KEGG   ORTHOLOGY: K17683Help
Entry
K17683            Tight     KO                                     

Name
CYP2A6
Definition
cytochrome P450 family 2 subfamily A polypeptide 6 [EC:1.14.13.-]
Pathway
ko00232  Caffeine metabolism
ko00830  Retinol metabolism
ko00980  Metabolism of xenobiotics by cytochrome P450
ko00982  Drug metabolism - cytochrome P450
ko00983  Drug metabolism - other enzymes
ko01100  Metabolic pathways
ko05204  Chemical carcinogenesis
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
   00982 Drug metabolism - cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
   00983 Drug metabolism - other enzymes
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-  
     K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6
BRITE hierarchy
Other DBs
RN: R07000 R07001 R07945 R08225 R08324 R08325 R08326 R08327 R08390 R08391 R08392 R09408 R09421 R09423 R09424 R09425
Genes
HSA: 1548(CYP2A6)
GGO: 101146638
TaxonomyKoalaUniProt
Reference
PMID:2726448
  Authors
Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR
  Title
Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.
  Journal
Nucleic Acids Res 17:2907-17 (1989)
DOI:10.1093/nar/17.8.2907
  Sequence
[hsa:1548]
Reference
  Authors
Xu C, Goodz S, Sellers EM, Tyndale RF
  Title
CYP2A6 genetic variation and potential consequences.
  Journal
Adv Drug Deliv Rev 54:1245-56 (2002)
DOI:10.1016/S0169-409X(02)00065-0

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