KEGG   ORTHOLOGY: K19521
Entry
K19521                      KO                                     

Name
RFX6
Definition
regulatory factor X 6
Pathway
ko04950  Maturity onset diabetes of the young
Disease
H01377  Mitchell-Riley syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04950 Maturity onset diabetes of the young
    K19521  RFX6; regulatory factor X 6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K19521  RFX6; regulatory factor X 6
Transcription factors [BR:ko03000]
 Eukaryotic type
  Other basic domains
   RF-X
    K19521  RFX6; regulatory factor X 6
Genes
HSA: 222546(RFX6)
PTR: 472210(RFX6)
PPS: 100970739(RFX6)
GGO: 101134703(RFX6)
PON: 100454914(RFX6)
NLE: 100600420(RFX6)
MCC: 715469(RFX6)
MCF: 102122638(RFX6)
CSAB: 103240499(RFX6)
RRO: 104670070(RFX6)
RBB: 108517480(RFX6)
CJC: 100413172(RFX6)
SBQ: 101030377(RFX6)
MMU: 320995(Rfx6)
MCAL: 110303652(Rfx6)
MPAH: 110326655(Rfx6)
RNO: 294395(Rfx6)
MUN: 110562972(Rfx6)
CGE: 100774034(Rfx6)
NGI: 103736305(Rfx6)
HGL: 101702134(Rfx6)
CCAN: 109674534(Rfx6)
OCU: 100346374(RFX6)
TUP: 102471606(RFX6)
CFA: 484096(RFX6)
VVP: 112922648(RFX6)
AML: 100476328(RFX6)
UMR: 103663464(RFX6)
UAH: 113259660(RFX6)
ORO: 101382413(RFX6)
ELK: 111147841
FCA: 101096653(RFX6)
PTG: 102956537(RFX6)
PPAD: 109248460(RFX6)
AJU: 106968344(RFX6)
BTA: 524074(RFX6)
BOM: 102275984(RFX6)
BIU: 109563495(RFX6)
BBUB: 102391308(RFX6)
CHX: 102171877(RFX6)
OAS: 101103984(RFX6)
SSC: 102161990(RFX6)
CFR: 102523887(RFX6)
CDK: 105088337(RFX6)
BACU: 102998305(RFX6)
LVE: 103084784(RFX6)
OOR: 101273164(RFX6)
DLE: 111164983(RFX6)
PCAD: 102977663(RFX6)
ECB: 100072753(RFX6)
EPZ: 103549546(RFX6)
EAI: 106847077(RFX6)
MYB: 102244275(RFX6)
MYD: 102763192(RFX6)
MNA: 107526308(RFX6)
HAI: 109396454(RFX6)
DRO: 112297342(RFX6)
PALE: 102884052(RFX6)
RAY: 107520188(RFX6)
MJV: 108398090(RFX6)
LAV: 100668405(RFX6)
TMU: 101349821
MDO: 100029995(RFX6)
SHR: 100932967(RFX6)
PCW: 110197609(RFX6)
OAA: 100091645(RFX6)
GGA: 421737(RFX6)
MGP: 100538514(RFX6)
CJO: 107311900(RFX6)
NMEL: 110396875(RFX6)
APLA: 101792509(RFX6)
ACYG: 106047576(RFX6)
TGU: 100219627(RFX6)
LSR: 110484670(RFX6)
SCAN: 103822098(RFX6)
GFR: 102037360(RFX6)
FAB: 101819153(RFX6)
PHI: 102114039(RFX6)
PMAJ: 107201275(RFX6)
CCAE: 111927268(RFX6)
CCW: 104694060(RFX6)
ETL: 114069611(RFX6)
FPG: 101910915(RFX6)
FCH: 102048682(RFX6)
CLV: 102095214(RFX6)
EGZ: 104131959(RFX6)
NNI: 104008782(RFX6)
ACUN: 113477844(RFX6)
PADL: 103918390(RFX6)
AAM: 106497872(RFX6)
ASN: 102374489(RFX6)
AMJ: 102565576(RFX6)
PSS: 102445234(RFX6)
CMY: 102934167(RFX6)
CPIC: 101944670(RFX6)
ACS: 100554273(rfx6)
PVT: 110083617(RFX6)
PBI: 103066069(RFX6)
PMUR: 107299087(RFX6)
TSR: 106540384(RFX6)
PMUA: 114594083(RFX6)
GJA: 107108597(RFX6)
XLA: 100529153(rfx6.L)
XTR: 100487566(rfx6)
NPR: 108792947(RFX6)
DRE: 556925(rfx6)
SRX: 107727678(rfx6) 107743320
SGH: 107549689(rfx6) 107576842
IPU: 108257977(rfx6)
PHYP: 113532314(rfx6)
AMEX: 103031646(rfx6)
EEE: 113572261(rfx6)
TRU: 101075983(rfx6)
LCO: 104934233(rfx6)
MZE: 101474757(rfx6)
ONL: 100701865(rfx6)
OLA: 101170242(rfx6)
XMA: 102231645(rfx6)
XCO: 114158313(rfx6)
PRET: 103457239(rfx6)
CVG: 107083509(rfx6)
NFU: 107377471(rfx6)
KMR: 108244869(rfx6)
ALIM: 106534289
AOCE: 111565477(rfx6)
CSEM: 103381251
POV: 109643911(rfx6)
LCF: 108885266(rfx6)
SDU: 111236380(rfx6)
SLAL: 111672550(rfx6)
HCQ: 109516779(rfx6)
BPEC: 110156252(rfx6)
MALB: 109968841(rfx6)
OTW: 112217333 112251709(rfx6)
SALP: 111954095(rfx6) 111972926
ELS: 105017960(rfx6)
SFM: 108928470(rfx6)
PKI: 111836085(rfx6)
LCM: 102353241(RFX6)
CMK: 103182609(rfx6)
RTP: 109921221(rfx6)
CIN: 100183450
TUT: 107369883
CSCU: 111623731
PTEP: 107452357
OBI: 106869153
 » show all
Reference
  Authors
Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Desir J, Vanden Eijnden S, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C, German MS
  Title
Rfx6 directs islet formation and insulin production in mice and humans.
  Journal
Nature 463:775-80 (2010)
DOI:10.1038/nature08748
  Sequence
[hsa:222546]
Reference
  Authors
Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, Ravassard P, Vermot J, Voz ML, Mellitzer G, Gradwohl G
  Title
Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.
  Journal
Development 137:203-12 (2010)
DOI:10.1242/dev.041673
Reference
  Authors
Pearl EJ, Jarikji Z, Horb ME
  Title
Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes.
  Journal
Dev Biol 351:135-45 (2011)
DOI:10.1016/j.ydbio.2010.12.043

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