNPLA2)

BTAX:

128068534(PNPLA2)

ODA:	120874195(PNPLA2)

CCAD:

122430658(PNPLA2)

MBEZ:

129548615(PNPLA2)

SSC:	100049704(PNPLA2)

CFR:	102522737(PNPLA2)

CBAI:

105069757(PNPLA2)

CDK:	105105445(PNPLA2)

VPC:	102545377(PNPLA2)

BACU:

102997570(PNPLA2)

BMUS:

118900116(PNPLA2)

LVE:	103080064(PNPLA2)

OOR:	101283683(PNPLA2)

DLE:	111170300(PNPLA2)

PCAD:

102980462(PNPLA2)

PSIU:

116758204(PNPLA2)

NASI:

112402260(PNPLA2)

ECB:	100146758(PNPLA2)

EPZ:	103544296(PNPLA2)

EAI:	106824961(PNPLA2)

MYB:	102242697(PNPLA2)

MYD:	102764823(PNPLA2)

MMYO:

118648996(PNPLA2)

PKL:	118717946(PNPLA2)

EFUS:

103302569(PNPLA2)

MNA:	107542321(PNPLA2)

DRO:	112317241(PNPLA2)

SHON:

118982231(PNPLA2)

AJM:	119062187(PNPLA2)

PDIC:

114499336(PNPLA2)

PHAS:

123807331(PNPLA2)

MMF:	118643197(PNPLA2)

PPAM:

129073133(PNPLA2)

HAI:	109375650(PNPLA2)

RFQ:	117029952(PNPLA2)

PALE:

102878066(PNPLA2)

PGIG:

120584680(PNPLA2)

PVP:	105305945(PNPLA2)

RAY:	107507296(PNPLA2)

MJV:	108408640(PNPLA2)

TOD:	119249833(PNPLA2)

SARA:

101547288(PNPLA2)

SETR:

126019058(PNPLA2)

LAV:	100657987(PNPLA2)

TMU:

101353614

ETF:	101649578(PNPLA2)

DNM:	101411289(PNPLA2)

MDO:	100031359(PNPLA2)

SHR:	100925043(PNPLA2)

AFZ:

127539605

PCW:	110202950(PNPLA2)

OAA:	103168938(PNPLA2)

GGA:	418233(PNPLA3) 431066(PNPLA2)

PCOC:

116231444 116239020(PNPLA2)

MGP:	100294555(PNPLA2)

CJO:	107314514(PNPLA2) 107317383

TPAI:

128084531 128085418(PNPLA2)

LMUT:

125694820(PNPLA2) 125701748

NMEL:

110396835 110401530(PNPLA2)

APLA:

101796497(PNPLA2) 101802708

ACYG:

106031781(PNPLA2) 106038244

CATA:

118250153 118250784(PNPLA2)

AFUL:

116489179 116489933(PNPLA2)

TGU:	100219060(PNPLA2) 100231669

LSR:	110473186 110484489(PNPLA2)

SCAN:

103819680 103824075(PNPLA2)

PMOA:

120507696 120511422(PNPLA2)

OTC:	121344884(PNPLA2) 121347853

PRUF:

121351902 121360899(PNPLA2)

GFR:	102044651 102044787(PNPLA2)

FAB:	101805858(PNPLA2) 101820592

OMA:	130253396(PNPLA2) 130267069

PHI:	102100353(PNPLA2) 102102532

PMAJ:

107205005 107205543(PNPLA2)

CCAE:

111923366 111930735(PNPLA2)

CCW:	104688026(PNPLA2) 104696128

CBRC:

103619970 103620898(PNPLA2)

ETL:	114064564 114068481(PNPLA2)

ZAB:	102068522(PNPLA2) 102072203

ACHL:

103801310 103808279(PNPLA2)

SVG:	106851535(PNPLA2) 106855985

MMEA:

130576635(PNPLA2) 130585125

HRT:	120752333 120753661(PNPLA2)

FPG:	101917296 101922710(PNPLA2)

FCH:	102055351 102059870(PNPLA2)

CLV:	102085397 102093271(PNPLA2)

EGZ:	104127095(PNPLA2) 104135158

NNI:	104012676(PNPLA5) 104017312(PNPLA2)

PCRI:

104024032 104024972(PNPLA2)

PLET:

104614711 104626945

EHS:	104506485(PNPLA2) 104507978

PCAO:

104047097 104048124(PNPLA1)

ACUN:

113480980(PNPLA2) 113490465

TALA:

104363487 104366877(PNPLA2)

PADL:

103916456(PNPLA2) 103924466

AFOR:

103896228(PNPLA2) 103898753

ACHC:

115351746(PNPLA2) 115352620

HALD:

104315696(PNPLA2) 104321468

HLE:	104828694(PNPLA2) 104829392(PNPLA5)

AGEN:

126046894 126047801

GCL:	127016675 127021437

CCRI:

104166270(PNPLA2) 104169570

CSTI:

104556172 104563559(PNPLA2)

CMAC:

104483937(PNPLA2) 104486759

MUI:	104541793 104546955

BREG:

104634617 104635585(PNPLA2)

FGA:	104074271 104076872(PNPLA2)

GSTE:

104251186 104257470(PNPLA2)

LDI:	104354916(PNPLA2)

OHA:	104326726(PNPLA2) 104326998

NNT:	104406957(PNPLA2) 104410541

SHAB:

115605506 115607738(PNPLA2)

DPUB:

104296337 104299845(PNPLA2)

PGUU:

104459071(PNPLA2) 104462038

ACAR:

104518832(PNPLA2) 104522273

CPEA:

104387655(PNPLA2) 104395097

AVIT:

104276410 104278299(PNPLA2)

CVF:	104281671 104290297(PNPLA2)

RTD:	128904139 128908432(PNPLA2)

CUCA:

104067327(PNPLA5) 104068918(PNPLA2)

TEO:	104379771 104381342(PNPLA2)

BRHI:

104500532 104502313(PNPLA2)

AAM:	106488311 106490004(PNPLA2)

AROW:

112962696(PNPLA2) 112967076

NPD:	112943580(PNPLA2) 112956866

TGT:	104569230 104575011(PNPLA2)

DNE:	112988036(PNPLA2) 112991526

SCAM:

104143770(PNPLA2) 104146640

ASN:	102378694 102381486(PNPLA2)

AMJ:	102563962(PNPLA3) 102569620(PNPLA2)

CPOO:

109316348 109321166(PNPLA2)

GGN:	109296345 109299202(PNPLA2)

PSS:	102443833 102450379(PNPLA2)

CMY:	102931307(PNPLA2) 102938324

CCAY:

125624502 125638800(PNPLA2)

DCC:	119847316 119856670(PNPLA2)

CPIC:

101936184 101948343(PNPLA2)

TST:	117871694 117877337(PNPLA2)

CABI:

116825742 116838665(PNPLA2)

MRV:	120392979 120403898(PNPLA2)

ACS:	100551847(pnpla2)

ASAO:

132771321(PNPLA2) 132776475

PVT:	110074181(PNPLA2)

SUND:

121930050(PNPLA2) 121931193

PBI:	103048393(PNPLA2)

PMUR:

107283959(PNPLA2)

CTIG:

120298306(PNPLA2)

TSR:	106542070(PNPLA2)

PGUT:

117665196(PNPLA2)

APRI:

131185140(PNPLA2) 131201731

PTEX:

113437587 113440298(PNPLA2)

NSS:	113412523(PNPLA2) 113418637

VKO:	123021115(PNPLA2) 123033938

PMUA:

114599534(PNPLA2)

PRAF:

128413554 128416734(PNPLA2)

ZVI:	118088392(PNPLA2)

HCG:	128326292 128340468(PNPLA2)

GJA:	107116418(PNPLA2)

STOW:

125426968(PNPLA2) 125435637(PNPLA3)

EMC:	129323962(PNPLA2) 129344269

XLA:	108713865(pnpla2.L) 108715180(pnpla2.S)

XTR:	780152(pnpla2)

NPR:	108794583(PNPLA2)

RTEM:

120917311(PNPLA2)

BBUF:

120981001(PNPLA2)

BGAR:

122920167(PNPLA2)

MUO:	115469020(PNPLA2)

GSH:	117352088(PNPLA2)

DRE:	101887155(pnpla2)

SRX:	107716673 107726855

SANH:

107665735 107674849 107679605

SGH:	107551437 107577070

CCAR:

109051066 109065140

CAUA:

113042895 113043026

CGIB:

128014486

PTET:

122330649(pnpla2)

LROH:

127156352(pnpla2)

OMC:	131534910(pnpla2)

RKG:	130106491(pnpla2)

MAMB:

125246844(pnpla2)

CIDE:

127506686

MASI:

127435748 127437191

TROS:

130551794(pnpla2)

TDW:	130413970(pnpla2)

IPU:	108269288 108274701

IFU:	128618041(pnpla2)

PHYP:

113529505(pnpla2) 113546554

SMEO:

124392162(pnpla2)

TFD:	113654047(pnpla2)

TVC:	132857035(pnpla2)

AMEX:

103023613 103029861(pnpla2)

CMAO:

118811911(pnpla2)

EEE:

113588195

CHAR:

105906388 105912037(pnpla2)

TRU:	101061643(pnpla2) 101066653 101066877 101077770

TFS:	130530596(pnpla1) 130535692(pnpla2) 130535934 130536250

TNG:	GSTEN00004542G001 GSTEN00004543G001 GSTEN00029863G001

LCO:	104928846(pnpla2) 104929551 104931885 104937568

NCC:	104941548 104956192(pnpla2) 104967347

TBEN:

117491271(pnpla2) 117494069 117497247

CGOB:

115009445 115009967 115010160(pnpla2) 115010995

PGEO:

117447708 117448238(pnpla2)

GACU:

117538853(pnpla2) 117542092 117557468

EMAC:

134868569(pnpla1) 134876047(pnpla2) 134879564 134883462

ELY:	117258923 117261910 117262194 117262738(pnpla2)

EFO:	125886905 125887442 125887874(pnpla2) 125891590(pnpla1)

PLEP:

121947371 121950525 121950590(pnpla2) 121950639

SLUC:

116046811 116046813 116058550

ECRA:

117947636 117948724(pnpla2) 117948731 117948735

ESP:	116692440 116693591 116693596 116694270

PFLV:

114558527 114559722 114560038 114560097

GAT:	120808694(pnpla2) 120809531 120829597

PPUG:

119195725(pnpla2) 119196411 119223144

AFB:	129108034 129108082(pnpla2)

CLUM:

117731956 117731957 117732303(pnpla2) 117733444

PSWI:

130194671 130194673 130195238(pnpla2)

MSAM:

119893301(pnpla2) 119905147

SCHU:

122874592 122874599 122875422(pnpla2) 122882417(pnpla1)

CUD:	121515003(pnpla2) 121515174 121515211 121517178

ALAT:

119023544 119023958 119023963 119024376(pnpla2)

MZE:	101470022 101482270 101483520

ONL:	100690902 100692445 100697369 100697903

OAU:	116313958 116314001 116326215(pnpla2) 116330832

OLA:	101155345 101155596 101156893 101168619

OML:	112151928 112151964 112152880(pnpla2) 112159858

CSAI:

133444136(pnpla2) 133456372(pnpla1)

XMA:	102226589 102228835 102237891

XCO:	114151724 114153411(pnpla2) 114156880 114156892

XHE:	116721947 116730918 116730988 116732186

PRET:

103465704 103465705 103466503(pnpla2) 103467428

PFOR:

103141311(pnpla2) 103149658 103156562 103156563

PLAI:

106938997 106939005 106942002(pnpla2) 106946660

PMEI:

106925505 106930769(pnpla2) 106933962 106933968

GAF:	122828025 122831272 122835711(pnpla2) 122835866

PPRL:

129367829 129367858 129367926(pnpla2) 129372342(pnpla1)

CVG:	107092186 107101198

CTUL:

119784346 119787400(pnpla2) 119798185

GMU:	124855728 124856623(pnpla2) 124865635(pnpla1)

NFU:	107388365 107388367 107388678 107390959

KMR:	108229859(pnpla2) 108235201 108245711 108245735

ALIM:

106521184 106522640 106522811

NWH:	119415787(pnpla2) 119416090 119417263

AOCE:

111573854 111577265 111580511

MCEP:

125011729(pnpla1) 125014442 125014443 125015534(pnpla2)

CSEM:

103379814 103379815 103380279(pnpla2)

POV:	109624276 109624498 109635035 109648188(pnpla2)

SSEN:

122775535 122776372 122776514(pnpla2) 122777289(pnpla1)

HHIP:

117762912(pnpla2) 117763670 117764010

HSP:	118109338 118109375(pnpla2) 118110631(pnpla1)

SMAU:

118314826 118315932 118316001(pnpla2) 118316723(pnpla1)

LCF:	108877866 108886921(pnpla2) 108889297 108889299

SDU:	111229787 111229788 111229822(pnpla2)

SLAL:

111650403 111650476 111667036 111669001

XGL:	120793349 120793552(pnpla2) 120803292

HCQ:	109507635(pnpla2) 109528676 109530843

SSCV:

125970117 125970939 125988917

SBIA:

133494447(pnpla1) 133501849 133501981 133502414(pnpla2)

PEE:	133398238(pnpla1) 133402382(pnpla2) 133403362

PTAO:

133478254 133478259 133478507(pnpla2) 133486958(pnpla1)

BPEC:

110160334 110160347 110164878 110169305(pnpla2)

MALB:

109951167 109956420 109968666 109972349

BSPL:

114857222 114857223 114857781(pnpla2) 114858894(pnpla1)

SJO:	128357601(pnpla1) 128359076 128359077 128359096(pnpla2)

SASA:

106572965 106584779 106590753 106596546 106612943

STRU:

115165257 115192928 115197722 115206838

OTW:	112238871 112242251(pnpla2)

OMY:	110503375 110512506 110522695

OGO:	124004937 124018191 124032000 124036978(pnpla2)

ONE:	115122496 115125484 115141301

OKI:	109882084 109883841 109909462

OKE:	118379499 118382408(pnpla2) 127913049(pnpla1)

SALP:

111957907 112070263

SNH:	120052317(pnpla2) 120066504

CCLU:

121531591 121540758 121587368

ELS:	105006487 105009990 105018061

SFM:	108939144 108941267(pnpla2)

PKI:	111848020(pnpla2)

AANG:

118207390 118227161(pnpla2)

LOC:	102689456 102693732

PSPA:

121294827(pnpla2) 121329755

ARUT:

117434920

PSEX:

120535878(pnpla2)

LCM:	102349054(PNPLA2) 102364578(PNPLA1)

CMK:	103186006(pnpla2)

CPLA:

122557934(pnpla2)

HOC:	132824372(pnpla2)

LERI:

129705845(pnpla2)

PMRN:

LRJ:

SPU:

APLC:

SKO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

CCIN:

TCA:	659311(bmm)

DPA:

ATD:

NVL:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

NLU:

PHU:	Phum_PHUM457610

ZNE:

110829229

FCD:

110857045

DPX:	DAPPUDRAFT_199604 DAPPUDRAFT_40590

PCHN:

HAZT:

EAF:

UDV:

SDM:

PMEO:

LGI:	LOTGIDRAFT_104376

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

OSN:

LAK:

SMM:	Smp_124390

OVI:	T265_08820

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130612278 130662643

AQU:

100642049

EHX:	EMIHUDRAFT_432975

» show all

Reference

PMID:16239926

Authors

Smirnova E, Goldberg EB, Makarova KS, Lin L, Brown WJ, Jackson CL

Title

ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells.

Journal

EMBO Rep 7:106-13 (2006)
DOI:10.1038/sj.embor.7400559

Reference

PMID:15550674

Authors

Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R

Title

Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.

Journal

Science 306:1383-6 (2004)
DOI:10.1126/science.1100747

Sequence

[hsa:57104]

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