KEGG   Loxodonta africana (African savanna elephant): 100671404
Entry
100671404         CDS       T04351                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X3
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav01521  EGFR tyrosine kinase inhibitor resistance
lav01522  Endocrine resistance
lav04010  MAPK signaling pathway
lav04012  ErbB signaling pathway
lav04068  FoxO signaling pathway
lav04270  Vascular smooth muscle contraction
lav04650  Natural killer cell mediated cytotoxicity
lav04720  Long-term potentiation
lav04726  Serotonergic synapse
lav04730  Long-term depression
lav04810  Regulation of actin cytoskeleton
lav04910  Insulin signaling pathway
lav04914  Progesterone-mediated oocyte maturation
lav04928  Parathyroid hormone synthesis, secretion and action
lav05010  Alzheimer disease
lav05022  Pathways of neurodegeneration - multiple diseases
lav05034  Alcoholism
lav05160  Hepatitis C
lav05161  Hepatitis B
lav05200  Pathways in cancer
lav05205  Proteoglycans in cancer
lav05208  Chemical carcinogenesis - reactive oxygen species
lav05210  Colorectal cancer
lav05211  Renal cell carcinoma
lav05212  Pancreatic cancer
lav05213  Endometrial cancer
lav05214  Glioma
lav05215  Prostate cancer
lav05218  Melanoma
lav05219  Bladder cancer
lav05220  Chronic myeloid leukemia
lav05221  Acute myeloid leukemia
lav05223  Non-small cell lung cancer
lav05224  Breast cancer
lav05225  Hepatocellular carcinoma
lav05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100671404 (ARAF)
   04012 ErbB signaling pathway
    100671404 (ARAF)
   04068 FoxO signaling pathway
    100671404 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100671404 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100671404 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100671404 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    100671404 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100671404 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100671404 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100671404 (ARAF)
   04720 Long-term potentiation
    100671404 (ARAF)
   04730 Long-term depression
    100671404 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100671404 (ARAF)
   05205 Proteoglycans in cancer
    100671404 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    100671404 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100671404 (ARAF)
   05212 Pancreatic cancer
    100671404 (ARAF)
   05225 Hepatocellular carcinoma
    100671404 (ARAF)
   05226 Gastric cancer
    100671404 (ARAF)
   05214 Glioma
    100671404 (ARAF)
   05221 Acute myeloid leukemia
    100671404 (ARAF)
   05220 Chronic myeloid leukemia
    100671404 (ARAF)
   05218 Melanoma
    100671404 (ARAF)
   05211 Renal cell carcinoma
    100671404 (ARAF)
   05219 Bladder cancer
    100671404 (ARAF)
   05215 Prostate cancer
    100671404 (ARAF)
   05213 Endometrial cancer
    100671404 (ARAF)
   05224 Breast cancer
    100671404 (ARAF)
   05223 Non-small cell lung cancer
    100671404 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100671404 (ARAF)
   05160 Hepatitis C
    100671404 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100671404 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100671404 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    100671404 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100671404 (ARAF)
   01522 Endocrine resistance
    100671404 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lav01001]
    100671404 (ARAF)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100671404 (ARAF)
Protein kinases [BR:lav01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100671404 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase C1_1 RBD Kinase-like zf-RING-like ABC1 Pkinase_fungal Kdo
Other DBs
NCBI-GeneID: 100671404
NCBI-ProteinID: XP_010596019
Position
Unknown
AA seq 572 aa
MSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTM
HNFVRKTFFSLVFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRHFYHSV
QDLSGVSRQHEAPSNHPLNELLTPLGPSLSTVSSRTQHRDPEHFFPAPANAPLQRIRSTS
TPNVHMVSTTAPTDSSLIQLTAQSFSTDAAGTRSGGDGAPRGNPSPASVSLGKKSPHSKS
PSEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVA
VKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHL
HVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVK
TRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGS
RDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSL
PKIERSASEPSLHRTQADELPACLLSAARLVP
NT seq 1719 nt   +upstreamnt  +downstreamnt
atgagtgtctacgactctctagacaaggcccttaaggtgcggggtctcaatcaagactgc
tgcgtggtctaccgactcatcaaggggcgaaagacggtcactgcctgggacactgccatt
gcccccctggatggcgaggagctcattgtcgaagtccttgaagatgtcccactgaccatg
cacaattttgtgcggaagacgttcttcagcctggtattctgtgacttctgtcttaagttt
ctgttccatggcttccgctgccaaacctgcggctacaaattccatcagcattgttcctcc
aaggtccccacagtctgtgtcgacatgagcaccaaccgccgacatttctaccacagtgtc
caggatttgtcaggagtctccagacagcacgaggctccctctaaccatcccctgaatgag
ctgctaacccccctgggtcccagcctttctactgtcagctcgcgcacccagcaccgcgac
cctgagcacttcttccctgccccggccaatgcccccctccagcgcatccgttccacgtcc
actcccaatgttcatatggtcagcaccacagcccccacagactccagcctcatccagctc
actgcccagagtttcagcactgatgctgctggtactagaagtggtggtgatggagccccc
cgggggaaccccagcccagctagcgtgtccttggggaagaagtctccacattccaagtca
ccttcagagcagcgggagcggaagtccttggctgatgacaagaagaaagtgaagaacctg
gggtaccgagattcaggctattactgggaggtgccacccagtgaagtgcagctgctgaag
aggattggaacgggctcatttggcactgtgtttcgtgggcggtggcatggtgatgtggct
gtaaaggtgctcaaggtggcccaacccacagctgagcaggcccaggccttcaagaatgag
atgcaggtgctcaggaagacacggcacgtcaacatcttgctgtttatgggcttcatgacc
cggccaggattcgccatcatcacacagtggtgtgagggctccagcctctaccaccatcta
catgtggctgacacacgcttcgacatggttcagctcatcgatgtggcccggcagactgcc
cagggcatggactacctccatgccaaaaacatcatccaccgagatctcaagtctaacaac
atcttcctacacgaggggctcacagtaaagattggtgacttcggcctggccacagtgaag
acgaggtggagtggagcccagcccttggagcagccctcgggctccgttctatggatggca
gctgaggtgatccggatgcaggacccgaacccctacagcttccagtcagatgtctacgcc
tacggggttgtgttgtatgagctcatgactggctcactgccttacagccacattggcagt
cgtgaccagattatctttatggttggccgtggctatctgtccccggacctcagcaaaatc
tccagcaactgccccaaggccatgcgtcgcctgctgtctgactgcctcaagttccagcgg
gaggagcgacccctcttcccacagatcctggccacgattgagctgctgcagcggtcactc
cccaagattgagaggagtgcctccgaaccgtccttgcaccgaacccaggctgatgagttg
cctgcctgcctactcagcgcagcccgccttgtgccttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (36)   
   KEGG PATHWAY (36)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (9)   
   Pfam (9)   
All databases (72)   

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