ko:K17684 : No such data.

KEGG   ORTHOLOGY: K17685
Entry
K17685                      KO                                     
Symbol
CYP2A13
Name
cytochrome P450 family 2 subfamily A13 [EC:1.14.14.1]
Pathway
map00980  Metabolism of xenobiotics by cytochrome P450
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R09406  
R09408  
R09421  
R09423  
R09424  
R09425  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
Genes
HSA: 1553(CYP2A13)
PTR: 101058187
PPS: 100982833(CYP2A13)
GGO: 101127384
PON: 100458875
PPYG: 129020009
NLE: 100579248 115830830
HMH: 116480658
SSYN: 129466953
MCC: 114674219 678689(CYP2A24) 678690(CYP2A23) 702954(CYP2A26) 722086
MCF: 102121341(CYP2A26) 102123758(CYP2A23) 102143277(CYP2A13)
PTEH: 111554024
CJC: 100399054(CYP2A7)
SBQ: 101046499
CIMI: 108285671(CYP2A6)
ANAN: 105723439(CYP2A6)
LCAT: 123624295
PCOQ: 105820478
PKL: 118730245
TOD: 119250434
CTIG: 120316367
APRI: 131204543
HCG: 128332693
STOW: 125424829
DPOL: 127863877
 » show all
Reference
  Authors
Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, Ding X
  Title
Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
  Journal
Cancer Res 60:5074-9 (2000)
  Sequence
[hsa:1553]

KEGG   ORTHOLOGY: K17728
Entry
K17728            Tight     KO                                     
Symbol
CYP4F8
Name
cytochrome P450 family 4 subfamily F8 [EC:1.14.14.1]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
Reaction
R07046  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17728  CYP4F8; cytochrome P450 family 4 subfamily F8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17728  CYP4F8; cytochrome P450 family 4 subfamily F8
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17728  CYP4F8; cytochrome P450 family 4 subfamily F8
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K17728  CYP4F8; cytochrome P450 family 4 subfamily F8
Genes
HSA: 11283(CYP4F8)
PTR: 748442(CYP4F8)
PPS: 100970184(CYP4F8)
GGO: 109024954
PON: 100461079
PPYG: 129020907
NLE: 100606376
HMH: 116478622
SSYN: 129460824
MCC: 718335(CYP4F8)
MCF: 102130053(CYP4F8)
MTHB: 126942254
MNI: 105494632
CSAB: 103234078
CATY: 105601615
PANU: 101006521
TGE: 112612401
MLEU: 105540097
RRO: 115891978
TFN: 117076173
PTEH: 111554197
CANG: 105519771
OGA: 100952013
 » show all
Reference
  Authors
Bylund J, Finnstrom N, Oliw EH
  Title
Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles.
  Journal
Biochem Biophys Res Commun 261:169-74 (1999)
DOI:10.1006/bbrc.1999.1011
  Sequence
[hsa:11283]

KEGG   ORTHOLOGY: K17729
Entry
K17729            Tight     KO                                     
Symbol
CYP4F11
Name
cytochrome P450 family 4 subfamily F11 [EC:1.14.14.1 1.14.14.78]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17729  CYP4F11; cytochrome P450 family 4 subfamily F11
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17729  CYP4F11; cytochrome P450 family 4 subfamily F11
    1.14.14.78  phylloquinone omega-hydroxylase
     K17729  CYP4F11; cytochrome P450 family 4 subfamily F11
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K17729  CYP4F11; cytochrome P450 family 4 subfamily F11
Genes
HSA: 57834(CYP4F11)
PTR: 100616514(CYP4F11)
PPS: 100995728(CYP4F11)
GGO: 101126416
PON: 100174280(CYP4F11) 100455064
PPYG: 129020908 129020915
NLE: 100592711
HMH: 116478629
SSYN: 129460116
MCC: 719353
MCF: 102132489 102135027(CYP4F11)
MTHB: 126942243
MNI: 105494300
CSAB: 103234090
CATY: 105601628
TGE: 112613096
MLEU: 105540131
RRO: 104661011
RBB: 108543295
TFN: 117074427
CANG: 105519779
CJC: 100411868(CYP4F11)
CSYR: 103271200
OGA: 100950748
 » show all
Reference
  Authors
Cui X, Nelson DR, Strobel HW
  Title
A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization.
  Journal
Genomics 68:161-6 (2000)
DOI:10.1006/geno.2000.6276
  Sequence
[hsa:57834]
Reference
  Authors
Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE
  Title
Cytochrome P450-dependent catabolism of vitamin K: omega-hydroxylation catalyzed by human CYP4F2 and CYP4F11.
  Journal
Biochemistry 52:8276-85 (2013)
DOI:10.1021/bi401208m

KEGG   ORTHOLOGY: K17720
Entry
K17720                      KO                                     
Symbol
CYP2C18
Name
cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Genes
HSA: 1562(CYP2C18)
GGO: 134756383
HMH: 116480603
MCC: 701855(CYP2C18)
MCF: 102145601(CYP2C18)
MTHB: 126962034 126962041
MNI: 105479956
CSAB: 103216300(CYP2C18)
CATY: 105586945
PANU: 101021773
TGE: 112631551
MLEU: 105545510
CJC: 100389345(CYP2C18)
SBQ: 101042223
CIMI: 108298685(CYP2C18)
ANAN: 105718959(CYP2C18)
CSYR: 103277155
MMUR: 105872416
LCAT: 123649683
PCOQ: 105822660
PLEU: 114689432
MFOT: 126511071
MMMA: 107149729
SHON: 118988004
MMF: 118632033
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1562]

KEGG   ORTHOLOGY: K17712
Entry
K17712                      KO                                     
Symbol
CYP2D6
Name
cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Pathway
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01522  Endocrine resistance
map04726  Serotonergic synapse
Reaction
R03697  
R08267  
R08270  
R08343  
R08344  
R08345  
R09421  
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
   00982 Drug metabolism - cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Genes
HSA: 107987478 107987479(CYP2D6) 1564(CYP2D7) 1565(CYP2D6)
PTR: 112206755 470228(CYP2D6)
PPS: 100969627 100988273
GGO: 101142890 109025371 115931944
PON: 100453198 100458527
PPYG: 129023327 129023330
NLE: 100580051 100593769 100606221
SSYN: 129467430 129468045 129468047
MCC: 100424965 678691(CYP2D6)
MCF: 102140079(CYP2D8) 102143092(CYP2D6)
CJC: 100385343(CYP2D19) 100415600
CIMI: 108290468(CYP2D6) 108290469(CYP2D8)
PCOQ: 105805151
DORD: 105992056
OPI: 101534880
GVR: 103591840
GAS: 123250293
 » show all
Reference
PMID:3410476 (CYP2D6)
  Authors
Gonzalez FJ, Vilbois F, Hardwick JP, McBride OW, Nebert DW, Gelboin HV, Meyer UA
  Title
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
  Journal
Genomics 2:174-9 (1988)
DOI:10.1016/0888-7543(88)90100-0
  Sequence
[hsa:1565]
Reference
PMID:15051713 (CYP2D7)
  Authors
Pai HV, Kommaddi RP, Chinta SJ, Mori T, Boyd MR, Ravindranath V
  Title
A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.
  Journal
J Biol Chem 279:27383-9 (2004)
DOI:10.1074/jbc.M402337200
  Sequence
[hsa:1564]
Reference
PMID:9056237 (CYP2D19)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100385343]

KEGG   ORTHOLOGY: K07428
Entry
K07428                      KO                                     
Symbol
CYP4X
Name
cytochrome P450 family 4 subfamily X [EC:1.14.14.1]
Pathway
map04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07428  CYP4X; cytochrome P450 family 4 subfamily X
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07428  CYP4X; cytochrome P450 family 4 subfamily X
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07428  CYP4X; cytochrome P450 family 4 subfamily X
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K07428  CYP4X; cytochrome P450 family 4 subfamily X
Genes
HSA: 260293(CYP4X1)
PTR: 456833(CYP4X1)
PPS: 100978561(CYP4X1)
GGO: 101141065
PON: 100441499
PPYG: 129041220
NLE: 100580500
HMH: 116473121
SSYN: 129468837
MCC: 709535
MCF: 102125667(CYP4X1)
MTHB: 126961403
MNI: 105494982
CSAB: 103224873(CYP4X1)
CATY: 105571708
PANU: 101014098
TGE: 112621265
MLEU: 105536683
RRO: 104662102
RBB: 108529622
TFN: 117092642
PTEH: 111548793
CANG: 105515243
CJC: 100413928(CYP4X1)
SBQ: 101042931
CIMI: 108312794(CYP4X1)
ANAN: 105705111(CYP4X1)
CSYR: 103249749
MMUR: 105877512
LCAT: 123634165
PCOQ: 105814051
OGA: 100958138
MMU: 81906(Cyp4x1)
MCAL: 110293095
MPAH: 110322973
RNO: 246767(Cyp4x1)
MCOC: 116096432
ANU: 117708828
MUN: 110542842
CGE: 100766854
MAUA: 101823991
PROB: 127225181
PLEU: 114706699
MORG: 121448317
MFOT: 126497995
AAMP: 119816746
NGI: 103732815
HGL: 101706848
CPOC: 100715178
CCAN: 109679796
DORD: 105986095
DSP: 122108548
PLOP: 125355119
NCAR: 124992327
MMMA: 107141791
OCU: 100338914
TUP: 102472827
GVR: 103595376
CFA: 482505(CYP4X1)
CLUD: 112642528
VVP: 112914748
VLG: 121481290
NPO: 129520787
AML: 100471717
UMR: 103670744
UAH: 113254711
UAR: 123793726
ELK: 111143307
LLV: 125098946
MPUF: 101672065
MNP: 132000829
MLK: 131809735
NVS: 122899940
ORO: 101379970
EJU: 114212146
ZCA: 113912514
MLX: 118019452
NSU: 110575026
LWW: 102725996
FCA: 101096906(CYP4X1)
PYU: 121027070
PCOO: 112872103
PBG: 122480468
PVIV: 125172293
LRUF: 124516047
PTG: 102968150
PPAD: 109266929
PUC: 125912636
AJU: 106973491
HHV: 120227404
BTA: 100847677
BIU: 109557089
BBUB: 102410132
BBIS: 104984606
CHX: 102174897
OAS: 101106121
BTAX: 128045296
ODA: 120856187
CCAD: 122437017
MBEZ: 129541059
CFR: 102523731
CBAI: 105065850
CDK: 105092931
VPC: 102540367
ECB: 100051552(CYP4X1)
EPZ: 103565687
EAI: 106833866
MYB: 102262973
MYD: 102768850
MMYO: 118675010
MLF: 102417369
PKL: 118724856
EFUS: 103284047
MNA: 107526777
SHON: 118985056
AJM: 119039830
PDIC: 114496555
MMF: 118626315
PPAM: 129069988
HAI: 109371958
RFQ: 117026837
PALE: 102895522
PGIG: 120620411
PVP: 105297195
RAY: 107514032
MJV: 108404960
TOD: 119237233
SARA: 101550807
SETR: 126011096
LAV: 100672903
TMU: 101345691
ETF: 101652047
DNM: 101423706
MDO: 100023529
GAS: 123247492
PCW: 110209311
TVP: 118846636
CANU: 128183126
CVN: 111138426
MAEA: 128208438
 » show all
Reference
PMID:12176035 (CYP4X1)
  Authors
Bylund J, Zhang C, Harder DR
  Title
Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.
  Journal
Biochem Biophys Res Commun 296:677-84 (2002)
DOI:10.1016/S0006-291X(02)00918-X
  Sequence
[rno:246767]

KEGG   ORTHOLOGY: K07429
Entry
K07429                      KO                                     
Symbol
CYP4Z
Name
cytochrome P450 family 4 subfamily Z [EC:1.14.14.1]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07429  CYP4Z; cytochrome P450 family 4 subfamily Z
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07429  CYP4Z; cytochrome P450 family 4 subfamily Z
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K07429  CYP4Z; cytochrome P450 family 4 subfamily Z
Genes
HSA: 199974(CYP4Z1)
PTR: 456834(CYP4Z1)
PPS: 100972566(CYP4Z1) 103785155
GGO: 115936030
PON: 100444727
PPYG: 129037166 129041216
NLE: 100580825
HMH: 116473119
SSYN: 129469029
CSAB: 103224875(CYP4Z1)
CATY: 105571715
PANU: 101014805
MLEU: 105536682
CJC: 100415609(CYP4Z1)
CIMI: 108312696
ANAN: 105705112(CYP4Z1)
CSYR: 103249748
TOD: 119237237
 » show all
Reference
PMID:15059886 (CYP4Z1)
  Authors
Rieger MA, Ebner R, Bell DR, Kiessling A, Rohayem J, Schmitz M, Temme A, Rieber EP, Weigle B
  Title
Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.
  Journal
Cancer Res 64:2357-64 (2004)
DOI:10.1158/0008-5472.CAN-03-0849
  Sequence
[hsa:199974]

KEGG   ORTHOLOGY: K07408
Entry
K07408                      KO                                     
Symbol
CYP1A1
Name
cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
Reaction
R02354  
R02355  
R03089  
R03408  
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08390  
R08392  
R09418  
R09423  
R09442  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05207 Chemical carcinogenesis - receptor activation
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Genes
HSA: 1543(CYP1A1)
PTR: 453744(CYP1A1)
PPS: 100976184(CYP1A1)
GGO: 101129522
PON: 100457153
PPYG: 129014419
NLE: 100585507
HMH: 116481900
SSYN: 129482256
MCC: 678694(CYP1A1)
MCF: 102129994(CYP1A1)
MTHB: 126960000
MNI: 105490958
CSAB: 103245331(CYP1A1)
CATY: 105600061
PANU: 101001307
TGE: 112627760
MLEU: 105530835
RRO: 104672151
RBB: 108531476
TFN: 117070364
PTEH: 111529702
CANG: 105505165
CJC: 100393083(CYP1A1)
SBQ: 101038217
CIMI: 108298444(CYP1A1)
CSYR: 103271646
MMUR: 105854864
LCAT: 123624369
PCOQ: 105807306
OGA: 100955410
MMU: 13076(Cyp1a1)
MCAL: 110301270
MPAH: 110328033
RNO: 24296(Cyp1a1)
MCOC: 116071961
ANU: 117698968
MUN: 110558545
CGE: 100751269
MAUA: 101844540
PROB: 127231800
PLEU: 114690337
MORG: 121445349
MFOT: 126507531
AAMP: 119808952
NGI: 103736921
HGL: 101707509
CPOC: 100135512(Cyp1a1)
CCAN: 109701505
DORD: 105982352
DSP: 122098438
NCAR: 124977051
MMMA: 107137939
OCU: 100328613
OPI: 101533768
TUP: 102484009
GVR: 103588057
CFA: 100686778(CYP1A1)
CLUD: 112675585
VVP: 112908776
VLG: 121484958
NPO: 129506483
AML: 100473028
UMR: 103678992
UAH: 113240972
UAR: 123790682
ELK: 111153267
LLV: 125105138
MPUF: 101676222
MNP: 131999167
MLK: 131835779
NVS: 122893452
ORO: 101382250
EJU: 114206471
ZCA: 113910089
MLX: 118003748
NSU: 110583893
LWW: 102739666
FCA: 554347(CYP1A1)
PYU: 121041992
PCOO: 112855107
PBG: 122468425
PVIV: 125168946
LRUF: 124508019
PTG: 102966263
PPAD: 109262691
PUC: 125910157
AJU: 106979443
HHV: 120235772
BTA: 282870(CYP1A1)
BOM: 102283235
BIU: 109575587
BBUB: 102399021
BBIS: 104990991
CHX: 102170823
OAS: 100170113(CYP1A1)
BTAX: 128066562
ODA: 120875451
CCAD: 122419730
MBEZ: 129550459
SSC: 403103(CYP1A1)
CFR: 102518111
CBAI: 105069192
CDK: 105087262
VPC: 102530468
BACU: 103008057
BMUS: 118891077
LVE: 103071513
OOR: 101287158
DLE: 111177818
PCAD: 102984326
PSIU: 116749907
NASI: 112410978
ECB: 100062285(CYP1A1)
EPZ: 103552317
EAI: 106831264
MYB: 102262349
MYD: 102762200
MMYO: 118675915
MLF: 102437172
PKL: 118728867
EFUS: 103300190
MNA: 107535216
DRO: 112301821
SHON: 118987754
PDIC: 114492343
PHAS: 123825280
MMF: 118643668
PPAM: 129064162
HAI: 109396247
RFQ: 117024155
PALE: 102892046
PGIG: 120597850
PVP: 105306836
RAY: 107510533
MJV: 108388606
TOD: 119237890
SARA: 101550604
SETR: 126015044
LAV: 100665901
TMU: 101359275
ETF: 101661225
DNM: 101423437
MDO: 100029871
GAS: 123232970
SHR: 100927711
AFZ: 127551979
PCW: 110213927
OAA: 100080942(CYP1A1)
ZVI: 118084457
STOW: 125424760
BBEL: 109480286
GAE: 121368990
CRG: 105329067
CANU: 128190897
DPOL: 127850854
HSY: 130646034
 » show all
Reference
PMID:2989797
  Authors
Jaiswal AK, Gonzalez FJ, Nebert DW
  Title
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
  Journal
Nucleic Acids Res 13:4503-20 (1985)
DOI:10.1093/nar/13.12.4503
  Sequence
[hsa:1543]
Reference
PMID:3019683
  Authors
Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y
  Title
Structure and drug inducibility of the human cytochrome P-450c gene.
  Journal
Eur J Biochem 159:219-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09857.x
  Sequence
[hsa:1543]

KEGG   ORTHOLOGY: K07409
Entry
K07409                      KO                                     
Symbol
CYP1A2
Name
cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00232  Caffeine metabolism
map00380  Tryptophan metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
Reaction
R03408  
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07055  
R07056  
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07939  caffeine:oxygen oxidoreductase (N3-demethylating)
R07943  
R07945  
R08293  
R08294  
R08392  
R09405  
R09407  
R09408  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00591 Linoleic acid metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00982 Drug metabolism - cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05207 Chemical carcinogenesis - receptor activation
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05208 Chemical carcinogenesis - reactive oxygen species
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Genes
HSA: 1544(CYP1A2)
PTR: 735881(CYP1A2)
PPS: 100975837(CYP1A2)
GGO: 101130358
PON: 100172368(CYP1A2)
PPYG: 129014441
NLE: 100586622
HMH: 116481901
SSYN: 129482258
MTHB: 126959999
MNI: 105490960
CSAB: 103245329(CYP1A2)
CATY: 105600060
PANU: 101002117
TGE: 112627775
MLEU: 105530834
RRO: 104672152
RBB: 108531494
TFN: 117071589
PTEH: 111529709
CANG: 105505164
CJC: 100392712(CYP1A2)
SBQ: 101037899
CSYR: 103271647
MMUR: 105854822
LCAT: 123624379
PCOQ: 105807254
OGA: 100955723
MMU: 13077(Cyp1a2)
MCAL: 110301271
MPAH: 110328034
RNO: 24297(Cyp1a2)
MCOC: 116071962
ANU: 117698970
MUN: 110558530
CGE: 100755851
MAUA: 101825565
PROB: 127231801
PLEU: 114690345
NGI: 103736875
CPOC: 100135513(Cyp1a2)
CCAN: 109695949
PLOP: 125368231
NCAR: 124977052
MMMA: 107137940
OCU: 100328937
TUP: 102484432
GVR: 103588056
CFA: 494010(CYP1A2)
VVP: 112917417
VLG: 121484959
NPO: 129506143
AML: 100472774
UMR: 103678991
UAH: 113240971
UAR: 123790681
ELK: 111153221
LLV: 125105139
MPUF: 101677117
MNP: 131999166
MLK: 131835777
NVS: 122893016
ORO: 101381962
EJU: 114206434
ZCA: 113910367
MLX: 118002935
NSU: 110584050
LWW: 102742108
FCA: 554345(CYP1A2)
PYU: 121041994
PCOO: 112855160
PBG: 122468422
PVIV: 125168378
LRUF: 124508017
PTG: 102966939
PPAD: 109262688
PUC: 125910173
AJU: 106979449
HHV: 120235751
BTA: 503552(CYP1A2)
BOM: 102280158
BIU: 109575670
BBUB: 102399561
BBIS: 104991054
CHX: 102170554
OAS: 101109214
BTAX: 128066814
ODA: 120875452
CCAD: 122419767
MBEZ: 129550128
SSC: 100152910(CYP1A2)
CFR: 102518362
CBAI: 105069191
CDK: 105087261
VPC: 102530734
BACU: 103007560
BMUS: 118891291
LVE: 103071784
OOR: 101287407
DLE: 111177607
PCAD: 102984795
PSIU: 116749085
NASI: 112410949
ECB: 100062244(CYP1A2)
EPZ: 103552315
EAI: 106831265
MYB: 102262040
MYD: 102761918
MMYO: 118675919
MLF: 102437484
MNA: 107535217
DRO: 112301801
SHON: 118987676
AJM: 119046569
PDIC: 114492026
PHAS: 123825158
MMF: 118637248
HAI: 109396253
RFQ: 117022727
PGIG: 120597823
PVP: 111732470
MJV: 108388607
TOD: 119237889
SARA: 101544097
SETR: 126015076
LAV: 100666189
TMU: 101359541
ETF: 101661749
MDO: 100029908
GAS: 123232968
SHR: 116421952
AFZ: 127551978
PCW: 110213926
TVP: 118828084
TCF: 131883248
MMER: 123552212
HSY: 130644429
 » show all
Reference
PMID:3755823
  Authors
Jaiswal AK, Nebert DW, Gonzalez FJ
  Title
Human P3(450): cDNA and complete amino acid sequence.
  Journal
Nucleic Acids Res 14:6773-4 (1986)
DOI:10.1093/nar/14.16.6773
  Sequence
[hsa:1544]

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