KEGG   ORTHOLOGY: K17712
Entry
K17712                      KO                                     
Symbol
CYP2D6
Name
cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Pathway
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01522  Endocrine resistance
map04726  Serotonergic synapse
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
   00982 Drug metabolism - cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Other DBs
RN: R03697 R08267 R08270 R08343 R08344 R08345 R09421
Genes
HSA: 107987478 107987479(CYP2D6) 1564(CYP2D7) 1565(CYP2D6)
PTR: 112206755 470228(CYP2D6)
PPS: 100969627 100988273
GGO: 101142890 109025371 115931944
PON: 100452833 100453198 100458527
NLE: 100580051 100593769 100606221
MCC: 100424965 678691(CYP2D6)
MCF: 102140079(CYP2D8) 102143092(CYP2D6)
CSAB: 103223410 103223412
CATY: 105572143 105573227
CJC: 100385343(CYP2D19) 100415600(CYP2D8)
DORD: 105992056
OPI: 101534880
GAS: 123250293
 » show all
Reference
PMID:3410476 (CYP2D6)
  Authors
Gonzalez FJ, Vilbois F, Hardwick JP, McBride OW, Nebert DW, Gelboin HV, Meyer UA
  Title
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
  Journal
Genomics 2:174-9 (1988)
DOI:10.1016/0888-7543(88)90100-0
  Sequence
[hsa:1565]
Reference
PMID:15051713 (CYP2D7)
  Authors
Pai HV, Kommaddi RP, Chinta SJ, Mori T, Boyd MR, Ravindranath V
  Title
A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.
  Journal
J Biol Chem 279:27383-9 (2004)
DOI:10.1074/jbc.M402337200
  Sequence
[hsa:1564]
Reference
PMID:9056237 (CYP2D19)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100385343]

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