KEGG   ORTHOLOGY: K19643Help
Entry
K19643            Tight     KO                                     

Name
dfrA10, dfr10
Definition
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Pathway
ko00670  One carbon pool by folate
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K19643  dfrA10, dfr10; dihydrofolate reductase (trimethoprim resistance protein)
   00670 One carbon pool by folate
    K19643  dfrA10, dfr10; dihydrofolate reductase (trimethoprim resistance protein)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19643  dfrA10, dfr10; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K19643  dfrA10, dfr10; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    K19643  dfrA10, dfr10; dihydrofolate reductase (trimethoprim resistance protein)
BRITE hierarchy
Other DBs
RN: R00936 R00937 R00939 R00940 R02235 R02236
COG: COG0262
GO: 0004146
Genes
ABY: ABAYE3614(dfrA10)
AG: AAA92749(dfrA10)
TaxonomyKoalaUniProt
Reference
PMID:1804022
  Authors
Parsons Y, Hall RM, Stokes HW
  Title
A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100.
  Journal
Antimicrob Agents Chemother 35:2436-9 (1991)
DOI:10.1128/AAC.35.11.2436
  Sequence
Reference
  Authors
Partridge SR, Hall RM
  Title
In34, a complex In5 family class 1 integron containing orf513 and dfrA10.
  Journal
Antimicrob Agents Chemother 47:342-9 (2003)
DOI:10.1128/AAC.47.1.342-349.2003

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