KEGG   Loxodonta africana (African savanna elephant): 100676827
Entry
100676827         CDS       T04351                                 
Symbol
DPYD
Name
(RefSeq) dihydropyrimidine dehydrogenase [NADP(+)]
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav00240  Pyrimidine metabolism
lav00410  beta-Alanine metabolism
lav00770  Pantothenate and CoA biosynthesis
lav00983  Drug metabolism - other enzymes
lav01100  Metabolic pathways
Module
lav_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
KEGG Orthology (KO) [BR:lav00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    100676827 (DPYD)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    100676827 (DPYD)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    100676827 (DPYD)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    100676827 (DPYD)
Enzymes [BR:lav01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     100676827 (DPYD)
SSDB
Motif
Pfam: DHO_dh Fer4_20 Fer4_21 Pyr_redox_2 Dus NAD_binding_8 Fer4_7 Fer4_10 Pyr_redox_3 Pyr_redox Fer4_6 Fer4_9 Fer4_2 FAD_oxidored Fer4
Other DBs
NCBI-GeneID: 100676827
NCBI-ProteinID: XP_010596386
UniProt: G3SP95
Position
Unknown
AA seq 1025 aa
MAPVLSKDAADIESILALNPRTQTHATLRSTAAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMNIPQIRNPSLPPPE
KMPEAYSAKIALFGGGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VDFEIELMKDLGVKIICGKSLSVNEMTLNTLKEEGYKAAFIGIGLPEANKDRIFEGLTQD
QGFYTSKDFLPLVAKGSKPGMCACHSPLPSIRGAVIVLGAGDTAFDCATSALRCGACRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVVVKGGRIVAMQFVRTEQDETGKWN
EDDDQIVHLKADVVISAFGSVLSDPKVKEALSPIKFNKWDLPEVDPETMQTSEPWVFAGG
DIVGMANTTVESVNDGKQASWHIHKYIQSQYGASVSAKPELPLFCTPIDLVDISVEMAGM
KFTNPFGLASATPATSASMIRRAFEAGWGFAVTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKAEFPDNIVIASIMCSYNKNDWMELSKMAEHS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVHVPFFAKLTPNVTDIVSI
ARAAKEGGADGVTATNTVSGLMGLNADGTPWPAVGVGKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPVLATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIGDYCTGLKALLYL
KSIEELQDWDGQSPATVRHQKGKPVPQIAELTGKKLPSFGPYLEQRKKIIAENKIRLKEQ
NAAFSPLERKYFVPKKPIPAIKDVIGKALKYLGMFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTVTDSCTGCTLCLSVCPIIDCIRMVSRTTPYEPKRGLPLA
VNPVC
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggcccctgtgcttagcaaggacgcggctgacatcgagagcatcctggctttaaatcct
cgaacacagactcatgcaactctgcgttctactgccgccaaaaaattagacaagaagcat
tggaaaagaaaccctgataagaactgctttaattgtgagaagctagagaataattttgat
gacatcaagcacacgactcttggtgagcgaggggctctccgagaagcaatgagatgcttg
aaatgtgcagatgctccctgtcagaagagctgcccaactaatctggacatcaaatcgttc
atcacaagtattgcaaacaagaattattatggagctgctaagatgattttttctgacaac
ccacttggtctgacttgtggaatggtatgtccaacctctgacctttgcgtaggtggatgc
aatttatatgctactgaagagggaccaattaatattggtggattacagcagtttgctact
gaggtgttcaaagcaatgaatatcccacaaatcagaaatccttctctgcctcccccagaa
aaaatgcctgaagcctattctgcaaagattgctctttttggtggtgggcctgcaagtata
agttgtgcttcctttttggctcgattaggctactctgacatcactatatttgaaaaacaa
gaatatgttggtggtttaagtacatctgaaatccctcaattccggctgccgtatgatgtt
gtggattttgaaattgagcttatgaaggaccttggtgtaaagataatttgtggtaaaagc
ctctcagtgaatgaaatgactcttaatactttgaaagaggaaggctacaaagctgctttc
attggaattggtctgccagaagcaaataaagaccgcatctttgaaggcctgacgcaggac
cagggattttacacatccaaagactttttgccacttgtagctaaaggcagtaaaccagga
atgtgcgcctgtcactctccattgccatcgatacggggagcagtgattgtactcggagct
ggagacactgcctttgactgtgcaacatccgctttacgttgtggagcctgccgcgtgttc
atcgtcttcagaaaaggctttgttaatataagagctgtcccagaggagatggagcttgct
aaggaagaaaagtgtgaatttttgccttttctctccccacgcaaggttgtagtaaaaggt
gggagaattgttgctatgcaatttgttcggacagagcaagatgaaactggaaaatggaat
gaagacgacgatcagatagtccatctgaaagccgatgtggtcatcagtgcctttggctca
gtgctgagtgatcctaaagtaaaagaagccttgagtcctataaagtttaacaaatgggat
ctcccagaagtagatccagaaactatgcaaaccagcgaaccatgggtatttgcaggtggc
gatattgttggtatggctaacactacagtggaatcggtgaatgacggaaagcaggcttct
tggcacattcataaatacatacagtcacaatatggagcttcggtttctgccaaacctgaa
ctgcccctcttttgcactcctattgatctggtggacattagcgtggaaatggctggaatg
aagtttacaaatccttttggtcttgctagtgcaactccagctaccagtgcatctatgatt
cgaagagcgtttgaagctggatggggtttcgctgtgaccaaaactttctcccttgataag
gacattgtgaccaatgtttcacccagaatcatccgggggaccacctctggccccatgtat
ggccctggacaaagctccttcctgaatattgagctcatcagtgagaaaacggctgcatat
tggtgtcaaagtgtcaccgaactaaaggctgaatttccagacaatattgtgattgctagc
atcatgtgcagttacaacaaaaatgactggatggagctctccaaaatggctgagcactct
ggagcagatgccctggagttaaatttatcatgtccacatggcatgggagaaagaggaatg
ggcctggcttgtggacaggatccagagctggtgcggaacatctgtcgctgggttaggcaa
gctgttcacgttcctttttttgccaagttgaccccaaatgtcactgatattgtaagcatc
gcaagagctgcaaaggaaggtggtgcagacggtgttacagccaccaacactgtctcaggt
ctgatgggattaaatgctgatggcacgccttggccggcagtgggcgttggaaagcggacc
acatatggtggagtgtctgggacagctatcagacccattgctttgagagccgtcacctcc
attgctcgtgctttgcctggatttcccgttttagccactggtggaatagactcagctgaa
agtgggctccagtttctccacagtggtgcttcagtcctacaggtatgcagtgctattcag
aatcaggatttcactgtaatcggtgactactgcactggcctcaaagcccttctttatctg
aaaagcattgaagaactgcaagactgggatgggcagagtccagccaccgtgcgtcaccag
aaagggaagccagttccacagattgctgaactcaccgggaagaaactgccaagttttgga
ccttaccttgagcagcgcaagaaaatcatagcagagaacaagattagactgaaggagcaa
aatgcagctttttcaccacttgaaagaaaatattttgtccccaaaaagcctattcctgcc
atcaaggatgtaattggaaaagcactgaagtaccttggaatgtttggtgaacttagcaac
gtagagcaagttgtggccatgatcgatgaagaaatgtgtatcaactgtggtaaatgctac
atgacctgcaatgactctggctaccaggctatacaatttgatccagaaacccacctgccc
accgttactgactcgtgtacaggctgtactctgtgtctcagcgtctgccctattatcgac
tgcatcagaatggtttccaggacaacaccttatgaaccaaagagaggcttacccttagct
gtgaatccagtgtgttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (15)   
   Pfam (15)   
All databases (59)   

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