KEGG ORTHOLOGY: K17447

ORTHOLOGY: K17447

Entry

K17447                      KO

Symbol

SHC2

Name

SHC-transforming protein 2

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04370

VEGF signaling pathway

map04510

Focal adhesion

map04650

Natural killer cell mediated cytotoxicity

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05034

Alcoholism

map05100

Bacterial invasion of epithelial cells

map05214

Glioma

map05220

Chronic myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04014 Ras signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04370 VEGF signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04072 Phospholipase D signaling pathway
    K17447  SHC2; SHC-transforming protein 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17447  SHC2; SHC-transforming protein 2
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17447  SHC2; SHC-transforming protein 2
   04062 Chemokine signaling pathway
    K17447  SHC2; SHC-transforming protein 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04915 Estrogen signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04917 Prolactin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04926 Relaxin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04935 Growth hormone synthesis, secretion and action
    K17447  SHC2; SHC-transforming protein 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17447  SHC2; SHC-transforming protein 2
   05226 Gastric cancer
    K17447  SHC2; SHC-transforming protein 2
   05214 Glioma
    K17447  SHC2; SHC-transforming protein 2
   05220 Chronic myeloid leukemia
    K17447  SHC2; SHC-transforming protein 2
   05224 Breast cancer
    K17447  SHC2; SHC-transforming protein 2
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17447  SHC2; SHC-transforming protein 2
  09165 Substance dependence
   05034 Alcoholism
    K17447  SHC2; SHC-transforming protein 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17447  SHC2; SHC-transforming protein 2
   01522 Endocrine resistance
    K17447  SHC2; SHC-transforming protein 2

Genes

HSA:	25759(SHC2)

PTR:	749831(SHC2)

PPS:	100974798(SHC2)

GGO:	101129046(SHC2)

PON:	100445042(SHC2)

NLE:	100591489(SHC2)

HMH:

116464630

MCC:	721021(SHC2)

MCF:	102125325(SHC2)

MTHB:

126942949

MNI:	105486618(SHC2)

CSAB:

103233559(SHC2)

CATY:

105591876(SHC2)

PANU:

101006054

TGE:	112612298(SHC2)

MLEU:

105548833(SHC2)

RBB:	108531776(SHC2) 108533994

TFN:	117074894(SHC2)

PTEH:

111528883(SHC2)

CANG:

105527663(SHC2)

CJC:	100415083(SHC2)

SBQ:	101048523(SHC2)

CIMI:

108297501(SHC2)

MMUR:

105860825(SHC2)

LCAT:

123632067(SHC2)

PCOQ:

105811228(SHC2)

OGA:	100957623(SHC2)

MMU:	216148(Shc2)

MCAL:

110303444(Shc2)

MPAH:

110326457(Shc2)

RNO:	314612(Shc2)

MCOC:

116076241(Shc2)

ANU:	117696653(Shc2)

MUN:	110551355(Shc2)

CGE:	100761269(Shc2)

MAUA:

101843435(Shc2)

PROB:

127216670(Shc2)

PLEU:

114684102(Shc2)

MORG:

121459499(Shc2)

MFOT:

126489227

AAMP:

119825434(Shc2)

NGI:	103737407(Shc2)

HGL:	101723930(Shc2)

CPOC:

100723025

CCAN:

109686083(Shc2)

DORD:

105990314(Shc2)

DSP:	122122823(Shc2)

PLOP:

125347922(Shc2)

NCAR:

124975378

OPI:	101522080(SHC2)

TUP:	102481863(SHC2)

GVR:	103600233(SHC2)

CFA:	611955(SHC2)

CLUD:

112666141(SHC2)

VVP:	112935467(SHC2)

VLG:	121494261(SHC2)

NPO:	129522289(SHC2)

AML:	100480694(SHC2)

UMR:	103681753(SHC2)

UAH:	113242690(SHC2)

UAR:

123794070

ELK:

111161808

LLV:

125087478

MPUF:

101692343(SHC2)

NVS:	122909991(SHC2)

ORO:	101384118(SHC2)

EJU:	114226321(SHC2)

ZCA:	113917867(SHC2)

MLX:	118004996(SHC2)

NSU:	110594105(SHC2)

LWW:	102727078(SHC2)

FCA:	101083489(SHC2)

PYU:	121021890(SHC2)

PCOO:

112852752(SHC2)

PBG:	122486600(SHC2)

LRUF:

124527699

PTG:	102954336(SHC2)

PPAD:

109257730(SHC2)

PUC:

125928763

AJU:

106978092

HHV:	120242345(SHC2)

BTA:	533455(SHC2)

BOM:	102281047(SHC2)

BIU:	109561056(SHC2)

BBUB:

102389953(SHC2)

BBIS:

104991966(SHC2)

CHX:	102169956(SHC2)

OAS:	101113847(SHC2)

BTAX:

128051196(SHC2)

ODA:	120864498(SHC2)

MBEZ:

129558379(SHC2)

SSC:	110259382(SHC2)

CFR:	102506382(SHC2)

CBAI:

105078342(SHC2)

CDK:	105093416(SHC2)

VPC:	102526634(SHC2)

BACU:

103006868(SHC2)

LVE:	103088833(SHC2)

OOR:	101275665(SHC2)

DLE:	111170483(SHC2)

PCAD:

102974315(SHC2)

PSIU:

116751918(SHC2)

NASI:

112396342(SHC2)

ECB:	100146209(SHC2)

EPZ:	103542441(SHC2)

EAI:	106834253(SHC2)

MYB:	102251506(SHC2)

MYD:	102752087(SHC2)

MMYO:

118659254(SHC2)

MNA:	107538554(SHC2)

PKL:	118711420(SHC2)

EFUS:

103294446(SHC2)

HAI:	109390676(SHC2)

DRO:	112312297(SHC2)

SHON:

118984370(SHC2)

AJM:	119044619(SHC2)

PDIC:

114504166(SHC2)

PHAS:

123813838(SHC2)

MMF:	118615745(SHC2)

RFQ:	117037962(SHC2)

PALE:

102885958(SHC2)

PGIG:

120589513(SHC2)

PVP:	105302278(SHC2)

RAY:	107500961(SHC2)

MJV:	108391745(SHC2)

TOD:	119240463(SHC2)

SARA:

101550526(SHC2)

TMU:

101359726

ETF:	101644867(SHC2)

DNM:	101447321(SHC2)

GAS:	123256803(SHC2)

SHR:	100917745(SHC2)

AFZ:

127545256

PCW:	110223483(SHC2)

OAA:	100081397(SHC2)

GGA:	770341(SHC2)

PCOC:

116235831(SHC2)

MGP:	100538500(SHC2)

CJO:	107325668(SHC2)

TPAI:

128090392(SHC2)

LMUT:

125684893(SHC2)

NMEL:

110389019(SHC2)

APLA:

101803969(SHC2)

ACYG:

106049094(SHC2)

CATA:

118260038(SHC2)

AFUL:

116499186(SHC2)

TGU:	100217581(SHC2)

LSR:	110475781(SHC2)

SCAN:

103822026(SHC2)

PMOA:

120496007(SHC2)

OTC:	121341581(SHC2)

PRUF:

121361768(SHC2)

GFR:	102034643(SHC2)

FAB:	101815242(SHC2)

OMA:	130264447(SHC2)

PHI:	102100749(SHC2)

PMAJ:

107215430(SHC2)

CCAE:

111940286(SHC2)

CCW:	104697005(SHC2)

CBRC:

103622163(SHC2)

ETL:	114066416(SHC2)

ZAB:

102072622

SVG:	106857053(SHC2)

MMEA:

130580224(SHC2)

HRT:	120763362(SHC2)

FPG:	101924524(SHC2)

FCH:	102049085(SHC2)

CLV:	102088882(SHC2)

EGZ:	104124436(SHC2)

NNI:	104016320(SHC2)

TALA:

116961635(SHC2)

PADL:

103923470(SHC2)

AFOR:

103899434(SHC2)

ACHC:

115349526(SHC2)

HLE:	104829150(SHC2)

AGEN:

126041747

GCL:

127025457

CSTI:

104553408(SHC2)

MNB:	103767954(SHC2)

SHAB:

115618057(SHC2)

DPUB:

104300737(SHC2)

CPEA:

104392436(SHC2)

CVF:	104294391(SHC2)

CUCA:

104067731(SHC2)

TEO:	104376503(SHC2)

AAM:	106486386(SHC2)

AROW:

112973886(SHC2)

NPD:	112946874(SHC2)

DNE:	112988087(SHC2)

ASN:	102383911(SHC2)

AMJ:	102565747(SHC2)

GGN:	109294913(SHC2)

CMY:	102933759(SHC2)

CCAY:

125627065(SHC2)

DCC:	119848306(SHC2)

CPIC:

101944228(SHC2)

TST:	117868957(SHC2)

CABI:

116814882(SHC2)

MRV:	120391919(SHC2)

ACS:	100553545(shc2)

PVT:	110079278(SHC2)

SUND:

121937364(SHC2)

PBI:	103061599(SHC2)

PMUR:

107298759

CTIG:

120297060(SHC2)

PGUT:

117668639(SHC2)

APRI:

131188198(SHC2)

PTEX:

113434988(SHC2)

NSS:	113425094(SHC2)

VKO:	123036581(SHC2)

PMUA:

114588608(SHC2)

PRAF:

128405810(SHC2)

ZVI:	118087871(SHC2)

HCG:	128347884(SHC2)

GJA:	107110440(SHC2)

STOW:

125433261(SHC2)

EMC:	129329904(SHC2)

XLA:	108706896(shc2.S) 108713169(shc2.L)

XTR:	100487416(shc2)

NPR:	108790334(SHC2)

RTEM:

120910109(SHC2)

BBUF:

120991599(SHC2)

BGAR:

122930875(SHC2)

MUO:	115479981(SHC2)

GSH:	117365739(SHC2)

DRE:	562011(shc2)

SRX:	107719564 107729700

SANH:

107676975(shc2) 107699410

SGH:	107586398 107593314

CCAR:

109096032

CAUA:

113039600 113070302

CGIB:

127943197 127987888

PTET:

122327715(shc2)

LROH:

127153208(shc2)

OMC:	131530701(shc2)

PPRM:

120495450(shc2)

MAMB:

125263808(shc2)

CIDE:

127519729

MASI:

127438117 127439285

TROS:

130548718(shc2)

IPU:

108270761

PHYP:

113547084(shc2)

SMEO:

124391651(shc2)

TFD:	113646129(shc2)

AMEX:

103026451

CMAO:

118819383(shc2)

EEE:	113587209(shc2)

CHAR:

105910744(shc2)

TRU:	101071160(shc2)

TFS:	130528532(shc2)

TNG:	GSTEN00028773G001

LCO:	104918475(shc2)

NCC:	104958981(shc2)

CGOB:

115007109(shc2)

ELY:	117254016(shc2)

EFO:	125895735(shc2)

PLEP:

121938139(shc2)

SLUC:

116055201(shc2)

ECRA:

117950057(shc2)

ESP:

116696202

PFLV:

114561987(shc2)

GAT:	120823634(shc2)

PPUG:

119216728(shc2)

AFB:	129094479(shc2)

CLUM:

117729725(shc2)

MSAM:

119900775(shc2)

SCHU:

122877343(shc2)

CUD:	121512814(shc2)

ALAT:

119028931(shc2)

MZE:

101463941

ONL:

100696779

OAU:	116317325(shc2)

OLA:	101156242(shc2)

OML:	112150934(shc2)

XMA:

102216631

XCO:

114150293

XHE:

116726316

PRET:

103463557(shc2)

PFOR:

103142600(shc2)

PLAI:

106947864(shc2)

PMEI:

106918340(shc2)

GAF:	122838868(shc2)

CVG:	107085719(shc2)

CTUL:

119794273(shc2)

GMU:	124874121(shc2)

NFU:	107393200(shc2)

KMR:	108230757(shc2)

ALIM:

106530194(shc2)

NWH:	119407858(shc2)

AOCE:

111573492(shc2)

MCEP:

125009776(shc2)

CSEM:

103398231

POV:	109625730(shc2)

SSEN:

122780993(shc2)

HHIP:

117760743(shc2)

HSP:	118120944(shc2)

LCF:

108881424

SDU:

111232138

SLAL:

111654285

XGL:	120790651(shc2)

HCQ:

109532226

SSCV:

125971263

BPEC:

110167820(shc2)

MALB:

109964050

BSPL:

114854040(shc2)

SASA:

106584416 106613792

STRU:

115158273 115192606

OTW:	112235421 112250883

OMY:	110521457 110524319(shc2)

OGO:	123997551 124037680

ONE:	115108329 115144908

OKI:	109897869 109902523

SALP:

111972117 111976010

SNH:	120052448(shc2) 120054467

CCLU:

121533510 121540343

ELS:	105011583(shc2)

SFM:	108919768(shc2)

PKI:	111860152(shc2)

AANG:

118226180(shc2)

LOC:

102690296

PSPA:

121301327(shc2)

ARUT:

117401420 117962910

PSEX:

120537706(shc2)

LCM:	102355047(SHC2)

CMK:

103182043

RTP:	109937865(shc2)

CPLA:

122565507(shc2)

LERI:

129711036(shc2)

IEL:

MCAF:

ATEN:

Reference

PMID:9507002

Authors

Nakamura T, Muraoka S, Sanokawa R, Mori N

Title

N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.

Journal

J Biol Chem 273:6960-7 (1998)
DOI:10.1074/jbc.273.12.6960

Sequence

[hsa:25759]

Reference

PMID:21658278

Authors

Sasaki H, Emi M, Iijima H, Ito N, Sato H, Yabe I, Kato T, Utsumi J, Matsubara K

Title

Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy.

Journal

Mol Brain 4:24 (2011)
DOI:10.1186/1756-6606-4-24

Sequence

[hsa:25759]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (44)   
   KEGG PATHWAY (44)   
Gene (464)   
   KEGG GENES (350)   
   KEGG MGENES (28)   
   RefGene (83)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (511)   

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