| Entry |
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| Symbol |
thnE
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| Name |
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| Pathway |
| map01110 | Biosynthesis of secondary metabolites |
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| Reaction |
| R10485 | malonyl-CoA:(S)-1-pyrroline-5-carboxylate malonyltransferase (cyclizing) |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09110 Biosynthesis of other secondary metabolites
00332 Carbapenem biosynthesis
K18583 thnE; carboxymethylproline synthase
Enzymes [BR:ko01000]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.226 carboxymethylproline synthase
K18583 thnE; carboxymethylproline synthase
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| Other DBs |
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| Genes |
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| Reference |
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| Authors |
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G |
|---|
| Title |
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya. |
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| Journal |
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| Sequence |
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| Reference |
|
|---|
| Authors |
Hamed RB, Batchelar ET, Mecinovic J, Claridge TD, Schofield CJ |
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| Title |
Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline. |
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| Journal |
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| Reference |
|
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| Authors |
Bodner MJ, Li R, Phelan RM, Freeman MF, Moshos KA, Lloyd EP, Townsend CA |
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| Title |
Definition of the common and divergent steps in carbapenem beta-lactam antibiotic biosynthesis. |
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| Journal |
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