KEGG ORTHOLOGY: K18050

ORTHOLOGY: K18050

Entry

K18050                      KO

Symbol

PRKCE

Name

novel protein kinase C epsilon type [EC:2.7.11.13]

Pathway

map04022

cGMP-PKG signaling pathway

map04071

Sphingolipid signaling pathway

map04270

Vascular smooth muscle contraction

map04371

Apelin signaling pathway

map04530

Tight junction

map04666

Fc gamma R-mediated phagocytosis

map04750

Inflammatory mediator regulation of TRP channels

map04925

Aldosterone synthesis and secretion

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04933

AGE-RAGE signaling pathway in diabetic complications

map05131

Shigellosis

map05206

MicroRNAs in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K18050  PRKCE; novel protein kinase C epsilon type
   04071 Sphingolipid signaling pathway
    K18050  PRKCE; novel protein kinase C epsilon type
   04022 cGMP-PKG signaling pathway
    K18050  PRKCE; novel protein kinase C epsilon type
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K18050  PRKCE; novel protein kinase C epsilon type
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K18050  PRKCE; novel protein kinase C epsilon type
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K18050  PRKCE; novel protein kinase C epsilon type
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K18050  PRKCE; novel protein kinase C epsilon type
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K18050  PRKCE; novel protein kinase C epsilon type
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K18050  PRKCE; novel protein kinase C epsilon type
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K18050  PRKCE; novel protein kinase C epsilon type
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K18050  PRKCE; novel protein kinase C epsilon type
   04931 Insulin resistance
    K18050  PRKCE; novel protein kinase C epsilon type
   04933 AGE-RAGE signaling pathway in diabetic complications
    K18050  PRKCE; novel protein kinase C epsilon type
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K18050  PRKCE; novel protein kinase C epsilon type
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     K18050  PRKCE; novel protein kinase C epsilon type
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  PKC family [OT]
   K18050  PRKCE; novel protein kinase C epsilon type

Other DBs

GO:

0004699

Genes

HSA:	5581(PRKCE)

PTR:	459203(PRKCE)

PPS:	100974922(PRKCE)

GGO:	101133595(PRKCE)

PON:	100440778(PRKCE)

NLE:	100606298(PRKCE)

HMH:	116483166(PRKCE)

MCC:	714533(PRKCE)

MCF:	102127282(PRKCE)

MTHB:

126933879

MNI:	105464958(PRKCE)

CSAB:

103220351(PRKCE)

CATY:

105590592(PRKCE)

PANU:

101022026(PRKCE)

TGE:	112604800(PRKCE)

MLEU:

105528827(PRKCE)

RRO:	104663184(PRKCE)

RBB:	108522504(PRKCE)

TFN:	117062364(PRKCE)

PTEH:

111550425(PRKCE)

CANG:

105507408(PRKCE)

CJC:	100388620(PRKCE)

SBQ:	101053832(PRKCE)

CIMI:

108292079(PRKCE)

CSYR:

103272114

MMUR:

105866526(PRKCE)

LCAT:

123636878(PRKCE)

PCOQ:

105818012(PRKCE)

OGA:	100943756(PRKCE)

MMU:	18754(Prkce)

MCAL:

110312510(Prkce)

MPAH:

110336160(Prkce)

RNO:	29340(Prkce)

MCOC:

116080908(Prkce)

ANU:	117717018(Prkce)

MUN:	110552342(Prkce)

CGE:	100763552(Prkce)

MAUA:

101839221(Prkce)

PROB:

127214920(Prkce)

PLEU:

114709090(Prkce)

MORG:

121432846(Prkce)

MFOT:

126504040

AAMP:

119807809(Prkce)

NGI:	103725757(Prkce)

HGL:	101700837(Prkce)

CPOC:

100721814(Prkce)

CCAN:

109689908

DORD:

105986806(Prkce)

DSP:	122104544(Prkce)

PLOP:

125356479(Prkce)

NCAR:

124962983

MMMA:

107137311(Prkce)

OCU:	100009103(PRKCE)

OPI:	101520570(PRKCE)

TUP:	102502025(PRKCE)

GVR:	103592021(PRKCE)

CFA:	609934(PRKCE)

CLUD:

112671518(PRKCE)

VVP:	112915218(PRKCE)

VLG:	121490590(PRKCE)

NPO:	129511727(PRKCE)

AML:	100468967(PRKCE)

UMR:	103671225(PRKCE)

UAH:	113246159(PRKCE)

UAR:	123785895(PRKCE)

ELK:

111155859

LLV:

125109503

MPUF:

101678238(PRKCE)

MNP:	132021606(PRKCE)

MLK:	131808516(PRKCE)

NVS:	122916358(PRKCE)

ORO:	101362539(PRKCE)

EJU:	114209682(PRKCE)

ZCA:	113937273(PRKCE)

MLX:	118008176(PRKCE)

NSU:	110590351(PRKCE)

LWW:	102749878(PRKCE)

FCA:	101100958(PRKCE)

PYU:	121016336(PRKCE)

PCOO:

112869711(PRKCE)

PBG:	122496797(PRKCE)

PVIV:

125162095(PRKCE)

LRUF:

124502915

PTG:	102956451(PRKCE)

PPAD:

109278788(PRKCE)

PUC:

125936002

AJU:

106977232

HHV:	120224286(PRKCE)

BTA:	507041(PRKCE)

BOM:	102266941(PRKCE) 102283594

BIU:	109566044(PRKCE)

BBUB:

102404606(PRKCE)

BBIS:

104987605(PRKCE)

CHX:	102169016(PRKCE)

OAS:	101110314(PRKCE)

BTAX:

128055243(PRKCE)

ODA:	120851733(PRKCE)

CCAD:

122441637(PRKCE)

MBEZ:

129539824(PRKCE)

SSC:	100524932(PRKCE)

CFR:	102509837(PRKCE)

CBAI:

105079021(PRKCE)

CDK:	105103566(PRKCE)

VPC:	102533967(PRKCE)

BACU:

103006250(PRKCE)

BMUS:

118905913(PRKCE)

LVE:	103068913(PRKCE)

OOR:	101276402(PRKCE)

DLE:	111174803(PRKCE)

PCAD:

102988770(PRKCE)

PSIU:

116764149(PRKCE)

NASI:

112405267(PRKCE)

ECB:	100053394(PRKCE)

EPZ:	103549602(PRKCE)

EAI:	106826113(PRKCE)

MYB:	102263707(PRKCE)

MYD:	102759931(PRKCE)

MMYO:

118669039(PRKCE)

MLF:	102435274(PRKCE)

PKL:	118717316(PRKCE)

EFUS:

103305423

MNA:

107530341

DRO:	112297947(PRKCE)

SHON:

119001241(PRKCE)

AJM:	119060907(PRKCE)

PDIC:

114499237(PRKCE)

PHAS:

123811487(PRKCE)

MMF:	118630650(PRKCE)

PPAM:

129065757(PRKCE)

HAI:	109393868(PRKCE)

RFQ:	117033065(PRKCE)

PALE:

102894641(PRKCE)

PGIG:

120621691(PRKCE)

PVP:	105292973(PRKCE)

RAY:	107509571(PRKCE)

MJV:	108406405(PRKCE)

TOD:	119259343(PRKCE)

SARA:

101543045(PRKCE)

SETR:

126023927(PRKCE)

LAV:	100655386(PRKCE)

TMU:

101349247

ETF:	101645703(PRKCE)

DNM:	101447884(PRKCE)

MDO:	100032210(PRKCE)

GAS:	123236843(PRKCE)

SHR:	100921656(PRKCE)

AFZ:

127548045

PCW:	110218526(PRKCE)

OAA:	103168168(PRKCE)

GGA:	421409(PRKCE)

PCOC:

116229894(PRKCE)

MGP:	100543758(PRKCE)

CJO:	107311186(PRKCE)

TPAI:

128081808(PRKCE)

LMUT:

125689059(PRKCE)

NMEL:

110395486(PRKCE)

APLA:

101795629(PRKCE)

ACYG:

106029794(PRKCE)

CATA:

118255097(PRKCE)

AFUL:

116487192(PRKCE)

TGU:	100230589(PRKCE)

LSR:	110480403(PRKCE)

SCAN:

103817167(PRKCE)

PMOA:

120496950(PRKCE)

OTC:	121340667(PRKCE)

PRUF:

121358709(PRKCE)

GFR:	102031365(PRKCE)

FAB:	101815711(PRKCE)

OMA:	130251296(PRKCE)

PHI:	102110578(PRKCE)

PMAJ:

107202015(PRKCE)

CCAE:

111927602(PRKCE)

CCW:	104685689(PRKCE)

CBRC:

103622726(PRKCE)

ETL:

114067530

ZAB:	102065634(PRKCE)

ACHL:

103807831(PRKCE)

SVG:	106853788(PRKCE)

MMEA:

130578213(PRKCE)

HRT:	120750148(PRKCE)

FPG:	101917755(PRKCE)

FCH:	102059448(PRKCE)

CLV:	102096207(PRKCE)

EGZ:	104123423(PRKCE)

NNI:	104019696(PRKCE)

PLET:

104628209(PRKCE)

EHS:

104503759

PCAO:

104046507(PRKCE)

ACUN:

113478353(PRKCE)

TALA:

104361523(PRKCE)

PADL:

103914308(PRKCE) 103918098

AFOR:

103904812(PRKCE)

ACHC:

115350386(PRKCE)

HALD:

104319501(PRKCE)

HLE:	104837397(PRKCE)

AGEN:

126052591

GCL:

127014266

CCRI:

104155932

BREG:

104634121(PRKCE)

FGA:	104075887(PRKCE)

LDI:

104352520

OHA:	104333589(PRKCE)

NNT:	104406853(PRKCE)

SHAB:

115613721(PRKCE)

DPUB:

104303422 104309317

CPEA:

104395276(PRKCE)

AVIT:

104271105(PRKCE)

CVF:	104282541(PRKCE)

RTD:	128907859(PRKCE)

CUCA:

104056824(PRKCE)

AAM:	106485510(PRKCE)

AROW:

112962912(PRKCE)

NPD:	112953217(PRKCE)

DNE:	112995937(PRKCE)

SCAM:

104144993(PRKCE)

ASN:	102368989(PRKCE)

AMJ:	102576791(PRKCE)

CPOO:

109319646(PRKCE)

GGN:	109296774(PRKCE)

PSS:	102452906(PRKCE)

CMY:	102936130(PRKCE)

CCAY:

125633553(PRKCE)

DCC:	119853443(PRKCE)

CPIC:

101951149(PRKCE)

TST:	117874374(PRKCE)

CABI:

116815013(PRKCE)

MRV:	120401443(PRKCE)

ACS:	100567346(prkce)

ASAO:

132761494(PRKCE)

PVT:

110080748

SUND:

121924436(PRKCE)

PBI:	103053780 103060295(PRKCE)

PMUR:

107287861(PRKCE)

CTIG:

120309857(PRKCE)

TSR:	106547762(PRKCE)

PGUT:

117671626(PRKCE)

APRI:

131189216(PRKCE)

PTEX:

113433329(PRKCE)

NSS:	113422569(PRKCE)

VKO:	123023205(PRKCE)

PMUA:

114594748(PRKCE)

PRAF:

128411222(PRKCE)

ZVI:	118083100(PRKCE)

HCG:	128351997(PRKCE)

GJA:	107115714 107125702

STOW:

125425192(PRKCE)

EMC:	129332684(PRKCE)

XLA:	108716426 108717735

XTR:	100135720(prkce)

NPR:	108804505(PRKCE)

RTEM:

120937971(PRKCE)

BBUF:

120999440(PRKCE)

BGAR:

122935079(PRKCE)

MUO:	115465374(PRKCE)

GSH:	117356490(PRKCE)

DRE:	100005075(prkcea) 100332055(prkceb)

SRX:	107708403 107727364 107739250 107749378

SANH:

107678509(prkce) 107698816 107699301

SGH:	107550054 107582770 107586499 107590020(prkce)

CCAR:

109069787 109083439 109099594 109100163 109113084

CAUA:

113056147 113057224 113111553 113113025

CGIB:

127969319 127970423 128025283 128026453

PTET:

122355618(prkcea) 122356745(prkceb)

LROH:

127174107(prkcea) 127174825(prkceb)

OMC:	131550962(prkcea) 131552387(prkceb)

PPRM:

120468589 120471522(prkcea)

RKG:	130088695(prkcea) 130106384(prkceb)

MAMB:

125255135(prkcea) 125277255(prkceb)

CIDE:

127523898 127523910 127524763

MASI:

127412171 127413761 127423589 127427261

TROS:

130559103(prkceb) 130568813(prkcea)

TDW:	130431487(prkceb) 130438918(prkcea)

MANU:

129416206(prkceb) 129420780(prkcea)

IPU:	108263296(prkceb) 108274197(prkcea)

IFU:	128605415(prkceb) 128616532(prkcea) 128622627

PHYP:

113527396 113543727(prkce)

SMEO:

124388742(prkcea) 124399767(prkceb)

TFD:	113644992(prkceb) 113645377 113645394 113653498(prkcea) 113656571 113657868

TVC:	132843324 132847138(prkceb) 132850560 132850561 132853428 132855741 132856634 132863297(prkcea)

AMEX:

103032491 103034301

CMAO:

118809266(prkcea) 118810223(prkceb)

EEE:	113572717 113572795

CHAR:

105900023(prkceb) 105904120

TRU:	101067313 101073327(prkce)

TFS:	130533229(prkcea) 130534076

TNG:	GSTEN00009554G001 GSTEN00018762G001

LCO:	104922490(prkce) 104931840

NCC:	104949865 104951027(prkce)

TBEN:

117473508(prkcea) 117487103

CGOB:

115019831 115024247(prkce)

PGEO:

117443136 117464447(prkcea)

GACU:

117541597 117544213(prkcea)

EMAC:

134859003 134870934(prkcea)

ELY:	117247057(prkcea) 117272631

EFO:	125881102(prkcea) 125903350

PLEP:

121958543(prkcea)

SLUC:

116061400(prkcea) 116061689

ECRA:

117936430(prkcea) 117960301

ESP:	116671724(prkce) 116705557

PFLV:

114548088(prkce) 114571931

GAT:	120818998(prkcea) 120821024

PPUG:

119212824(prkcea) 119214162

AFB:	129090911(prkcea) 129092029

CLUM:

117743861 117748961(prkcea)

PSWI:

130203303(prkcea) 130207122

MSAM:

119912380 119916371(prkcea)

SCHU:

122867302(prkcea) 122884321

CUD:	121510997 121528149(prkcea)

ALAT:

119010144(prkcea) 119033782

MZE:	101468101 101486794

ONL:	100692040 100695466

OAU:	116309925 116328797

OLA:	101168247(prkce) 101172355

OML:	112154223(prkcea) 112161503

CSAI:

133419631(prkcea) 133463220

XMA:	102224280 102236119(prkce)

XCO:	114137801 114151921(prkce)

XHE:	116712859 116726861(prkce)

PRET:

103476621 103481826(prkce)

PFOR:

103145135(prkce) 103155522

PLAI:

106940220 106948767

PMEI:

106904308(prkce) 106908205

GAF:	122823820(prkcea) 122842574

PPRL:

129353970 129367963(prkcea)

CVG:	107085540(prkce) 107090628

CTUL:

119781897(prkcea) 119795240

GMU:	124858840 124875100(prkcea)

NFU:	107387753(prkce)

KMR:	108249079(prkcea)

ALIM:

106516627(prkce)

NWH:	119424048(prkcea)

AOCE:

111562817 111577888(prkce)

MCEP:

125018826 125022292(prkcea)

CSEM:

103381531(prkce) 103387794

POV:	109627017 109635952

SSEN:

122759157(prkcea)

HHIP:

117752974(prkcea) 117775705

HSP:	118100742(prkcea) 118118579

SMAU:

118283545 118287636(prkcea)

LCF:	108872883 108882782(prkcea)

SDU:	111219758(prkce) 111223864

SLAL:

111645457 111655236(prkce)

XGL:	120794674(prkcea) 120796188

HCQ:	109510070 109530172(prkce)

SSCV:

125990884

SBIA:

133495401(prkcea) 133509501

PEE:	133409489 133418078(prkcea)

PTAO:

133469277(prkcea) 133485977

BPEC:

110162858 110174578(prkce)

MALB:

109963057(prkce) 109963810

BSPL:

114845652(prkcea)

SJO:	128373305 128381755(prkcea)

SASA:

106589411 106589721(prkce) 106591157 106611052

STRU:

115152826 115201192 115201530(prkce)

OTW:	112224299 112224582 112261469

OMY:	110498742 110499309 110503000

OGO:	124038633 124040057 124040294

ONE:	115144077 115144498(prkce)

OKI:	109869986 109870171(prkce) 109898971

OKE:	118357702 118357744 118378942

SALP:

111967801 111968048 111968262 111978759

SNH:	120029376 120029801 120045351

CCLU:

121547367 121547663 121556241 121586923

ELS:	105006029 105021252(prkce)

SFM:	108918044(prkce)

PKI:	111839985(prkce)

AANG:

118218235 118221346

LOC:	102694770(prkce)

PSPA:

121316343 121316681

ARUT:

117403245 117411020

PSEX:

120516604(prkcea)

LCM:

102363817

CMK:	103180812 103185381(prkcha)

CPLA:

122552746(prkcea) 122553462(prkcha)

HOC:	132818369(prkcha) 132819714

LERI:

129699659 129700114

PMRN:

116947747 116948332 116953858

LRJ:	133341414 133352798 133356189 133356190

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG1954(Pkc98E)

DER:

6555094

DSE:

6612641

DSI:	Dsimw501_GD21405(Dsim_GD21405)

DYA:	Dyak_GE23824

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24186

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108372482 108374017 108382512

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ020037

CPII:

120413782

CNS:	116339603 116339700

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	103313855 663551(Pkc98E)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212831

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105387893 105393816

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM513980

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_301963

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129223741 129224358

SDM:

118199924

LPOL:

106462674 106464630

PMEO:

129584930 129584932

CEL:	CELE_F57F5.5(pkc-1)

CBR:	CBG_23354(Cbr-pkc-1)

CRQ:	GCK72_018163

NAI:	NECAME_11125

BMY:	BM_BM4529(Bma-pkc-1)

LOA:	LOAG_04164

TSP:

Tsp_08348

HRO:	HELRODRAFT_64769 HELRODRAFT_78764

LGI:	LOTGIDRAFT_127378

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_131700

SHX:	MS3_00000224(PRKC2_1)

OVI:	T265_10146

EGL:

NVE:

EPA:

ATEN:

ADF:	107331208 107357650

AMIL:

114962843

PDAM:

113681488

SPIS:

111329101

DGT:	114520044 114542531

XEN:

124441045

HMG:

100208590

HSY:

130656869

TAD:	TRIADDRAFT_30067

AQU:

100633428

SOM:	SOMG_01504(pck2)

NCE:	NCER_101503

MBR:	MONBRDRAFT_20766 MONBRDRAFT_21555

SRE:	PTSG_01655 PTSG_11595

» show all

Reference

PMID:2917656

Authors

Schaap D, Parker PJ, Bristol A, Kriz R, Knopf J

Title

Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity.

Journal

FEBS Lett 243:351-7 (1989)
DOI:10.1016/0014-5793(89)80160-7

Sequence

[mmu:18754]

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