KEGG ORTHOLOGY: K16914

ORTHOLOGY: K16914

Entry

K16914                      KO

Symbol

RIOX1, NO66

Name

protein-L-histidine (3S)-3-hydroxylase / [histone H3]-trimethyl-L-lysine4/36 demethylase [EC:1.14.11.79 1.14.11.67 1.14.11.69]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03009 Ribosome biogenesis
    K16914  RIOX1, NO66; protein-L-histidine (3S)-3-hydroxylase / [histone H3]-trimethyl-L-lysine4/36 demethylase
   03036 Chromosome and associated proteins
    K16914  RIOX1, NO66; protein-L-histidine (3S)-3-hydroxylase / [histone H3]-trimethyl-L-lysine4/36 demethylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.67  [histone H3]-trimethyl-L-lysine4 demethylase
     K16914  RIOX1, NO66; protein-L-histidine (3S)-3-hydroxylase / [histone H3]-trimethyl-L-lysine4/36 demethylase
    1.14.11.69  [histone H3]-trimethyl-L-lysine36 demethylase
     K16914  RIOX1, NO66; protein-L-histidine (3S)-3-hydroxylase / [histone H3]-trimethyl-L-lysine4/36 demethylase
    1.14.11.79  protein-L-histidine (3S)-3-hydroxylase
     K16914  RIOX1, NO66; protein-L-histidine (3S)-3-hydroxylase / [histone H3]-trimethyl-L-lysine4/36 demethylase
Ribosome biogenesis [BR:ko03009]
Eukaryotic type
  Pre-60S particles
   Other pre-60S particles
    K16914  RIOX1, NO66; protein-L-histidine (3S)-3-hydroxylase / [histone H3]-trimethyl-L-lysine4/36 demethylase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   Histone demethylases
    K16914  RIOX1, NO66; protein-L-histidine (3S)-3-hydroxylase / [histone H3]-trimethyl-L-lysine4/36 demethylase

Other DBs

GO:	0032453 0051864

Genes

HSA:	79697(RIOX1)

PTR:	104002100(RIOX1)

PPS:	103787047(RIOX1)

GGO:	129526525(RIOX1)

PON:	103892384(RIOX1)

PPYG:

129013099(RIOX1)

NLE:	105739243(RIOX1)

HMH:	116484625(RIOX1)

SSYN:

129487681(RIOX1)

MCC:	696773(RIOX1)

MCF:	102135352(RIOX1)

MTHB:

126959510

MNI:	105494285(RIOX1)

CSAB:

103229309(RIOX1)

CATY:

105599557

PANU:

103886364(RIOX1)

TGE:	112629404(RIOX1)

MLEU:

105541877

RRO:	104656344(RIOX1)

RBB:	108536225(CUNH14orf169)

TFN:	117069369(RIOX1)

PTEH:

111520542(RIOX1)

CANG:

105517321

CJC:	100404196(RIOX1)

SBQ:

104650789

CIMI:

108304494(RIOX1)

ANAN:

105707301(RIOX1)

CSYR:

103273243(RIOX1)

MMUR:

105858343(RIOX1)

LCAT:

123647004(RIOX1)

PCOQ:

105819790

OGA:	105886713(RIOX1)

MMU:	71952(Riox1)

MCAL:

110307186(Riox1)

MPAH:

110324497(Riox1)

RNO:	314300(Riox1)

MCOC:

116080287(Riox1)

ANU:	117697455(Riox1)

MUN:	110558535(Riox1)

MAUA:

101837244(Riox1)

PLEU:

114698396(Riox1)

MORG:

121452248(Riox1)

MFOT:

126515167

AAMP:

119818543(Riox1)

NGI:	103747411(Riox1)

HGL:	101712659(Riox1)

CPOC:

100729659(Riox1)

CCAN:

109691362(Riox1)

DORD:

105982898

DSP:	122118818(Riox1)

PLOP:

125359832 125363228(Riox1)

NCAR:

124977643

MMMA:

107148940(Riox1)

OPI:	105941772(RIOX1)

TUP:	102484507(RIOX1)

GVR:

103599802

CFA:	106559177(RIOX1)

CLUD:

112657830(RIOX1)

VVP:	112927248(RIOX1)

VLG:	121493577(RIOX1)

NPO:	129496022(RIOX1)

AML:	100468557(RIOX1)

UMR:	103673481(RIOX1)

UAH:	113270360(RIOX1)

UAR:	123799008(RIOX1)

ELK:

111148493

LLV:

125103705

MPUF:

101671929

MNP:	132000193(RIOX1)

MLK:	131836899(RIOX1)

NVS:	122893635(RIOX1)

ORO:

101379219

EJU:	114199294(RIOX1)

ZCA:	113909018(RIOX1)

MLX:	118002325(RIOX1)

NSU:	110571430(RIOX1)

LWW:	102739562(RIOX1)

FCA:	102900260(RIOX1)

PYU:	121032016(RIOX1)

PCOO:

112856086(RIOX1)

PBG:	122469294(RIOX1)

PVIV:

125167723(RIOX1)

LRUF:

124512053

PTG:	102960977(RIOX1)

PPAD:

109253798(CUNH14orf169)

PUC:

125908683

AJU:	106974332(RIOX1)

HHV:	120231954(RIOX1)

BTA:	511031(RIOX1)

BOM:	102285244(RIOX1)

BIU:	109565323(RIOX1)

BBIS:

105000131

CHX:	102173094(C10H14orf169)

OAS:	105606501(RIOX1)

BTAX:

128054035(RIOX1)

ODA:	120853602(RIOX1)

MBEZ:

129563562(RIOX1)

SSC:	100523074(RIOX1)

CFR:	102505373(RIOX1)

CBAI:

105075429

CDK:	105086126(RIOX1)

VPC:	102544596(RIOX1)

BACU:

103014019(RIOX1)

BMUS:

118890284(RIOX1)

LVE:

103069841

OOR:	101275960(RIOX1)

DLE:	111176276(RIOX1)

PCAD:

102980914(RIOX1)

PSIU:

116749506(RIOX1)

NASI:

112394900(RIOX1)

ECB:	100146448(RIOX1)

EPZ:	103567990(RIOX1)

EAI:	106827705(RIOX1)

MYB:	102256784(RIOX1)

MYD:	102757410(RIOX1)

MMYO:

118657792(RIOX1)

MLF:	102440102(RIOX1)

MDT:	132231617(RIOX1)

PKL:	118715502(RIOX1)

EFUS:

103283861(RIOX1)

MNA:

107533472

DRO:	112311546(RIOX1)

SHON:

118976654(RIOX1)

AJM:	119036137(RIOX1)

PDIC:

114492357(RIOX1)

PHAS:

123808581(RIOX1)

MMF:	118616455(RIOX1)

PPAM:

129065909(RIOX1)

HAI:	109381570(CUNH14orf169)

RFQ:	117022753(RIOX1)

PALE:

102887644(RIOX1)

PGIG:

120619476(RIOX1)

PVP:	105299251(RIOX1)

RAY:

107505016

MJV:	108397196(RIOX1)

TOD:	119239271(RIOX1)

SARA:

105943148

SETR:

126003951(RIOX1)

LAV:	100668526(RIOX1)

TMU:

101348575

ETF:	105979987(RIOX1)

DNM:	101437091(RIOX1)

MDO:	100024523(RIOX1)

GAS:	123235838(RIOX1)

SHR:	105750349(RIOX1)

AFZ:

127549524

PCW:	110208359(RIOX1)

TVP:	118828096(RIOX1)

OAA:	100086314(RIOX1)

GGA:	423249(C5H14ORF169)

PCOC:

116229243(RIOX1)

MGP:	100545882(RIOX1)

CJO:	107314864(RIOX1)

TPAI:

128087152(RIOX1)

LMUT:

125694806(RIOX1)

NMEL:

110401899(RIOX1)

APLA:

101796505(RIOX1)

ACYG:

106040700(RIOX1)

CATA:

118244483(RIOX1)

AFUL:

116489571(RIOX1)

TGU:	100219109(RIOX1)

LSR:	110472176(RIOX1)

SCAN:

103826967(RIOX1)

PMOA:

120500278(RIOX1)

OTC:	121334309(RIOX1)

PRUF:

121349550(RIOX1)

GFR:	102035608(RIOX1)

FAB:	101819482(RIOX1)

OMA:	130254087(RIOX1)

PHI:

102111633

PMAJ:

107205486(RIOX1)

CCAE:

111930251(RIOX1)

CCW:	104688287(RIOX1)

CBRC:

103620966(CUNH14orf169)

ETL:	114055505(RIOX1)

ZAB:	102060487(RIOX1)

ZLE:	135448388(RIOX1)

ACHL:

103807375

SVG:

106848947

MMEA:

130572410(RIOX1)

HRT:	120753916(RIOX1)

SATI:

136362603(RIOX1)

FPG:	101922675(RIOX1)

FCH:	102052952(RIOX1)

CCRI:

104158036

NNT:

104399702

SHAB:

115606848(RIOX1)

ACUN:

113480503(RIOX1)

TALA:

104357502(RIOX1)

ACHC:

115338395(RIOX1)

HALD:

AGEN:

GCL:

CSTI:

LDI:

MNB:

DPUB:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

103898887(CUNH14orf169)

FGA:

104080124

GSTE:

104251195

CLV:	102085791(RIOX1)

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

104061865(RIOX1)

TEO:

104373599

BREG:

104637387

OHA:

104328193

ACAR:

104518307(RIOX1)

CPEA:

104390585

CVF:

104284091

RTD:	128908789(RIOX1)

AAM:	106498095(RIOX1)

AROW:

112964060(RIOX1)

TGT:

104579083

DNE:	112980748(RIOX1)

SCAM:

104141222

ASN:	102376489(RIOX1)

AMJ:	102560036(RIOX1)

CPOO:

109321529(CUNH14orf169)

GGN:	109298811(CUNH14orf169)

PSS:	102450180(RIOX1)

CMY:	102933242(RIOX1)

CCAY:

125638866(RIOX1)

DCC:	119857115(RIOX1)

CPIC:

101944414(RIOX1)

TST:	117876967(RIOX1)

CABI:

116825381(RIOX1)

MRV:	120404335(RIOX1)

ACS:	100557464(riox1)

ASAO:

132766854(RIOX1)

PVT:	110088098(RIOX1)

SUND:

121919007(RIOX1)

PBI:	103064072(RIOX1)

PMUR:

107290099(RIOX1)

CTIG:

120302776(RIOX1)

TSR:

106540035

PGUT:

117665617(RIOX1)

APRI:

131187564(RIOX1)

PTEX:

113441931(RIOX1)

NSS:	113414275(RIOX1)

VKO:	123026708(RIOX1)

PMUA:

114594532(RIOX1)

PRAF:

128411750(RIOX1)

ZVI:	118097647(RIOX1)

HCG:	128334145(RIOX1)

GJA:	107111814(RIOX1)

STOW:

125435934(RIOX1)

EMC:	129324814(RIOX1)

XLA:	108716657(riox1.L)

XTR:	100488246(riox1)

NPR:	108788943(CUNH14orf169)

RTEM:

120937491(RIOX1)

BBUF:

120998764(RIOX1)

BGAR:

122934417(RIOX1)

MUO:	115465794 115465796

GSH:	117356692(RIOX1)

DRE:	560815(riox1)

SRX:

107719421

SANH:

107669424 107704066

SGH:	107548410 107559126

CCAR:

109068503 109081363

CAUA:

113068568 113068613 113120605

CGIB:

127938534 127984595

PTET:

122324290(riox1)

LROH:

127182538(riox1)

OMC:	131527045(riox1)

PPRM:

120491947(riox1)

RKG:	130096183(riox1)

MAMB:

125278713(riox1)

CIDE:

127502362

CERY:

137019224(riox1)

MASI:

127415547

TROS:

130566408(riox1)

TDW:	130434528(riox1)

MANU:

129429436(riox1)

IPU:	108257725(riox1)

IFU:	128601108(riox1)

PHYP:

113532105(riox1)

SMEO:

124377246(riox1)

TFD:	113655601(riox1)

TVC:	132843164(riox1)

TRN:	134320351(riox1)

AMEX:

103035470(riox1)

CMAO:

118815814(riox1)

EEE:	113571701(riox1)

CHAR:

105907308(riox1)

TRU:	101069081(riox1)

TFS:	130516182(riox1)

TNG:	GSTEN00023017G001

LCO:	104930843(riox1)

NCC:

104950067

TBEN:

117486965(riox1)

PGEO:

117439807(riox1)

GACU:

117548837(riox1)

EMAC:

134876555(riox1)

ELY:	117270465(riox1)

EFO:	125896950(riox1)

PLEP:

121955439(riox1)

SLUC:

116066116(riox1)

ECRA:

117961991(riox1)

ESP:	116706862(riox1)

PFLV:

114572971(riox1)

GAT:	120807956(riox1)

PPUG:

119194751(riox1)

AFB:	129107309(riox1)

CLUM:

117727315(riox1)

PSWI:

130202273(riox1)

MSAM:

119908808(riox1)

SCHU:

122863217(riox1)

CUD:	121521468(riox1)

ALAT:

119013099(riox1)

MZE:	101466884(riox1)

ONL:	100712195(riox1)

OAU:	116312736(riox1)

OLA:	101163704(riox1)

OML:	112157677(riox1)

CSAI:

133464849(riox1)

XMA:

102226754

XCO:

114158239

XHE:	116734273(riox1)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122825053(riox1)

PPRL:

129375346(riox1)

CVG:

107080779

CTUL:

119771556(riox1)

GMU:	124882140(riox1)

NFU:

107377721

KMR:	108233352(riox1)

ALIM:

106525670

NWH:	119418309(riox1)

AOCE:

111571796

MCEP:

124999565(riox1)

CSEM:

103381232(c7h14orf169)

POV:

109636096

SSEN:

122784601(riox1)

HHIP:

117758517(riox1)

HSP:	118099488(riox1)

PPLT:

128460409(riox1)

SMAU:

118290325(riox1)

LCF:	108873507(riox1)

SDU:	111237580(riox1)

SLAL:

111661395(riox1)

XGL:	120788910(riox1)

HCQ:	109514677(riox1)

SSCV:

125990074

SBIA:

133496215(riox1)

PEE:	133416638(riox1)

PTAO:

133468720(riox1)

BPEC:

110164233(riox1)

MALB:

109962343

BSPL:

114849888(riox1)

SJO:	128377078(riox1)

SASA:

106571660 106608197

STRU:

115159950 115174601

OTW:	112217927 112250477

OMY:	110522552 110529775

OGO:	123990907 123995725

ONE:	115107911 115139161

OKI:	109866362 109900884

OKE:	118387122 118398503

SALP:

111954191 112069089

SNH:	120019127 120024164

CCLU:

121548544 121552393

ELS:	105017561(riox1)

SFM:	108924117(riox1)

PKI:	111841139(riox1)

AANG:

118229175(riox1)

LOC:	102690247(clg1h14orf169)

PSPA:

121317174(riox1)

ARUT:

117411433(riox1)

PSEX:

120525792(riox1)

LCM:	102352369(RIOX1)

CMK:	103181758(riox1)

RTP:	109921777(riox1)

CPLA:

122552664(riox1)

HOC:	132819674(riox1)

LERI:

129699485(riox1)

PMRN:

116939463(RIOX1)

LRJ:	133347105(RIOX1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG2982(NO66)

DER:

6550993

DSE:	116802029 6612514

DYA:	Dyak_GE16340

DAN:

6503484

DSR:

110176117

DPO:	117183205 117185202 117185203 117185205 26533390 6903974

DPE:	113566194 6597402

DMN:	108164587 117187195 117187196 117187199 117187200 117190646

DWI:

6652943

DGR:

6565600

DMO:	Dmoj_GI16410

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:	129236806 129248416

TDA:	119669989 119670000

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ008401

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105669936(NO66)

PGC:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_214532

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119833729 119833950

CCRC:

123696902

LSIN:

126974425

AAGE:

121733651

HAW:	110376084(No66)

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106689248(NO66)

NLU:	111061999 120353620

HVI:

124356760

MQU:	128986018 128986873

PHU:	Phum_PHUM117430

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_T28F2.4(jmjc-1)

CBR:	CBG_11988(Cbr-jmjc-1)

CRQ:	GCK72_002167

NAI:	NECAME_11131

BMY:	BM_BM6073(Bma-jmjc-1)

LOA:	LOAG_00418

HRO:	HELRODRAFT_116230

LGI:	LOTGIDRAFT_194127

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

OVI:	T265_03702

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_50673

AQU:

100636565

PPP:

112277103

CSL:	COCSUDRAFT_64552

CVR:	CHLNCDRAFT_140729

APRO:

F751_3734

OLU:	OSTLU_15879

OTA:	OT_ostta06g03570

BPG:	Bathy10g01340

MIS:	MICPUN_68455

MPP:	MICPUCDRAFT_55966

CCP:	CHC_T00004130001

MBR:	MONBRDRAFT_25525

SRE:	PTSG_10023

DDI:	DDB_G0287513(jcdG)

DPP:	DICPUDRAFT_32138

DFA:	DFA_11703(jcdG)

ACAN:

ACA1_163410

BBES:

BESB_045530

PTI:	PHATRDRAFT_14981

FCY:	FRACYDRAFT_140013

TPS:	THAPSDRAFT_21082

AAF:	AURANDRAFT_67230

PIF:	PITG_15871

PSOJ:

PHYSODRAFT_330429

SPAR:

SPRG_19899

EHX:	EMIHUDRAFT_204434 EMIHUDRAFT_251857 EMIHUDRAFT_468207

GTT:	GUITHDRAFT_137055

TCR:

508141.30

LMA:	LMJF_31_0240

LIF:	LINJ_31_0250

LDO:	LDBPK_310250

LMI:	LMXM_30_0240

LMAT:

92511462(LSCM1_01328)

LBZ:	LBRM_31_0350

LPAN:

LPMP_310240

LOI:	92359067(LSCM4_03116)

LEIS:

94176972(GH5_01369)

LENR:

94169830(CUR178_02565)

LEIN:

94186322(JIQ42_02603)

PHET:

94289839(JKF63_03764)

NGR:	NAEGRDRAFT_50047

» show all

Reference

PMID:23103944

Authors

Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, Hamed RB, Chowdhury R, Gong L, Robinson CV, Trudgian DC, Jiang M, Mackeen MM, McCullagh JS, Gordiyenko Y, Thalhammer A, Yamamoto A, Yang M, Liu-Yi P, Zhang Z, Schmidt-Zachmann M, Kessler BM, Ratcliffe PJ, Preston GM, Coleman ML, Schofield CJ

Title

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

Journal

Nat Chem Biol 8:960-2 (2012)
DOI:10.1038/nchembio.1093

Sequence

[hsa:79697]

Reference

PMID:19927124

Authors

Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B

Title

Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase.

Journal

EMBO J 29:68-79 (2010)
DOI:10.1038/emboj.2009.332

Sequence

[hsa:79697]

All links

Ontology (6)   
   KEGG BRITE (4)   
   GO (2)   
Chemical reaction (3)   
   KEGG ENZYME (3)   
Gene (3934)   
   KEGG GENES (718)   
   KEGG MGENES (777)   
   RefGene (2432)   
   OC (7)   
Literature (2)   
   PubMed (2)   
All databases (3945)   

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