KEGG ORTHOLOGY: K19758

ORTHOLOGY: K19758

Entry

K19758                      KO

Symbol

DNAAF4, DYX1C1

Name

dynein axonemal assembly factor 4

Disease

H00564

Primary ciliary dyskinesia

H01899

Dyslexia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19758  DNAAF4, DYX1C1; dynein axonemal assembly factor 4
   04812 Cytoskeleton proteins
    K19758  DNAAF4, DYX1C1; dynein axonemal assembly factor 4
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Dynein assembly factors
   K19758  DNAAF4, DYX1C1; dynein axonemal assembly factor 4
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     Dynein-related proteins
      K19758  DNAAF4, DYX1C1; dynein axonemal assembly factor 4

Genes

HSA:	161582(DNAAF4)

PTR:	453458(DNAAF4)

PPS:	100995246(DNAAF4)

GGO:	101126613(DNAAF4)

PON:	100454979(DNAAF4)

NLE:	100599584(DNAAF4)

HMH:	116481609(DNAAF4)

MCC:	100429795(DNAAF4)

MCF:	102140810(DNAAF4)

MTHB:

126959969

MNI:	105489879(DNAAF4)

CSAB:

103245589(DYX1C1)

CATY:

105601117(DYX1C1)

PANU:

101014408(DNAAF4) 116275909

TGE:	112627432(DNAAF4)

MLEU:

105544298(DYX1C1)

RRO:	104669561(DNAAF4)

RBB:	108535315(DYX1C1)

TFN:	117070617(DNAAF4)

PTEH:

111553653(DNAAF4)

CANG:

105510686(DYX1C1)

CJC:	100388594(DNAAF4)

SBQ:	101033300(DYX1C1)

CIMI:

108314463(DNAAF4)

CSYR:

103266910(DNAAF4)

MMUR:

105861372 105881420(DYX1C1)

LCAT:

123623038(DNAAF4)

PCOQ:

105821370(DYX1C1)

OGA:	100957907(DNAAF4)

MMU:	67685(Dnaaf4)

MCAL:

110301880(Dnaaf4)

MPAH:

110328482(Dnaaf4)

RNO:	363096(Dnaaf4)

MCOC:

116072307(Dnaaf4)

ANU:	117699769(Dnaaf4)

MUN:	110549128(Dnaaf4)

CGE:	100769043(Dnaaf4)

MAUA:

101829801(Dnaaf4)

PROB:

127231967(Dnaaf4)

PLEU:

114690568(Dnaaf4)

MORG:

121466068(Dnaaf4)

MFOT:

126490523

AAMP:

119810220(Dnaaf4)

NGI:	103745711(Dyx1c1)

HGL:	101716523(Dyx1c1)

CPOC:

100724579(Dnaaf4)

CCAN:

109700617(Dyx1c1)

DORD:

105981069(Dyx1c1)

DSP:	122114561(Dnaaf4)

PLOP:

125340609(Dnaaf4)

NCAR:

124976166

OCU:	100350030(DNAAF4)

OPI:	101530418(DNAAF4)

TUP:	102485286(DYX1C1)

GVR:	103600039(DYX1C1)

CFA:	487567(DNAAF4)

CLUD:

112675895(DNAAF4)

VVP:	112917946(DNAAF4)

VLG:	121481519(DNAAF4)

NPO:	129506464(DNAAF4)

AML:	100484448(DNAAF4)

UMR:	103676772(DNAAF4)

UAH:	113269653(DNAAF4)

UAR:	123801801(DNAAF4)

ELK:

111153355

LLV:

125105088

MPUF:

101684533(DYX1C1)

NVS:	122894345(DNAAF4)

ORO:	101362641(DYX1C1)

EJU:	114206565(DNAAF4)

ZCA:	113909762(DNAAF4)

MLX:	118003678(DNAAF4)

NSU:	110583982(DNAAF4)

LWW:	102731951(DNAAF4)

FCA:	101085981(DNAAF4)

PYU:	121041739(DNAAF4)

PCOO:

112856321(DNAAF4)

PBG:	122468612(DNAAF4)

LRUF:

124508050

PTG:	102971984(DYX1C1)

PPAD:

109262951(DYX1C1)

PUC:

125910019

AJU:	106988927(DNAAF4)

HHV:	120219715(DNAAF4)

BTA:	527393(DNAAF4)

BOM:	102275551(DYX1C1)

BIU:	109565104(DYX1C1)

BBUB:

102411812(DNAAF4)

BBIS:

104986277(DYX1C1)

CHX:	102186314(DYX1C1)

OAS:	101122030(DNAAF4)

BTAX:

128054496(DNAAF4)

ODA:	120853022(DNAAF4)

CCAD:

122443578(DNAAF4)

MBEZ:

129563120(DNAAF4)

SSC:	100513251(DNAAF4)

CFR:	102511796(DNAAF4)

CBAI:

105080482(DYX1C1)

CDK:	105088676(DNAAF4)

VPC:	102539117(DNAAF4)

BACU:

103006655(DYX1C1)

LVE:

103082218

OOR:	101270297(DNAAF4)

DLE:	111177639(DNAAF4)

PCAD:

102987997(DNAAF4)

PSIU:

116749573(DNAAF4)

NASI:

112415032(DNAAF4)

ECB:	100054782(DNAAF4)

EPZ:	103543706(DYX1C1)

EAI:	106843423(DNAAF4)

MYB:	102240069(DYX1C1)

MYD:	102769702(DYX1C1)

MMYO:

118652454(DNAAF4)

MLF:	102437159(DNAAF4)

MNA:	107546528(DYX1C1)

PKL:	118720855(DNAAF4)

EFUS:

103287569(DNAAF4)

HAI:	109394791(DYX1C1)

DRO:	112311708(DNAAF4)

SHON:

118992241(DNAAF4)

AJM:	119053501(DNAAF4)

PDIC:

114492742(DNAAF4)

PHAS:

123808531(DNAAF4)

MMF:	118635635(DNAAF4)

RFQ:	117023405(DNAAF4)

PALE:

102878176(DNAAF4)

PGIG:

120604611(DNAAF4)

PVP:	105294295(DNAAF4)

RAY:	107517526(DYX1C1)

TOD:	119238651(DNAAF4)

SARA:

101539645(DYX1C1)

LAV:	100663076(DNAAF4)

ETF:	101640695(DNAAF4)

DNM:	101447489(DNAAF4)

MDO:	100028057(DYX1C1)

GAS:	123236109(DNAAF4)

SHR:	100914764(DNAAF4)

AFZ:

127551178

PCW:	110205007(DNAAF4)

OAA:	100083782(DNAAF4)

GGA:	415409(DYX1C1)

MGP:	100547947(DNAAF4)

CJO:	107318680(DNAAF4)

TPAI:

128075648(DNAAF4)

LMUT:

125698486(DNAAF4)

NMEL:

110403656(DNAAF4)

APLA:

101797948(DNAAF4)

ACYG:

106033684(DNAAF4)

CATA:

118251544(DNAAF4)

AFUL:

116493610(DNAAF4)

TGU:	100220614(DNAAF4)

LSR:	110474168(DNAAF4)

SCAN:

103815990(DNAAF4)

PMOA:

120508958(DNAAF4)

OTC:	121343485(DNAAF4)

PRUF:

121354367(DNAAF4)

GFR:	102042285(DYX1C1)

FAB:	101810562(DYX1C1)

OMA:	130257443(DNAAF4)

PHI:	102112864(DYX1C1)

PMAJ:

107209084(DNAAF4)

CCAE:

111934149(DNAAF4)

CCW:	104684024(DNAAF4)

CBRC:

103621231(DYX1C1)

ETL:	114056348(DNAAF4)

ZAB:	102065407(DNAAF4)

ACHL:

103805970(DYX1C1)

SVG:	106851864(DYX1C1)

MMEA:

130577026(DNAAF4)

HRT:	120758706(DNAAF4)

FPG:	101912238(DYX1C1)

FCH:	102056027(DNAAF4)

CLV:	102092195(DNAAF4)

EGZ:	104130891(DYX1C1)

NNI:	104017273(DYX1C1)

PCRI:

104030763(DYX1C1)

PLET:

104614654(DYX1C1)

EHS:	104502969(DYX1C1)

PCAO:

104039318(DYX1C1)

ACUN:

113484219(DNAAF4)

TALA:

104367699(DNAAF4)

PADL:

103916434(DYX1C1)

AFOR:

103893533(DYX1C1)

ACHC:

115341661(DNAAF4)

HALD:

104324564(DYX1C1)

HLE:	104834467(DYX1C1)

AGEN:

126043879

GCL:

127020725

CCRI:

104155681(DYX1C1)

CSTI:

104549591(DYX1C1)

CMAC:

104483729(DYX1C1)

MUI:	104537266(DYX1C1)

BREG:

104632595(DYX1C1)

FGA:	104070729(DYX1C1)

GSTE:

104254447(DYX1C1)

LDI:	104340521(DYX1C1)

MNB:	103772024(DYX1C1)

OHA:	104334622(DYX1C1)

NNT:	104399079(DYX1C1)

SHAB:

115613187(DNAAF4)

DPUB:

104309860(DYX1C1)

PGUU:

104458978(DYX1C1)

ACAR:

104518694(DNAAF4)

CPEA:

104385902(DYX1C1)

AVIT:

104274456(DYX1C1)

CVF:	104287072(DYX1C1)

CUCA:

104061733(DYX1C1)

TEO:	104376151(DYX1C1)

BRHI:

104498287(DYX1C1)

AAM:	106496546(DYX1C1)

AROW:

112963645(DNAAF4)

NPD:	112952888(DNAAF4)

TGT:	104572168(DYX1C1)

DNE:	112985826(DNAAF4)

SCAM:

104148418(DYX1C1)

ASN:	102385646(DNAAF4)

AMJ:	102558444(DYX1C1)

CPOO:

109308996(DYX1C1)

GGN:	109288627(DYX1C1)

PSS:

102452344

CMY:	102941770(DNAAF4)

CCAY:

125644110(DNAAF4)

DCC:	119862061(DNAAF4)

CPIC:

101939176(DNAAF4)

TST:	117883688(DNAAF4)

CABI:

116826958(DNAAF4)

MRV:	120373205(DNAAF4)

ACS:	100553549(dyx1c1)

PVT:	110074528(DNAAF4)

SUND:

121932429(DNAAF4)

PBI:	103056736(DNAAF4)

PMUR:

107283158(DNAAF4)

CTIG:

120306541(DNAAF4)

TSR:	106542892(DYX1C1)

PGUT:

117660936(DNAAF4)

APRI:

131184653(DNAAF4)

PTEX:

113442275(DNAAF4)

NSS:	113421632(DNAAF4)

VKO:	123027639(DNAAF4)

PMUA:

114584786(DNAAF4)

PRAF:

128402182(DNAAF4)

ZVI:	118092861(DNAAF4)

HCG:	128334735(DNAAF4)

GJA:	107108689(DYX1C1)

STOW:

125424544(DNAAF4)

EMC:	129345770(DNAAF4)

XLA:	446699(dnaaf4.L)

XTR:	496594(dnaaf4)

NPR:	108787884(DYX1C1)

RTEM:

120931367(DNAAF4)

BBUF:

120985780(DNAAF4)

BGAR:

122929648(DNAAF4)

MUO:	115460644(DNAAF4)

GSH:	117348080(DNAAF4)

DRE:	402988(dnaaf4)

SRX:	107708296(dyx1c1)

SANH:

107659253 107662497(dyx1c1)

SGH:	107575795(dyx1c1)

CCAR:

109072475(dyx1c1)

CAUA:

113118091(dnaaf4)

CGIB:

127977481

PTET:

122362584(dnaaf4)

OMC:	131524438(dnaaf4)

PPRM:

120487783(dnaaf4)

MAMB:

125254089(dnaaf4)

CIDE:

127499973

MASI:

127455833

TROS:

130563317(dnaaf4)

IPU:

124627080

PHYP:

113534516(dnaaf4)

SMEO:

124396029(dnaaf4)

TFD:	113635316(dnaaf4)

AMEX:

103026332(dnaaf4)

CMAO:

118818182(dnaaf4)

EEE:	113584076(dnaaf4)

CHAR:

105888991(dnaaf4)

TRU:	105418493(dnaaf4)

TFS:	130536658(dnaaf4)

TNG:	GSTEN00013795G001

LCO:	104939435(dnaaf4)

NCC:	104961302(dyx1c1)

CGOB:

115010002(dnaaf4)

ELY:	117262676(dnaaf4)

EFO:	125887251(dnaaf4)

PLEP:

121950210(dnaaf4)

SLUC:

116048657(dnaaf4)

ECRA:

117948642(dnaaf4)

ESP:	116693959(dnaaf4)

PFLV:

114559520(dnaaf4)

GAT:	120809589(dnaaf4) 120812174

PPUG:

119229238(dnaaf4)

AFB:	129108816(dnaaf4)

CLUM:

117731734(dnaaf4)

MSAM:

119894147(dnaaf4)

SCHU:

122874476(dnaaf4)

CUD:	121515348(dnaaf4)

ALAT:

119024789(dnaaf4)

MZE:	101484256(dnaaf4)

ONL:	100711870(dnaaf4)

OAU:	116321367(dnaaf4)

OLA:	101172900(dnaaf4)

OML:	112151886(dnaaf4)

XMA:	102235536(dnaaf4)

XCO:	114152047(dnaaf4)

XHE:	116730104(dnaaf4)

PRET:

103466767(dyx1c1)

PFOR:

103148653(dyx1c1)

PLAI:

106935355(dyx1c1)

PMEI:

106906917(dyx1c1)

GAF:	122836146(dnaaf4)

CVG:	107090426(dyx1c1)

CTUL:

119793435(dnaaf4)

GMU:	124855181(dnaaf4)

NFU:	107396207(dyx1c1)

KMR:	108251444(dnaaf4)

ALIM:

106527951(dyx1c1)

NWH:	119415944(dnaaf4)

AOCE:

111578076(dnaaf4)

MCEP:

125015033(dnaaf4)

CSEM:

103379789 103392525

POV:	109643371(dyx1c1) 109643992

SSEN:

122762031 122785719

HHIP:

117763066(dnaaf4)

HSP:	118109059(dnaaf4)

LCF:	108879944 108902238

SDU:	111229847(dnaaf4)

SLAL:

111647719(dnaaf4)

XGL:	120793440(dnaaf4)

HCQ:	109520700(dyx1c1)

SSCV:

125970973

BPEC:

110169484(dnaaf4)

MALB:

109951275(dnaaf4)

BSPL:

114857702(dnaaf4)

SASA:

106562220(dyx1c1)

STRU:

115203110(dnaaf4)

OTW:	112249210(dnaaf4)

OMY:	110506549(dnaaf4)

OGO:	124035711(dnaaf4)

ONE:	115113667(dnaaf4)

OKI:	109895373(dnaaf4)

SALP:

111969124

SNH:	120025305(dnaaf4)

CCLU:

121540891 121548291

ELS:	105016366(dnaaf4)

SFM:	108926734(dnaaf4)

PKI:	111845047(dnaaf4)

AANG:

118214707(dnaaf4)

LOC:	102687822(dyx1c1)

PSPA:

121294416 121299227

ARUT:

117428329 117429029(dnaaf4)

PSEX:

120539919(dnaaf4)

LCM:	102346463(DYX1C1)

CMK:	103187189(dnaaf4)

RTP:	109914925(dyx1c1)

CPLA:

122540826(dnaaf4)

LERI:

129712653(dnaaf4)

BFO:

118407842

BBEL:

109472231

CIN:	493858(ekn1)

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG14921(CG14921)

DER:

6541939

DSE:

6612125

DSI:	Dsimw501_GD22192(Dsim_GD22192)

DYA:	Dyak_GE12988

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18152

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:	108371837 108375368

TDA:

MDE:

SCAC:

LCQ:

LSQ:

AGA:	AgaP_AGAP001727

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ011554

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210387

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

HAW:	110375530 126056696

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111052183 120356618

HVI:

124356213

PHU:	Phum_PHUM467930

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

EAF:

LSM:

PPOI:

CSCU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_94727

LGI:	LOTGIDRAFT_112670

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_151350

SHX:	MS3_00001853(DYX1C1_1)

OVI:	T265_04901

EGL:

EGR_05203

NVE:	116610125 5500672

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:

SMO:	SELMODRAFT_412442

PPP:

112293571

CRE:	CHLRE_11g467560v5

VCN:	VOLCADRAFT_99235

MBR:	MONBRDRAFT_31996

SRE:	PTSG_08307

TET:	TTHERM_00540410

PTM:	GSPATT00015546001

SMIN:

v1.2.007824.t1(symbB.v1.2.007824.t1)

AAF:	AURANDRAFT_65844

PIF:	PITG_01276

PSOJ:

PHYSODRAFT_499265

SPAR:

SPRG_16728 SPRG_20556

GTT:	GUITHDRAFT_147945

TBR:	Tb11.01.7710

TBG:	TbgDal_XI17990

TCR:	508707.120 509073.90

LMA:	LMJF_32_2850

LIF:	LINJ_32_2990

LDO:	LDBPK_322990

LMI:	LMXM_31_2850

LBZ:	LBRM_32_3090

LPAN:

LPMP_322990

NGR:	NAEGRDRAFT_61317

TVA:	TVAG_2v0925590

» show all

Reference

PMID:23872636

Authors

Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, Hjeij R, Kohler G, Griese M, Li Y, Lemke K, Klena N, Liu X, Gabriel G, Tobita K, Jaspers M, Morgan LC, Shapiro AJ, Letteboer SJ, Mans DA, Carson JL, Leigh MW, Wolf WE, Chen S, Lucas JS, Onoufriadis A, Plagnol V, Schmidts M, Boldt K, Roepman R, Zariwala MA, Lo CW, Mitchison HM, Knowles MR, Burdine RD, Loturco JJ, Omran H

Title

DYX1C1 is required for axonemal dynein assembly and ciliary motility.

Journal

Nat Genet 45:995-1003 (2013)
DOI:10.1038/ng.2707

Sequence

[hsa:161582]

All links

Ontology (3)   
   KEGG BRITE (3)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (1471)   
   KEGG GENES (600)   
   KEGG MGENES (64)   
   RefGene (803)   
   OC (4)   
Literature (1)   
   PubMed (1)   
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