KEGG   ORTHOLOGY: K20570
Entry
K20570            Tight     KO                                     

Name
btrF
Definition
NADPH-dependent reductase [EC:1.1.1.-]
Pathway
ko00524  Neomycin, kanamycin and gentamicin biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20570  btrF; NADPH-dependent reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K20570  btrF; NADPH-dependent reductase
Other DBs
RN: R08911 R11266
COG: COG1028
Genes
AG: BAE07070(btrF)
Reference
  Authors
Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K
  Title
Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.
  Journal
J Antibiot (Tokyo) 58:373-9 (2005)
DOI:10.1038/ja.2005.47
  Sequence
Reference
  Authors
Takeishi R, Kudo F, Numakura M, Eguchi T
  Title
Epimerization at C-3'' in butirosin biosynthesis by an NAD(+) -dependent dehydrogenase BtrE and an NADPH-dependent reductase BtrF.
  Journal
Chembiochem 16:487-95 (2015)
DOI:10.1002/cbic.201402612

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