KEGG ORTHOLOGY: K21027

ORTHOLOGY: K21027

Entry

K21027 KO

Name

TRMU, SLM3

Definition

tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14]

Disease

H01367

Infantile liver failure

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis
    K21027  TRMU, SLM3; tRNA-5-taurinomethyluridine 2-sulfurtransferase
Enzymes [BR:ko01000]
2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.1  Sulfurtransferases
    2.8.1.14  tRNA-5-taurinomethyluridine 2-sulfurtransferase
     K21027  TRMU, SLM3; tRNA-5-taurinomethyluridine 2-sulfurtransferase
Transfer RNA biogenesis [BR:ko03016]
Eukaryotic type
  tRNA modification factors
   Thiolation factors
    K21027  TRMU, SLM3; tRNA-5-taurinomethyluridine 2-sulfurtransferase

Other DBs

COG:

COG0482

GO:

0061708

Genes

HSA:	55687(TRMU)

PTR:	458914(TRMU)

PPS:	100973612(TRMU)

PON:	100172484(TRMU)

NLE:	100603500(TRMU)

MCC:	714268(TRMU)

MCF:	102129282(TRMU)

CSAB:

103223497(TRMU)

RRO:	104664012(TRMU)

RBB:	108514523(TRMU)

CJC:	100387554(TRMU)

SBQ:	101033704(TRMU)

MMU:	72026(Trmu)

MCAL:

110310296(Trmu)

MPAH:

110334748(Trmu)

RNO:	362976(Trmu)

MUN:	110545050(Trmu)

CGE:	100759274(Trmu)

NGI:	103743413(Trmu)

HGL:	101722647(Trmu)

CCAN:

109699747(Trmu)

OCU:	100358226(TRMU)

TUP:	102496242(TRMU)

CFA:	481204(TRMU)

VVP:	112935816(TRMU)

AML:	100475980(TRMU)

UMR:	103674020(TRMU)

UAH:	113241641(TRMU)

ORO:	101364965(TRMU)

ELK:

111157612

FCA:	101097570(TRMU)

PTG:	102972617(TRMU)

PPAD:

109265733(TRMU)

AJU:	106967319(TRMU)

BTA:	616451(TRMU)

BOM:	102278045(TRMU)

BIU:	109559918(TRMU)

BBUB:

102392714(TRMU)

CHX:	102178891(TRMU)

OAS:	101110834(TRMU)

SSC:	100521087(TRMU)

CFR:	102518156(TRMU)

CDK:	105091837(TRMU)

BACU:

103002692(TRMU)

LVE:	103081768(TRMU)

OOR:	101279169(TRMU)

DLE:	111186289(TRMU)

PCAD:

102985429

ECB:	100053410(TRMU)

EPZ:	103560115(TRMU)

EAI:	106845985(TRMU)

MYB:	102256198(TRMU)

MYD:	102753178(TRMU)

MNA:	107544347(TRMU)

HAI:	109387626(TRMU)

DRO:	112321903(TRMU)

PALE:

102885445(TRMU)

RAY:	107500997(TRMU)

MJV:	108406722(TRMU)

LAV:	100655782(TRMU)

TMU:

101343788

MDO:	100028714(TRMU)

SHR:	100918139(TRMU)

PCW:	110201629(TRMU)

OAA:	100076445(TRMU)

GGA:	425909(TRMU)

MGP:	100550785(TRMU)

CJO:	107308174(TRMU)

NMEL:

110392408(TRMU)

APLA:

101802835(TRMU)

ACYG:

106042036(TRMU)

TGU:	100224137(TRMU)

LSR:	110467623(TRMU)

SCAN:

103813502(TRMU)

GFR:	102033839(TRMU)

FAB:	101806466(TRMU)

PHI:	102112982(TRMU)

PMAJ:

107205018(TRMU)

CCAE:

111923024(TRMU)

CCW:	104686853(TRMU)

ETL:	114069682(TRMU)

FPG:	101912064(TRMU)

FCH:	102052400(TRMU)

CLV:	102097558(TRMU)

EGZ:	104123801(TRMU)

NNI:	104010787(TRMU)

ACUN:

113491540(TRMU)

PADL:

103917276(TRMU)

AAM:	106487756(TRMU)

ASN:	102371522(TRMU)

AMJ:	102567756(TRMU)

PSS:	102461306(TRMU)

CMY:	102935326(TRMU)

CPIC:

101950938(TRMU)

ACS:	100557100(trmu)

PVT:	110080800(TRMU)

PBI:	103064949(TRMU)

PMUR:

107294525(TRMU)

TSR:	106542853(TRMU)

PMUA:

114605398(TRMU)

GJA:	107113948(TRMU)

XLA:	100381124(trmu.L)

XTR:	100379803(trmu)

NPR:	108783834(TRMU)

DRE:	553625(trmu)

SRX:	107710739(trmu) 107721150

SANH:

107666209(trmu)

SGH:	107569222(trmu)

CCAR:

109069263(trmu) 109070259

IPU:	108279433(trmu)

PHYP:

113532210(trmu)

AMEX:

103028805(trmu)

EEE:	113580197(trmu)

TRU:	101064363(trmu)

TNG:	GSTEN00019838G001

LCO:	109137718(trmu)

NCC:	104959436(trmu)

MZE:	101471286(trmu)

ONL:	100704876(trmu)

OLA:	101157506(trmu)

XMA:	102227683(trmu)

XCO:	114145964(trmu)

PRET:

103459529(trmu)

CVG:	107099051(trmu)

NFU:	107383769(trmu)

KMR:	108244057(trmu)

ALIM:

106524851 106534360

AOCE:

111582997(trmu)

CSEM:

103382934(trmu)

POV:	109632659(trmu)

LCF:	108899836(trmu)

SDU:	111224740(trmu)

SLAL:

111667344(trmu)

HCQ:	109520136(trmu)

BPEC:

110161813(trmu)

MALB:

109960984(trmu)

SASA:

106575989(trmu)

OTW:	112216779(trmu)

SALP:

111951495(trmu)

ELS:	105028211(trmu)

SFM:	108920952(trmu)

PKI:	111843377(trmu)

LCM:	102348161(TRMU)

CMK:	103188286(trmu)

RTP:	109937289(trmu)

BFO:	BRAFLDRAFT_87680

CIN:

100175674

SPU:	100891218 754211

APLC:

110989551

SKO:

100366403

DME:	Dmel_CG3021(CG3021)

DER:

6555789

DSE:

6615936

DSI:	Dsimw501_GD16539(Dsim_GD16539)

DYA:	Dyak_GE16655

DAN:

6504791

DSR:

110179447

DPO:	Dpse_GA22395

DPE:

6596719

DMN:

108152874

DWI:

6644776

DGR:	Dgri_GH11989

DMO:	Dmoj_GI15611

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP011960

AAG:

5566184

AALB:

109401317

CQU:	CpipJ_CPIJ004441 CpipJ_CPIJ009178

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:	105285409 113563210

PCF:

NVI:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_206643

PMAC:

PRAP:

HAW:

TNL:

PXY:	105385683 105388253

BTAB:

109036590

CLEC:

106661562

PHU:	Phum_PHUM450610

ZNE:

110833460

FCD:

110861811

DPX:	DAPPUDRAFT_202999

PVM:

113817903

ISC:	IscW_ISCW008832

CSCU:

111619872 111619873 111619874

PTEP:

107440988

CEL:	CELE_B0035.16(mttu-1)

CBR:

CBG06062

BMY:

Bm1_08740

LOA:	LOAG_02754

NAI:	NECAME_10748

TSP:

Tsp_04039

HRO:	HELRODRAFT_66727

LGI:	LOTGIDRAFT_200906

PCAN:

CRG:

MYI:

OBI:

LAK:	106152782 106171341 106180295

SMM:	Smp_178920

SHX:

MS3_11397

OVI:	T265_08850

TAD:	TRIADDRAFT_20051

AQU:	100637194 100638698

ATH:

AT1G51310

ALY:

9330370

CRB:	17874892 17900723

CSAT:

104742640 104758421 109124552

EUS:	EUTSA_v10011432mg

BRP:	103832852 103868579

BNA:

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10006706mg

TCC:

18589832

GRA:

105770275

GHI:	107906693 107959305

GAB:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_011G059600g

VRA:

VAR:

VUN:

CCAJ:

MTR:	MTR_4g065023

CAM:

101491281

LJA:	Lj3g3v3237870.1(Lj3g3v3237870.1)

ADU:	107473222 107485020

AIP:	107610164 107624756 107639665

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:	103407743 103448102

PXB:	103938986 103938987 103963898 103965543

ZJU:

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:	105112267 105140344

JRE:

108985391

QSU:	112001972 112010338

VVI:

SLY:

SPEN:

SOT:

CANN:

NTA:	107802744 107827275

NSY:

NTO:

NAU:

INI:

SIND:

OEU:

HAN:

LSV:

CCAV:

DCR:

BVG:

SOE:

CQI:	110696024 110736209

NNU:	104597469 104607112

PSOM:

113310442 113320329

OSA:

4331793

DOSA:

Os03t0174600-01(Os03g0174600)

OBR:

BDI:

ATS:

SBI:

ZMA:

SITA:

PDA:

EGU:

MUS:

DCT:	110104299 110111001

PEQ:

110031690

AOF:

109851309

ATR:

18439991

SMO:	SELMODRAFT_44688 SELMODRAFT_44690

PPP:

112292046

CRE:	CHLREDRAFT_102762

VCN:	VOLCADRAFT_55676

MNG:	MNEG_0539 MNEG_12593

CSL:	COCSUDRAFT_18285 COCSUDRAFT_35346

CVR:	CHLNCDRAFT_139672 CHLNCDRAFT_35486

APRO:

F751_0768 F751_2846

OLU:	OSTLU_17350 OSTLU_43910

OTA:	OT_ostta11g01810

BPG:	Bathy12g01880 Bathy13g01570

MIS:	MICPUN_69547 MICPUN_87017

MPP:	MICPUCDRAFT_4302 MICPUCDRAFT_44717

CME:	CYME_CMT278C CYME_CMT380C

GSL:	Gasu_55970

CCP:	CHC_T00004341001 CHC_T00007882001

SCE:	YDL033C(SLM3)

AGO:	AGOS_AEL087C

ERC:

Ecym_3551

KLA:	KLLA0_F24706g

KMX:	KLMA_60278(SLM3)

LTH:	KLTH0C08844g

VPO:	Kpol_479p27

ZRO:	ZYRO0B04994g

CGR:	CAGL0K01529g

NCS:	NCAS_0I02100(NCAS0I02100)

NDI:	NDAI_0A06680(NDAI0A06680)

TPF:	TPHA_0A00900(TPHA0A00900)

TBL:	TBLA_0F00880(TBLA0F00880)

TDL:	TDEL_0D04640(TDEL0D04640)

KAF:	KAFR_0F02180(KAFR0F02180)

PPA:	PAS_chr1-4_0029

DHA:	DEHA2D04818g

PIC:	PICST_34443

PGU:	PGUG_04995

SPAA:

SPAPADRAFT_138558

LEL:	LELG_03638

CAL:	CAALFM_C114330WA(CaO19.7245)

CTP:	CTRG_03709

COT:	CORT_0G00590

CDU:	CD36_13300

CTEN:

CANTEDRAFT_124609

YLI:	YALI0F25069g

CLU:	CLUG_01737

CLUS:

A9F13_13g01848

CAUR:

CJI97_003131

SLB:	AWJ20_803(SLM3)

PKZ:	C5L36_0A11390

TML:	GSTUM_00003665001

SPO:	SPAC23H4.04

CNE:

CNM00110

CNB:

CNBM0130

CGI:	CGB_M0080C

TMS:	TREMEDRAFT_38116

TASA:

A1Q1_07924

PPL:	POSPLDRAFT_90859

TVS:	TRAVEDRAFT_35922

DSQ:	DICSQDRAFT_132346

PCO:	PHACADRAFT_255702

SHS:	STEHIDRAFT_51567

HIR:	HETIRDRAFT_311357

PSQ:	PUNSTDRAFT_53421

ADL:	AURDEDRAFT_142235

FME:	FOMMEDRAFT_141375

GTR:	GLOTRDRAFT_36658

LBC:	LACBIDRAFT_307468

MPR:	MPER_08255

MRR:	Moror_11515

CCI:	CC1G_10554

SCM:	SCHCODRAFT_232108

ABP:	AGABI1DRAFT67935(AGABI1DRAFT_67935)

ABV:	AGABI2DRAFT215705(AGABI2DRAFT_215705)

CPUT:

CONPUDRAFT_141651

SLA:	SERLADRAFT_441606

WSE:	WALSEDRAFT_44633

WIC:	J056_003522

UMA:	UMAG_00288

PFP:	PFL1_00641

MGL:

MGL_0546

MSYM:

MSY001_3467

MLR:	MELLADRAFT_35034

MBR:	MONBRDRAFT_11336

SRE:	PTSG_05428

DDI:	DDB_G0288979(trmu)

DPP:	DICPUDRAFT_154197

DFA:	DFA_11029(trmu)

ACAN:

ACA1_150050

PFA:	PF3D7_1019800

PFH:	PFHG_01493 PFHG_05474

PYO:	PY17X_0505100

PCB:	PCHAS_050410(PC000786.01.0)

PBE:	PBANKA_0504000

PKN:	PKH_060380

PVX:	PVX_001855

PCY:	PCYB_061410

TAN:

TA12620

TPV:

TP02_0339

TOT:	TOT_020001047

BEQ:	BEWA_020540

BBO:	BBOV_III005960(17.m07526)

BMIC:

BMR1_03g03155

PTI:	PHATRDRAFT_15294 PHATRDRAFT_3425

FCY:	FRACYDRAFT_182371 FRACYDRAFT_205230

TPS:	THAPSDRAFT_269988 THAPSDRAFT_37327

SPAR:

SPRG_08169

EHX:	EMIHUDRAFT_437795 EMIHUDRAFT_70246

GTT:	GUITHDRAFT_62025 GUITHDRAFT_76798

TBR:	Tb927.8.1830

TBG:	TbgDal_VIII1460

LMA:	LMJF_07_0130

LIF:	LINJ_07_0280

LDO:	LDBPK_070280

LMI:	LMXM_07_0130

LBZ:	LBRM_07_0130

LPAN:

LPMP_070150

SFC:	Spiaf_0440

SPER:

EW093_11015(mnmA)

SLR:	L21SP2_0400

OCK:	EXM22_14405(mnmA)

PAH:	Poras_0554

PCRE:

NCTC12858_01528(mnmA)

PBT:	ING2E5B_0031(mnmA)

PMUC:

ING2E5A_3047(mnmA)

PET:	PEIBARAKI_4321

PPN:	Palpr_2508

PDI:

BDI_3778

PARC:

CI960_02350

TFO:	BFO_1595(trmU)

PARY:

A4V02_08170

PSAC:

PSM36_3271(mnmA)

DYS:	G7050_17095(mnmA)

APS:

CFPG_332

PRU:	PRU_0077(trmU)

PMZ:	HMPREF0659_A7159(trmU)

PDN:	HMPREF9137_1005(trmU)

PIT:	PIN17_A1075(trmU)

PDT:	Prede_1516

PRO:	HMPREF0669_00133

PFUS:

ADJ77_12230

PEO:	AS203_10785

PJE:	CRM71_12350(mnmA)

POC:	NCTC13071_00151(mnmA)

ALQ:	C7Y71_005160(mnmA)

IAL:

IALB_2752

DPB:	BABL1_gene_715(mnmA)

» show all

Reference

PMID:15509579

Authors

Umeda N, Suzuki T, Yukawa M, Ohya Y, Shindo H, Watanabe K, Suzuki T

Title

Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.

Journal

J Biol Chem 280:1613-24 (2005)
DOI:10.1074/jbc.M409306200

Sequence

[hsa:55687] [sce:YDL033C]

Reference

PMID:16513084

Authors

Yan Q, Bykhovskaya Y, Li R, Mengesha E, Shohat M, Estivill X, Fischel-Ghodsian N, Guan MX

Title

Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations.

Journal

Biochem Biophys Res Commun 342:1130-6 (2006)
DOI:10.1016/j.bbrc.2006.02.078

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