KEGG   Klebsiella pneumoniae PMK1: PMK1_02321
Entry
PMK1_02321        CDS       T03419                                 
Symbol
thrA
Name
(GenBank) Aspartokinase I/homoserine dehydrogenase I
  KO
K12524  bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
Organism
kpx  Klebsiella pneumoniae PMK1
Pathway
kpx00260  Glycine, serine and threonine metabolism
kpx00261  Monobactam biosynthesis
kpx00270  Cysteine and methionine metabolism
kpx00300  Lysine biosynthesis
kpx01100  Metabolic pathways
kpx01110  Biosynthesis of secondary metabolites
kpx01120  Microbial metabolism in diverse environments
kpx01230  Biosynthesis of amino acids
Module
kpx_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
kpx_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
kpx_M00018  Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:kpx00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    PMK1_02321 (thrA)
   00270 Cysteine and methionine metabolism
    PMK1_02321 (thrA)
   00300 Lysine biosynthesis
    PMK1_02321 (thrA)
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    PMK1_02321 (thrA)
Enzymes [BR:kpx01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.3  homoserine dehydrogenase
     PMK1_02321 (thrA)
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.2  Phosphotransferases with a carboxy group as acceptor
    2.7.2.4  aspartate kinase
     PMK1_02321 (thrA)
SSDB
Motif
Pfam: Homoserine_dh AA_kinase NAD_binding_3 ACT_7 ACT DUF6247
Other DBs
NCBI-ProteinID: AIT01786
UniProt: A0A086IN02
Position
2498188..2500650
AA seq 820 aa
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA
LPNIADAERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNA
ALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHYLESTVDIAESTRRIAASQIP
ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDDLPVKGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISF
CVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSLDYYHQLRHAASSSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSLSFIFGKLDEGVSFSAATAMA
REMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALPPDFDASGDVETFMA
RLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq 2463 nt   +upstreamnt  +downstreamnt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcggaacggtttctgcgggtt
gccgatattctggagagtaatgccaggcaggggcaggtagcgacggtcctgtctgccccg
gcgaagatcactaaccatctggtagcaatgattgaaaagaccattggcggccaggatgcc
ctccccaatattgccgacgccgaacgcatttttgccgaacttcttcagggccttgccgac
gcccagcccgctttcccgcttgcccagttaaaagccttcgtggagcaggaatttgctcag
attaagcatgttctgcacggcatcagcctgctgggtcagtgcccggacagcgtcaatgcc
gcgctgatctgccgcggcgaaaagctctccatcgccatcatggcgggtctgctggaagcc
cgtggacataaagtcagtgtcattaacccggtcgaaaaactgctcgccgtgggccactat
ctggaatccaccgtcgatatcgccgaatccacccgccgcattgccgccagccagatcccg
gcagaccatatgatcctgatggccgggtttaccgccggcaatgagaaaggcgagctggtg
gtgctggggcgtaacggctccgactactcggctgcggtactggccgcctgcctgcgcgct
gactgctgcgaaatctggaccgatgtcgacggagtgtacacctgcgatccgcgtcaggtg
ccggatgcgcgcctgctgaaatcgatgtcttatcaggaggcgatggagctctcctacttt
ggcgcgaaagtgctgcacccgcgcaccatcgcccctatcgcccagttccaaatcccatgc
ctgattaaaaataccggcaacccacaggcgccgggaacgcttatcggcgccagccgcgac
gaggacgatttgccggtgaaaggcatctctaacctcaacaacatggcgatgttcaacgtc
tccgggccggggatgaaagggatggtcggcatggcggcccgcgtcttcgccaccatgtcc
cgcgccggcatctcagtggtgttgatcactcaatcttcttcggagtacagcatcagtttc
tgcgtgccgcagagcgactgcgcacgtgccaaacgggcgatggaagatgagttttatctg
gagctgaaagaggggctgctggagccgctggcgattatggagcgtctggcgatcatctcc
gtggtgggcgacggaatgcgtaccctgcgcggtatctcggcgaaattctttgcggcactg
gcccgcgccaatatcaatatcgtggcgattgcccagggctcttccgagcgctcaatttcg
gtagtggtcagcaatgacgacgccaccaccggcgtgcgcgtgacccatcagatgctgttc
aacaccgaccaggtgattgaagtgtttgtcatcggcgtcggcggcgtcggcggcgcgctg
ctagagcagatcaagcgccagcaggggtggctgaagaacaaacatatcgatctgcgcgtc
tgcggtgtagccaattctcaggcgctgctgaccagcgtgcatggcctgaatctggaaaac
tggagtgcggaactggcggaggcgaaagagccgtttaatcttggccgcctgatccgcctg
gtgaaagagtaccacctgctcaatccggtgatcgtcgactgtacctccagccaggcggtc
gccgatcagtatgccgacttcctgcgcgaaggtttccatgtggtgacgccgaacaaaaag
gccaatacctcttcgctggattactatcaccagctgcgccatgcggccagcagctcgcgg
cgtaagttcctctatgacactaacgttggcgcgggcctgccggtgattgagaacctgcag
aacctgctcaacgccggcgatgagctgcgccatttctccgggatcctgtccggctccctg
tcgtttatcttcggcaagctggacgagggggtgagtttctccgcggcgacggcgatggcc
cgtgagatggggtataccgagccggatccgcgcgacgatttatccggggtggatgtggcg
cgtaaactgctgattctggcccgtgagaccgggcgtgaactggagctggcggacattatc
gtcgagtcggcgctgccgccggacttcgacgccagcggcgatgtcgagacctttatggcc
cgcctgccgtcgctggacgatggttttgcctcgcgggttgctaaggcgcgcgatgaaggt
aaagtcttgcgctacgtcggtaacatcgaagaggatggtacctgccgggtaaaaatagcc
gcggttgacggcaacgatccgctgttcaaagttaagaatggtgagaacgcgctggctttt
tatagccattattatcagccattgccgctggtgctgcgcggctatggcgccgggaacgac
gtcacggcggccggcgtattcgccgacctgctgcgcaccctgtcctggaagttaggagtt
taa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (13)   
   KEGG PATHWAY (8)   
   KEGG MODULE (5)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (6)   
   Pfam (6)   
All databases (42)   

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