KEGG   Loxodonta africana (African savanna elephant): 100675525
Entry
100675525         CDS       T04351                                 

Gene name
ADCY4
Definition
(RefSeq) adenylate cyclase type 4
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav00230  Purine metabolism
lav01100  Metabolic pathways
lav01522  Endocrine resistance
lav04015  Rap1 signaling pathway
lav04020  Calcium signaling pathway
lav04022  cGMP-PKG signaling pathway
lav04024  cAMP signaling pathway
lav04062  Chemokine signaling pathway
lav04072  Phospholipase D signaling pathway
lav04114  Oocyte meiosis
lav04211  Longevity regulating pathway
lav04213  Longevity regulating pathway - multiple species
lav04261  Adrenergic signaling in cardiomyocytes
lav04270  Vascular smooth muscle contraction
lav04371  Apelin signaling pathway
lav04540  Gap junction
lav04611  Platelet activation
lav04713  Circadian entrainment
lav04714  Thermogenesis
lav04723  Retrograde endocannabinoid signaling
lav04724  Glutamatergic synapse
lav04725  Cholinergic synapse
lav04727  GABAergic synapse
lav04742  Taste transduction
lav04750  Inflammatory mediator regulation of TRP channels
lav04911  Insulin secretion
lav04912  GnRH signaling pathway
lav04913  Ovarian steroidogenesis
lav04914  Progesterone-mediated oocyte maturation
lav04915  Estrogen signaling pathway
lav04916  Melanogenesis
lav04918  Thyroid hormone synthesis
lav04921  Oxytocin signaling pathway
lav04923  Regulation of lipolysis in adipocytes
lav04925  Aldosterone synthesis and secretion
lav04926  Relaxin signaling pathway
lav04927  Cortisol synthesis and secretion
lav04928  Parathyroid hormone synthesis, secretion and action
lav04934  Cushing syndrome
lav04935  Growth hormone synthesis, secretion and action
lav04970  Salivary secretion
lav04971  Gastric acid secretion
lav04972  Pancreatic secretion
lav04976  Bile secretion
lav05032  Morphine addiction
lav05163  Human cytomegalovirus infection
lav05166  Human T-cell leukemia virus 1 infection
lav05200  Pathways in cancer
lav05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:lav00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    100675525 (ADCY4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100675525 (ADCY4)
   04371 Apelin signaling pathway
    100675525 (ADCY4)
   04020 Calcium signaling pathway
    100675525 (ADCY4)
   04072 Phospholipase D signaling pathway
    100675525 (ADCY4)
   04024 cAMP signaling pathway
    100675525 (ADCY4)
   04022 cGMP-PKG signaling pathway
    100675525 (ADCY4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    100675525 (ADCY4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100675525 (ADCY4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100675525 (ADCY4)
   04062 Chemokine signaling pathway
    100675525 (ADCY4)
  09152 Endocrine system
   04911 Insulin secretion
    100675525 (ADCY4)
   04923 Regulation of lipolysis in adipocytes
    100675525 (ADCY4)
   04912 GnRH signaling pathway
    100675525 (ADCY4)
   04913 Ovarian steroidogenesis
    100675525 (ADCY4)
   04915 Estrogen signaling pathway
    100675525 (ADCY4)
   04914 Progesterone-mediated oocyte maturation
    100675525 (ADCY4)
   04921 Oxytocin signaling pathway
    100675525 (ADCY4)
   04926 Relaxin signaling pathway
    100675525 (ADCY4)
   04935 Growth hormone synthesis, secretion and action
    100675525 (ADCY4)
   04918 Thyroid hormone synthesis
    100675525 (ADCY4)
   04928 Parathyroid hormone synthesis, secretion and action
    100675525 (ADCY4)
   04916 Melanogenesis
    100675525 (ADCY4)
   04925 Aldosterone synthesis and secretion
    100675525 (ADCY4)
   04927 Cortisol synthesis and secretion
    100675525 (ADCY4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100675525 (ADCY4)
   04270 Vascular smooth muscle contraction
    100675525 (ADCY4)
  09154 Digestive system
   04970 Salivary secretion
    100675525 (ADCY4)
   04971 Gastric acid secretion
    100675525 (ADCY4)
   04972 Pancreatic secretion
    100675525 (ADCY4)
   04976 Bile secretion
    100675525 (ADCY4)
  09156 Nervous system
   04724 Glutamatergic synapse
    100675525 (ADCY4)
   04727 GABAergic synapse
    100675525 (ADCY4)
   04725 Cholinergic synapse
    100675525 (ADCY4)
   04723 Retrograde endocannabinoid signaling
    100675525 (ADCY4)
  09157 Sensory system
   04742 Taste transduction
    100675525 (ADCY4)
   04750 Inflammatory mediator regulation of TRP channels
    100675525 (ADCY4)
  09149 Aging
   04211 Longevity regulating pathway
    100675525 (ADCY4)
   04213 Longevity regulating pathway - multiple species
    100675525 (ADCY4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100675525 (ADCY4)
   04714 Thermogenesis
    100675525 (ADCY4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100675525 (ADCY4)
  09165 Substance dependence
   05032 Morphine addiction
    100675525 (ADCY4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    100675525 (ADCY4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100675525 (ADCY4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100675525 (ADCY4)
   05163 Human cytomegalovirus infection
    100675525 (ADCY4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100675525 (ADCY4)
Enzymes [BR:lav01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     100675525 (ADCY4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N CD52
Other DBs
NCBI-GeneID: 100675525
NCBI-ProteinID: XP_010598850
Position
Unknown
AA seq 1075 aa
MAGLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLVIVLCALVALFAVSWASGRELASDPG
FLTTVVCALGGFSLLLGLASCEQRLQRWTRPLSGLVWAALLALGHGFLFTGGVVSAWDQV
SFFLFVIFTVYAMLPLGMRDAAAAGLVSSLSHLLALGLYLGPQPDSRPALLPQLVANAVL
FLCGNVAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
AYAVEDAAMEHRDPYLRELGEPTYLVIDPRAEEDEKGTAGGLLSSLEGPKMRPSLLMTRY
LESWGAAKPFAHLSHIDSPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDDELDTGDAKF
FQVIEQLNSQKQWKQSKDFNPLTLYFRKKEMEKEYRLSALPAFKYYAACTFLVFLSNFII
QMLVTNRPPALAITYSITFLLFLLLLFVCFSEHLTRCVLKGPKMLHWLPALSGLVATRPG
LRVALGTATLKPLSPYLLLQFLLPASSNCPFRAANVSAMAFNLSWELPGSLPLISVPYSM
HCCVLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSDCLIARLYMGSLDSRP
GVLKEPKLMGVISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLL
ENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLL
NEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEF
AVALGCKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGV
LGKIQVTEETARALQSLGYTCYRRGIIKVKGKGQLCTYFLNTDLTRAGPPSATLG
NT seq 3228 nt   +upstreamnt  +downstreamnt
atggccggcctcttcagtcctcggccgccccccagcgaagacctcttctacgagacctac
tacagcctaagccagcagtacccgctgctgctactgctgctggtaatcgtgctctgcgcg
ctggtggcgctgttcgccgtctcctgggccagcggcagggagctggcctctgacccgggc
ttcctgaccaccgtggtgtgcgcactgggcggcttctcgctgctgctggggctggcttcc
tgcgagcagcgactgcagcgctggacgcgtcccctgtctggcctggtgtgggccgcgctg
cttgcgctaggccacggcttcctattcaccgggggcgtggtcagtgcttgggaccaggtg
tccttctttctcttcgttatcttcacggtgtacgccatgttgcccctgggtatgcgggac
gccgccgccgcgggcctcgtctcctcactctctcacctgcttgcccttggactgtacctt
gggccccagccagactcacggccagcgctgctgccccagctagtggcaaatgcggtgctg
ttcctgtgcgggaacgtggctggagcgtaccacaaggcgctgatggagcgcgcgctgcgt
gccacgttccgggaggcgctcagctccctacactcacgccggcggctggacaccgagaag
aagcaccaggaacaccttctcttgtccatccttcctgcctacctggcccgagagatgaag
gcagagatcatggcccggctgcaggctggacaggggtcacggcctgagagcaccaacaat
ttccacagcctctatgtcaagaggcaccagggagtcagcgtgctgtatgcggacatagtg
ggcttcacacgactagccagcgagtgctcccccaaggagctggtgctcatgctcaatgaa
ctctttggcaagttcgaccagattgccaaggagcatgagtgcatgcggatcaagattctg
ggagactgttactactgtgtctctgggttgcccctctccttgccagaccatgccatcaac
tgtgtgcgcatggggctggacatgtgccgggccatcaggaaacttcgggcagccaccggc
gtggacatcaacatgcgtgtgggcgtgcactcgggcagtgtgctctgtggagtcattggc
ttgcagaaatggcaatatgatgtctggtcccatgatgtcaccctggccaaccacatggag
gcaggcggtgtgccaggacgagtgcacatcacaggggccaccctggccctgctggcaggg
gcttatgctgtggaggatgcagccatggaacaccgggacccataccttcgggagctaggg
gagcctacctacctggtcatcgatccccgggctgaggaggatgagaagggcactgcagga
gggttgttgtcctctctggagggccccaagatgcgtccatcactgctgatgacccgctat
ctggagtcctggggtgcagccaagccttttgctcacctgagccacatagacagccctgta
tccacctccacccctctcccggagaaggccctagcttccttcagcccccagtggagcctg
gaccggagccgtaccccccggggactagatgatgaactagacactggggatgccaagttc
ttccaggtcatcgagcagctcaactctcagaaacagtggaaacaatcgaaggatttcaac
ccactgacactgtacttcagaaagaaggagatggagaaggagtaccggctctctgcactc
cccgccttcaaatactatgcagcctgcaccttcctggtttttctctccaatttcatcatc
cagatgctggtgacaaacaggcctccagctctggccatcacctatagcatcaccttcctc
ctcttcctcctcctcctctttgtctgcttctcagagcacctgacgaggtgtgtcctgaaa
ggccccaagatgctgcactggctgcctgcactgtctggcctggtggccacgcggcccggc
ttgcgagtcgccctgggcacggccacccttaagcccttatctccttatctcctactgcag
ttcctcttaccagcatcatccaactgccctttccgggctgccaatgtgtccgccatggct
ttcaacctctcctgggagcttcctgggtccttgcctctcatcagtgtcccgtactccatg
cactgctgtgttctgggtttcctctcctgctcccttttcctacacatgagcttcgaattg
aagctgctgctgctcctgctgtggctggcagcctcctgctccctcttcctgcactcccat
gcctggctgtctgactgcctcatcgcccgcctctatatgggttccttggactccaggcca
ggggtgctgaaggagcccaaactgatgggagtcatctctttcttcatctttttcttcacc
ctcctcgtcctggctcggcagaatgagtattactgccgcctggacttcctgtggaagaag
aagctgaggcaggagagagaagagacagagacaatggagaaccttactcggctgctcttg
gagaatgtgctccctgcacacgtggccccccagttcattggccaaaaccggcgcaatgag
gacctctaccaccagtcctatgagtgtgtttgtgtcctcttcgcctcagtcccggacttc
aaggagttttactctgaatccaacatcaaccacgaggggctggagtgtctgcgactgctc
aacgagataattgctgattttgatgagctgctctccaagcccaagttcagtggggtagag
aaaatcaaaaccatcggcagcacctacatggcagccacaggtttaaatgccacctctgga
caggatgcacagcaggatgctgaacgaagttgcagccaccttggcaccatggtggaattt
gcagtggctctggggtgtaaactggatgtcatcaacaagcactcattcaacaacttccgc
ctgcgtgtggggttgaaccatggaccagtagtggctggtgtgattggagcccaaaagcca
caatatgacatctggggcaacacagtgaatgtggccagccgcatggagagtacaggggtc
ctgggcaagatccaagtgactgaggagacagcccgggccctgcaatccctgggctatacc
tgctacaggcggggcatcatcaaagtcaaaggcaaagggcagctttgcacatactttctg
aacacagacttaacacgcgctggacccccctcagccaccctaggctaa

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