KEGG   ORTHOLOGY: K22517Help
Entry
K22517                      KO                                     

Name
CBLB
Definition
E3 ubiquitin-protein ligase CBL-B [EC:2.3.2.27]
Pathway
ko04012  ErbB signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko04625  C-type lectin receptor signaling pathway
ko04660  T cell receptor signaling pathway
ko04910  Insulin signaling pathway
ko05162  Measles
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
   04660 T cell receptor signaling pathway
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
  09152 Endocrine system
   04910 Insulin signaling pathway
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09160 Human Diseases
  09172 Infectious diseases: Viral
   05162 Measles
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
   04121 Ubiquitin system
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   CBL proteins
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
BRITE hierarchy
Genes
HSA: 868(CBLB)
PTR: 460566(CBLB)
PPS: 100984607(CBLB)
GGO: 101124684(CBLB)
PON: 100452289(CBLB)
NLE: 100588040(CBLB)
MCC: 703879(CBLB)
MCF: 102114949(CBLB)
CSAB: 103228406(CBLB)
RRO: 104674409(CBLB)
RBB: 108544485(CBLB)
CJC: 100409801(CBLB)
SBQ: 101035841(CBLB)
MMU: 208650(Cblb)
RNO: 171136(Cblb)
CGE: 100774600(Cblb)
NGI: 103747585(Cblb)
HGL: 101719173(Cblb)
CCAN: 109699003(Cblb)
OCU: 100355469(CBLB)
TUP: 102485272(CBLB)
CFA: 487965(CBLB)
AML: 100473515(CBLB)
UMR: 103677350(CBLB)
ORO: 101374044(CBLB)
FCA: 101101498(CBLB)
PTG: 102962133(CBLB)
AJU: 106972259(CBLB)
BTA: 525906(CBLB)
BOM: 102287221(CBLB)
BIU: 109568926(CBLB)
PHD: 102317029(CBLB)
CHX: 102186998(CBLB)
OAS: 101114404(CBLB)
SSC: 100621690(CBLB)
CFR: 102515465(CBLB)
CDK: 105087708(CBLB)
BACU: 103002776(CBLB)
LVE: 103083966(CBLB)
OOR: 101280577(CBLB)
ECB: 100061819(CBLB)
EPZ: 103549198(CBLB)
EAI: 106838872(CBLB)
MYB: 102245653(CBLB)
MYD: 102759944(CBLB)
HAI: 109395019(CBLB)
RSS: 109453323(CBLB)
PALE: 102890283(CBLB)
LAV: 100669603(CBLB)
TMU: 101345632
MDO: 100011932(CBLB)
SHR: 100913401(CBLB)
OAA: 100089052(CBLB)
GGA: 418406(CBLB)
MGP: 100546892(CBLB)
CJO: 107321076(CBLB)
APLA: 101799051(CBLB)
ACYG: 106038875(CBLB)
TGU: 100226776(CBLB)
SCAN: 103820721(CBLB)
GFR: 102033221(CBLB)
FAB: 101810847(CBLB)
PHI: 102103800(CBLB)
PMAJ: 107208416(CBLB)
CCW: 104687176(CBLB)
FPG: 101912806(CBLB)
FCH: 102053933(CBLB)
CLV: 102097605
EGZ: 104129286(CBLB)
NNI: 104014116(CBLB)
ACUN: 113482374(CBLB)
AAM: 106490686(CBLB)
ASN: 102384451(CBLB)
AMJ: 102563760(CBLB)
PSS: 102454526(CBLB)
CMY: 102943844(CBLB)
CPIC: 101947986(CBLB)
ACS: 100561034(cblb)
PVT: 110087890(CBLB)
PBI: 103059707(CBLB) 103067394
PMUR: 107287381(CBLB)
GJA: 107121592(CBLB)
XLA: 431829(cblb.S) 443854(cblb.L)
XTR: 448509(cblb)
NPR: 108789887(CBLB)
DRE: 556277(cblb)
IPU: 108276857(cblb)
PHYP: 113543494(cblb)
AMEX: 103034711(cblb)
TRU: 101063765(cblb)
LCO: 104935532(cblb)
MZE: 101484242(cblb)
OLA: 101157475(cblb)
CSEM: 103395038(cblb)
LCF: 108900056(cblb)
SDU: 111222177(cblb)
BPEC: 110169053(cblb)
MALB: 109972711(cblb)
SASA: 106602828(cblb)
OTW: 112216734(cblb)
SALP: 111950391 111950986(cblb)
ELS: 105028781(cblb)
SFM: 108936157(cblb)
LCM: 102346401(CBLB)
CMK: 103180132(cblb)
SPU: 100890602
EGL: EGR_00761
EPA: 110242011
ADF: 107345262
PDAM: 113686100
HMG: 100208241
AQU: 100639103
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH, Lipkowitz S
  Title
cbl-b inhibits epidermal growth factor receptor signaling.
  Journal
Oncogene 18:1855-66 (1999)
DOI:10.1038/sj.onc.1202499
  Sequence
[hsa:868]
Reference
PMID:7784085
  Authors
Keane MM, Rivero-Lezcano OM, Mitchell JA, Robbins KC, Lipkowitz S
  Title
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.
  Journal
Oncogene 10:2367-77 (1995)
  Sequence
[hsa:868]

DBGET integrated database retrieval system