KEGG   Loxodonta africana (African savanna elephant): 100661814
Entry
100661814         CDS       T04351                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic isoform X2
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav00670  One carbon pool by folate
lav01100  Metabolic pathways
lav01240  Biosynthesis of cofactors
Module
lav_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:lav00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    100661814 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:lav04147]
    100661814 (MTHFD1)
Enzymes [BR:lav01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     100661814 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     100661814 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     100661814 (MTHFD1)
Exosome [BR:lav04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   100661814 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH OCD_Mu_crystall
Other DBs
NCBI-GeneID: 100661814
NCBI-ProteinID: XP_010586987
Position
Unknown
AA seq 942 aa
MPEDRSPAARERGLGYNCVCRQIRERLKNQVTQMKEQVPGFTPGLAILQVGNRDDSNLYI
NVKLKAAEEIGIKATHTKLPRTATESEVLKCIISLNEDSTVHGLLVQLPLDSENPINTET
VINTIVPEKDVDGLTSISAGKLARGDLNDCFIPCTPKGCLELIKETGVQIAGRHAVVVGR
SKIVGAPMHDLLLWNNATVTTCHSKTANLDEEVSKGDILVVATGRPEMVKGEWIKPGAVV
IDCGINYVPDDTKPNGRKVVGDVAYNEAKERAGFITPVPGGVGPMTVAMLMQSTVESAKR
FLEKFKPGEWVIQYNSLNLKTPVPSDIDISRAYKPKPIGNLAREIGLLSEEVELYGETKA
KVLLSALERLRHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAYLHQNVFACVRQPS
QGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARMFHELTQTDK
ALFNRLVPSVNGVRKFSDIQIRRLRRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRV
LDTNDRFLRKITIGQAPTEKGYTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVAS
NKKGEPISAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADR
IALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATVRALKMHGGGPTV
TAGLPLPKAYAEENLELVEKGFSNLKKQIENAKLFGVPVVVAVNVFKTDTEAELDLVSRL
AKEHGAFDAVKCTHWAEGGKGALALANAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKI
YGADDIELLPEAQQKAEVYTKQGFGDLPICMAKTHLSLSHNPELKGVPKGFVLPIRDIRA
SVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETKQVNGLF
NT seq 2829 nt   +upstreamnt  +downstreamnt
atgcctgaagatcggtctcctgcagccagagaaaggggtctcggatacaactgcgtttgc
aggcaaataagggagagactgaagaaccaagtcactcagatgaaggagcaagtacctggg
ttcacaccaggcctagcaattttgcaggttggcaacagagatgattcaaatctttatata
aatgtgaagctgaaggctgctgaagagattgggataaaagccactcacactaagttacca
agaacagccacagaatccgaggtgttaaagtgcatcatatctttgaatgaagactccact
gtgcatggattgctagtgcagctccctttagactcagagaatcccattaacactgaaaca
gtgatcaataccattgtacccgaaaaggacgtggatggattgactagcatcagtgctgga
aaacttgctagaggtgacctaaatgactgtttcattccttgtacacctaaaggatgcttg
gaactcatcaaagagacaggggtgcagattgccggaaggcatgctgtggttgttgggcgc
agtaaaatagttggtgccccgatgcatgacttgcttctgtggaacaatgccacagtgacc
acttgccactcaaagactgccaatctggatgaggaggtaagtaaaggtgatatcctggtg
gttgcaactggtcggccagaaatggtgaaaggggagtggattaaacccggggcagtcgtc
atcgactgtggaatcaattatgttccagatgatacaaaaccgaacgggagaaaagttgtg
ggtgacgtggcatacaacgaggccaaagagagggcaggcttcatcacccctgttcctggc
ggtgtcgggcccatgacggtggcaatgctaatgcagagcacagtggagagtgcaaaacgt
ttcctggagaaatttaagccgggagagtgggtgattcagtataacagccttaacctcaag
acacctgtccctagtgacattgatatatcacgagcttacaaaccaaagcccattggtaac
ctggctcgagaaattggtctgctctctgaagaggtggaattgtatggtgaaaccaaggcc
aaggttctgctttcagcgctagaacgcctcaggcatcagcctgatggaaaatatgtggtg
gtgacgggaataactccaacacccctgggagaagggaaaagcacgacgacaattgggctg
gtacaagcccttggtgcctaccttcatcagaatgtatttgcgtgtgtacgacagccttct
cagggcccgacctttggaataaaaggtggcgctgcaggaggtggctactcgcaggttatt
cccatggaagagtttaatctccacctcacaggggacatccatgccatcactgcagctaat
aacctcgttgctgcagccatcgatgcccggatgttccatgaactgacacagacagacaag
gctctctttaatcgtttggtaccatcagtaaatggagtgagaaagttctctgatattcaa
attcgaaggctacggagactaggcattgaaaagaccgaccctaccacactgacagatgaa
gagataaacagatttgcaagactggatattgatccggaaaccataacttggcagagagtg
ttggataccaatgatagattcctgaggaagatcacaattggacaggctccaacggagaaa
gggtacacgcggacggcccagtttgatatctctgtggccagtgaaatcatggctgtcctg
gctctcaccacttctctagaagacatgagagagagactgggcaaaatggtggtagcttcc
aacaagaaaggggagcccatcagtgctgaagacctgggggtgagtggtgcattgacggtg
cttatgaaggatgctatcaagcccaacctcatgcagaccctggagggcactccagtgttt
gttcatgctggaccgtttgccaacattgcacatgggaattcctctatcatagcagaccgg
attgcactcaaacttgttggccctgaagggtttgtagtgactgaagcaggattcggagcc
gacattggaatggaaaagttttttaacatcaaatgccgatattctggtctccgccctcac
gttgtggtgcttgttgccactgtcagggctcttaaaatgcacgggggcggccccacggtc
acggctggactgcctctgcccaaggcttacgcagaggagaacctggagctggttgaaaaa
ggcttcagtaacttgaagaaacaaattgaaaacgccaaactcttcggagtcccggtagtg
gtggctgtgaatgtattcaagacggacacggaggctgagctggacctcgtcagccgcctt
gccaaagaacatggggcttttgatgctgtgaagtgcactcactgggcagaagggggcaag
ggagccttagccctggctaacgccgtccagagagcagcacaggcccccagcagcttccag
ctcctttatgacctcaagctcccagttgaggataagatcaggatcatcgcacagaaaatc
tacggggcagacgacattgaattgctccccgaagcccagcaaaaagccgaagtctacacg
aagcagggctttggggatctacccatctgcatggcgaaaacacacttgtccctgtctcat
aacccagagctaaaaggtgtgccgaaaggctttgtgctgcccatccgcgacatccgcgcc
agcgtgggggctggttttctgtaccccttagtaggaacgatgagcacgatgcctggactc
cccacccggccctgtttctatgatattgatttggaccctgaaaccaagcaggtgaatggg
ctcttctaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (4)   
   Pfam (4)   
All databases (49)   

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