KEGG ORTHOLOGY: K19360

ORTHOLOGY: K19360

Entry

K19360                      KO

Symbol

NPHP3

Name

nephrocystin-3

Disease

H00261

Meckel syndrome

H00537

Nephronophthisis

H00543

Renal-hepatic-pancreatic dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19360  NPHP3; nephrocystin-3
Cilium and associated proteins [BR:ko03037]
Primary cilia and associated proteins
  Nephronophthisis-related proteins
   K19360  NPHP3; nephrocystin-3

Genes

HSA:	27031(NPHP3)

PTR:	460706(NPHP3)

PPS:	100987703(NPHP3)

GGO:	101149941(NPHP3)

PON:	103890244(NPHP3)

PPYG:

129033589(NPHP3)

NLE:	100592653(NPHP3)

HMH:	116462004(NPHP3)

SSYN:

129491300(NPHP3)

MCC:	717622(NPHP3)

MCF:	102121572(NPHP3)

MTHB:

126948131

MNI:	105490372(NPHP3)

CSAB:

103241666(NPHP3)

CATY:

105586442(NPHP3)

PANU:

101003572(NPHP3)

TGE:	112618143(NPHP3)

MLEU:

105538173(NPHP3)

RRO:	104675612(NPHP3)

RBB:	108527196(NPHP3)

TFN:	117084178(NPHP3)

PTEH:

111539529(NPHP3)

CANG:

105523384(NPHP3)

CJC:	100387733(NPHP3)

SBQ:	101044357(NPHP3)

CIMI:

108287344(NPHP3)

ANAN:

105716520(NPHP3)

CSYR:

103257186(NPHP3)

MMUR:

105872673(NPHP3)

LCAT:

123628816(NPHP3)

PCOQ:

105825509(NPHP3)

OGA:	100965821(NPHP3)

MMU:	74025(Nphp3)

MCAL:

110301348(Nphp3)

MPAH:

110327278(Nphp3)

RNO:	363126(Nphp3)

MCOC:

116073912(Nphp3)

ANU:	117693600(Nphp3)

MUN:	110554896(Nphp3)

CGE:	100768113(Nphp3)

MAUA:

101838329(Nphp3)

PROB:

127237597(Nphp3)

PLEU:

114693520(Nphp3)

MORG:

121464256(Nphp3)

MFOT:

126499959

AAMP:

119810510(Nphp3)

NGI:

103733792

HGL:	101713364(Nphp3)

CPOC:

100720089(Nphp3)

CCAN:

109695564(Nphp3)

DORD:

105994494(Nphp3)

DSP:	122095573(Nphp3)

PLOP:

125342690(Nphp3)

NCAR:

124993345

MMMA:

107143390(Nphp3)

OCU:

100340509

OPI:	101527721(NPHP3)

TUP:	102483638(NPHP3)

GVR:

103581109

CFA:	100856544(NPHP3)

CLUD:

112661009(NPHP3)

VVP:	112932546(NPHP3)

VLG:	121478821(NPHP3)

NPO:	129506992(NPHP3)

AML:	100478688(NPHP3)

UMR:	103681800(NPHP3)

UAH:	113253943(NPHP3)

UAR:	123788382(NPHP3)

ELK:

111155106

LLV:

125104322

MPUF:

101679302(NPHP3)

MNP:	132011792(NPHP3)

MLK:	131824546(NPHP3)

NVS:	122908936(NPHP3)

ORO:	101368025(NPHP3)

EJU:	114205624(NPHP3)

ZCA:	113917850(NPHP3)

MLX:	118003688(NPHP3)

NSU:	110570743(NPHP3)

LWW:	102738690(NPHP3)

FCA:	101090135(NPHP3)

PYU:	121033680(NPHP3)

PCOO:

112850176(NPHP3)

PBG:	122491986(NPHP3)

PVIV:

125175612(NPHP3)

LRUF:

124526470

PTG:	102952268(NPHP3)

PPAD:

109259185(NPHP3)

PUC:

125921994

AJU:

106987501

HHV:	120239537(NPHP3)

BTA:	507522(NPHP3)

BOM:	102282873(NPHP3)

BIU:	109560290(NPHP3)

BBUB:

102392165(NPHP3)

BBIS:

104988298(NPHP3)

CHX:	102173132(NPHP3)

OAS:	101118406(NPHP3)

BTAX:

128050988(NPHP3)

ODA:	120857081(NPHP3) 120860373

CCAD:

122445327(NPHP3)

MREE:

136173072(NPHP3)

MBEZ:

129547741(NPHP3)

SSC:	100521403(NPHP3)

CFR:	102518011(NPHP3)

CBAI:

105063268(NPHP3)

CDK:	105095632(NPHP3)

VPC:	102545760(NPHP3)

BACU:

103018214(NPHP3)

BMUS:

118894586(NPHP3)

LVE:

103070918

OOR:	101272334(NPHP3)

DLE:	111179187(NPHP3)

PCAD:

102988558(NPHP3)

PSIU:

116752769(NPHP3)

NASI:

112410878(NPHP3)

ECB:	100064940(NPHP3)

EPZ:	103560333(NPHP3)

EAI:	106841810(NPHP3)

MYB:	102252577(NPHP3)

MYD:	102770303(NPHP3)

MMYO:

118668172(NPHP3)

MLF:	102427585(NPHP3)

MDT:	132215559(NPHP3)

PKL:	118715339(NPHP3)

EFUS:

103296494(NPHP3)

MNA:	107546093(NPHP3)

DRO:	112309533(NPHP3)

SHON:

118997566(NPHP3)

AJM:	119048283(NPHP3)

PDIC:

114501731(NPHP3)

PHAS:

123830579(NPHP3)

MMF:	118633579(NPHP3)

PPAM:

129088106(NPHP3)

RFQ:	117036969(NPHP3)

PALE:

102889380(NPHP3)

PGIG:

120582081(NPHP3)

PVP:	105288492(NPHP3)

RAY:	107508475(NPHP3)

MJV:	108391755(NPHP3)

TOD:	119256546(NPHP3)

SARA:

101552346(NPHP3)

SETR:

125998221(NPHP3)

LAV:	100663370(NPHP3)

TMU:

101349212

ETF:	101645373(NPHP3)

DNM:	101411864(NPHP3)

MDO:	100023577(NPHP3)

GAS:	123248939(NPHP3)

SHR:	100917613(NPHP3)

AFZ:

127538077

PCW:	110209083(NPHP3)

TVP:	118850590(NPHP3)

OAA:	100083471(NPHP3)

GGA:	420690(NPHP3)

PCOC:

116227178(NPHP3)

MGP:	100539554(NPHP3)

CJO:	107309354(NPHP3)

TPAI:

128086030(NPHP3)

LMUT:

125696063(NPHP3)

NMEL:

110394054(NPHP3)

APLA:

101804461(NPHP3)

ACYG:

106038320(NPHP3)

CATA:

118249654(NPHP3)

AFUL:

116485728(NPHP3)

TGU:	100220611(NPHP3)

LSR:	110471041(NPHP3)

SCAN:

103812975(NPHP3)

PMOA:

120501631(NPHP3)

OTC:	121337592(NPHP3)

PRUF:

121352946(NPHP3)

GFR:	102037726(NPHP3)

FAB:	101808902(NPHP3)

OMA:	130249874(NPHP3)

PHI:	102102610(NPHP3)

PMAJ:

107199721(NPHP3)

CCAE:

111923892(NPHP3)

CCW:	104689283(NPHP3)

CBRC:

103615873(NPHP3)

ETL:	114064230(NPHP3)

ZAB:	102073739(NPHP3)

ZLE:	135443917(NPHP3)

ACHL:

103797783(NPHP3)

SVG:	106854468(NPHP3)

MMEA:

130580022(NPHP3)

HRT:	120750183(NPHP3)

SATI:

136362371(NPHP3)

FPG:	101919500(NPHP3)

FCH:	102049440(NPHP3)

CCRI:

104155044(NPHP3)

NNT:	104405739(NPHP3)

SHAB:

115618246(NPHP3)

ACUN:

113476495(NPHP3)

TALA:

104367154(NPHP3)

ACHC:

115339539(NPHP3)

HALD:

104316059(NPHP3)

HLE:	104828387(NPHP3)

AGEN:

126045651

GCL:

127012612

CSTI:

104557323(NPHP3)

LDI:	104354870(NPHP3)

MNB:	103768276(NPHP3)

DPUB:

104298331(NPHP3)

AVIT:

104275471(NPHP3)

BRHI:

104496528(NPHP3)

EGZ:	104127533(NPHP3)

NNI:	104012170(NPHP3)

PCRI:

104036658(NPHP3)

PCAO:

104043024(NPHP3)

PADL:

103923005(NPHP3)

AFOR:

103899829(NPHP3)

FGA:	104069631(NPHP3)

GSTE:

104257615(NPHP3)

CLV:	102086851(NPHP3)

MUI:	104538148(NPHP3)

PGUU:

104462845(NPHP3)

PLET:

104614038(NPHP3)

EHS:	104515954(NPHP3)

CMAC:

104476580(NPHP3)

CUCA:

104067647(NPHP3)

TEO:	104380918(NPHP3)

BREG:

104640276(NPHP3)

OHA:	104337083(NPHP3)

ACAR:

104517605(NPHP3)

CPEA:

104397591(NPHP3)

CVF:	104295281(NPHP3)

RTD:	128905461(NPHP3)

AAM:	106491163(NPHP3)

AROW:

112976981(NPHP3)

NPD:	112943607(NPHP3)

TGT:	104573101(NPHP3)

DNE:	112979669(NPHP3)

SCAM:

104152559(NPHP3)

ASN:	102383934(NPHP3)

AMJ:	102562822(NPHP3)

CPOO:

109311293(NPHP3)

GGN:	109291754(NPHP3)

PSS:	102457566(NPHP3)

CMY:	102941650(NPHP3)

CCAY:

125631706(NPHP3)

DCC:	119851936(NPHP3)

CPIC:

101942659(NPHP3)

TST:	117872462(NPHP3)

CABI:

116839731(NPHP3)

MRV:	120397221(NPHP3)

ACS:	100563412(nphp3)

ASAO:

132778626(NPHP3)

PVT:	110084870(NPHP3)

SUND:

121933577(NPHP3)

PBI:	103056292(NPHP3)

PMUR:

107293897(NPHP3)

CTIG:

120304975(NPHP3)

TSR:	106540143(NPHP3)

PGUT:

117656087 132710214

APRI:

131197225(NPHP3)

PTEX:

113449316(NPHP3)

NSS:	113421366(NPHP3)

VKO:	123036592(NPHP3)

PMUA:

114607197(NPHP3)

PRAF:

128398340(NPHP3)

ZVI:	118091845(NPHP3)

HCG:	128332129(NPHP3)

GJA:	107107301(NPHP3)

STOW:

125440790(NPHP3)

EMC:	129337510(NPHP3)

XLA:	446530(nphp3.L)

XTR:	780190(nphp3)

NPR:	108786617(NPHP3)

RTEM:

120940328(NPHP3)

BBUF:

121001986(NPHP3)

BGAR:

122939669(NPHP3)

MUO:

115472384

GSH:	117353726(NPHP3)

DRE:	562601(nphp3)

SRX:	107722029 107748295

SANH:

107691422 107696494

SGH:	107558328 107589980

CCAR:

109052307 109052308

CAUA:

113042340(nphp3)

CGIB:

128013026

PTET:

122332273

LROH:

127155710(nphp3)

OMC:	131533213(nphp3)

PPRM:

120475876(nphp3)

RKG:	130087711(nphp3)

MAMB:

125258007(nphp3)

CIDE:

127506483

CERY:

137013540(nphp3)

MASI:

127434085

TROS:

130546940(nphp3)

TDW:	130413244(nphp3)

MANU:

129425872(nphp3)

IPU:

108265101

IFU:	128605957(nphp3)

PHYP:

113526609(nphp3)

SMEO:

124385002(nphp3)

TFD:	113647525(nphp3)

TVC:	132846278(nphp3)

TRN:	134310391(nphp3)

AMEX:

103025830(nphp3)

CMAO:

118804070(nphp3)

EEE:	113575636(nphp3)

CHAR:

105894699(nphp3)

TRU:	101067330(nphp3)

TFS:	130513603(nphp3)

TNG:	GSTEN00023965G001

LCO:	104937375(nphp3)

NCC:

104943335

TBEN:

117494290(nphp3)

CGOB:

115025520(nphp3)

PGEO:

117442848(nphp3)

GACU:

117533598(nphp3)

EMAC:

134858041(nphp3)

ELY:	117264805(nphp3)

EFO:	125881860(nphp3)

PLEP:

121960622(nphp3)

SLUC:

116053757(nphp3)

ECRA:

117938096(nphp3)

ESP:	116672295(nphp3)

PFLV:

114548879(nphp3)

GAT:	120811384(nphp3)

PPUG:

119198810(nphp3)

AFB:	129110809(nphp3)

CLUM:

117749614(nphp3)

PSWI:

130206720(nphp3)

CANA:

137788575(nphp3)

MSAM:

119910588(nphp3)

SCHU:

122866748(nphp3)

CUD:	121527334(nphp3)

ALAT:

119008884(nphp3)

ASTR:

137587774(nphp3)

MZE:	101465934(nphp3)

ONL:	100690253(nphp3)

OAU:	116314479(nphp3)

OLA:	101173097(nphp3)

OML:	112151504(nphp3)

CSAI:

133423009(nphp3)

XMA:	102236057(nphp3)

XCO:	114136877(nphp3)

XHE:	116711838(nphp3)

PRET:

103456915(nphp3)

PFOR:

103140441(nphp3)

PLAI:

106957915(nphp3)

PMEI:

106926139(nphp3)

GAF:	122824523(nphp3)

CVG:	107094580(nphp3)

CTUL:

119785979(nphp3)

GMU:	124858362(nphp3)

NFU:	107382465(nphp3)

KMR:	108230524(nphp3)

ALIM:

106521006(nphp3)

NWH:	119426520(nphp3)

AOCE:

111580549(nphp3)

MCEP:

125024434(nphp3)

CSEM:

103377520(nphp3)

POV:	109629601(nphp3)

SSEN:

122782308(nphp3)

HHIP:

117754016(nphp3)

HSP:

118098690

PPLT:

128425847

SMAU:

118290872(nphp3)

LCF:

108881668

SDU:	111237865(nphp3)

SLAL:

111665155(nphp3)

XGL:	120789629(nphp3)

HCQ:	109515605(nphp3)

SSCV:

125985825(nphp3)

PTAO:

133470502(nphp3)

BPEC:

110170062(nphp3)

MALB:

109961436(nphp3)

BSPL:

114854029(nphp3)

SJO:	128382688(nphp3)

SASA:

106590117(nphp3)

STRU:

115195821(nphp3)

OTW:	112227991(nphp3)

OMY:	110489967(nphp3)

OGO:	124039809(nphp3)

ONE:	115130395(nphp3)

OKI:	109899506(nphp3)

OKE:	118373812(nphp3)

SALP:

111953688(nphp3)

SNH:	120051168(nphp3)

CCLU:

121569861(nphp3)

ELS:	105027369(nphp3)

SFM:	108937080(nphp3)

PKI:	111836225(nphp3)

AANG:

118225878(nphp3)

LOC:	102691345(nphp3)

PSPA:

121314550(nphp3)

ARUT:

117394965(nphp3)

PSEX:

120529414(nphp3)

LCM:	102348250(NPHP3)

CMK:	103180824(nphp3)

RTP:	109912232(nphp3)

CPLA:

122564514(nphp3)

HOC:	132832101(nphp3)

LERI:

129693308 129708241

PMRN:

116940870(NPHP3)

LRJ:	133344629(NPHP3)

BFO:	118428474 118432595

BBEL:

109462773

SCLV:

120330464

SPU:	100889111 590447 752994 762747

LPIC:

129260118 129265052 129269508

APLC:

110973602 110973672 110977797 110988292

ARUN:

117291255

AJC:

117114293

SKO:	100374574 102809027 102809758 102810095

LGI:	LOTGIDRAFT_126945 LOTGIDRAFT_229331 LOTGIDRAFT_234908

PVUL:

126831454

PCAN:

112564243 112564244 112569791 112571013

BGT:

106062615

GAE:

121387533

HRF:	124112299 124119774

HRJ:

HASI:

CRG:

CANU:

CVN:	111124940 111127531

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106152622 106154021 106155013

LLON:

135483333

NVE:	116615274 5503351 5509131

EPA:	110235490 110254649

ATEN:

116294780 116307115

ADF:	107334247 107336204 107343806

AMIL:

114958779 114965295 114968003 114970124

PDAM:

113671339 113677674 113681978

SPIS:

111321259 111324921 111338362

DGT:	114517744 114521895

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_22397 TRIADDRAFT_51888 TRIADDRAFT_54460 TRIADDRAFT_59003

AQU:

105312716

SRE:	PTSG_10922

KIN:	AB182_20310

PDZ:	HHA33_22700

METY:

MRY16398_45100

EBC:	C2U52_01815

MHYD:

BXY:

PGI:

PGN:

PGT:	PGTDC60_1085

CTS:

Ctha_0459

» show all

Reference

PMID:18371931

Authors

Bergmann C, Fliegauf M, Bruchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kranzlin B, Nurnberg G, Becker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Senderek J, Neuhaus TJ, Stallmach T, Zentgraf H, Nurnberg P, Gretz N, Lo C, Lienkamp S, Schafer T, Walz G, Benzing T, Zerres K, Omran H

Title

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia.

Journal

Am J Hum Genet 82:959-70 (2008)
DOI:10.1016/j.ajhg.2008.02.017

Sequence

[hsa:27031]

All links

Ontology (2)   
   KEGG BRITE (2)   
Disease (3)   
   KEGG DISEASE (3)   
Gene (2353)   
   KEGG GENES (502)   
   KEGG MGENES (892)   
   RefGene (942)   
   OC (17)   
Literature (1)   
   PubMed (1)   
All databases (2359)   

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