KEGG   ORTHOLOGY: K17985
Entry
K17985                      KO                                     

Name
AMBRA1
Definition
activating molecule in BECN1-regulated autophagy protein 1
Pathway
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   04137 Mitophagy - animal
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   05014 Amyotrophic lateral sclerosis
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   05016 Huntington disease
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   05017 Spinocerebellar ataxia
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   05022 Pathways of neurodegeneration - multiple diseases
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
   03029 Mitochondrial biogenesis
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
Membrane trafficking [BR:ko04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
Genes
HSA: 55626(AMBRA1)
PTR: 451154(AMBRA1)
PPS: 100976893(AMBRA1)
GGO: 101144271(AMBRA1)
PON: 100456410(AMBRA1)
NLE: 100595128(AMBRA1)
MCC: 714434(AMBRA1)
MCF: 101925989(AMBRA1)
CSAB: 103236448(AMBRA1)
RRO: 104668391(AMBRA1)
CJC: 100385379(AMBRA1)
SBQ: 101046668(AMBRA1)
MMU: 228361(Ambra1)
MCAL: 110309853(Ambra1)
MPAH: 110317534(Ambra1)
RNO: 59319(Ambra1)
MUN: 110549887(Ambra1)
CGE: 100753101(Ambra1)
NGI: 103748789(Ambra1)
HGL: 101725050(Ambra1)
CCAN: 109692005(Ambra1)
OCU: 100349558(AMBRA1)
TUP: 102491780(AMBRA1)
CFA: 483634(AMBRA1)
VVP: 112924090(AMBRA1)
AML: 100471614(AMBRA1)
UMR: 103672328(AMBRA1)
UAH: 113264983(AMBRA1)
ORO: 101383471(AMBRA1)
ELK: 111149427
FCA: 101088613(AMBRA1)
PTG: 102950173(AMBRA1)
PPAD: 109245100(AMBRA1)
AJU: 106978066(AMBRA1)
BTA: 517263(AMBRA1)
BOM: 102269275(AMBRA1)
BIU: 109569559(AMBRA1)
BBUB: 102409652(AMBRA1)
CHX: 102184456(AMBRA1)
OAS: 101117963(AMBRA1)
SSC: 100519700(AMBRA1)
CFR: 102512599(AMBRA1)
CDK: 105106861(AMBRA1)
BACU: 103009999(AMBRA1)
LVE: 103084043(AMBRA1)
OOR: 101287189(AMBRA1)
DLE: 111183981(AMBRA1)
PCAD: 102989160
ECB: 100050652(AMBRA1)
EPZ: 103566525(AMBRA1)
EAI: 106843993(AMBRA1)
MYB: 102248838(AMBRA1)
MYD: 102768382(AMBRA1)
MNA: 107530323(AMBRA1)
HAI: 109390228(AMBRA1)
DRO: 112303248(AMBRA1)
PALE: 102896507(AMBRA1)
RAY: 107511862(AMBRA1)
LAV: 100676710(AMBRA1)
TMU: 101345407
MDO: 100015431
SHR: 100914667(AMBRA1)
PCW: 110224007(AMBRA1)
OAA: 100093574(AMBRA1)
GGA: 423194(AMBRA1)
CJO: 107314775(AMBRA1)
NMEL: 110400981(AMBRA1)
APLA: 101794362(AMBRA1)
ACYG: 106043506(AMBRA1)
TGU: 100219120(AMBRA1)
LSR: 110472074(AMBRA1)
SCAN: 103826682(AMBRA1)
GFR: 102033425(AMBRA1)
FAB: 101809327(AMBRA1)
PHI: 102099944(AMBRA1)
PMAJ: 107206049(AMBRA1)
CCAE: 111930182(AMBRA1)
CCW: 104698116(AMBRA1)
ETL: 114059061(AMBRA1)
FPG: 101913027(AMBRA1)
FCH: 102046086(AMBRA1)
CLV: 102094839(AMBRA1)
EGZ: 104134079(AMBRA1)
NNI: 104020375(AMBRA1)
ACUN: 113480722(AMBRA1)
PADL: 103921736(AMBRA1)
AAM: 106498255(AMBRA1)
ASN: 102372892(AMBRA1)
AMJ: 102566830(AMBRA1)
PSS: 102450852(AMBRA1)
CMY: 102938796(AMBRA1)
CPIC: 101935107(AMBRA1)
ACS: 100553616(ambra1)
PVT: 110081812(AMBRA1)
PBI: 103063553(AMBRA1)
TSR: 106552302(AMBRA1)
PMUA: 114595975(AMBRA1)
XLA: 108715245(ambra1.S)
XTR: 100497158(ambra1)
NPR: 108797317(AMBRA1)
DRE: 100332642(ambra1a) 559106(ambra1b)
CCAR: 109050618
IPU: 108274968(ambra1)
PHYP: 113529725(ambra1)
AMEX: 103040690(ambra1)
EEE: 113584511(ambra1)
TRU: 101071809(ambra1)
LCO: 104936096
MZE: 101473599(ambra1)
ONL: 100691687(ambra1)
OLA: 101170429(ambra1)
XMA: 102237588(ambra1)
XCO: 114154499(ambra1)
PRET: 103466795(ambra1)
CVG: 107100530(ambra1)
NFU: 107389120(ambra1)
KMR: 108250131(ambra1b)
ALIM: 106527974(ambra1)
AOCE: 111578061(ambra1)
CSEM: 103379694(ambra1)
LCF: 108885219(ambra1)
SDU: 111233714(ambra1)
SLAL: 111666039
MALB: 109969085(ambra1)
SFM: 108929067(ambra1)
PKI: 111846697(ambra1)
LCM: 102357663(AMBRA1)
BFO: 118414217
CIN: 100176090
AME: 727634
NVI: 100680119
TCA: 662121
BMOR: 101743043
BMAN: 114251737
SHX: MS3_03612
HMG: 100199635
GMX: 100817857
GSJ: 114398453
VRA: 106757677
VAR: 108323001
VUN: 114196205
CCAJ: 109796173
LJA: Lj1g3v4528630.1(Lj1g3v4528630.1)
ADU: 107491704
AIP: 107647863
FVE: 101295040
RCN: 112197055
PPER: 18793419
PMUM: 103323811
PAVI: 110750876
ZJU: 107422615
CSV: 101210946
CMO: 103499474
MCHA: 111009861
VVI: 100246400
SLY: 101247260
SPEN: 107031074
SOT: 102584562
CANN: 107864542
NSY: 104238476
NTO: 104085667
NAU: 109229400
DOSA: Os02t0290300-01(Os02g0290300) Os09t0296900-01(Os09g0296900)
BDI: 100829808
ATS: 109743723
ZMA: 100382568
 » show all
Reference
  Authors
Van Humbeeck C, Cornelissen T, Vandenberghe W
  Title
Ambra1: a Parkin-binding protein involved in mitophagy.
  Journal
Autophagy 7:1555-6 (2011)
DOI:10.4161/auto.7.12.17893
Reference
  Authors
Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F
  Title
Ambra1 regulates autophagy and development of the nervous system.
  Journal
Nature 447:1121-5 (2007)
DOI:10.1038/nature05925
  Sequence
[mmu:228361]

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