KEGG   ORTHOLOGY: K17398Help
Entry
K17398                      KO                                     

Name
DNMT3A
Definition
DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
Pathway
ko00270  Cysteine and methionine metabolism
ko01100  Metabolic pathways
ko05206  MicroRNAs in cancer
Module
M00035  Methionine degradation
Disease
H01481  Myelodysplastic syndrome
H01892  Peripheral T cell lymphoma
H02294  Tatton-Brown-Rahman syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
 09160 Human Diseases
  09161 Cancers: Overview
   05206 MicroRNAs in cancer
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
   03036 Chromosome and associated proteins
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
KEGG modules [BR:ko00002]
 Pathway module
  Amino acid metabolism
   Cysteine and methionine metabolism
    M00035  Methionine degradation
     K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Replication Termination Factors
   DNA methylation enzymes
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
BRITE hierarchy
Other DBs
RN: R04858
GO: 0003886
Genes
HSA: 1788(DNMT3A)
PTR: 739139(DNMT3A)
PPS: 100973478(DNMT3A)
GGO: 101149451(DNMT3A)
PON: 100459471(DNMT3A)
NLE: 100594618(DNMT3A)
MCC: 694822(DNMT3A)
MCF: 102123287(DNMT3A)
CSAB: 103220651(DNMT3A)
RRO: 104677880(DNMT3A)
RBB: 108532669(DNMT3A)
CJC: 100413373(DNMT3A)
SBQ: 101042504(DNMT3A)
MMU: 13435(Dnmt3a)
RNO: 444984(Dnmt3a)
CGE: 100771064(Dnmt3a)
NGI: 103746385(Dnmt3a)
HGL: 101718745(Dnmt3a)
CCAN: 109685692(Dnmt3a)
OCU: 100344715(DNMT3A)
TUP: 102497213(DNMT3A)
CFA: 482996(DNMT3A)
AML: 100481405(DNMT3A)
UMR: 103671927(DNMT3A)
ORO: 101366930(DNMT3A)
FCA: 100510798(DNMT3A)
PTG: 102951977(DNMT3A)
AJU: 106967901(DNMT3A)
BTA: 359716(DNMT3A)
BOM: 102284316(DNMT3A)
BIU: 109566324(DNMT3A)
PHD: 102329828(DNMT3A)
CHX: 102190884(DNMT3A)
OAS: 100500776(DNMT3A)
SSC: 100037301(DNMT3A)
CFR: 102513850(DNMT3A)
CDK: 105100034(DNMT3A)
BACU: 102998753(DNMT3A)
LVE: 103077720
OOR: 101285073(DNMT3A)
ECB: 100055881(DNMT3A)
EPZ: 103547819(DNMT3A)
EAI: 106841074(DNMT3A)
MYB: 102260433(DNMT3A)
MYD: 102755471 102756688(DNMT3A)
HAI: 109384340(DNMT3A)
RSS: 109435116(DNMT3A)
PALE: 102887578(DNMT3A)
LAV: 100669385(DNMT3A)
TMU: 101350464
MDO: 100030681(DNMT3A)
SHR: 100926710(DNMT3A)
PCW: 110206518(DNMT3A)
OAA: 100077964(DNMT3A) 100090801
GGA: 421991(DNMT3A)
MGP: 100548727(DNMT3A)
CJO: 107312403(DNMT3A)
ACYG: 106029375
SCAN: 103824693
GFR: 102035722(DNMT3A)
FAB: 101822230(DNMT3A)
PHI: 102103159(DNMT3A)
PMAJ: 107198691(DNMT3A)
CCW: 104683136(DNMT3A)
FPG: 101914320(DNMT3A)
FCH: 102056931(DNMT3A)
CLV: 102097066(DNMT3A)
NNI: 104015768(DNMT3A)
AAM: 106489769
ASN: 102368302(DNMT3A)
AMJ: 102561346(DNMT3A) 106740158
CMY: 102939867(DNMT3A)
CPIC: 101946629(DNMT3A)
ACS: 100529107(dnmt3a)
PVT: 110086977(DNMT3A)
PBI: 103057534 103060050(DNMT3A)
PMUR: 107295539
GJA: 107113771(DNMT3A)
XTR: 100492187 100496503(dnmt3a)
DRE: 553187(dnmt3aa) 553189(dnmt3ab)
IPU: 108257425(dnmt3a) 108270301
PHYP: 113528792(dnmt3a) 113539015
AMEX: 103043892(dnmt3a) 103045261
OLA: 101158497(dnmt3a)
NFU: 107377776 107392003(dnmt3a)
CSEM: 103380388(dnmt3a) 103381119
MALB: 109962317 109964554(dnmt3a)
ELS: 105015448 105018056(dnmt3a)
SFM: 108922141 108929284(dnmt3a)
PKI: 111851525(dnmt3a) 111857940
LCM: 102358591(DNMT3A)
CMK: 103183140(dnmt3a)
CIN: 100176613
SPU: 582367
APLC: 110980297
SKO: 102802091
AME: 410798(Dnmt3)
BTER: 100648272
SOC: 105205288
MPHA: 105830581
AEC: 105154006
ACEP: 105618015
PBAR: 105422696
HST: 105182605
DQU: 106746476
CFO: 105259403
LHU: 105671755
PGC: 109858126
OBO: 105285577
NVI: 100114044(Dmnt3)
NVL: 108557902
AGS: 114129277
ZNE: 110828018
TUT: 107365877
TSP: Tsp_09280
ADF: 107336440
PDAM: 113680843
SPIS: 111333223
HMG: 100209870
AQU: 100642138
BRP: 103837173
BOE: 106317917
THJ: 104802799
CPAP: 110815398
CIT: 102607628
TCC: 18593109
GRA: 105770274
GAB: 108453111
EGR: 104415567
CAM: 101500730
LJA: Lj1g3v4921070.1(Lj1g3v4921070.1) Lj5g3v1496770.1(Lj5g3v1496770.1) Lj5g3v1496780.1(Lj5g3v1496780.1)
ADU: 107492131
AIP: 107645905
FVE: 101313815
PPER: 18775569
PMUM: 103344610
PAVI: 110759203
PXB: 103965325
ZJU: 107411883
CSV: 101211600
CMO: 103494758
MCHA: 111018799
RCU: 8287069
HBR: 110648673
MESC: 110622519
JRE: 109009749
SLY: 101248143
SPEN: 107007748
SOT: 102596406
NSY: 104238459
NTO: 104087003
NAU: 109217400
INI: 109182070
CCAV: 112506549
BVG: 104890824
SOE: 110786905
NNU: 104599005
OSA: 4337816
DOSA: Os05t0149200-01(Os05g0149200)
OBR: 102714097
BDI: 100833788
ATS: 109761235
SBI: 8069497
SITA: 101781565
DCT: 110099856
PEQ: 110025386
SMIN: v1.2.015215.t1(symbB.v1.2.015215.t1)
RCH: RUM_20080
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jurkowski TP, Jeltsch A
  Title
On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2.
  Journal
PLoS One 6:e28104 (2011)
DOI:10.1371/journal.pone.0028104
Reference
  Authors
Ponger L, Li WH
  Title
Evolutionary diversification of DNA methyltransferases in eukaryotic genomes.
  Journal
Mol Biol Evol 22:1119-28 (2005)
DOI:10.1093/molbev/msi098
Reference
  Authors
Okano M, Bell DW, Haber DA, Li E
  Title
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
  Journal
Cell 99:247-57 (1999)
DOI:10.1016/S0092-8674(00)81656-6
  Sequence
[mmu:13435]

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