KEGG   ORTHOLOGY: K18552
Entry
K18552                      KO                                     
Symbol
cmlA, cmlB, floR
Name
MFS transporter, DHA1 family, chloramphenicol/florfenicol resistance protein
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K18552  cmlA, cmlB, floR; MFS transporter, DHA1 family, chloramphenicol/florfenicol resistance protein
   01504 Antimicrobial resistance genes
    K18552  cmlA, cmlB, floR; MFS transporter, DHA1 family, chloramphenicol/florfenicol resistance protein
Transporters [BR:ko02000]
 Major facilitator superfamily (MFS)
  Drug transporters
   Drug:H+ antiporter-1 (12 spanner) (DHA1) family
    K18552  cmlA, cmlB, floR; MFS transporter, DHA1 family, chloramphenicol/florfenicol resistance protein
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Phenicol resistance genes
   Transporters
    K18552  cmlA, cmlB, floR; MFS transporter, DHA1 family, chloramphenicol/florfenicol resistance protein
Antimicrobial resistance: KEGG signatures [br01600.html]
 Signature KOs for antimicrobial resistance
  K18552
Other DBs
COG: COG0477 COG2814
TC: 2.A.1.2.3
Genes
ECOO: ECRM13514_5837(floR)
EUN: pUMNK88_132(cmlA1) pUMNK88_38(floR)
SETU: STU288_1p00745
SEND: DT104_38591
SENI: CY43_20075
SEC: SCH_052(cmlA)
SEE: SNSL254_p_0040(floR)
SEW: SeSA_B0064
EHM: AB284_00670
KPN: KPN_pKPN5p08202(cmlA1)
KPM: KPHS_p300660
KPH: KPNIH24_27465
KPJ: N559_5247
KPNE: KU54_01025
KPNU: LI86_28240
KOK: KONIH1_31125
KGR: JJJ10_29390
CFQ: C2U38_21225(cmlA)
CSED: JY391_23180
CITZ: E4Z61_00235(floR)
YRE: HEC60_24085(floR) HEC60_24135
EBC: C2U52_01455(cmlA)
PQU: IG609_006095(cml)
PCOL: F1325_16205(floR) F1325_16225(floR)
PCIB: F9282_16485(floR)
XBV: XBW1_3430(cmlA)
XNE: XNC1_4570
XNM: XNC2_4417
XHO: A9255_15710
XBU: HGO23_19385(cml)
PRQ: CYG50_00645
PHAG: PZ638_20795 PZ638_21150(floR)
PMP: Pmu_02820(floR)
BTO: WQG_1010
BTRH: F543_22850
BTRA: F544_3070
SMT: Smal_3550
STEM: CLM74_18600
STES: MG068_18365(bcr_cflA)
SINC: DAIF1_36680(ydhC_2)
SGEN: RKE57_18480(cml)
VCF: IR04_08310
VCE: Vch1786_I0081(floR)
VCQ: EN18_05240 EN18_06310 EN18_06360
VCJ: VCD_003740
VNL: D3H41_03120(floR)
PMAI: CF386_07580
PAEU: BN889_06186
PPUH: B479_26979
PALD: LU682_024220
PKH: JLK41_05945(cml)
PJU: L1P09_08655 L1P09_12665 L1P09_25420
DCE: O6P33_04495(floR)
ABY: ABAYE3620(cmlA) ABAYE3640
ABAB: BJAB0715_p0013
ABK: LX00_17550
ABAU: IX87_13195
AJO: RZ95_18855
ADV: DJ533_02050(bcr_cflA)
ACHI: CDG60_00660(bcr_cflA)
ATG: J4G44_12930(floR)
AVZ: HWI77_18585
MBL: AAX09_10120
SHN: Shewana3_2204
SALG: BS332_13540 BS332_22220
SCHK: GII14_16180
SDEO: D0436_11100
SMAY: K0H60_11010
CBU: CBU_1179
CBS: COXBURSA331_A1329
CBD: CBUD_1271
CBG: CbuG_0832
CBC: CbuK_1042
CEA: Z664_02620
CEND: EGQ50_02520
CEQ: B1F76_02605
LOK: Loa_00903
LIB: E4T55_09065
LSS: NCTC12082_01316(bcr_2)
TMC: LMI_2509
FTU: FTT_1727c
FTQ: RO31_2052
FTF: FTF1727c
FTW: FTW_0071
FTR: NE061598_10045
FTT: FTV_1645
FTG: FTU_1730
FTL: FTL_1868
FTH: FTH_1796
FTA: FTA_1975
FTS: F92_10320
FTI: FTS_1820
FTO: X557_09600
FTC: DA46_856
FTV: CH67_138
FTZ: CH68_2023
FTM: FTM_1678
FTN: FTN_1706
FTX: AW25_282
FTD: AS84_782
FTY: CH70_200
FCF: FNFX1_1747
FCN: FN3523_1778
FHI: FSC454_08850
FPH: Fphi_0896
FPT: BZ13_1136
FPI: BF30_1123
FPM: LA56_1282
FPX: KU46_433
FPZ: LA55_1786 LA55_2003
FPJ: LA02_360
FRT: F7308_0495
FNA: OOM_1761
FNL: M973_10000
FRF: LO80_05825
FPER: ACH24_06410
FHA: CDV26_00325
FRX: F7310_08680 F7310_09730
FRM: BBG19_1660
FRC: KX01_1702 KX01_214
FAD: CDH04_02430
FMI: F0R74_07990
FOO: CGC45_08420
FNN: FSC774_08555
FSR: KQR59_08990
FRL: FIP56_08755 FIP56_09745
FGU: SD28_01775
AFRI: E3E15_00500
AII: E4K63_00550
CYS: NYP54_10080
RHH: E0Z06_12460(floR) E0Z06_12480(floR)
HHH: CLM76_10155
HPRO: LMS44_03830(cml)
HASO: B2G49_00820
HALK: CUU95_02115
HVN: EI420_03800(bcr_cflA)
HOL: HORIV_12070
SAJS: QO259_16325(cml)
AEA: C2U39_23840(cmlA)
ASIM: FE240_15560 FE240_15670(floR)
BUR: Bcep18194_B2449
BCM: Bcenmc03_3862
BCH: Bcen2424_3659
BCEP: APZ15_20995
BCON: NL30_22410
BMEC: WJ16_22365
BARI: NLX30_19260(cml)
BAEN: L3V59_33140(cml)
PAND: DRB87_20565(floR)
BTRM: SAMEA390648703168(mdtL)
ACHR: C2U31_22525
APES: FOC84_02940(bcr_cflA)
PUS: CKA81_11645
AFA: UZ73_11555
AFQ: AFA_17715
AAQU: D3M96_18995(bcr_cflA)
AAMM: FE795_16395
CKE: B5M06_08260
CRJ: QMY55_04435(floR) QMY55_12315
DIH: G7047_30150
SIMP: C6571_18315(cmlA)
MJE: LVC68_09505 LVC68_09525
THU: AC731_003640
MLN: A9174_20565
MCI: Mesci_3448
MCIC: A4R28_09485
MESW: A9K65_018625
MESP: C1M53_29420
MES: Meso_3944
AAK: AA2016_0721
AMIH: CO731_00811(bcr_1)
AMIS: Amn_00780
ANJ: AMD1_0746(cmlA)
PHYL: HB779_16405
NKI: KW403_11795(cml)
NRH: T8J41_04700(cml)
SME: SMc00744
SMK: Sinme_2683
SMQ: SinmeB_2459
SMX: SM11_chr2788
SMI: BN406_02486(cmlA)
SMEG: C770_GR4Chr2739
SMEL: SM2011_c00744
SMER: DU99_14590
SMD: Smed_2519
SIX: BSY16_6255
SKM: PZL22_002929(cml)
EAD: OV14_1063
EAH: FA04_18635
ECAA: J3R84_18570(cml)
ENP: JVX98_21615(cml)
AGR: AGROH133_13586
RET: RHE_CH01569(floR)
REL: REMIM1_CH01583
RLE: RL1670
RLT: Rleg2_1232
RLG: Rleg_1320
RLB: RLEG3_17030
RLU: RLEG12_17215
RTR: RTCIAT899_PC04380
RHN: AMJ98_CH01599
RHX: AMK02_CH01606
REZ: AMJ99_CH01678
RHR: CKA34_21925
RHID: FFM81_013270(bcr_cflA)
RLN: J0663_16770
RBAN: J2J98_07795(cml)
RRG: J3P73_09365(cml)
RLS: HB780_15870(bcr_cflA)
RAW: NE851_18135(cml)
RLW: RlegWSM1455_06630(cml)
ARA: Arad_1809(floR)
RIF: U5G49_001358(cml)
OIN: IAR37_12740(bcr_cflA)
OAN: Oant_1335
OAH: DR92_899
BPSN: NIK97_06420(cml)
OCR: HGK82_09365(bcr_cflA)
OCL: GTN27_09675(bcr_cflA)
PSCQ: KHQ08_09070(cml)
LNE: FZC33_29940(bcr_cflA)
MIV: C4E04_05375
MLD: U0023_17540(cml)
RHJ: HZY79_02675
CHEL: AL346_23530
LABT: FIU93_30015(ydhC)
CMB: CSW64_14270
BRD: JL11_12475
BND: KWG56_13855(floR)
BFQ: JX001_02925(floR)
RHP: LPB142_18185 LPB142_18265
PALP: JHW40_12525 JHW40_14775(floR)
PDIM: PAF18_09805(floR)
GEH: HYN69_19835(floR)
SWI: Swit_3389
POT: E2E27_17840(floR)
GXL: H845_57
RCE: RC1_2952
RPM: RSPPHO_00751
MXA: MXAN_2566
MYM: A176_004472
MFB: MFUL124B02_28895
MYX: QEG98_13590
CCX: COCOR_02270(cmlA)
MFU: LILAB_20505
MMAS: MYMAC_002527
AVM: JQX13_28955(cml)
SCU: SCE1572_04945
LLU: AKJ09_04088
PUV: PUV_09750
SFAE: MUK51_21340(floR)
CSUP: MTP09_11305(floR)
BPOR: BPO_2257
AG: AAA26079(cml) AAB60004(cmlA1) AAD33243(floR) CAL30186(cmlB1)
 » show all
Reference
PMID:1648560
  Authors
Bissonnette L, Champetier S, Buisson JP, Roy PH
  Title
Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins.
  Journal
J Bacteriol 173:4493-502 (1991)
DOI:10.1128/JB.173.14.4493-4502.1991
  Sequence
[ag:AAB60004]
Reference
PMID:10103189
  Authors
Briggs CE, Fratamico PM
  Title
Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104.
  Journal
Antimicrob Agents Chemother 43:846-9 (1999)
DOI:10.1128/AAC.43.4.846
Reference
PMID:17224413
  Authors
Kadlec K, Kehrenberg C, Schwarz S
  Title
Efflux-mediated resistance to florfenicol and/or chloramphenicol in Bordetella bronchiseptica: identification of a novel chloramphenicol exporter.
  Journal
J Antimicrob Chemother 59:191-6 (2007)
DOI:10.1093/jac/dkl498
  Sequence
[ag:CAL30186]
Reference
PMID:23162539
  Authors
Roberts MC, Schwarz S, Aarts HJ
  Title
Erratum: Acquired antibiotic resistance genes: an overview.
  Journal
Front Microbiol 3:384 (2012)
DOI:10.3389/fmicb.2012.00384

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Gene (411)   
   KEGG GENES (277)   
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