KEGG   ORTHOLOGY: K20980
Entry
K20980            Tight     KO                                     

Name
LOVA, CYP68R1
Definition
dihydromonacolin L/monacolin L hydroxylase [EC:1.14.14.124 1.14.14.125]
Pathway
ko00999  Biosynthesis of various secondary metabolites - part 1
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various secondary metabolites - part 1
    K20980  LOVA, CYP68R1; dihydromonacolin L/monacolin L hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K20980  LOVA, CYP68R1; dihydromonacolin L/monacolin L hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.124  dihydromonacolin L hydroxylase
     K20980  LOVA, CYP68R1; dihydromonacolin L/monacolin L hydroxylase
    1.14.14.125  monacolin L hydroxylase
     K20980  LOVA, CYP68R1; dihydromonacolin L/monacolin L hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP68 family
   K20980  LOVA, CYP68R1; dihydromonacolin L/monacolin L hydroxylase
Other DBs
RN: R10791 R10792 R10794
COG: COG2124
Genes
AG: AAD34552(LOVA)
Reference
  Authors
Barriuso J, Nguyen DT, Li JW, Roberts JN, MacNevin G, Chaytor JL, Marcus SL, Vederas JC, Ro DK
  Title
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.
  Journal
J Am Chem Soc 133:8078-81 (2011)
DOI:10.1021/ja201138v
  Sequence

DBGET integrated database retrieval system