KEGG   ORTHOLOGY: K17723
Entry
K17723                      KO                                     

Name
preA
Definition
dihydropyrimidine dehydrogenase (NAD+) subunit PreA [EC:1.3.1.1]
Pathway
ko00240  Pyrimidine metabolism
ko00410  beta-Alanine metabolism
ko00770  Pantothenate and CoA biosynthesis
ko01100  Metabolic pathways
Module
M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K17723  preA; dihydropyrimidine dehydrogenase (NAD+) subunit PreA
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K17723  preA; dihydropyrimidine dehydrogenase (NAD+) subunit PreA
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    K17723  preA; dihydropyrimidine dehydrogenase (NAD+) subunit PreA
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.1  dihydropyrimidine dehydrogenase (NAD+)
     K17723  preA; dihydropyrimidine dehydrogenase (NAD+) subunit PreA
Other DBs
RN: R00977 R01414 R11026
COG: COG0167
GO: 0004159
Genes
ECO: b2147(preA)
ECJ: JW2134(yeiA)
ECD: ECDH10B_2304(yeiA)
EBW: BWG_1929(yeiA)
ECOK: ECMDS42_1716(yeiA)
ECE: Z3402(yeiA)
ECS: ECs3039
ECF: ECH74115_3279
ETW: ECSP_3025(yeiA)
ELX: CDCO157_2802
EOI: ECO111_2864(yeiA)
EOJ: ECO26_3059(yeiA)
EOH: ECO103_2622(yeiA)
ECOO: ECRM13514_2909(yeiA)
ECOH: ECRM13516_2850(yeiA)
ESL: O3K_08710
ESO: O3O_16925
ESM: O3M_08660
ECK: EC55989_2397(yeiA)
ECG: E2348C_2293(yeiA)
EOK: G2583_2690(yeiA)
ELH: ETEC_2282
ECP: ECP_2186
ECOS: EC958_2484(yeiA)
ECV: APECO1_4404(yeiA)
ECY: ECSE_2414
ECR: ECIAI1_2224(yeiA)
ECQ: ECED1_2594(yeiA)
EUM: ECUMN_2480(yeiA)
ECT: ECIAI39_2286(yeiA)
EOC: CE10_2518(yeiA)
EBR: ECB_02076(yeiA)
EBL: ECD_02076(preA)
EBE: B21_02035(yeiA)
EBD: ECBD_1511
ECI: UTI89_C2420(yeiA)
ECZ: ECS88_2293(yeiA)
ECC: c2680(yeiA)
ESE: ECSF_2029
EKF: KO11_11895(yeiA)
EAB: ECABU_c24770(yeiA)
EDJ: ECDH1ME8569_2083(yeiA)
ELW: ECW_m2348(yeiA)
ELL: WFL_11485(yeiA)
ELC: i14_2479(yeiA)
ELD: i02_2479(yeiA)
ELF: LF82_3007(yeiA)
ECOI: ECOPMV1_02308(preA)
ECOJ: P423_12085
EFE: EFER_2232(yeiA)
ESZ: FEM44_00960(preA)
STM: STM2187(yeiA)
SEO: STM14_2694(yeiA)
SEY: SL1344_2164(yeiA)
SEJ: STMUK_2217(yeiA)
SEB: STM474_2276(yeiA)
SEF: UMN798_2361(yeiA)
SENR: STMDT2_21641(yeiA)
SEND: DT104_22471(yeiA)
SENI: CY43_11760
SPT: SPA0664(yeiA)
SEK: SSPA0623
SEI: SPC_1515(yeiA)
SEC: SCH_2204(yeiA)
SHB: SU5_02779
SENS: Q786_10855
SED: SeD_A2534
SEG: SG2223(yeiA)
SEL: SPUL_0702(yeiA)
SEGA: SPUCDC_0702(yeiA)
SET: SEN2180(yeiA)
SENA: AU38_11020
SENO: AU37_11030
SENV: AU39_11030
SENQ: AU40_12330
SENL: IY59_11325
SEEP: I137_03190
SENE: IA1_10940
SBG: SBG_1999
SBZ: A464_2312
SALZ: EOS98_08030(preA)
SFN: SFy_3166
SFS: SFyv_3242
SFT: NCTC1_02453(preA_2)
SSN: SSON_2203(yeiA)
SDY: SDY_2140a
PDZ: HHA33_21080(preA)
EBF: D782_1475
DAQ: DAQ1742_04384(pydA)
BRB: EH207_15705(preA)
BNG: EH206_00395(preA)
XBC: ELE36_04655(preA)
PAE: PA0439
PAEV: N297_450
PAEI: N296_450
PAU: PA14_05740(pydA)
PNC: NCGM2_5758(pydA)
PAEB: NCGM1900_0449(pydA)
PAEP: PA1S_02225
PAEM: U769_02260
PAEL: T223_02220
PAEG: AI22_01675
PAEC: M802_449
PAEO: M801_450
PPSE: BN5_0328(pydA)
PPU: PP_4038(pydA)
PPF: Pput_1800
PPT: PPS_3443
PPI: YSA_08710
PPX: T1E_3294(yeiA)
PPUH: B479_17145
PPUT: L483_22585
PPUN: PP4_17170(preA)
PPUD: DW66_3890
PMON: X969_16410
PMOT: X970_16055
PFL: PFL_2546
PPRO: PPC_2590(pyrD)
PFS: PFLU_3944
PFB: VO64_1025
PMAN: OU5_6135
PEN: PSEEN3251
PPUU: PputUW4_02930(pyrD1)
PSEM: TO66_12385
PSEC: CCOS191_3346(preA)
PSOS: POS17_2548(pyrD)
PANR: A7J50_3599
PSIL: PMA3_15570
PUM: HGP31_14095(preA)
RVI: RVIR1_01660(pyrD)
GAI: IMCC3135_08100(preA)
HAM: HALO0745
HVN: EI420_17610(preA)
NIK: F5I99_11705(preA)
BVE: AK36_5010
BCN: Bcen_1595
BCJ: BCAS0733
BCEN: DM39_6821
BCEW: DM40_5427
BCEO: I35_7856
BAM: Bamb_5965
BMJ: BMULJ_06147(pyrD)
BMU: Bmul_5351
BMK: DM80_5565
BMUL: NP80_5414
BCED: DM42_7359
BCON: NL30_33400
BUB: BW23_6311
BLAT: WK25_17805
BTEI: WS51_29925
BSEM: WJ12_18650
BPSL: WS57_14315
BMEC: WJ16_16620
BSTG: WT74_17365
BGO: BM43_5489
BUK: MYA_5114
BXE: Bxe_A1429
BXB: DR64_3593
BPH: Bphy_1534
BFN: OI25_2721
PMEG: FNZ07_25845(preA)
CABA: SBC2_67360(preA)
RHF: EUB48_01595(preA)
RHG: EXZ61_00725(preA)
PNA: Pnap_4020
AAV: Aave_0967
AAA: Acav_0940
ACIO: EAG14_17630(preA)
AMON: H9L24_21230(preA)
VEI: Veis_4151
DAC: Daci_2862
DIH: G7047_29225(preA)
DRG: H9K76_18520(preA)
JAG: GJA_4397
JAS: FJQ89_23070(preA)
JLV: G3257_06250(preA)
MALI: EYF70_23350(preA)
MUM: FCL38_25995(preA)
MFLA: GO485_21540(preA)
MPLI: E1742_21525(preA)
OFO: BRW83_1760(preA)
UPV: EJN92_05345(preA)
UPI: EJG51_008855(preA)
DUG: HH213_16810(preA)
THI: THI_3627(pydA)
GLO: Glov_2025
DMS: E8L03_05135(preA)
DPI: BN4_11187
SUR: STAUR_8046(yeiA)
SCL: sce6397(yeiA)
MLO: mll1643
MESM: EJ066_27060(preA)
MHUA: MCHK_3249(preA)
MJR: EB229_18360(preA)
MERD: EB233_15690(preA)
MES: Meso_2055
AMIH: CO731_02731(preA)
RPOD: E0E05_11570(preA)
NIY: FQ775_02840(preA)
ORM: HTY61_03195(preA)
SME: SMc01815
SMER: DU99_13640
SMD: Smed_2361
SFD: USDA257_c49090(preA)
SIX: BSY16_145
SAME: SAMCFNEI73_Ch2816(preA)
EAD: OV14_4004
EMX: FKV68_16010(preA)
ARA: Arad_3441
AVI: Avi_3449
REC: RHECIAT_CH0003524(pydA)
REL: REMIM1_CH03339(preA)
REP: IE4803_CH03513(preA)
REI: IE4771_CH03550(preA)
RLE: RL3708(pydA)
RLG: Rleg_3281
RGA: RGR602_CH02886(preA)
RHN: AMJ98_CH03476(preA)
RPHA: AMC79_CH03445(preA)
RHT: NT26_2520(pydA)
RHX: AMK02_CH03365(preA)
RHK: Kim5_CH03554(preA)
REZ: AMJ99_CH03525(preA)
RJG: CCGE525_15780(preA)
RGR: FZ934_11275(preA)
RAD: CO657_15525(preA)
NEN: NCHU2750_25270(preA)
SHZ: shn_14235
ABAW: D5400_09270(preA)
BME: BMEI1639
BMEL: DK63_1852
BMEE: DK62_1099
BMF: BAB1_0313
BABO: DK55_332
BABR: DO74_1555
BABT: DK49_95
BABB: DK48_1794
BABU: DK53_322
BABS: DK51_1142
BABC: DO78_239
BMS: BR0282
BSZ: DK67_1228
BOV: BOV_0296
BCAR: DK60_381
BCAS: DA85_01390
BMR: BMI_I288
BPP: BPI_I317
BPV: DK65_1058
OIN: IAR37_04505(preA)
OAN: Oant_0365
OAH: DR92_2575
BBT: BBta_6035
LNE: FZC33_29565(preA)
YTI: FNA67_21460(preA)
PLEO: OHA_1_01605(preA)
MMED: Mame_01300(preA)
AALA: IGS74_07560(preA)
BRN: D1F64_19160(preA)
HDI: HDIA_1459(preA)
NOH: G5V57_07655(preA)
SIL: SPO1777
RUA: D1823_07200(preA)
RUT: FIU92_06020(preA)
RSP: RSP_0187
JAN: Jann_2712
RDE: RD1_3103
RPON: G3256_02275(preA)
PARR: EOJ32_12395(preA)
PKD: F8A10_17155(preA)
DSH: Dshi_1363(pyrD1)
PGD: Gal_02122
PHQ: D1820_02445(preA)
OAT: OAN307_c41920(yeiA)
OAR: OA238_c03780(yeiA)
OTM: OSB_04390(preA)
OCT: FTO60_10475(preA)
LEJ: ETW24_08685(preA)
LAQU: R2C4_10090(preA)
CID: P73_3029
MALG: MALG_04749
RSU: NHU_03019
RHC: RGUI_0789
LABP: FJ695_02730(preA)
LABT: FIU93_04720(preA)
SPSE: SULPSESMR1_00094(preA)
SPOT: G6548_03820(preA)
RMM: ROSMUCSMR3_02671(preA)
RID: RIdsm_00427(preA)
ROM: EI983_14705(preA)
ROH: FIU89_18035(preA)
LVS: LOKVESSMR4R_03345(preA)
AHT: ANTHELSMS3_00016(preA)
TAW: EI545_00685(preA)
SALO: EF888_09830(preA)
SEDI: EBB79_07770(preA)
BOO: E2K80_09375(preA)
PSEB: EOK75_13405(preA)
LIT: FPZ52_18435(preA)
OCD: FHY55_07670(preA)
MARU: FIU81_07475(preA)
ROT: FIV09_11715(preA)
PPRU: FDP22_17780(preA)
SIW: GH266_13945(preA)
PAED: G5B38_16070(preA)
MON: G8E03_00130(preA)
MALU: KU6B_40950
TGL: HFZ77_13800(preA)
PAMO: BAR1_04245(preA)
PSHQ: F3W81_08810(preA)
FAQ: G5B39_07595(preA)
HDH: G5B40_19400(preA)
SECH: B18_05670
GOH: B932_1609
GTI: FXF46_03295(preA)
GDI: GDI1503
GDJ: Gdia_2199
GXY: GLX_03930
GXL: H845_1598
KEU: S101446_01662(preA)
KSC: CD178_02985(preA)
KRE: GWK63_07025(preA)
ASZ: ASN_1389
AOY: EOV40_010375(preA)
NTN: D5366_09875(preA)
AZL: AZL_d01290(dpyD)
AOZ: HUE56_07125(preA)
TMO: TMO_c0377(yeiA)
TXI: TH3_13455
TII: DY252_16145(preA)
ECOG: FIV45_16545(preA)
BMQ: BMQ_4423
BMD: BMD_4409
BMEG: BG04_1340
BAG: Bcoa_0943
BEO: BEH_19335
BFD: NCTC4823_03106(preA)
BCL: ABC3782
GKA: GK1422
ANM: GFC28_991
ANL: GFC29_636
AND: GRQ40_07820(preA)
ACAI: ISX45_04825(preA)
LSP: Bsph_2011
LPAK: GDS87_07715(preA)
HLI: HLI_04715
PSYO: PB01_12590
SALE: EPH95_13745(preA)
MEKU: HUW50_24015(preA)
PMW: B2K_13835
PSAB: PSAB_23035
PRI: PRIO_6432
PSWU: SY83_21835
PALB: EJC50_22515(preA)
AAD: TC41_2982
SIV: SSIL_0761
PANC: E2636_14820(preA)
LRE: Lreu_1309
LRF: LAR_1241
LRT: LRI_0658
LNN: F0161_03900(preA)
VCP: H9L18_05125(preA)
CTC: CTC_00816
CBO: CBO2819
CBA: CLB_2762
CBH: CLC_2695
CBY: CLM_3182
CBL: CLK_2206
CBK: CLL_A2317
CBB: CLD_1756
CBI: CLJ_B3046
CBN: CbC4_1672
CBT: CLH_2060
CBF: CLI_2868
CBM: CBF_2860
CBE: Cbei_1943
CBZ: Cbs_1943
CBEI: LF65_02110
CKL: CKL_2399(pyrD1)
CKR: CKR_2115
CSR: Cspa_c41330(preA)
CPAT: CLPA_c03300(pyrD1) CLPA_c11100(preA)
CPAE: CPAST_c03300(pyrD1) CPAST_c11100(preA)
CBV: U729_2289
CLD: CLSPO_c28940(preA)
CDY: F3K33_09640(preA)
CCOH: SAMEA4530647_0673(preA)
AOE: Clos_2455
CRS: FQB35_04730(preA)
ESR: ES1_26140
ESU: EUS_26160
RCH: RUM_00500
CEW: EKH84_05970(preA)
BPRL: CL2_22260
ACAC: EYQ97_00720(preA)
CPRO: CPRO_21510(preA)
EHL: EHLA_1850
PXV: FXF36_04200(preA)
SGY: Sgly_1379
SAY: TPY_1320
TPZ: Tph_c23940(pyrD2) Tph_c24020(pyrD3)
CCHA: ELD05_01770(preA)
HALS: D7D81_09710(preA)
SPOA: EQM13_05785(preA)
ACIT: HPK19_11270(preA)
GOB: Gobs_3131
ATM: ANT_03030
DGO: DGo_CA0639(yeiA)
DEIN: DAAJ005_02045(preA)
TRA: Trad_0920
MRB: Mrub_1889
MIN: Minf_0626(pyrD)
MKC: kam1_1712
GRW: FTO74_00990(preA)
TALB: FTW19_18225(preA)
ABAS: ACPOL_5081
SUS: Acid_7660
ABAC: LuPra_00912(preA_1)
PDI: BDI_1170
PRU: PRU_1814
ALQ: C7Y71_003520(preA)
CPI: Cpin_3448
CHIH: GWR21_06515(preA)
FGG: FSB75_07475(preA)
SPIK: EXU85_15850(preA)
SPIB: G8759_09100(preA)
HSW: Hsw_1064
HYJ: FHG12_17235(preA)
HQI: H9L05_15525(preA)
FSN: GS03_00746(preA)
MARN: LN42_06090
CEX: CSE_02230
SMR: Smar_0238
DKA: DKAM_0183
TAG: Tagg_0303
STO: STK_11200(pydA)
ABRI: DFR85_02865(preA)
AAMB: D1866_09810(preA)
STEP: IC006_2427
BARC: AOA65_0974(hdlA_1)
 » show all
Reference
  Authors
Hidese R, Mihara H, Kurihara T, Esaki N
  Title
Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil.
  Journal
J Bacteriol 193:989-93 (2011)
DOI:10.1128/JB.01178-10
  Sequence
[eco:b2147]

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