KEGG ORTHOLOGY: K18026

ORTHOLOGY: K18026

Entry

K18026                      KO

Symbol

PTPN2, PTPT

Name

tyrosine-protein phosphatase non-receptor type 2 [EC:3.1.3.48]

Pathway

map04630

JAK-STAT signaling pathway

Disease

H00408

Type 1 diabetes mellitus

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K18026  PTPN2, PTPT; tyrosine-protein phosphatase non-receptor type 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K18026  PTPN2, PTPT; tyrosine-protein phosphatase non-receptor type 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K18026  PTPN2, PTPT; tyrosine-protein phosphatase non-receptor type 2
Protein phosphatases and associated proteins [BR:ko01009]
Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K18026  PTPN2, PTPT; tyrosine-protein phosphatase non-receptor type 2

Other DBs

GO:

0004725

Genes

HSA:	5771(PTPN2)

PTR:	455504(PTPN2)

PPS:	100969647(PTPN2)

GGO:	101134272 101137356(PTPN2)

PON:	100445655(PTPN2) 103892420

PPYG:

129012782 129018918(PTPN2)

NLE:	100603034(PTPN2)

HMH:	116468775(PTPN2) 116473188

SSYN:

129460803(PTPN2) 129487318

MCC:	114673846(PTPN2)

MCF:	101866630(PTPN2)

MTHB:

126941218

MNI:	105478932(PTPN2)

CSAB:

103222817(PTPN2)

CATY:

105598932(PTPN2)

PANU:

101010207(PTPN2)

TGE:	112611533(PTPN2)

MLEU:

105543562(PTPN2)

RRO:	104671929(PTPN2)

RBB:	108533096(PTPN2)

TFN:	117064184(PTPN2)

PTEH:

111553504(PTPN2)

CANG:

105507921(PTPN2)

CJC:	100412533(PTPN2)

SBQ:	101027825(PTPN2)

CIMI:

108282483(PTPN2)

ANAN:

105730980(PTPN2)

CSYR:

103261295(PTPN2)

MMUR:

105861001(PTPN2)

LCAT:

123621841(PTPN2)

PCOQ:

105814869(PTPN2)

OGA:	100942558(PTPN2)

MMU:	19255(Ptpn2)

MCAL:

110285003(Ptpn2)

MPAH:

110333049(Ptpn2)

RNO:	117063(Ptpn2)

MCOC:

116087306(Ptpn2)

ANU:	117719838(Ptpn2)

MUN:	110562689(Ptpn2)

CGE:	103163089(Ptpn2)

MAUA:

101827418(Ptpn2)

PROB:

127234028(Ptpn2)

PLEU:

114681601 114682347(Ptpn2)

MORG:

121438840(Ptpn2)

MFOT:

126511054

AAMP:

119814150(Ptpn2)

HGL:	101725549(Ptpn2)

CPOC:

100732081(Ptpn2)

CCAN:

109685072(Ptpn2)

DORD:

105990085 105993783(Ptpn2)

DSP:	122110967(Ptpn2) 122125339

PLOP:

125363781(Ptpn2)

NCAR:

124965471

MMMA:

107159441(Ptpn2)

OCU:

100338151

OPI:	101534533(PTPN2)

TUP:	102485713(PTPN2)

GVR:	103590500(PTPN2)

CFA:	490563(PTPN2)

CLUD:

112648110(PTPN2)

VVP:	112925308(PTPN2)

VLG:	121494901(PTPN2)

NPO:	129508931(PTPN2)

AML:	100483443(PTPN2)

UMR:	103673356(PTPN2)

UAH:	113245907(PTPN2)

UAR:	123803539(PTPN2)

ELK:

111142429

LLV:

125081995

MPUF:

101682157(PTPN2)

MNP:	132023455(PTPN2)

MLK:	131810849(PTPN2)

NVS:	122903138(PTPN2)

ORO:	101383123(PTPN2)

EJU:	114198065(PTPN2)

ZCA:	113912326(PTPN2) 113912402

MLX:	118016447(PTPN2)

NSU:	110574348(PTPN2)

LWW:	102741717(PTPN2)

FCA:	101095923(PTPN2)

PYU:	121033214(PTPN2)

PCOO:

112868109(PTPN2)

PBG:	122471042(PTPN2)

PVIV:

125149052(PTPN2)

LRUF:

124519791

PTG:	102953894(PTPN2)

PPAD:

109257633(PTPN2)

PUC:

125914856

AJU:

106981464

HHV:	120220202(PTPN2)

BTA:	540888(PTPN2)

BOM:	102281612(PTPN2)

BIU:	109577870(PTPN2)

BBUB:

102414227(PTPN2)

BBIS:

105002441(PTPN2)

CHX:	102179903(PTPN2)

OAS:	101106987(PTPN2)

BTAX:

128067581(PTPN2)

ODA:	120881044(PTPN2)

CCAD:

122425519(PTPN2)

MBEZ:

129549806(PTPN2)

SSC:	100171401(PTPN2)

CFR:	102509923(PTPN2)

CBAI:

105071448(PTPN2)

CDK:	105086470(PTPN2)

VPC:	102534698(PTPN2)

BACU:

103014463(PTPN2)

BMUS:

118906842(PTPN2)

LVE:	103091407(PTPN2)

OOR:	101279319(PTPN2)

DLE:	111163085(PTPN2)

PCAD:

102987085(PTPN2)

PSIU:

116738717(PTPN2)

NASI:

112412184(PTPN2)

ECB:	100057795(PTPN2)

EPZ:	103554305(PTPN2)

EAI:	106828641(PTPN2)

MYB:	102241649(PTPN2)

MYD:	102756120(PTPN2)

MMYO:

118663756(PTPN2)

MLF:	102432209(PTPN2)

MDT:	132239807(PTPN2)

PKL:	118708223(PTPN2)

EFUS:

103302561(PTPN2)

MNA:	107525236(PTPN2)

DRO:	112322685(PTPN2)

SHON:

119001955(PTPN2)

AJM:	119035815(PTPN2)

PDIC:

114506294(PTPN2)

PHAS:

123826159(PTPN2)

MMF:	118618282(PTPN2) 118625335

PPAM:

129081653(PTPN2)

HAI:	109396445(PTPN2)

RFQ:	117011840(PTPN2)

PALE:

102880076(PTPN2)

PGIG:

120588972(PTPN2)

PVP:	105306359(PTPN2)

RAY:	107497714(PTPN2)

MJV:	108406768(PTPN2) 118972990

TOD:	119243216(PTPN2)

SARA:

101542359(PTPN2)

SETR:

126003744(PTPN2)

LAV:	100654678(PTPN2)

TMU:

101346964

ETF:	101640728 101646358(PTPN2)

DNM:	101432204(PTPN2)

MDO:	100018164(PTPN2)

GAS:	123244430 123253671 123254142(PTPN2)

SHR:	100935022(PTPN2)

AFZ:	127542642 127542813 127544043

PCW:	110207799(PTPN2)

TVP:	118829031(PTPN2) 118832703

OAA:	100083956(PTPN2)

GGA:	396409(PTPN2)

PCOC:

116226220(PTPN2)

MGP:	100545675(PTPN2)

CJO:	107310024(PTPN2)

TPAI:

128091128(PTPN2)

LMUT:

125690657(PTPN2)

NMEL:

110393189(PTPN2)

APLA:

101802229(PTPN2)

ACYG:

106034930(PTPN2)

CATA:

118257393(PTPN2)

AFUL:

116485756(PTPN2) 116500726

TGU:	100225009(PTPN2)

LSR:	110469243(PTPN2)

SCAN:

103826514(PTPN2)

PMOA:

120500716(PTPN2)

OTC:	121333163(PTPN2)

PRUF:

121359000(PTPN2)

GFR:	102033724(PTPN2)

FAB:	101807816(PTPN2)

OMA:	130248911(PTPN2)

PHI:	102110181(PTPN2)

PMAJ:

107199798(PTPN2)

CCAE:

111924854(PTPN2)

CCW:	104687339(PTPN2)

CBRC:

103612455(PTPN2)

ETL:	114058219(PTPN2)

ZAB:	102067726(PTPN2)

ZLE:	135444327(PTPN2)

ACHL:

103807057(PTPN2)

SVG:	106849939(PTPN2)

MMEA:

130575208(PTPN2)

HRT:	120752706(PTPN2)

SATI:

136367188(PTPN2)

FPG:	101917001(PTPN2)

FCH:	102048689(PTPN2)

CCRI:

104156099

NNT:	104411050(PTPN2)

SHAB:

115600691(PTPN2)

ACUN:

113476100(PTPN2)

TALA:

104361045(PTPN2)

ACHC:

115340776(PTPN2)

HALD:

104323647(PTPN2)

HLE:	104841563(PTPN2)

AGEN:

126051382

GCL:

127029896

CSTI:

104560976(PTPN2)

LDI:	104341603(PTPN2)

MNB:

103779201

DPUB:

104308692(PTPN2)

AVIT:

104269326(PTPN2)

BRHI:

104491013(PTPN2)

EGZ:	104132865(PTPN2)

NNI:	104017656(PTPN2)

PCRI:

104037631(PTPN2)

PCAO:

104050783(PTPN2)

PADL:

103912275(PTPN2)

AFOR:

103902966(PTPN2)

FGA:	104071709(PTPN2)

GSTE:

104251499(PTPN2)

CLV:	102096578(PTPN2)

MUI:	104534677(PTPN2)

PGUU:

104460252(PTPN2)

PLET:

104628875(PTPN2)

EHS:	104510641(PTPN2)

CMAC:

104474823(PTPN2)

CUCA:

104065537(PTPN2)

TEO:	104381097(PTPN2)

BREG:

104630756(PTPN2)

OHA:	104333446(PTPN2)

ACAR:

104519468(PTPN2)

CPEA:

104396964(PTPN2)

CVF:	104290015(PTPN2)

RTD:	128906068(PTPN2)

AAM:	106484308(PTPN2)

AROW:

112964663(PTPN2)

NPD:	112948222(PTPN2)

TGT:	104574381(PTPN2)

DNE:	112979834(PTPN2)

SCAM:

104151308(PTPN2)

ASN:	102367862(PTPN2)

AMJ:	102567939(PTPN2)

CPOO:

109317135(PTPN2)

GGN:	109302978(PTPN2)

PSS:	102456619(PTPN2)

CMY:	102945334(PTPN2)

CCAY:

125632290(PTPN2)

DCC:	119850449(PTPN2)

CPIC:

101935962(PTPN2)

TST:	117873328(PTPN2)

CABI:

116830259(PTPN2)

MRV:	120397425(PTPN2)

ACS:	100558082(ptpn2)

ASAO:

132774699(PTPN2)

PVT:	110078033(PTPN2)

SUND:

121927899(PTPN2)

PBI:	103053565(PTPN2)

PMUR:

107288173(PTPN2)

CTIG:

120306290(PTPN2)

TSR:	106545742(PTPN2)

PGUT:

117672616(PTPN2)

APRI:

131195254(PTPN2)

PTEX:

113435533(PTPN2)

NSS:	113414855(PTPN2)

VKO:	123021531(PTPN2)

PMUA:

114600765(PTPN2)

PRAF:

128417643(PTPN2)

ZVI:	118078967 118089926(PTPN2)

HCG:	128322782(PTPN2)

GJA:	107113098(PTPN2)

STOW:

125438886(PTPN2)

EMC:	129333202(PTPN2)

XLA:	431888(ptpn2.L) 446745(ptpn2.S)

XTR:	100492067(ptpn2)

NPR:	108787318(PTPN2)

RTEM:

120940848(PTPN2)

BBUF:

121000676(PTPN2)

BGAR:

122939612(PTPN2)

MUO:	115476191(PTPN2)

GSH:	117355491(PTPN2)

DRE:	393438(ptpn2a) 561613(ptpn2b)

SRX:	107738314 107748370 107748621 107751897

SANH:

107656702 107666587 107672871 107686952

SGH:	107552315 107564854 107575508 107596739

CCAR:

109061663 109076103 109085638 109104640

CAUA:

113060119 113068282(ptpn2) 113116202 113119183

CGIB:

127935701 127974464 127978847 128030851

PTET:

122323666(ptpn2b) 122360024(ptpn2a)

LROH:

127178520(ptpn2a) 127181998(ptpn2b)

OMC:	131522404(ptpn2a) 131526160(ptpn2b)

PPRM:

120485249(ptpn2b) 120495085(ptpn2a)

RKG:	130077519(ptpn2a) 130088008(ptpn2b)

MAMB:

125243221(ptpn2a) 125275191(ptpn2b)

CIDE:

127497209 127501212

CERY:

137030839(ptpn2a) 137037067(ptpn2b)

MASI:

127420735 127424847 127452483 127454272

TROS:

130558604(ptpn2a) 130567153(ptpn2b)

TDW:	130415405(ptpn2b) 130433446(ptpn2a)

MANU:

129447749(ptpn2a) 129455380(ptpn2b)

IPU:	108257293(ptpn2b) 108272944(ptpn2a)

IFU:	128600441(ptpn2b) 128611464(ptpn2a)

PHYP:

113533704 113546229

SMEO:

124376167(ptpn2b) 124385031(ptpn2a)

TFD:	113644513(ptpn2a) 113653448(ptpn2b)

TVC:	132845814(ptpn2a) 132863829(ptpn2b)

TRN:	134310606(ptpn2a) 134328226(ptpn2b)

AMEX:

103041465(ptpn2a) 103047208(ptpn2b)

CMAO:

118805234(ptpn2b) 118818067(ptpn2a)

EEE:	113585422 113585633

CHAR:

105907723(ptpn2b)

TRU:	101063867(ptpn2) 101065622

TFS:	130517999(ptpn2b) 130532013(ptpn2a)

TNG:	GSTEN00017369G001 GSTEN00024909G001

LCO:	104918639 104936248(ptpn2)

NCC:

104942157

TBEN:

117478037(ptpn2b) 117497374(ptpn2a)

CGOB:

115015668 115021646(ptpn2)

PGEO:

117455171(ptpn2b) 117460930(ptpn2a)

GACU:

117536149(ptpn2b) 117545873(ptpn2a)

EMAC:

134861891(ptpn2a) 134874797(ptpn2b)

ELY:	117263984(ptpn2b) 117266337(ptpn2a)

EFO:	125892811(ptpn2a) 125904769(ptpn2b)

PLEP:

121945990(ptpn2a) 121957598

SLUC:

116043288(ptpn2a) 116047408(ptpn2b)

ECRA:

117946040(ptpn2a) 117956867(ptpn2b)

ESP:	116691421 116701358

PFLV:

114556686 114567878

GAT:	120810041(ptpn2a) 120826090(ptpn2b)

PPUG:

119197000(ptpn2a) 119219265(ptpn2b)

AFB:	129097558(ptpn2b) 129109339(ptpn2a)

CLUM:

117728042(ptpn2a) 117738973(ptpn2b)

PSWI:

130206710(ptpn2a)

MSAM:

119898093(ptpn2a) 119906454(ptpn2b)

SCHU:

122864123(ptpn2b) 122882261(ptpn2a)

CUD:	121514059(ptpn2a) 121523893(ptpn2b)

ALAT:

119006121(ptpn2a) 119017122(ptpn2b)

MZE:	101475243 101484899

ONL:	100702382 100711916

OAU:	116322458(ptpn2b) 116328663(ptpn2a)

OLA:	101158780 101161671

OML:	112143477(ptpn2a) 112163307(ptpn2b)

CSAI:

133425194(ptpn2a) 133461058(ptpn2b)

XMA:	102224419(ptpn2) 102229317

XCO:	114144543(ptpn2) 114155628

XHE:	116717089 116731406

PRET:

103465904(ptpn2) 103472442

PFOR:

103135179 103136973 103137015

PLAI:

106938041 106958674(ptpn2) 106964363

PMEI:

106904396 106904808 106926948(ptpn2)

GAF:	122830498(ptpn2a) 122844198(ptpn2b)

PPRL:

129367446(ptpn2a) 129375103(ptpn2b)

CVG:	107088377 107089979

CTUL:

119784831(ptpn2b) 119797258(ptpn2a)

GMU:	124865831(ptpn2a) 124879478(ptpn2b)

NFU:	107378879(ptpn2) 107394678

KMR:	108234147(ptpn2a) 108241382(ptpn2b)

ALIM:

106518165 106519263(ptpn2)

NWH:	119410265(ptpn2a) 119425849(ptpn2b)

AOCE:

111565512(ptpn2) 111566760

MCEP:

125016690(ptpn2a) 125020387(ptpn2b)

CSEM:

103388897(ptpn2) 103394276

POV:	109632192 109638842

SSEN:

122775127(ptpn2a) 122786542(ptpn2b)

HHIP:

117770188(ptpn2b) 117777119(ptpn2a)

HSP:	118113620(ptpn2a) 118124705(ptpn2b)

PPLT:

128448971(ptpn2a) 128461666(ptpn2b)

SMAU:

118292186(ptpn2b) 118301141(ptpn2a)

LCF:	108876292(ptpn2a) 108898162(ptpn2b)

SDU:	111223475 111227823(ptpn2)

SLAL:

111659360 111664187(ptpn2)

XGL:	120784649(ptpn2a) 120786716(ptpn2b)

HCQ:	109514592 109521924(ptpn2)

SSCV:

125974806 125987252

SBIA:

133500252(ptpn2b) 133500373(ptpn2a)

PEE:	133396084(ptpn2b) 133401141(ptpn2a)

PTAO:

133471284(ptpn2b) 133479301(ptpn2a)

BPEC:

110167244 110171483(ptpn2)

MALB:

109958764 109963839(ptpn2)

BSPL:

114843141(ptpn2a) 114865675(ptpn2b)

SJO:	128365755(ptpn2a) 128374317(ptpn2b)

SASA:

106570769(ptpn2) 106591389 106598563

STRU:

115176263(ptpn2) 115188996 115188997

OTW:	112229372(ptpn2b)

OMY:	110487802(ptpn2b) 110514311

OGO:	124017984 124017987 124017988 124043107(ptpn2b)

ONE:

115125833

OKI:	109881175(ptpn2) 109884148 116373138

OKE:	118375957(ptpn2b) 127920227

SALP:

112076838

SNH:	120027117(ptpn2b)

CCLU:

121555488(ptpn2b) 121559469 121575670

ELS:	105006553 105016480

SFM:	108919221 108940714

PKI:	111844781 111852532(ptpn2)

AANG:

118219592 118234132(ptpn2b)

LOC:	102684808(ptpn2)

PSPA:

121313134(ptpn2b)

ARUT:

117400549(ptpn2b)

PSEX:

120517017(ptpn2b)

LCM:	102364029(PTPN2)

CMK:	103179645(ptpn2b)

RTP:	109933050(ptpn2b)

CPLA:

122548846

HOC:

132815105

LERI:

129696453(ptpn2b)

BBEL:

SCLV:

ARUN:

AJC:

TPRE:

SOY:

AGRG:

DVV:

ACOO:

DVT:

DCI:

HHAL:

HVI:

MQU:

SGRE:

BROR:

IEL:

PVM:	113802296 113811808

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:	121117518 121130558

PPOI:

DSV:

RSAN:

RMP:

LPOL:

PMEO:

NAI:	NECAME_00362

HRO:	HELRODRAFT_119705 HELRODRAFT_149796

PCAN:

GAE:

CVN:

MCAF:

LJP:

ATEN:

ADF:

HSY:

RES:

NGR:	NAEGRDRAFT_30645

» show all

Reference

PMID:11909529

Authors

Simoncic PD, Lee-Loy A, Barber DL, Tremblay ML, McGlade CJ

Title

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

Journal

Curr Biol 12:446-53 (2002)
DOI:10.1016/S0960-9822(02)00697-8

Sequence

[hsa:5771] [mmu:19255]

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Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1061)   
   KEGG GENES (599)   
   KEGG MGENES (105)   
   RefGene (354)   
   OC (3)   
Literature (1)   
   PubMed (1)   
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