KEGG   ORTHOLOGY: K17721
Entry
K17721                      KO                                     

Name
CYP2C19
Definition
cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
Pathway
ko00590  Arachidonic acid metabolism
ko00591  Linoleic acid metabolism
ko00982  Drug metabolism - cytochrome P450
ko01100  Metabolic pathways
ko04726  Serotonergic synapse
ko05204  Chemical carcinogenesis
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
   00591 Linoleic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.-  
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Other DBs
RN: R07046 R07055 R07056 R08275 R08285 R08343
GO: 0018675 0018676 0052741
Genes
HSA: 1557(CYP2C19)
PTR: 740956(CYP2C19)
PPS: 100995695
GGO: 101151965
PON: 100439483
NLE: 100601437
CJC: 100389947(CYP2C19)
SBQ: 101041912
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1557]

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