KEGG ORTHOLOGY: K23144

ORTHOLOGY: K23144

Entry

K23144                      KO

Symbol

K23144

Name

UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.7.7.24 2.7.7.83 2.3.1.157 2.3.1.276]

Pathway

map00520

Amino sugar and nucleotide sugar metabolism

map00521

Streptomycin biosynthesis

map00523

Polyketide sugar unit biosynthesis

map00525

Acarbose and validamycin biosynthesis

map00541

Biosynthesis of various nucleotide sugars

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01250

Biosynthesis of nucleotide sugars

Module

M00909

UDP-GlcNAc biosynthesis, prokaryotes, Fru-6P => UDP-GlcNAc

M01002

UDP-GalNAc biosynthesis, Fru-6P => UDP-GalNAc

Reaction

R00416

UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase

R02328

dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase

R05332

acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase

R12242

acetyl-CoA:alpha-D-galactosamine-1-phosphate N-acetyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
   00541 Biosynthesis of various nucleotide sugars
    K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
  09110 Biosynthesis of other secondary metabolites
   00521 Streptomycin biosynthesis
    K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
   00525 Acarbose and validamycin biosynthesis
    K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.157  glucosamine-1-phosphate N-acetyltransferase
     K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
    2.3.1.276  galactosamine-1-phosphate N-acetyltransferase
     K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.23  UDP-N-acetylglucosamine diphosphorylase
     K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
    2.7.7.24  glucose-1-phosphate thymidylyltransferase
     K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
    2.7.7.83  UDP-N-acetylgalactosamine diphosphorylase
     K23144  K23144; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase

Other DBs

COG:

COG1208

GO:	0003977 0008879 0052630 0019134

Genes

BROC:

IPI25_07910

BPIT:

BPIT_25190

JET:	L3J17_08470

LBV:	JYG24_10695

LBAC:

LJT99_00570

NLI:	G3M70_00770

NWT:	NSPWAT_1004

NVA:	G3M78_13570

DET:

DET0529

DEH:	cbdbA499(rfbA)

DEB:	DehaBAV1_0505

DEV:

DhcVS_470

DEG:	DehalGT_0468

DMC:	btf_492(glmU1)

DMD:	dcmb_538(glmU1)

DMG:	GY50_0455(rfbA)

DMX:	X792_02565

DMY:	X793_02320

DMZ:	X794_02060

DUC:	UCH007_04570

DLY:	Dehly_0583

DEW:	DGWBC_0738

DFO:	Dform_01180 Dform_01834

DETH:

HX448_07245

DLF:	V8247_07615(glmU)

CAU:

Caur_1799

CHL:	Chy400_1946

CAG:

Cagg_2516

PMET:

G4Y79_09885

PRF:	PeribacterA2_1018

MARW:

MNSC_10410

TMG:	US01_C0001G0691

MIB:	UY43_C0001G0625

KBN:	HYS26_00005

NBN:	HYY55_03975 HYY55_04575

GBG:	HYW15_01485

MJA:

MJ_1101

MFE:	Mefer_0780

MVU:	Metvu_1273

MFS:	MFS40622_1224

MIF:	Metin_0997

MJH:	JH146_0795

MESG:

MLAUSG7_0979(glmU)

MESA:

MLASG1_0313(glmU)

MIG:	Metig_0354

MMP:

MMP1076

MMQ:	MmarC5_0513

MMX:	MmarC6_1583

MMZ:	MmarC7_0329

MMD:

GYY_06215

MMAK:

MMKA1_12550

MMAO:

MMOS7_11870

MMAD:

MMJJ_17730(glmU)

MAE:

Maeo_0642

MVN:	Mevan_0399

MVO:

Mvol_0247

MOK:	Metok_0856

METF:

CFE53_04600

MTH:

MTH_1589

MMG:	MTBMA_c01750

MWO:	MWSIV6_0133(glmU)

MTEE:

MTTB_12600

METC:

MTCT_1448

METE:

tca_01538(glmU_3)

METZ:

METK:

MTHM:

METJ:

MST:

METB:

MEIS:

PXD04_00930(glmU)

MRU:	mru_0456(glmU)

MSI:

Msm_0655

MEB:	Abm4_0226(glmU)

MMIL:

sm9_0316(glmU)

MEYE:

MOL:

MARO:

METV:

MEL:	Metbo_2293

MEW:	MSWAN_0358

METH:

MBMB1_0406(glmU)

MFC:	BRM9_1856(glmU)

MFI:	DSM1535_0040

MCUB:

MSUB:

METN:

METT:

METO:

MEME:

MFEG:

MRID:

MFV:

MKA:

AST:	Asulf_01979

FPL:

GAC:

GAH:

PFU:

PFI:

PHO:	PH1925(PH1925)

PAB:	PAB1115(graD-2)

PYN:

PNA2_0881

PYA:	PYCH_13140

PYS:

Py04_0389

PYC:	TQ32_01175

TKO:

TON:

TGA:

TSI:

TBA:	TERMP_00699

THE:

THA:

THM:

TLT:

THS:

TNU:

TEU:

TGY:	X802_07040

THV:	ADU37_CDS05730

TCH:	CHITON_0452

TPEP:

A0127_09000

TPIE:

A7C91_07810

TGG:	A3K92_03495

TCE:	A3L02_09590

TBS:	A3L01_02500

THH:	CDI07_02450

TSL:	A3L11_06425

TTD:	A3L14_03965

TPRF:

A3L09_08885

TRL:	A3L10_04085

TPAF:

A3L08_05490

THY:	A3L12_06225

TIC:	FH039_04770

TCQ:	TIRI35C_0723(glmU)

THEM:

THEI:

TAGG:

PPAC:

MBA:	Mbar_A2020

MBY:	MSBRM_2483

MBW:	MSBRW_2717

MBAR:

MSBR2_2453

MBAK:

MSBR3_2500

MAC:	MA_3025(rfbA)

MMA:

MM_0302

MMAZ:

MmTuc01_0307

MMJ:	MSMAS_0998

MMAC:

MSMAC_2357

MVC:	MSVAZ_1931

MEK:	MSKOL_1916

MLS:	MSLAZ_1276

METM:

MSMTP_2241

MEF:	MSWH1_2137

MEQ:	MSWHS_2961

MSJ:	MSSAC_3286

MSZ:	MSSIH_1143

MSW:	MSSIT_1193

MTHR:

MSTHT_2542

MTHE:

MSTHC_0741

MHOR:

MSHOH_1189

MFZ:	AOB57_002635

MHAB:

RSJ42_10550

METW:

AAY43_06905

MBU:	Mbur_2341(glmU)

MMET:

MELO:

MMH:

MHAZ:

MPOT:

MEV:	Metev_2274

MZH:	Mzhil_1657

MPY:

Mpsy_2687

MZI:	HWN40_09290

MMAV:

RE476_00895

MSEB:

RE474_10640

MHZ:	Metho_1847

MTP:

Mthe_0901

MCJ:	MCON_2572(glmU)

MHI:

MHU:

MRTJ:

MLA:

MEM:	Memar_2229

MBG:	BN140_1431(glmU2)

MEMA:

MMAB1_1836(rfbA)

MCHK:

MchiMG62_25460

MSUM:

OH143_05430

MRC:	R6Y96_03625

MEND:

L6E24_05400

MEFW:

F1737_07775

MAQE:

RJ40_07020

MFK:	E2N92_07175

MOU:	OU421_07650

MESB:

L1S32_11035

MANQ:

L1994_08270

MBN:

Mboo_0254

MFO:	Metfor_2859

MESK:

METHP_00608

MPL:

Mpal_0314

MPD:

MCP_0802

MEZ:	Mtc_2010(glmU-2)

RCI:	RCIX1438(rfbA-4)

HAL:	VNG_0009G(graD2)

HSL:	OE_1016R(graD2)

HANR:

LJ422_00055

HDL:	HALDL1_11065

HAGS:

JT689_01700

HABO:

JRZ79_00035

HNO:	LT974_06355

HLU:	LT972_05190 LT972_06675 LT972_06685

HANX:

ABSL23_06020(glmU)

HALH:

HTSR_0890(glmU)

HHSR:

HSR6_0623(glmU) HSR6_0906(glmU2)

HSU:	HLASF_0890(glmU)

HSF:	HLASA_0887(glmU)

HAHS:

HSRCO_1680(gcd1-2) HSRCO_1828(gcd1-3)

SALR:

FQU85_07715

HALR:

EFA46_011310

HJE:	HacjB3_01710

HDO:	MUK72_04425

HALX:

M0R89_14165 M0R89_17845 M0R89_21585

HAXZ:

M0R88_14560 M0R88_18190

HAYC:

NGM10_01105 NGM10_15470

HAXY:

NGM07_04380 NGM07_23245

SALI:

L593_04855 L593_11420

SAIM:

K0C01_03520

HARA:

AArcS_0504(gcd1-2) AArcS_0848(gcd1-4)

HMA:	rrnAC1081(rffH1)

HHI:	HAH_1684(rffH2)

HHN:	HISP_08605

HAB:	SG26_16325

HTA:	BVU17_08150

HALJ:

G9465_11675

HSIN:

KDQ40_05000

NPH:	NP_4276A(graD6) NP_4656A(graD2)

NHO:	HWV23_16335

NSAL:

HUT:

HTI:

HALA:

HASV:

SVXHr_1663(gcd1-2)

HABN:

HBNXHr_1645(gcd1-2)

HMU:

HALZ:

HALL:

HAZP:

HALI:

BV210_15455 BV210_17765

HSN:	DV733_11360

HDS:	HSR122_0731(gcd1)

HRR:	HZS55_16345

HPEL:

HZS54_19110

HLT:	I7X12_19550

HARC:

HARCEL1_07290 HARCEL1_11810

SSAI:

N0B31_07295

HAAD:

MW046_03485

HWA:	HQ_2992A(graD4)

HWC:	Hqrw_3506(graD4)

HVO:	HVO_A0586(graD3)

HALE:

G3A49_06005

HLN:	SVXHx_2523 SVXHx_4046

HME:	HFX_2130(rffH1) HFX_6127(rffH1) HFX_6312(rffH1)

HGI:	ABY42_17090 ABY42_17735

HLS:	KU306_15965 KU306_17485

HBO:	Hbor_36520

HAQ:	DU484_07230 DU484_15325

HAJ:	DU500_07420 DU500_15345

HAER:

DU502_13420

HRA:	EI982_08225

HLM:	DV707_04355

HALM:

FCF25_01345

HLA:	Hlac_1083 Hlac_2874

HALP:

HALB:

HEZZ:

HALQ:

HSS:	J7656_09830

HSAI:

HPS36_00170

HAZZ:

KI388_04345

HAE:	halTADL_3349

HALN:

B4589_016415

HALG:

HUG10_14685 HUG10_19495 HUG10_21365

HALU:

HUG12_01005 HUG12_01615 HUG12_21255

HMP:	K6T50_17185 K6T50_17195

HRE:	K6T36_14770 K6T36_17300 K6T36_17310

HACB:

Hbl1158_15540 Hbl1158_15550

HDF:	AArcSl_1933(glmU)

HAH:	Halar_2341

HTU:	Htur_1202 Htur_5109

HSAL:

JMJ58_02645 JMJ58_21810

HAKZ:

J0X25_12685 J0X25_20995

NMG:	Nmag_3048(graD2)

HXA:	Halxa_3081

NAT:

NJ7G_3629

NPE:	Natpe_2880

NVR:	FEJ81_06885 FEJ81_13465

NPL:	FGF80_12905

NAY:	HYG81_16615

HALY:

HYG82_00675

HJT:	DVR14_04525

HLO:	J0X27_15140

NGE:	Natgr_3335

HLC:	CHINAEXTREME04935 CHINAEXTREME16435

HRU:	Halru_1029

SAWL:

NGM29_08885

HALV:

NGM15_01055

NOU:	Natoc_3409

HLR:	HALLA_08700 HALLA_14150

NAJ:	B1756_09540

NAG:	AArcMg_1271

NAN:	AArc1_2346

NARA:

QQ977_00170

NBG:	DV706_01385 DV706_15885

NAS:	GCU68_12305

HDA:	BB347_02615

NAC:	AQV86_00490 AQV86_00500

MEAE:

QEN48_01250

MER:	MMINT_02670

ABI:

Aboo_0280

ACF:	AciM339_0783

APE:	APE_1202.1

ACJ:

ACAM_0762

SMR:

Smar_0849

SHC:	Shell_1620

IHO:

Igni_0873

IPC:

IPA_00455

DKA:

DKAM_1334

DFD:	Desfe_1429

DMU:	Desmu_1325

TAG:

Tagg_1347

TCS:	IMZ38_00705

IAG:

Igag_1093

THG:	TCELL_0401

HBU:

Hbut_1036

PFM:	Pyrfu_1473

PDL:	Pyrde_1774

PABI:

PABY_18660(spn)

PARE:

PYJP_02370(glmU)

STO:

STK_04520

SOH:	D1869_02050

SJV:	SJAV_14560(spn)

SSO:

SOL:

SSOA:

SSOL:

SSOF:

SSHI:

SCAS:

SIS:	LS215_1492

SIA:	M1425_1397

SIM:	M1627_1447

SID:

M164_1391

SIY:	YG5714_1392

SIN:	YN1551_1451

SII:

SIH:

SIR:

SIC:

SULA:

SULE:

SAI:

SACN:

SACR:

SACS:

SULO:

SULL:

MSE:

MEMJ:

MCN:

MHK:	DFR87_06630

MPRU:

DFR88_06325

MTEN:

GWK48_05495

MJN:	MjAS7_0658

AHO:

AMAN:

ABRI:

ASUL:

AAMB:

ACIH:

SACD:

SAZO:

CSTY:

STEP:

SMET:

RQ359_000105(spn)

SAHS:

HS7_08090

ASC:

ASAC_1091

ACIA:

SE86_06590

CLG:	Calag_0445

FFO:	FFONT_0438

KCR:

Kcr_1379

CSU:	CSUB_C1499

BARC:

AOA65_1819(glmU_2)

BARB:

AOA66_1497(glmU_3)

FLT:	Sv326_0194

NCON:

LC1Nh_1149(glmU) LC1Nh_1150(glmU2)

NOCC:

SVXNc_0559(gcd1-2) SVXNc_0561(gcd1-3)

NHF:	HBNXNv_1157(glmU)

LOKI:

Lokiarch_02940(glmU_1) Lokiarch_26580(glmU_5)

LOB:	NEF87_000117 NEF87_001245

PSYT:

DSAG12_02719(glmU)

OYW:	OdinLCB4_001065

AGW:	QT03_C0001G0478 QT03_C0001G1263

» show all

Reference

PMID:29507091

Authors

Dadashipour M, Iwamoto M, Hossain MM, Akutsu JI, Zhang Z, Kawarabayasi Y

Title

Identification of a Direct Biosynthetic Pathway for UDP-N-Acetylgalactosamine from Glucosamine-6-Phosphate in Thermophilic Crenarchaeon Sulfolobus tokodaii.

Journal

J Bacteriol 200:e00048-18 (2018)
DOI:10.1128/JB.00048-18

Sequence

[sto:STK_04520]

Reference

PMID:20400541

Authors

Zhang Z, Akutsu J, Kawarabayasi Y

Title

Identification of novel acetyltransferase activity on the thermostable protein ST0452 from Sulfolobus tokodaii strain 7.

Journal

J Bacteriol 192:3287-93 (2010)
DOI:10.1128/JB.01683-09

Sequence

[sto:STK_04520]

Reference

PMID:18263721

Authors

Namboori SC, Graham DE

Title

Acetamido sugar biosynthesis in the Euryarchaea.

Journal

J Bacteriol 190:2987-96 (2008)
DOI:10.1128/JB.01970-07

Sequence

[mja:MJ_1101] [mmp:MMP1076]

All links

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