KEGG   ORTHOLOGY: K18094
Entry
K18094                      KO                                     
Symbol
mexX, amrA
Name
membrane fusion protein, multidrug efflux system
Pathway
map01501  beta-Lactam resistance
map02020  Two-component system
Module
M00643  Multidrug resistance, efflux pump MexXY-OprM
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
   01504 Antimicrobial resistance genes
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
Transporters [BR:ko02000]
 Other transporters
  Accessory factors involved in transport
   K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  Multipdrug resistance modules
   Multidrug resistance, efflux pump MexXY-OprM
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
Other DBs
COG: COG0845
TC: 8.A.1 2.A.6.2.21 2.A.6.2.24
Genes
PAE: PA2019
PAEV: N297_2083
PAEI: N296_2083
PAU: PA14_38395
PAP: PSPA7_3269
PAG: PLES_33041
PAF: PAM18_3025
PNC: NCGM2_2994
PAEB: NCGM1900_4467
PDK: PADK2_15550
PSG: G655_15005
PRP: M062_10525
PAEP: PA1S_15595
PAEM: U769_15180
PAEL: T223_16870
PAES: SCV20265_3372
PAEU: BN889_02201
PAEG: AI22_18180
PAEC: M802_2081
PAEO: M801_2082
PPAA: B7D75_14880(mexX)
PLUL: FOB45_08220
RPI: Rpic_0841
RPF: Rpic12D_0910
RMN: TK49_09120
RIN: ACS15_2428
RWE: KOL96_12250
BMV: BMASAVP1_A1662
BML: BMA10229_A0317
BMN: BMA10247_0843
BMAL: DM55_2949
BMAE: DM78_1413
BMAQ: DM76_2932
BMAI: DM57_12
BMAZ: BM44_2229
BMAB: BM45_1794
BPS: BPSL1804(amrA)
BPM: BURPS1710b_2057(amrA)
BPL: BURPS1106A_1903(amrA)
BPD: BURPS668_1889(amrA)
BPR: GBP346_A1927
BPSE: BDL_330
BPSM: BBQ_1667
BPSU: BBN_1793
BPSD: BBX_2269
BPZ: BP1026B_I1762(amrA)
BPQ: BPC006_I1957
BPK: BBK_3294
BPSH: DR55_2905
BPSA: BBU_505
BPSO: X996_2522
BUT: X994_975
BTE: BTH_I2445
BTJ: BTJ_881
BTZ: BTL_2124
BTD: BTI_2084
BTV: BTHA_2323
BTHE: BTN_2644
BTHM: BTRA_2403
BTHA: DR62_2791
BTHL: BG87_2345
BOK: DM82_1238
BOC: BG90_3452
BUU: WS70_08030
BSAV: WS86_09910
BHG: I6G56_10245
BUD: AQ610_10115
BVI: Bcep1808_1574
BVE: AK36_2271
BUR: Bcep18194_A4767
BCM: Bcenmc03_1598
BCH: Bcen2424_1622
BCJ: BCAL1674(amrA)
BCEN: DM39_1589
BCEW: DM40_2256
BCEO: I35_1585(amrA)
BAM: Bamb_1520
BAC: BamMC406_1543
BMJ: BMULJ_01628(acrA)
BMU: Bmul_1616
BMK: DM80_19
BMUL: NP80_1716
BCT: GEM_1793
BCED: DM42_76
BCEP: APZ15_12685
BDL: AK34_1473
BPYR: ABD05_13960
BCON: NL30_14975
BUB: BW23_105
BDF: WI26_07740
BLAT: WK25_07990
BTEI: WS51_18650
BSEM: WJ12_08045
BPSL: WS57_26605
BMEC: WJ16_08140
BSTG: WT74_08375
BSTL: BBJ41_03940
BANN: JFN94_08235
BARI: NLX30_09410
BAEN: L3V59_08860
BUK: MYA_1455
BUL: BW21_2151
BURK: DM992_13070
PPNO: DA70_22500
PPNM: LV28_08220
PRB: X636_04170
PPUL: RO07_02350
PAPI: SG18_25025
PVE: UC34_18520
POX: MB84_23400
PFG: AB870_05550
PNR: AT302_02025
PAND: DRB87_17015
PFIB: PI93_009460
PCOM: NTU39_20370
AXY: AXYL_01446(amrA)
AXO: NH44784_006241
AXN: AX27061_1362
AXX: ERS451415_01359(acrA_1)
ADT: APT56_06330
AIS: BUW96_19175
ACHR: C2U31_12300
APES: FOC84_05460
AAEG: RA224_25700
AMON: H9L24_02360
CKE: B5M06_08355
CRJ: QMY55_04415
NEU: NE1113
MFA: Mfla_1361
MMB: Mmol_0005
MEI: Msip34_2718
MEP: MPQ_2659
MEU: ACJ67_10270
SECH: B18_22000
AMU: Amuc_0889
AGL: PYTT_0666
ABIW: Abiwalacus_23150(amrA)
AMAK: J5W79_05475
 » show all
Reference
PMID:21149619
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
PMID:19258280
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08
Reference
PMID:10582892
  Authors
Westbrock-Wadman S, Sherman DR, Hickey MJ, Coulter SN, Zhu YQ, Warrener P, Nguyen LY, Shawar RM, Folger KR, Stover CK
  Title
Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.
  Journal
Antimicrob Agents Chemother 43:2975-83 (1999)
DOI:10.1128/AAC.43.12.2975
  Sequence
[pae:PA2019]

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Ontology (7)   
   KEGG BRITE (3)   
   TC (3)   
   COG (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Gene (239)   
   KEGG GENES (138)   
   KEGG MGENES (91)   
   RefGene (8)   
   OC (2)   
Literature (4)   
   PubMed (4)   
All databases (255)   

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